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Case Reports : Application of Sentinel Lymph Node Biopsy in Cutaneous Basosquamous Carcinoma
( Irena Jankovic ),( Predrag Kovacevic ),( Milan Visnjic ),( Dimitrije Jankovic ),( Ivana Binic ),( Aleksandar Jankovic ),( Ivan Ilic ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.1S
Basosquamous carcinoma of the skin is a relatively rare cutaneous neoplasm that has significant metastatic potential and a metastatic rate greater than that of basal cell and squamous cell carcinoma. We describe the use of lymphatic mapping and sentinel lymph node biopsy in a 63-year-old man after identification of basosquamous carcinoma. Sentinel lymph node biopsy, which is a standard tool to detect regional lymphatic metastasis in cutaneous melanoma, has been rarely employed to detect lymphatic metastasis of basosquamous carcinoma. The approach was successful in detecting a regional lymphatic metastasis of two nodal basins with minor morbidity. Sentinel lymph node biopsy may be useful for certain high-risk lesions of basosquamous carcinoma. (Ann Dermatol 23(S1) S123~S126, 2011)
Application of Sentinel Lymph Node Biopsy in Cutaneous Basosquamous Carcinoma
Irena Jankovic,Predrag Kovacevic,Milan Visnjic,Dimitrije Jankovic,Ivana Binic,Aleksandar Jankovic,Ivan Ilic 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-
Basosquamous carcinoma of the skin is a relatively rare cutaneous neoplasm that has significant metastatic potential and a metastatic rate greater than that of basal cell and squamous cell carcinoma. We describe the use of lymphatic mapping and sentinel lymph node biopsy in a 63-year-old man after identification of basosquamous carcinoma. Sentinel lymph node biopsy, which is a standard tool to detect regional lymphatic metastasis in cutaneous melanoma, has been rarely employed to detect lymphatic metastasis of basosquamous carcinoma. The approach was successful in detecting a regional lymphatic metastasis of two nodal basins with minor morbidity. Sentinel lymph node biopsy may be useful for certain high-risk lesions of basosquamous carcinoma. (Ann Dermatol 23(S1) S123∼S126, 2011)
Health care and the ‘Common Pool’ Federalism in Canada
Ivan Jankovic(Ivan Jankovic ) 한국캐나다학회 2013 Asia-Pacific Journal of Canadian Studies (APJCS) Vol.19 No.2
Canadian federal system is often praised as a ‘laboratory of change’ capable of producing gradually a high quality policy innovation. In the same time, the system is described as extremely decentralized. This paper challenges both claims by concentrating on the case study of health care policy which is usually taken as an ultimate success story of Canadian federalism. By using the model of ‘common pool’ federalism, the paper argues that Canadian system is characterized by a systematic mismatch between who makes the taxing and who makes the spending decisions, which leads to a paradoxical situation in which the new programs are relatively easy to ‘federalize’, whereas it is very difficult to scale them back or reform, once they are entrenched. Combination of spending decentralization and taxing centralization blurs the lines of accountability allowing both orders of government to profit from increased spending and protect-ing them from blame if the program fails to deliver. The case study of health care system provides the evidence for this theory.
Rizvic, Eldina,Jankovic, Goran,Savic, Miroslav M. The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.4
Vasoconstrictive properties of sympathomimetic drugs are the basis of their widespread use as decongestants and possible source of adverse responses. Insufficiently substantiated practice of combining decongestants in some marketed preparations, such are those containing phenylephrine and lerimazoline, may affect the overall contractile activity, and thus their therapeutic utility. This study aimed to examine the interaction between lerimazoline and phenylephrine in isolated rat aortic rings, and also to assess the substrate of the obtained lerimazoline-induced attenuation of phenylephrine contraction. Namely, while lower concentrations of lerimazoline ($10^{-6}M$ and especially $10^{-7}M$) expectedly tended to potentiate the phenylephrine-induced contractions, lerimazoline in higher concentrations ($10^{-4}M$ and above) unexpectedly and profoundly depleted the phenylephrine concentration-response curve. Suppression of NO with NO synthase (NOS) inhibitor $N^w$-nitro-L-arginine methyl ester (L-NAME; $10^{-4}M$) or NO scavanger $OHB_{12}$ ($10^{-3}M$), as well as non-specific inhibition of $K^+$-channels with tetraethylammonium (TEA; $10^{-3}M$), have reversed lerimazoline-induced relaxation of phenylephrine contractions, while cyclooxygenase inhibitor indomethacin ($10^{-5}M$) did not affect the interaction between two vasoconstrictors. At the receptor level, non-selective 5-HT receptor antagonist methiothepin reversed the attenuating effect of lerimazoline on phenylephrine contraction when applied at $3{\times}10^{-7}$ and $10^{-6}M$, but not at the highest concentration ($10^{-4}M$). Neither the 5-$HT_{1D}$-receptor selective antagonist BRL 15572 ($10^{-6}M$) nor 5-$HT_7$ receptor selective antagonist SB 269970 ($10^{-6}M$) affected the lerimazoline-induced attenuation of phenylephrine activity. The mechanism of lerimazoline-induced suppression of phenylephrine contractions may involve potentiation of activity of NO and $K^+$-channels and activation of some methiothepin-sensitive receptors, possibly of the 5-$HT_{2B}$ subtype.