Is It Possible to Delay or Prevent Age-Related Cognitive Decline?

Jean-Pierre Michel 대한가정의학회 2016 Korean Journal of Family Medicine Vol.37 No.5

Already in the 90s, Khachaturian stated that postponing dementia onset by five years would decrease the preva-lence of the late onset dementia by 50%. After two decades of lack of success in dementia drug discovery and devel-opment, and knowing that worldwide, currently 36 million patients have been diagnosed with Alzheimer’s disease, a number that will double by 2030 and triple by 2050, the World Health Organization and the Alzheimer’s Disease International declared that prevention of cognitive decline was a ‘public health priority.’ Numerous longitudinal studies and meta-analyses were conducted to analyze the risk and protective factors for dementia. Among the 93 identified risk factors, seven major modifiable ones should be considered: low education, sedentary lifestyle, midlife obesity, midlife smoking, hypertension, diabetes, and midlife depression. Three other important modifi-able risk factors should also be added to this list: midlife hypercholesterolemia, late life atrial fibrillation, and chronic kidney disease. After their identification, numerous authors attempted to establish dementia risk scores; however, the proposed values were not convincing. Identifying the possible interventions, able to either postpone or delay dementia has been an important challenge. Observational studies focused on a single life-style interven-tion increased the global optimism concerning these possibilities. However, a recent extensive literature review of the randomized control trials (RCTs) conducted before 2014 yielded negative results. The first results of RCTs of multimodal interventions (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability, Multidomain Alzheimer Prevention Study, and Prediva) brought more optimism. Lastly, interventions targeting compounds of beta amyloid started in 2012 and no results have yet been published.

Identification of the Best Societal Measurement of Healthy Aging

Jean-Pierre Michel 대한노인병학회 2019 Annals of geriatric medicine and research Vol.23 No.2

Almost six decades after the first proposals to define and evaluate the quality of individual aging, the first indexes for assessing the aging process at the societal level have ap-peared. Moreover, in five years, three different scores for measuring societal aging have been developed and tested in different areas. The Global AgeWatch Index focused on 96 countries from around the world, while the Active Ageing index is limited to the European Union countries and the Ageing Society Index targets Organization for Economic Co-oper-ation and Development countries. This paper analyzed and compared the results of these three indexes. The rankings vary little at the bottom end of the scale, with the same coun-tries consistently ranked among the lowest scores (for example, Poland ranked last among the European countries in the three indexes). The same is true at the top of the rankings, with Sweden, the Netherlands, and Ireland consistently among the high-scoring countries. However, the three indices tend to differently rank the countries in the middle. The United States, for example, is ranked ninth in the Global Age Watch 2015 and third in the Age-ing Societal Index 2018. In cases in which the results are not consistent, it is difficult for politicians and policymakers to adequately identify needs and orient the policy to promote active and healthy aging. There is clearly a compelling need for wide-scale debate to reach a consensus on a comprehensive score or index at the societal level.

Lactose Sensitivity and Lactose Malabsorption: The 2 Faces of Lactose Intolerance

( Michel Bouchoucha ),( Marinos Fysekidis ),( Pierre Rompteaux ),( Jean-jacques Raynaud ),( Jean-marc Sabate ),( Robert Benamouzig ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.2

Background/Aims Self-reported lactose intolerance (LI) is frequent in patients with functional bowel disorders (FBD) that could be interpreted as irritable bowel syndrome (IBS). The present study aims to characterize the responses of patients with FBD, without small intestinal bacterial overgrowth (SIBO), and LI, in terms of lactose malabsorption (LM) and lactose sensitivity (LS) according to psychological and clinical features. Methods One hundred and fifty-eight consecutive FBD outpatients with LI, and no SIBO, were classified according to the Rome III questionnaire and filled Beck Depression Inventory, and State and Trait Anxiety questionnaires. They underwent a lactose tolerance test in which glycemia during 60 minutes and digestive symptoms for 3 hours were recorded. Results Abnormal lactose tolerance tests were found in 110 patients (70%), 44 (28%) with LM, 96 (61%) with LS, and 30 (19%) having both LM and LS. LM patients had a higher frequency of functional diarrhea (P = 0.040) and a lower frequency of dysphagia (P = 0.031). LS patients had a higher depression score (P = 0.007), higher frequency of globus (P = 0.042), irritable bowel syndrome (IBS) (P = 0.027) and mixed IBS (P = 0.049), and lower frequency of abdominal pain (P = 0.040). LS was significantly associated with a higher depression score (P = 0.002), and a higher frequency of globus (P = 0.046). Conclusions Thirty percent of LI patients have normal lactose absorption and normal LS. In the other 70% of patients, LI could be associated with LM and/or LS. (J Neurogastroenterol Motil 2021;27:257-264)

Influence of Age and Body Mass Index on Total and Segmental Colonic Transit Times in Constipated Subjects

Michel Bouchoucha,Marinos Fysekidis,Pierre Rompteaux,Gheorge Airinei,Jean-Marc Sabate,Robert Benamouzig 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.2

Background/Aims Discordant data are found in the literature for the relationships between total and segmental colonic transit time (CTT) and demographic parameters. The aim of this study is to examine the influence of age, and body mass index (BMI) on total and segmental CTT in constipated subjects. Methods We included 354 constipated patients on this cross-sectional study. According to the Rome III criteria, patients were classified as having irritable bowel syndrome with constipation, or functional constipation. All patients filled the Bristol stool form, and reported the severity of constipation, bloating, and abdominal pain on a 10-point Likert scale. Total and segmental CTT were measured using radiopaque markers. Results Females were 84% of patients, with a mean age of 46.0 ± 15.9 years. The association between total and segmental CTT with age and BMI was significant after adjustment for gender, clinical phenotype, the presence of defecation disorders, and abdominal pain or bloating intensity despite the severity of symptoms, and the frequency of defecation disorders were higher in irritable bowel syndrome with constipation than in functional constipation patients. By comparison with subjects less than 30 years, rectosigmoid transit time (RSTT) was lower in patients between 30 and 60 years. Age was negatively associated with RSTT (P = 0.004). By comparison with patients with normal BMI, RSTT and total CTT were lower in patients of the overweight group. BMI was negatively associated with RSTT (P < 0.001). The severity of constipation was correlated with total (P < 0.001), right (P = 0.002), and left CTT (P = 0.049). Conclusion Age and BMI are both associated with RSTT in constipated patients. Background/Aims Discordant data are found in the literature for the relationships between total and segmental colonic transit time (CTT) and demographic parameters. The aim of this study is to examine the influence of age, and body mass index (BMI) on total and segmental CTT in constipated subjects. Methods We included 354 constipated patients on this cross-sectional study. According to the Rome III criteria, patients were classified as having irritable bowel syndrome with constipation, or functional constipation. All patients filled the Bristol stool form, and reported the severity of constipation, bloating, and abdominal pain on a 10-point Likert scale. Total and segmental CTT were measured using radiopaque markers. Results Females were 84% of patients, with a mean age of 46.0 ± 15.9 years. The association between total and segmental CTT with age and BMI was significant after adjustment for gender, clinical phenotype, the presence of defecation disorders, and abdominal pain or bloating intensity despite the severity of symptoms, and the frequency of defecation disorders were higher in irritable bowel syndrome with constipation than in functional constipation patients. By comparison with subjects less than 30 years, rectosigmoid transit time (RSTT) was lower in patients between 30 and 60 years. Age was negatively associated with RSTT (P = 0.004). By comparison with patients with normal BMI, RSTT and total CTT were lower in patients of the overweight group. BMI was negatively associated with RSTT (P < 0.001). The severity of constipation was correlated with total (P < 0.001), right (P = 0.002), and left CTT (P = 0.049). Conclusion Age and BMI are both associated with RSTT in constipated patients.

Current situation and future prospects for beef production in Europe - A review

Hocquette, Jean-Francois,Ellies-Oury, Marie-Pierre,Lherm, Michel,Pineau, Christele,Deblitz, Claus,Farmer, Linda Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.7

The European Union (EU) is the world's third largest producer of beef. This contributes to the economy, rural development, social life, culture and gastronomy of Europe. The diversity of breeds, animal types (cows, bulls, steers, heifers) and farming systems (intensive, extensive on permanent or temporary pastures, mixed, breeders, feeders, etc) is a strength, and a weakness as the industry is often fragmented and poorly connected. There are also societal concerns regarding animal welfare and environmental issues, despite some positive environmental impacts of farming systems. The EU is amongst the most efficient for beef production as demonstrated by a relative low production of greenhouse gases. Due to regional differences in terms of climate, pasture availability, livestock practices and farms characteristics, productivity and incomes of beef producers vary widely across regions, being among the lowest of the agricultural systems. The beef industry is facing unprecedented challenges related to animal welfare, environmental impact, origin, authenticity, nutritional benefits and eating quality of beef. These may affect the whole industry, especially its farmers. It is therefore essential to bring the beef industry together to spread best practice and better exploit research to maintain and develop an economically viable and sustainable beef industry. Meeting consumers' expectations may be achieved by a better prediction of beef palatability using a modelling approach, such as in Australia. There is a need for accurate information and dissemination on the benefits and issues of beef for human health and for environmental impact. A better objective description of goods and services derived from livestock farming is also required. Putting into practice "agroecology" and organic farming principles are other potential avenues for the future. Different future scenarios can be written depending on the major driving forces, notably meat consumption, climate change, environmental policies and future organization of the supply chain.

Inclusive Growth and Innovation

Georges Bresson,Jean-Michel Etienne,Pierre Mohnen 과학기술정책연구원 2015 STI Policy Review Vol.6 No.1

Based on the work of Anand et al. (2013) we measure inclusive income growth, which combines growth in gross domestic product (GDP) per capita and growth in the equity of the income distribution. Extending the work of Causa et al. (2014), we estimate a dynamic simultaneous structural equations model of GDP per capita and inclusive income on panel data for 63 countries over the 1990-2013 period. We estimate both equations in error correction form by difference GMM (generalized method of moments). Among the explanatory variables of the level and the distribution of GDP per capita we include R&D (research and development) expenditure per capita. In OECD countries we obtain a large positive effect of R&D on GDP. R&D is found to have a positive effect on the social mobility index but its impact on the income equity index at first decreases, then switches around to become slightly positive in the long run. In non- OECD countries, R&D is found to decrease inclusive income, mostly through a negative growth effect but also because of a slightly increasing income inequity effect.

Glenohumeral joint capsular tissue tension loading correlates moderately with shear wave elastography: a cadaveric investigation

Charles W. Nichols,Jean-Michel Brismée,Troy L. Hooper,Antony Bertrand-Grenie,Kerry K. Gilbert,Marc-Olivier St-Pierre,Jeegisha Kapila,Stéphane Sobczak 대한초음파의학회 2020 ULTRASONOGRAPHY Vol.39 No.2

Purpose: The purpose of this study was to investigate changes in the mechanical properties of capsular tissue using shear wave elastography (SWE) and a durometer under various tensile loads, and to explore the reliability and correlation of SWE and durometer measurements to evaluate whether SWE technology could be used to assess tissue changes during capsule tensile loading. Methods: The inferior glenohumeral joint capsule was harvested from 10 fresh human cadaveric specimens. Tensile loading was applied to the capsular tissue using 1-, 3-, 5-, and 8-kg weights. Blinded investigators measured tissue stiffness and hardness during loading using SWE and a durometer, respectively. Intraobserver reliability was established for SWE and durometer measurements using intraclass correlation coefficients (ICCs). The Pearson product-moment correlation was used to assess the associations between SWE and durometer measurements. Results: The ICC3,5 for durometer measurements was 0.90 (95% confidence interval [CI], 0.79 to 0.96; P<0.001) and 0.95 (95% CI, 0.88 to 0.98; P<0.001) for SWE measurements. The Pearson correlation coefficient values for 1-, 3-, and 5-kg weights were 0.56 (P=0.095), 0.36 (P=0.313), and -0.56 (P=0.089), respectively. When the 1- and 3-kg weights were combined, the ICC3,5 was 0.72 (P<0.001), and it was 0.62 (P<0.001) when the 1-, 3-, and 5-kg weights were combined. The 8-kg measurements were severely limited due to SWE measurement saturation of the tissue samples. Conclusion: This study suggests that SWE is reliable for measuring capsular tissue stiffness changes in vitro at lower loads (1 and 3 kg) and provides a baseline for the non-invasive evaluation of effects of joint loading and mobilization on capsular tissues in vivo.

THE NEXT GENERATION VIRGO CLUSTER SURVEY. XXII. SHELL FEATURE EARLY-TYPE DWARF GALAXIES IN THE VIRGO CLUSTER

Paudel, Sanjaya,Smith, Rory,Duc, Pierre-Alain,Cô,té,, Patrick,Cuillandre, Jean-Charles,Ferrarese, Laura,Blakeslee, John P.,Boselli, Alessandro,Cantiello, Michele,Gwyn, S. D. J.,Guhathakurta American Astronomical Society 2017 The Astrophysical Journal Vol.834 No.1

<P>The Next Generation Virgo Cluster Survey is a deep (with a 2 sigma detection limit mu g = 29 mag arcsec(-2) in the g-band) optical panchromatic survey targeting the Virgo cluster from its core to virial radius, for a total areal coverage of 104 square degrees. As such, the survey is well suited for the study of galaxies' outskirts, haloes, and low surface brightness features that arise from dynamical interactions within the cluster environment. We report the discovery of extremely faint (mu g > 25 mag arcsec(-2)) shells in three Virgo cluster early-type dwarf galaxies: VCC. 1361, VCC. 1447, and VCC. 1668. Among them, VCC. 1447 has an absolute magnitude Mg = -11.71 mag and is the least massive galaxy with a shell system discovered to date. We present a detailed study of these low surface brightness features. We detect between three and four shells in each of our galaxies. Within the uncertainties, we find no evidence of a color difference between the galaxy main body and shell features. The observed arcs of the shells are located up to several effective radii of the galaxies. We further explore the origin of these low surface brightness features with the help of idealized numerical simulations. We find that a near equal mass merger is best able to reproduce the main properties of the shells, including their quite symmetric appearance and their alignment along the major axis of the galaxy. The simulations provide support for a formation scenario in which a recent merger, between two near-equal mass, gas-free dwarf galaxies, forms the observed shell systems.</P>

NMPC of an industrial crystallization process using model-based observers

Cedric Damour,Lionel Boillereaux,Brigitte Grondin-Perez,Jean-Pierre Chabriat,Michel Benne 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.5

This paper illustrates the benefits of a nonlinear model-based predictive control (NMPC) approach applied to an industrial crystallization process. This relevant approach proposes a setpoint tracking of the crystal mass. The controlled variable, unavailable, is obtained using an extended Luenberger observer. A neural network model is used as internal model to predict process outputs. An optimization problemis solved to compute future control actions taking into account real-time control objectives. The performances of this strategy are demonstrated via simulation in cases of setpoint tracking and disturbance rejection. The results reveal a significant improvement in terms of robustness and energy efficiency. 2010 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

CROSS FLOW EFFECTS ON THE FLAME HEIGHT OF AN INTERMEDIATE SCALE DIFFUSION FLAME

Kolb,Gilles,Torero,Jose L,Most,Jean-Michel,Joulain,Pierre 한국화재소방학회 1997 한국화재소방학회 학술대회 논문집 Vol.1997 No.-

An experimental study has been conducted at an intermediate scale to study the effect of a cross flow on a purely buoyant fire. Video taping of the flame and post processing of the images by means of a novel technique provide a contour of a mean flame for all cases studied. This flame contour allows the determination of a mean flame length and a mean flame height. The mean flame length and height are recorded as functions of the forced flow velocity. Three dimensional flow patterns are formed in the flame trailing edge affecting both the mean flame length and height. The three dimensional patterns are studied systematically as functions of the cross flow velocity to quantify the effect of confinement on the flame geometry.