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Circulating miR-221 and miR-222 as Potential Biomarkers for Screening of Breast Cancer
Jungho Kim,Sehee Oh,Sunyoung Park,Sungwoo Ahn,Yeonim Choi,Geehyuk Kim,Seung Il Kim,Hyeyoung Lee 대한의생명과학회 2019 Biomedical Science Letters Vol.25 No.2
Breast cancer is the second most common cancer in women with approximately 522,000 deaths annually worldwide. microRNAs have recently been studied as potential biomarkers that regulate gene expression and are involved in tumorigenesis. Here we evaluated circulating miR-221 and miR-222 as potential biomarkers for breast cancer by quantitative reverse transcription PCR using blood plasma of 30 healthy controls and 30 breast cancer patients. The TNM stage on circulating miR-221 and miR-222 was also investigated. Circulating miR-221 and miR-222 were significantly up-regulated in breast cancer patients compared to those in healthy controls (P < 0.0022 and P = 0.0058, respectively). Furthermore, the relative expression level of circulating miR-221 in patients with stage III breast cancer was higher than in those with stage I and II. Taken together, we have shown circulating miR-221 and miR-222 could be useful biomarkers for the screening of breast cancer patients.
Kim, Jonggi,Yun, Myoung Hee,Kim, Gi-Hwan,Lee, Jungho,Lee, Sang Myeon,Ko, Seo-Jin,Kim, Yiho,Dutta, Gitish K.,Moon, Mijin,Park, Song Yi,Kim, Dong Suk,Kim, Jin Young,Yang, Changduk American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.10
<P>The introduction of fluorine (F) atoms onto conjugated polymer backbone has verified to be an effective way to enhance the overall performance of polymer-based bulk-heterojunction (BHJ) solar cells, but the underlying working principles are not yet fully uncovered. As our attempt to further understand the impact of F, herein we have reported two novel fluorinated analogues of PCDTBT, namely, <B>PCDTFBT</B> (1F) and <B>PCDT2FBT</B> (2F), through inclusion of either one or two F atoms into the benzothiadiazole (BT) unit of the polymer backbone and the characterization of their physical properties, especially their performance in solar cells. Together with a profound effect of fluorination on the optical property, nature of charge transport, and molecular organization, F atoms are effective in lowering both the HOMO and LUMO levels of the polymers without a large change in the energy bandgaps. <B>PCDTFBT</B>-based BHJ solar cell shows a power conversion efficiency (PCE) of 3.96 % with high open-circuit voltage (<I>V</I><SUB>OC</SUB>) of 0.95 V, mainly due to the deep HOMO level (−5.54 eV). To the best of our knowledge, the resulting <I>V</I><SUB>OC</SUB> is comparable to the record <I>V</I><SUB>OC</SUB> values in single junction devices. Furthermore, to our delight, the best <B>PCDTFBT</B>-based device, prepared using 2 % v/v diphenyl ether (DPE) additive, reaches the PCE of 4.29 %. On the other hand, doubly-fluorinated polymer <B>PCDT2FBT</B> shows the only moderate PCE of 2.07 % with a decrease in <I>V</I><SUB>OC</SUB> (0.88 V), in spite of the further lowering of the HOMO level (−5.67 eV) with raising the number of F atoms. Thus, our results highlight that an improvement in efficiency by tuning the energy levels of the polymers by means of molecular design can be expected only if their truly optimized morphologies with fullerene in BHJ systems are materialized.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-10/am500891z/production/images/medium/am-2014-00891z_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am500891z'>ACS Electronic Supporting Info</A></P>
Jungho Kim,Young-Hwa Kim,KwangSeok Kim,Wonsik Yu,SeongHwan Cho IEEE 2015 IEEE Transactions on Circuits and Systems II: Expr Vol. No.
<P>In this brief, an energy-efficient time-to-digital converter (TDC) using a hybrid of time- and voltage-domain circuits is presented. The proposed TDC operates in two steps, i.e., first in the time domain by using a delay-line TDC and then in the voltage domain by using a successive-approximation-register analog-to-digital converter. The time residue of the first stage is converted to voltage by using a switch-based time-to-voltage converter (TVC) that eliminates the need for a current source with large output impedance. To improve the linearity of the proposed TVC, pseudodifferential time-domain signaling is presented. A prototype chip fabricated in the 65-nm CMOS achieves 630 fs of time resolution at 120 megasamples/s while consuming 3.7 mW from a 1.2-V supply. The figure of merit is 244 fJ/conversion-step, which is the best among the recently published high-speed TDCs.</P>
Kim, Min-gu,Kim, Yong-Ho,Kim, Hong-Lae,Park, Chul Woo,Joe, Yun-Haeng,Hwang, Jungho,Kim, Yong-Jun IOP 2010 JOURNAL OF MICROMECHANICS AND MICROENGINEERING - Vol.20 No.3
<P>Wall loss is a major cause of deteriorating performance and reliability in air-based miniaturized analytical devices and it can cause unexpected changes in structures and operational conditions. Therefore, there is a great demand for the reduction of the wall loss on airborne particle processing chips. This paper demonstrates a wall loss reduction technique using an electrodynamic disturbance. The proposed technique is applied to a serpentine microchannel for a feasibility test, and then it is applied to a virtual impactor, which is an inertial airborne particle classifier. An electrodynamic disturbance is generated by applying ac electric potentials to an interdigitated electrode pair integrated at the bottom of the microchannel. In the serpentine microchannel, the application of electric potentials from 0 to 3 kV at 1 kHz caused the wall loss to decrease exponentially as a function of the aerodynamic diameter. When the electric potential was 3 kV, the wall loss decreased by 17.2 ± 1.8% for particles with a 0.96 µm diameter. In the virtual impactor, the wall loss curve at 1 kV and 1 kHz had an estimated maximum reduction of 11.6% compared to the wall loss curve at 0 V. Furthermore, the collection efficiency curves approached the ideal cut-off curve as the applied electric potential was increased from 0 to 1 kV.</P>
Kim, Sol,Lee, Jungwoon,Kim, Ja Young,Lim, Bobae,Shin, Eung-Kyun,Han, Yong-Mahn,Kim, Sung-Su,Song, Jin-Ho,Kim, Jungho Wiley Subscription Services, Inc., A Wiley Company 2009 International journal of cancer: Journal internati Vol.124 No.10
<P>The EWS-Oct-4 protein is a chimeric molecule in which the amino terminal domain (NTD) of the EWS becomes fused to the carboxy terminal domain (CTD) of the Oct-4 transcription factor. It was identified in human bone and soft-tissue tumors associated with t(6;22)(p21;q12). Using in vitro and in vivo systems, we found that the EWS-Oct-4 protein self-associates. The major domains required for self-association mapped to the EWS NTD (amino acids 70–163) and the POU DNA-binding domain. EWS-Oct-4 protein also associated with EWS-Oct-4 (V351P), which contains a mutation in the POU DNA-binding domain. Using electrophoretic mobility shift assays, we found that the EWS-Oct-4 (V351P) mutant interfered with wild-type EWS-Oct-4 DNA-binding activity. In addition, we found that EWS-Oct-4-mediated transcriptional activation was inhibited by EWS-Oct-4 (V351P) protein in vivo. Thus, this mutation in the POU DNA-binding domain results in a dominant negative protein. These findings suggest that the biological functions of the EWS-Oct-4 oncogene can be modulated by the dominant negative mutant EWS-Oct-4 (V351P). © 2008 Wiley-Liss, Inc.</P>
Kim, Jungho,Wang, Hye-young,Kim, Seoyong,Park, Soon Deok,Yu, Kwangmin,Kim, Hyo Youl,Uh, Young,Lee, Hyeyoung Elsevier Biomedical 2016 Journal of microbiological methods Vol.128 No.-
<P><B>Abstract</B></P> <P>DNA extraction efficiency affects the success of PCR-based method applications. The Punch-it™ NA-Sample kit for extracting DNA by using paper chromatography is technically easy to use and requires just two reagents and only 10min to complete. The Punch-it™ NA-Sample kit could be offered as a rapid, accurate, and convenient method for extracting bacterial and fungal DNA from blood culture bottles. We compared the efficiencies of the commercial kit (Punch-it™ NA-Sample kit) and an in-house conventional boiling method with Chelex-100 resin for DNA extraction from blood culture bottles. The efficiency of the two DNA extraction methods was assessed by PCR-reverse blot hybridization assay (PCR-REBA, REBA Sepsis-ID) for detecting Gram positive (GP) bacteria, Gram negative (GN) bacteria, and <I>Candida</I> species with 196 positive and 200 negative blood culture bottles. The detection limits of the two DNA extraction methods were 10<SUP>3</SUP> CFU/mL for GP bacteria, 10<SUP>3</SUP> CFU/mL for GN bacteria, and 10<SUP>4</SUP> CFU/mL for <I>Candida</I>. The sensitivity and specificity of the Punch-it™ NA-Sample kit by REBA Sepsis-ID were 95.4% (187/196) and 100% (200/200), respectively. The overall agreement of the two DNA extraction methods was 98.9% (392/396). Three of four samples showing discrepant results between the two extraction methods were more accurately matched up with the Punch-it™ NA-Sample kit based on conventional culture methods. The results indicated that the Punch-it™ NA-Sample kit extracted bacterial and fungal DNA in blood culture bottles and allowed extracted DNA to be used in molecular assay.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Punch-it™ NA-Sample kit and boiling method for DNA extraction were compared. </LI> <LI> Punch-it™ NA-Sample kit extracted bacterial and fungal DNA in blood culture bottles. </LI> <LI> The Punch-it™ NA-Sample kit does not require enzyme to digest cell walls. </LI> </UL> </P>
Kim, Nam Hoon,Hwang, Wooseup,Baek, Kangkyun,Rohman, Md. Rumum,Kim, Jeehong,Kim, Hyun Woo,Mun, Jungho,Lee, So Young,Yun, Gyeongwon,Murray, James,Ha, Ji Won,Rho, Junsuk,Moskovits, Martin,Kim, Kimoon American Chemical Society 2018 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.140 No.13
<P>Single-molecule surface-enhanced Raman spectroscopy (SERS) offers new opportunities for exploring the complex chemical and biological processes that cannot be easily probed using ensemble techniques. However, the ability to place the single molecule of interest reliably within a hot spot, to enable its analysis at the single-molecule level, remains challenging. Here we describe a novel strategy for locating and securing a single target analyte in a SERS hot spot at a plasmonic nanojunction. The “smart” hot spot was generated by employing a thiol-functionalized cucurbit[6]uril (CB[6]) as a molecular spacer linking a silver nanoparticle to a metal substrate. This approach also permits one to study molecules chemically reluctant to enter the hot spot, by conjugating them to a moiety, such as spermine, that has a high affinity for CB[6]. The hot spot can accommodate at most a few, and often only a single, analyte molecule. Bianalyte experiments revealed that one can reproducibly treat the SERS substrate such that 96% of the hot spots contain a single analyte molecule. Furthermore, by utilizing a series of molecules each consisting of spermine bound to perylene bisimide, a bright SERS molecule, with polymethylene linkers of varying lengths, the SERS intensity as a function of distance from the center of the hot spot could be measured. The SERS enhancement was found to decrease as 1 over the square of the distance from the center of the hot spot, and the single-molecule SERS cross sections were found to increase with AgNP diameter.</P> [FIG OMISSION]</BR>