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( Jae Bin Kang ),( Ran Song ),( Sang Hoon Lee ),( Jiyoung Choi ),( Yeon Ah Lee ),( Seung Jae Hong ),( Hyung In Yang ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Adalimumab is a tumor necrosis factor (TNF) alpha inhibitor. It has been used to control various autoimmune diseases including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn`s disease, ulcerative colitis, etc. It binds to TNF alpha and suppresses TNF receptor`s activity. Down-regulated TNF receptor activity reduces in. ammatory reaction in autoimmune diseases. TNF also has many physiological roles, including tumor surveillance. Therefore, there have always been concerned about the safety of anti-TNF therapy on malignancy. There have been several case reports regarding T cell lymphoma occurring in patients using Adalimumab. However, it is controversial whether TNF alpha inhibitor increases risk of T cell lymphoma or not. Case: 70-year-old Asian male with known Ankylosing Spondylitis with uveitis presented with fever, rash and generalized edema. He was first diagnosed with Ankylosing Spondylitis in 2003. Due to insufficient effect of NSAIDs in controlling his disease activity, Adalimumab was started on November 2008. The patient continues to take it until October 2013. Two months after finishing Adalimumab treatment, he presented with above complaint. On physical examination, he has lymphadenopathy in head, neck, both axilla and inguinal area. Supraclavicular lymph node biopsy was performed, which later showed mature cell lymphoma, with favor of angioimmunoblastic T cell lymphoma.
Longitudinal associations between glucocorticoid receptor methylation and late-life depression
Kang, Hee-Ju,Bae, Kyung-Yeol,Kim, Sung-Wan,Shin, Il-Seon,Kim, Hye-Ran,Shin, Myung-Geun,Yoon, Jin-Sang,Kim, Jae-Min Elsevier 2018 Progress in neuro-psychopharmacology & biological Vol.84 No.1
<P><B>Abstract</B></P> <P>It has been suggested that hypothalamus–pituitary–adrenal (HPA) axis dysregulation plays a role in the etiology of depression. HPA axis function is mediated by glucocorticoid receptors (GRs), which are influenced by epigenetic mechanisms (DNA methylation). The association between the DNA methylation of the GR gene (nuclear receptor subfamily 3, group C, member 1; <I>NR3C1</I>) and late-life depression as well as the role of <I>NR3C1</I> methylation in the prediction of the incidence of depression have not yet been investigated. Therefore, we examined the independent and longitudinal effects of the methylation of three CpG sites in exon 1<SUB>F</SUB> of <I>NR3C1</I> on late-life depression using peripheral blood. In total, 732 Korean community residents aged ≥65 years were assessed; 521 individuals in this group without depression at baseline were followed 2 years later. The Geriatric Mental State Schedule was used to identify depression, and demographic and clinical covariates were evaluated. The effects of <I>NR3C1</I> methylation (the individual methylation status of three CpG sites and their average values) on current and follow-up depression were calculated using a multivariate logistic regression model. Higher <I>NR3C1</I> methylation levels at CpG 2 and 3 and the average methylation value were independently associated with the prevalence of depression at baseline. Additionally, a higher <I>NR3C1</I> methylation level at CpG 2 was associated with depression incidence 2 years later in this population. These findings suggest an association between the methylation of <I>NR3C1</I> exon 1<SUB>F</SUB>, especially at CpG 2, and depression later in life.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Higher <I>NR3C1</I> exon 1<SUB>F</SUB> methylation, except at CpG 1, is related to prevalence of late life depression. </LI> <LI> Hypermethylation of <I>NR3C1</I> exon 1<SUB>F</SUB> at CpG 2 predicts depression incidence 2 years later. </LI> <LI> These associations were independent of potential covariates. </LI> <LI> Altered epigenetic regulation in the HPA axis in late-life depression was supported. </LI> </UL> </P>
Kang Hee Cho,Kwang-Sik Cho,Jeom Hwa Han,Hyun Ran Kim,Il Sheob Shin,Se Hee Kim,Jae An Chun,Hae-Sung Hwang 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
The precise, fast, and cost-effective identification of important fruit crop cultivars is essential for practical breeding and plant breeder’s rights. Traditional methods for identification of persimmon cultivars are based on the evaluation of sets of morphological characteristics. However, the identification using only morphological traits is difficult to distinguish among genetically closely related cultivars. This study was conducted to develop more reliable DNA markers for identification of the 32 persimmon cultivars in Korea and Japan. In total, 309 random amplified polymorphic DNA (RAPD) markers were identified using 40 different random primers. The 4 (OPP-08) to 14 (UBD159) polymorphic bands were detected with an average of 7.7. The resulting 57 RAPD fragments were selected, and their sequences were determined for developing sequence-characterized amplified region (SCAR) markers. As a result, 15 of 57 RAPD fragments were successfully converted to SCAR markers. A single polymorphic band of the same size as the RAPD fragments or smaller DNA fragments were amplified depending on primer combinations in the 15 SCAR markers. Among these markers, a combination of eight SCAR markers (PS225_200, PSN05_420, PSF13_523, PSN11_540, PS372_567, PS485_569, PSP08_635, and PS631_735) provided sufficient polymorphisms to identify 32 persimmon cultivars depending on number and size of amplicons. These newly developed markers will be useful as a fast and reliable tool to identify persimmon cultivars.
Is Laparoscopy-assisted Radical Gastrectomy Safe in Patients with Child-Pugh Class A Cirrhosis?
Kang, Sin Jae,Jung, Mi Ran,Cheong, Oh,Park, Young Kyu,Kim, Ho Goon,Kim, Dong Yi,Kim, Hoi Won,Ryu, Seong Yeob The Korean Gastric Cancer Association 2013 Journal of gastric cancer Vol.13 No.4
Purpose: We investigated early postoperative morbidity and mortality in patients with liver cirrhosis who had undergone radical gastrectomy for gastric cancer. Materials and Methods: We retrospectively reviewed the medical records of 41 patients who underwent radical gastrectomy at the Chonnam National University Hwasun Hospital (Hwasun-gun, Korea) between August 2004 and June 2009. There were few patients with Child-Pugh class B or C; therefore, we restricted patient selection to those with Child-Pugh class A. Results: Postoperative complications were observed in 22 (53.7%) patients. The most common complications were ascites (46.3%), postoperative hemorrhage (22.0%) and wound infection (12.2%). Intra-abdominal abscess developed in one (2.4%) patient who had undergone open gastrectomy. Massive ascites occurred in 4 (9.8%) patients. Of the patients who underwent open gastrectomy, nine (21.9%) patients required blood transfusions as a result of postoperative hemorrhage. However, most of these patients had advanced gastric cancer. In contrast, most patients who underwent laparoscopic gastrectomy had early stage gastric cancer, and when the confounding effect from the different stages between the two groups was corrected statistically, no statistically significant difference was found. There was also no significant difference between open and laparoscopic gastrectomy in the occurrence rate of other postoperative complications such as ascites, wound infection, and intra-abdominal abscess. No postoperative mortality occurred. Conclusions: Laparoscopic gastrectomy is a feasible surgical procedure for patients with moderate hepatic dysfunction.