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증례 : 내분비-대사 ; 융모 상피성 종양을 진단받은 환자에서 발병한 갑상선 유두암 1예
김재현 ( Jae Hyun Kim ),김송이 ( Song Yi Kim ),이미영 ( Mi Young Lee ),신장열 ( Jang Yel Shin ),신영구 ( Young Goo Shin ),정춘희 ( Choon Hee Chung ) 대한내과학회 2011 대한내과학회지 Vol.80 No.4
갑상선 암은 가장 흔한 내분비암 중 하나이다. 갑상선은 성호르몬과 β-HCG 등의 영향을 받기 때문에 β-HCG가 증가되는 임신시나 융모 상피성 질환에서 갑상선 질환의 발생이 촉진 될 수 있다고 알려져 왔다. 하지만 융모 상피성 종양 환자에서 갑상선 암이 동반된 경우는 아직까지 국내에서 보고되지 않았다. 이에 저자는 융모 상피성 종양 환자에서 갑상선 유두암이 동반된 사례를 경험하였기에 문헌고찰과 함께 보고한다. Thyroid cancer is one of the most common endocrine malignancies. It is known that thyroid cancer can develop during reproductive periods, possibly due to the effects of sex hormones and growth factors such human chorionic gonadotrophin (HCG). Some data suggest that elevated HCG levels during pregnancy or gestational trophoblastic disease can stimulate thyroid cellular proliferation and promote cancer formation; however, a case of papillary thyroid cancer accompanied by a gestational trophoblastic tumor has not been reported. Here, we report the case of a 44-year-old woman with papillary thyroid cancer during treatment for a gestational trophoblastic tumor. (Korean J Med 2011;80:464-468)
( Nam-joon Yi ),( Hyo-sin Kim ),( Jong Man Kim ),( Suk Kyun Hong ),( Kyung Chul Yoon ),( Choon Hyuck David Kwon ),( Jae-won Joh ),( Kwang-woong Lee ),( Kyung-suk Suh ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: The outcome of primary hepatic resection in patients with hepatocellular carcinoma (HCC) within the Milan criteria (MC) has improved in recent years. However, the impact of the HCC status at the time of recurrence after primary hepatic resection remains unknown. Methods: A total of 959 patients who experienced recurrence after primary hepatic resection for HCC were classified into 4 groups according to the HCC status at 2 different periods: IN-IN (within MC at the initial resection and within MC at recurrence after resection), IN-OUT, OUT-IN, and OUT-OUT. Results: Overall survival rates (OS) for the entire cohort after 1, 3, and 5 years were 81%, 55%, and 45%, and the re-recurrence free survival rates (RFS) were 63%, 46%, and 42%, respectively. The IN-IN MC group had the best outcome, with a 5-year OS and RFS of 54% and 45% (P ≤ 0.05), respectively. There was no statistical difference between the 5-year OS and RFS for the IN-OUT and OUT-IN MC groups. The OUT-OUT MC group had the worst outcome. Curative treatment showed better OS in all subgroups than non-curative treatment (5-year OS, IN-IN: 63% vs. 45.5, P < 0.00; IN-OUT: 59% vs. 38%, P = 0.015; OUT-IN: 53.5% vs. 30.7%, P = 0.005; OUT-OUT: 56.9% vs. 37%, P < 0.000). Conclusions: The survival outcome was affected by MC at the time of both the initial resection and recurrence. Curative treatment improved the OS after recurrence regardless of the recurrence type.
HCC : Single center experience of Liver transplnatation in patients with portal vein thrombosis (초)
( Sang Hyun Song ),( Choon Hyuck David Kwon ),( Jong Man Kim ),( Mill Jae Shin ),( Hyung Hwan Moon ),( Sang Hoon Lee ),( Tae Suk Kim ),( Jae Won Joh ),( Sung Joo Kim ),( Suk Koo Lee ),( Hye Ran Yi ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)
Hong, Kyung-Won,Yi, Joo-Mi,Shin, Kyung-Mi,Kim, Tae-Hyung,Huh, Jae-Won,Lee, Young-Choon,Lee, Won-Ho,Crow, Timothy J.,Kim, Heui-Soo 한국유전학회 2003 Genes & Genomics Vol.25 No.2
A human endogenous retroviral family (HERV-W) has been related to multiple sclerosis associated retrovirus (MSRV) and schizophrenia associated retrovirus (SZRV) sequences. The HERV-W family was identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Using cDNA libraries derived from human brains, we performed PCR amplification and identified new 16 HERV-W env elements (9 from human adult brain and 7 from human fetal brain). Those sequences showed a high degree of sequence similarity (89.2-99.6%) with HERV-W env (GenBank accession no. AF072506). Clones HB-1, HB-9 from adult brain and FB-2, FB-5 from fetal brain showed no frameshift and termination codons by deletion/insertion or point mutation. Synonymous and nonsynonymous calculation indicated that these sequences (HB-1, HB-9, FB-2, FB-5) could be associated with an active provirus in human brain tissues. In phylogenetic analysis, clones HB-1, HB-9, FB-2, FB-5 containing putative amino acid sequences showed sister relationship with the HERV-W and W-7-1 derived from human chromosome 7. Taken together, our data suggest that the related genes of the HERV-W env sequences are expressed in human brains and may contribute to an understanding of biological function connected to neuropsychiatric diseases.