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오늘 본 자료
Ethnic Differences of two Non-synonymous Single Nucleotide Polymorphisms in CDA Gene
Sugiyama, E.,Lee, S.J.,Lee, S.S.,Kim, W.Y.,Kim, S.R.,Tohkin, M.,Hasegawa, R.,Okuda, H.,Kawamoto, M.,Kamatani, N.,Sawada, J.i.,Kaniwa, N.,Saito, Y.,Shin, J.G. 日本藥物動態學會 2009 DRUG METABOLISM AND PHARMACOKINETICS Vol.24 No.6
Cytidine deaminase, encoded by the CDA gene, catalyzes anti-cancer drugs gemcitabine and ara-C into their respective inactive metabolites. In CDA, two functionally significant non-synonymous polymorphisms, 79A>C (Lys27Gln) and 208G>A (Ala70Thr), have been found and their minor allele frequencies (MAFs) were reported in Japanese and Chinese patients and a relatively small numbers of healthy volunteers in Caucasians and Africans. In this study, we determined the MAFs of both polymorphisms in 200 healthy volunteers of Koreans, along with 206 Japanese, 200 Chinese-Americans, 150 Caucasian-Americans and 150 African-Americans to reveal ethnic differences. MAFs of 79A>C (Lys27Gln) were 0.153 in Koreans and 0.327 in Caucasian-Americans, 0.204 in Japanese, 0.155 in Chinese-Americans and 0.087 in African-Americans. MAFs of 208G>A (Ala70Thr) were 0.005 in Koreans and 0.022 in Japanese and the minor allele was not detected in Chinese-Americans, Caucasian-Americans or African-Americans. Thus possibly, MAF of 208G>A in Japanese is likely to be somewhat higher than in Koreans and Chinese-Americans. These data would provide fundamental and useful information for pharmacogenetic studies on cytidine deaminase-catalyzing drugs.
우주 유연 붐의 열적 환경 변화 및 대기압과 진공 챔버내에서 열 유기 진동에 관한 실험적 연구
Y. Sugiyama,공창덕,박현범,오경원 朝鮮大學校 機械技術硏究所 2004 機械技術硏究 Vol.7 No.2
본 연구에서는 인공위성 성능에 주요한 영향을 미칠 수 있는 열 유기에 따른 진동 현상을 이론적으로 규명하고 실험을 통하여 조사하였다. 유연 붐의 지상실험 장치에서 실험을 하였으며 특히 우주 환경과 유사한 진공 환경을 제공하여 대기에서의 열 유기 진동현상과 비교하였다. 대기 조건에서 열 유기 진동 실험 후 수치해석과 실험과 비교분석했으며, 진공조건에서 열 유기 진동 실험 후 실험결과를 분석하였다. The Coupled thermal-structural response of a rapidly heated model spacecraft boom was studied both experimentally and computationally. Two types of test were conducted during the study: (1) thermally-induced vibration in atmospheric (2) thermally-induced vibration in vacuum. The test results that were to explain the phenomena of the thermally-induced vibration for the flexible space structure due to abrupt change of radiation heating circumstance. In order to investigate this. numerical approaches on the simplified flexible tube were compared with experimental test results at the various ground experimental facility. In this analyze, it was found that the thermal deformation occurred firstly due to fast radiation heating of flexible structure and then the thermally-induced vibration would be induced due to small periodic change of temperature.
로켓 추진력을 받는 외팔보의 동적 안정성에 관한 수치 및 실험적 연구
류봉조,삼산길언,Sugiyama, Y. 대한기계학회 1993 대한기계학회논문집 Vol.17 No.11
The paper deals with the flutter of a cantilevered beam subjected to a rocket thrust generated by a solid rocket motor. It is saaumed that the rocket thrust is to be a constant follower thrust, and produced by the installation of a solid rocket motor to the tip end of the cantilevered beam. The rocket motor is considered to be a rigid body having finite sizes, but not a mass point as it has been assumed so far. Governing equations are derived through the extended Hamilton's principle, and finite element method is applied to obtain the theoretical prediction for critical follower thrust. The maximum follower thrust is also calculated through the change of shear deformation parameter of the beam in the numerical simulation. The theoretical prediction for flutter or stability is verified by experiment. The experimental results show that critical follower thrust in theory agrees well with the experimental value taking account of the magnitude, rotary inertia of the rocket motor and the distance from the tip end of the beam to the center of gravity of the rocket motor.
M. Shimizu,Y. Ohsawa,H. Yoda,S. Shirotori,B. Altansargai,N. Shimomura,Y. Kato,S. Oikawa,H. Sugiyama,T. Inokuchi,K. Koi,M. Ishikawa,K. Ikegami,A. Kurobe Korean Magnetics Society 2018 Journal of Magnetics Vol.23 No.4
A voltage-control spintronics memory (VoCSM) which has a potential of low energy consumption uses the spin-Hall effect (SHE) and the voltage-controlled magnetic anisotropy (VCMA) effect for its write operation. In this work, the relationship between the critical switching current (Icsw) and the SHE electrode thickness (tN) is investigated in the range of 5 nm < tN < 8 nm. In the fabrication process, we develop highly-selective patterning process to stop MTJ etching precisely on the surface of the SHE electrode. Using the technique, Icsw is reduced by half as tN is varied from 8 nm to 5 nm, and Icsw of 112 mA at 20 ns write current pulse is obtained for MTJ size of 50 × 150 nm2 on Ta(2 nm)/TaB (3 nm) electrode. The results indicate that the decrease in the SHE electrode thickness is a promised method to reduce Icsw, which leads VoCSM to a low-energy-consumption device.
H. Yoda,Y. Ohsawa,Y. Kato,N. Shimomura,M. Shimizu,K. Koi,S. Shirotori,T. Inokuchi,H. Sugiyama,S. Oikawa,B. Altansargai,M. Ishikawa,A. Kurobe 한국자기학회 2019 Journal of Magnetics Vol.24 No.1
We designed a voltage-control spintronics memory unit-cell, VoCSM, with high write-efficiency to prove a potential to reduce writing energy per bit. By optimizing a self-aligned structure, the cell has the critical switching current (Icsw) smaller than 50 μA at 20 nsec. for designed MTJ size of about 50 × 150 ㎚². The value is much smaller than that for mature STT-MRAM with the similar dimension. VoCSM also was proved to have unlimited endurance. Finally, with an empirical equation of Icsw further reduction of Icsw is estimated to clarify that VoCSM has a potential to reduce Icsw down to several μA.