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Jee-youn Shim,Yoo Jung Kim,Hye-Sung Lee 대한지역사회영양학회 2008 Nutrition Research and Practice Vol.2 No.4
The present study evaluated the effects of various dosages of soybean isoflavone extract on lipid profiles, lipid peroxidation and antioxidant activities in streptozotocin-induced diabetic rats. The one normal control group was fed an AIN-76-based experimental diet and four diabetic groups were fed the same diet, supplemented with four different levels of soybean isoflavone extract for seven weeks. The daily dosages of pure isoflavone for four diabetic groups were set to be 0 ㎎ (diabetic control), 0.5 ㎎ (ISO-Ⅰ), 3.0 ㎎ (ISO-Ⅱ) and 30.0 ㎎ (ISO-Ⅲ) per kilogram of body weight, respectively. The plasma total cholesterol levels and the TBA-reactive substances contents in the liver and kidney were significantly lowered in ISO-Ⅱ and ISO-Ⅲ groups compared to those in the diabetic control group. The levels of plasma HDL-cholesterol, plasma vitamin A and hepatic superoxide dismutase were significantly increased in those two groups compared with the diabetic control group. The present study demonstrated the possibility that the diets supplemented with 3.0 ㎎ and 30.0 ㎎ of soybean isoflavone extract may have beneficial effects on the plasma lipids, tissue lipid peroxidation and partly on antioxidant system in diabetic animals and there were no significant differences between the ISO-Ⅱ and ISO-Ⅲ groups. The results suggest that the effective daily dosage level of isoflavone for improving lipid metabolism in diabetic rats may be above 3.0 ㎎ per kilogram body weight.
Jee-Youn Shim,Kwang-Ok Kim,Bo-Hyun Seo,Hye-Sung Lee 한국영양학회 2007 Nutrition Research and Practice Vol.1 No.4
The present study evaluated the effect of various dosages of soybean isoflavone extract on body weight changes, glucose tolerance and liver function in streptozotocin-induced diabetic rats. One group of normal rats (normal control) was fed an AIN-76-based experimental diet and four groups of diabetic rats were fed the same diet supplemented with four different levels of soybean isoflavone extract for seven weeks. The daily dosages of pure isoflavone for four diabetic groups were set to be 0 ㎎ (diabetic control), 0.5 ㎎ (ISO-I), 3.0 ㎎ (ISO-Ⅱ) and 30.0 ㎎ (ISO-Ⅲ) per kilogram of body weight, respectively. The daily consumption of isoflavone at the level of 3.0㎎ per kilogram of body weight resulted in the suppression of body weight loss and increased the survival rate of diabetic animals one and half times compared to that of the diabetic control group. Blood glucose levels in a fasting state and after the oral administration of glucose were significantly lower in the ISO-Ⅱ group during the oral glucose tolerance test. The ISO-Ⅱ group showed a tendency to elongate the gastrointestinal transit time. The activity of serum aminotransferases, indicator of liver function, was not negatively affected by any intake level of isoflavone. The present study demonstrated that the soybean isoflavone extract may be beneficial to diabetic animals by improving their glucose tolerance and suppressing weight loss without incurring hepatotoxicity at the daily dosage of 3.0 ㎎ per ㎏ of body weight.
( Jee Youn Oh ),( Kyung Hoon Min ),( Jae Kyeom Sim ),( Gyu Young Hur ),( Sung Yong Lee ),( Jae Jeong Shim ),( Kyung Ho Kang ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Smoke is a mixture of heated particles and gases, and smoke inhalation occurs when a person breathe in the products of combustion. Smoke inhalation lung injury can occur by lack of oxygen, chemical/thermal irritation, and chemical asphyxiation. We report a case of acute smoke inhalation lung injury after accidently boiling soup overnight. The patient was 34-year-old woman, and she was referred to our hospital with dyspnea and chest tightness. She was a non-smoker and had no other past medical history. The day before visit, she started boiling soup and then accidently fell asleep, so all the stuffs on the pot were burned out. She got up after 4 hours and started to feel dyspnea, chest tightness and headache. She was alert and her vital signs were stable. Breathing sounds were course with crackle on pulmonary auscultation. Initial blood gas analysis showed pH 7.44, PCO2 36.1mmHg, PO2 65.8mmHg, HCO3 24mmol/L, and SaO2 93%. Electrocardiography showed sinus tachycardia. Carbon monoxide hemoglobin level was 1.8%. Initial chest radiograph showed opacities in both lung fi elds. A chest computed tomography scan showed poorly defi ned consolidation and ground glass opacities in both upper lung, right middle lung and right lower lung fi eld. After 1 day, opacities in both lung on chest radiography decreased, and after 2 days, opacities dissapeared. In conclusion, we report a case of acute inhalation lung injury after accidently boiling soup overnight which was relieved after 2 days without any specifi c treatment except oxygen supply.
Osteoporosis in Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome
( Jee Youn Oh ),( Young Seok Lee ),( Kyung Hoon Min ),( Sung Yong Lee ),( Jae Jeong Shim ),( Kyung Ho Kang ),( Gyu Young Hur ) 대한결핵 및 호흡기학회 2018 Tuberculosis and Respiratory Diseases Vol.81 No.1
Background: Osteoporosis is a common disease that occurs comorbidly in patients with chronic inflammatory airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap syndrome (ACOS). However, the prevalence of osteoporosis in patients with ACOS has not widely been evaluated. Therefore, we investigated the prevalence of osteoporosis and its relationship with the clinical parameters of patients with asthma, COPD, and ACOS. Methods: This was a retrospective, cross-sectional study. Bone mineral density (BMD), lung function tests, and disease status evaluations were conducted. Results: A total of 321 patients were enrolled: 138 with asthma, 46 with ACOS, and 137 with COPD. One hundred and ninety-three patients (60.1%) were diagnosed with osteoporosis (53.6% of asthma, 65.2% of ACOS, and 65.0% of COPD). Patients with ACOS showed a significantly lower BMD and T-score than did those with asthma. In addition to age, sex, and body mass index (BMI), which were previously reported to be associated with BMD, BMD also had a negative correlation with the diagnosis of ACOS, as compared to a diagnosis of asthma, after adjusting for age, sex, BMI, smoking, and inhaled corticosteroid use (p=0.001). Among those patients with COPD and ACOS, BMD was negatively associated with the COPD Assessment Test (CAT) after adjustment (p<0.001). Inhaled corticosteroid was not associated with the prevalence of osteoporosis and BMD. Conclusion: Patients with ACOS, particularly aged and lean women, should be more carefully monitored for osteoporosis as compared to patients with asthma.
( Jee Youn Oh ),( Jae Kyeom Sim ),( Kyung Hoon Min ),( Gyu Young Hur ),( Jae Jeong Shim ),( Kyung Ho Kang ),( Sung Yong Lee ) 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
The programmed death-1 (PD-1) mediates tumor-induced immune suppression. Expression of mutant EGFR in bronchial epithelial cells induces PD-1 ligand (PD-L1) and PD-L1 expression is reduced by EGFR inhibitors in lung cancer cell lines with activated EGFR. Thus, we compared the levels of PD-1 in peripheral blood according to stage and tyrosine kinase inhibitor(TKI) treatment response in lung cancer patients. Blood samples of lung cancer were obtained from Korea university guro hospital, and additional samples were done for patients with EGFR mutant adenocarcinoma after EGFR TKI treatment. Flow cytometry was used to detect PD-1 expression. Total 40 patients were enrolled for relationship of stage and PD-1, and among them 7 patients were EGFR mutant and treated with EGFR TKI. The expression levels of CD8+PD-1+ cells in Stage I/II patients tended to be lower than stage III/IV (0.18±0.19% vs. 0.90±1.18%, P=0.09). For patients treated with EGFR TKI, expression levels of CD8+PD-1+ cells significantly decreased after TKI treatment (1.85±1.56% vs. 0.77±0.83%, P=0.02). Post/pre TKI treatment ratio of CD8+PD-1+ cells expression was lower in partial response (n=3) than stable disease (n=4) (0.15±0.10 vs. 0.67±0.25, P=0.04). We confirmed the role of PD-1 of immune escape and tumor development by comparing levels of peripheral blood according to stage. We also verified that EGFR mutant lung tumor inhibited antitumor immunity by activating PD-1 and PD-1 expression was reduced by EGFR TKI, which was proportional to treatment response. Further large studies should be followed.
Poster Session 2 : Cloning of Xenopus Laevis TRPV2 by gene prediction
( Shim Won Sik ),( Lee Jung Youn ),( Yang Young Duk ),( Seung Pyo Park ),( Heo Jee Yeon ),( Yun Jong Lee ),( Sang Hee Lee ),( Yong Woo Jang ),( Mi Hyun Lee ),( Mi Sook Kim ),( Byung Moon Kim ),( Uh Ta 한국생화학분자생물학회 (구 한국생화학회) 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-
( Jee Youn Oh ),( Kyung Hoon Min ),( Jae Kyeom Sim ),( Gyu Young Hur ),( Sung Yong Lee ),( Jae Jeong Shim ),( Kyung Ho Kang ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Smoke is a mixture of heated particles and gases, and smoke inhalation occurs when a person breathe in the products of combustion. Smoke inhalation lung injury can occur by lack of oxygen, chemical/thermal irritation, and chemical asphyxiation. We report a case of acute smoke inhalation lung injury after accidently boiling soup overnight. The patient was 34-year-old woman, and she was referred to our hospital with dyspnea and chest tightness. She was a non-smoker and had no other past medical history. The day before visit, she started boiling soup and then accidently fell asleep, so all the stuffs on the pot were burned out. She got up after 4 hours and started to feel dyspnea, chest tightness and headache. She was alert and her vital signs were stable. Breathing sounds were course with crackle on pulmonary auscultation. Initial blood gas analysis showed pH 7.44, PCO2 36.1mmHg, PO2 65.8mmHg, HCO3 24mmol/L, and SaO2 93%. Electrocardiography showed sinus tachycardia. Carbon monoxide hemoglobin level was 1.8%. Initial chest radiograph showed opacities in both lung fields. A chest computed tomography scan showed poorly defined consolidation and ground glass opacities in both upper lung, right middle lung and right lower lung field. After 1 day, opacities in both lung on chest radiography decreased, and after 2 days, opacities dissapeared. In conclusion, we report a case of acute inhalation lung injury after accidently boiling soup overnight which was relieved after 2 days without any specific treatment except oxygen supply.
Jee, Seung W,Cho, Jung S,Oh, Jae H,Shim, Sun B,Hwang, Dae Y,Lee, Su H,Song, Youn S,Lee, Seok H,Kim, Yong K UNKNOWN 2005 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.16 No.4
<P>cDNA microarray technique has been widely used for the detection and elucidation of differentially expressed genes on a large scale and at a speed never before possible. The aim of this study was to gain insight into the potentially overexpressed effects of APPsw on the modulation of genes for Alzheimer's disease (AD), which is central to understanding the complexity of AD. APPsw transgenic mice, which we previously produced, provide an important resource for identifying differentially expressed genes since this transgenic line was shown to have cognitive deficits along with Abeta-42 deposits at 12 months of age. To identify differentially expressed genes, cDNA microarray technique was conducted to get a large-scale screening of brain mRNA from 18 month-old NSE/APPsw transgenic and non-transgenic mice. A total of 52 differentially expressed genes, 10 up-regulated and 42 down-regulated, were found in the brains of moderately transgenic mice compared to non-transgenic littermates. Thus, the results suggest the need for future studies on gene functions, pathology, toxicogenomics, and pharmacogenomics.</P>