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Risk of New Native-Vessel Occlusion After Coronary Artery Bypass Grafting
Yoon, S.H.,Kim, Y.H.,Yang, D.H.,Roh, J.H.,Lee, E.Y.,Lee, P.H.,Sugiyama, D.,Chang, M.,Ahn, J.M.,Choi, W.J.,Kang, J.W.,Lim, T.H.,Kim, J.B.,Jung, S.H.,Chung, C.H.,Choo, S.J.,Lee, J.W.,Kang, S.J.,Park, D. Cahners Pub. Co., etc.] ; Elsevier Science Ltd 2017 The American journal of cardiology Vol.119 No.1
<P>Coronary computed tomography angiography is widely used to evaluate the graft patency, but information on the progression of native-vessel disease remains limited. We sought to evaluate the impact of bypass grafting on native-vessel progression after. coronary artery bypass grafting. We evaluated new native-vessel occlusion defined as occlusion length >= 15 mm as a surrogate marker of native-vessel progression. We evaluated 911 patients with 2,271 nonoccluded vessels who underwent coronary artery bypass grafting and received follow-up coronary computed tomography angiography. Over a mean follow-up period of 4.7 years, the new occlusion rates were 9.2% for left anterior descending artery (LAD), and 13.9% for non-LAD, respectively. For non-LAD, new occlusion rate of vessels with bypass grafts was higher compared to those without bypass graft regardless of baseline native vessel stenosis (intermediate stenosis: 8.6% vs 1.7%, p <0.001; severe stenosis: 20.5% vs 9.9%, p = 0.003). Furthermore, new occlusion rate of vessels with venous graft was the highest, followed by vessels with arterial graft and vessels without bypass graft, regardless of baseline stenosis (intermediate stenosis: 11.1% vs 5.2% vs 1.7%, p <0.001; severe stenosis: 23.7% vs 15.9% vs 9.9%, p <0.001). By multivariate analysis, bypass grafting was associated with new native-vessel occlusion for non-LAD (odds ratio 3.04, 95% confidence interval 1.79 to 5.14; p <0.001). Bypass graft was associated with new native-vessel disease progression regardless of baseline stenosis. In conclusion, the decision to bypass or leave a native vessel with intermediate stenosis should cautiously be considered. (C) 2016 Elsevier Inc. All rights reserved.</P>
Ethnic Differences of two Non-synonymous Single Nucleotide Polymorphisms in CDA Gene
Sugiyama, E.,Lee, S.J.,Lee, S.S.,Kim, W.Y.,Kim, S.R.,Tohkin, M.,Hasegawa, R.,Okuda, H.,Kawamoto, M.,Kamatani, N.,Sawada, J.i.,Kaniwa, N.,Saito, Y.,Shin, J.G. 日本藥物動態學會 2009 DRUG METABOLISM AND PHARMACOKINETICS Vol.24 No.6
Cytidine deaminase, encoded by the CDA gene, catalyzes anti-cancer drugs gemcitabine and ara-C into their respective inactive metabolites. In CDA, two functionally significant non-synonymous polymorphisms, 79A>C (Lys27Gln) and 208G>A (Ala70Thr), have been found and their minor allele frequencies (MAFs) were reported in Japanese and Chinese patients and a relatively small numbers of healthy volunteers in Caucasians and Africans. In this study, we determined the MAFs of both polymorphisms in 200 healthy volunteers of Koreans, along with 206 Japanese, 200 Chinese-Americans, 150 Caucasian-Americans and 150 African-Americans to reveal ethnic differences. MAFs of 79A>C (Lys27Gln) were 0.153 in Koreans and 0.327 in Caucasian-Americans, 0.204 in Japanese, 0.155 in Chinese-Americans and 0.087 in African-Americans. MAFs of 208G>A (Ala70Thr) were 0.005 in Koreans and 0.022 in Japanese and the minor allele was not detected in Chinese-Americans, Caucasian-Americans or African-Americans. Thus possibly, MAF of 208G>A in Japanese is likely to be somewhat higher than in Koreans and Chinese-Americans. These data would provide fundamental and useful information for pharmacogenetic studies on cytidine deaminase-catalyzing drugs.
Sun, S.j.,Horikawa, Y.,Wada, M.,Sugiyama, J.,Imai, T. Elsevier Scientific Pub 2016 Carbohydrate research Vol.434 No.-
<P>Cellulose is one of the most abundant biological polymers on Earth, and is synthesized by the cellulose synthase complex in cell membranes. Although many cellulose synthase genes have been identified over the past 25 years, functional studies of cellulose synthase using recombinant proteins have rarely been conducted. In this study, we conducted a functional analysis of cellulose synthase with site-directed mutagenesis, by using recombinant cellulose synthase reconstituted in living Escherichia coil cells that we recently constructed (cellulose-synthesizing E. coli, CESEC). We demonstrated that inactivating mutations at an important amino acid residue reduced cellulose production. In this study, an interesting loss-of-function mutation occurred on Cys308, whose main chain carbonyl plays an important role for locating the cellulose terminus. Mutating this cysteine to serine, thus changing sulfur to oxygen in the side chain, abolished cellulose production in addition to other apparent detrimental, mutations. This unexpected result highlights that the thiol side-chain of this cysteine plays an active role in catalysis, and additional mutation experiments indicated that the sulfur arene interaction around Cys308 is a key in cellulose-synthesizing activity. Data obtained by CESEC shed light on the function of cellulose synthase in living cells, and will deepen our understanding of the mechanism of cellulose synthase. (C) 2016 The Authors. Published by Elsevier Ltd.</P>
Kim, J.H.,Funakubo, H.,Sugiyama, Y.,Ishiwara, H. Elsevier 2011 Current Applied Physics Vol.11 No.3
Mn-doped BiFeO<SUB>3</SUB> (BFMO) films with various thicknesses were deposited on Pt(111) and SrRuO<SUB>3</SUB>(SRO)/Pt(111) bottom electrodes using radio-frequency (RF) sputtering at 550 <SUP>o</SUP>C. As the thickness of BFMO films was decreased, the coercive voltages (V<SUB>c</SUB>) decreased while the coercive fields increased in the films on both Pt and SRO/Pt bottom electrodes. At a BFMO film thickness of 70 nm formed on the SRO/Pt(111) electrode, V<SUB>c</SUB> was reduced to 3.4 V, while the remanent polarization was kept at a value as large as 56 μC/cm<SUP>2</SUP>2.