Polarization-dependent Photore Quantum Well Structure

G. J. Jan,C. M. Lai,J. H. Huang 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.42 No.III

We have measured the polarization-dependent photore ectance spectra of InGaP/GaAs quantum well structure. These quantum well specimens were grown by gas source molecular beam epitaxy at the growth temperature 440 C, 480 C and 520 C for C1007, C1008 and C1009, respectively. Each of these samples consists of a 7 nm GaAs well, 0.2 m (top) and 1 m (bottom) InGaP barrier. The properties of InGaP layer were obtained by characterized the InGaP/GaAs epilayer sample using double X-ray diraction and low temperature photoluminescence experiments. The results show that the strains of InGaP for all samples are less than 0.2 % and the ordered parameters are about 0.3. The PR spectra demonstrate the anisotropic optical properties. Besides, the energy dierences between the ground states are almost equal to the dierences between bandgap of the InGaP barrier. And the ground state energy is 4 meV less than GaAs bandgap for sample C1009. These results suggest that the transitions of QW structure strongly involve with the partial ordered InGaP barrier by type II band alignment.??

c-Cbl-Mediated Neddylation Antagonizes Ubiquitination and Degradation of the TGF-β Type II Receptor

Zuo, W.,Huang, F.,Chiang, Y.,Li, M.,Du, J.,Ding, Y.,Zhang, T.,Lee, H.,Jeong, L.,Chen, Y.,Deng, H.,Feng, X.H.,Luo, S.,Gao, C.,Chen, Y.G. Cell Press 2013 Molecular cell Vol.49 No.3

Transforming growth factor β (TGF-β) is a potent antiproliferative factor in multiple types of cells. Deregulation of TGF-β signaling is associated with the development of many cancers, including leukemia, though the molecular mechanisms are largely unclear. Here, we show that Casitas B-lineage lymphoma (c-Cbl), a known proto-oncogene encoding an ubiquitin E3 ligase, promotes TGF-β signaling by neddylating and stabilizing the type II receptor (TβRII). Knockout of c-Cbl decreases the TβRII protein level and desensitizes hematopoietic stem or progenitor cells to TGF-β stimulation, while c-Cbl overexpression stabilizes TβRII and sensitizes leukemia cells to TGF-β. c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TβRII at Lys556 and Lys567. Neddylation of TβRII promotes its endocytosis to EEA1-positive early endosomes while preventing its endocytosis to caveolin-positive compartments, therefore inhibiting TβRII ubiquitination and degradation. We have also identified a neddylation-activity-defective c-Cbl mutation from leukemia patients, implying a link between aberrant TβRII neddylation and leukemia development.

DISCOVERY OF X-RAY PULSATION FROM THE GEMINGA-LIKE PULSAR PSR J2021+4026

Lin, L. C. C.,Hui, C. Y.,Hu, C. P.,Wu, J. H. K.,Huang, R. H. H.,Trepl, L.,Takata, J.,Seo, K. A.,Wang, Y.,Chou, Y.,Cheng, K. S. IOP Publishing 2013 ASTROPHYSICAL JOURNAL LETTERS - Vol.770 No.1

<P>We report the discovery of an X-ray periodicity of similar to 265.3 ms from a deep XMM-Newton observation of the radio-quiet gamma-ray pulsar, PSR J2021+4026, located at the edge of the supernova remnant G78.2+2.1 (gamma-Cygni). The detected frequency is consistent with the gamma-ray pulsation determined by the observation of the Fermi Gamma-ray Space Telescope at the same epoch. The X-ray pulse profile resembles the modulation of a hot spot on the surface of the neutron star. The phase-averaged spectral analysis also suggests that the majority of the observed X-rays have thermal origins. This is the third member in the class of radio-quiet pulsars with significant pulsations detected from both X-ray and gamma-ray regimes.</P>

The 14-3-3 Gene Function of Cryptococcus neoformans Is Required for its Growth and Virulence

( Jingbo Li ),( Yun C. Chang ),( Chun Hua Wu ),( Jennifer Liu ),( Kyung J. Kwon Chung ),( Sheng He Huang ),( Hiro Shimada ),( Rob Fante ),( Xiaowei Fu ),( Ambrose Jong ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.5

Cryptococcus neoformans is a life-threatening pathogenic yeast that causes devastating meningoencephalitis. The mechanism of cryptococcal brain invasion is largely unknown, and recent studies suggest that its extracellular microvesicles may be involved in the invasion process. The 14-3-3 protein is abundant in the extracellular microvesicles of C. neoformans, and the 14-3-3-GFP fusion has been used as the microvesicle’s marker. However, the physiological role of 14-3-3 has not been explored. In this report, we have found that C. neoformans contains a single 14-3-3 gene that apparently is an essential gene. To explore the functions of 14-3-3, we substituted the promoter region of the 14-3-3 with the copper-controllable promoter CTR4. The CTR4 regulatory strain showed an enlarged cell size, drastic changes in morphology, and a decrease in the thickness of the capsule under copper-enriched conditions. Furthermore, the mutant cells produced a lower amount of total proteins in their extracellular microvesicles and reduced adhesion to human brain microvascular endothelial cells in vitro. Proteomic analyses of the protein components under 14-3-3-overexpressed and -suppressed conditions revealed that the 14-3-3 function(s) might be associated with the microvesicle biogenesis. Our results support that 14-3-3 has diverse pertinent roles in both physiology and pathogenesis in C. neoformans. Its gene functions are closely relevant to the pathogenesis of this fungus.

Experimental Study of the Runaway Current in the J-TEXT Tokamak

Y. H. Luo,Z. Y. Chen,X. Q. Zhang,D. W. Huang,W. Jin,Y. H. Huang,Y. Tang,J. C. Li,R. H. Tong,W. Yan,G. Zhuang 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.64 No.3

Major plasma disruptions in tokamaks often generate runaway currents, which contain electronswith energies of several tens of megaelectron-volts (MeV). These currents can cause substantialdamage when control is lost and the current hits the limiters or the vessel wall. The interactionbetween the runaway electrons and the impurities inside the plasma results in soft X-ray emission,which can provide detailed information about the runaway generation process and the confinementof runaway electrons. A vertical soft X-ray array at the top of Joint Texas Experimental Tokamak(J-TEXT) was used to study the runaway beams resulting from major disruptions. Runawayelectron production and confinement of runaway current were observed by using soft X-ray images.

Inhomogeneous Level Splitting inPr2−xBixRu2O7

van Duijn, J.,Kim, K. H.,Hur, N.,Adroja, D.,Adams, M. A.,Huang, Q. Z.,Jaime, M.,Cheong, S.-W.,Broholm, C.,Perring, T. G. American Physical Society 2005 Physical review letters Vol.94 No.17

<P>We report that Bi doping drives Pr 2-x BixRu2O7 from an antiferromagnetic insulator (x = 0) to a metallic paramagnet (x approximately 1) with a broad low T maximum in C/T. Neutron scattering reveals local low energy spin excitations (variant Planck's omega approximately 1 meV) with a spectrum that is unaffected by heating to k(B)T >> variant Planck's omega. We show that a continuous distribution of splittings of the non-Kramers Pr3+ ground-state doublet such as might result from various types of lattice strain can account for all the data.</P>

Integrated cladding-pumped multicore few-mode erbium-doped fibre amplifier for space-division-multiplexed communications

Chen, H.,Jin, C.,Huang, B.,Fontaine, N. K.,Ryf, R.,Shang, K.,Gré,goire, N.,Morency, S.,Essiambre, R.-J.,Li, G.,Messaddeq, Y.,LaRochelle, S. Nature Publishing Group 2016 Nature photonics Vol.10 No.8

Space-division multiplexing (SDM), whereby multiple spatial channels in multimode and multicore optical fibres are used to increase the total transmission capacity per fibre, is being investigated to avert a data capacity crunch and reduce the cost per transmitted bit. With the number of channels employed in SDM transmission experiments continuing to rise, there is a requirement for integrated SDM components that are scalable. Here, we demonstrate a cladding-pumped SDM erbium-doped fibre amplifier (EDFA) that consists of six uncoupled multimode erbium-doped cores. Each core supports three spatial modes, which enables the EDFA to amplify a total of 18 spatial channels (six cores × three modes) simultaneously with a single pump diode and a complexity similar to a single-mode EDFA. The amplifier delivers >20 dBm total output power per core and <7 dB noise figure over the C-band. This cladding-pumped EDFA enables combined space-division and wavelength-division multiplexed transmission over multiple multimode fibre spans.

Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CL^Pro inhibitors

Kumar, V.,Shin, J.S.,Shie, J.J.,Ku, K.B.,Kim, C.,Go, Y.Y.,Huang, K.F.,Kim, M.,Liang, P.H. Elsevier/North-Holland 2017 ANTIVIRAL RESEARCH Vol.141 No.-

<P>Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory illness with fever, cough and shortness of breath. Up to date, it has resulted in 1826 human infections, including 649 deaths. Analogous to picornavirus 3C protease (3C(PrO)), 3C-like protease (3CL(PrO)) is critical for initiation of the MERS-CoV replication cycle and is thus regarded as a validated drug target. As presented here, our peptidomimetic inhibitors of enterovirus 3C(PrO) (6b. 6c and 6d) inhibited 3CLPr0 of MERS-CoV and severe acute respiratory syndrome coronavirus (SARS-CoV) with IC50 values ranging from 1.7 to 4.7 M and from 0.2 to 0.7 M, respectively. In MERS-CoV-infected cells, the inhibitors showed antiviral activity with EC50 values ranging from 0.6 to 1.4 1.1M, by downregulating the viral protein production in cells as well as reducing secretion of infectious viral particles into culture supernatants. They also suppressed other cc and 8-CoVs from human and feline origin. These compounds exhibited good selectivity index (over 70 against MERS-CoV) and could lead to the development of broad-spectrum antiviral drugs against emerging CoVs and picornaviruses. (C) 2017 Elsevier B.V. All rights reserved.</P>

The Corrosion Behavior of Cold-Rolled 304 Stainless Steel In Salt Spray Environments

Chiang, M.F.,Young, M.C.,Huang, J.Y. Korean Radioactive Waste Society 2011 방사성폐기물학회지 Vol.9 No.2

염분분위기에서의 부식은 사용후핵연료의 중간저장 기간동안 304 스테인레스 강재 건식저장용기의 주 열화기구들 중 하나다. 본 연구에서는 감소정도가 서로 다른 냉연 304 스테인레스 강 시편들에 0.5wt.%의 염화나트륨 연무를 분사시키면서 느린 변형속도시험(SSRT)과 중성염 분사시험(NSS)을 $85^{\circ}C$와 $200^{\circ}C$ 에서 수행하였다. $85^{\circ}C$에서 2000 시간 동안 시험한 NSS시편의 무게 변화는 $200^{\circ}C$에서 시험한 시편의 무게 변화와 크게 달랐다. NSS 시편의 $85^{\circ}C$에서 무게 감량은 미미하였지만, 냉연 감소율이 증가함에 따라서 무게 변화는 점진적으로 감소하였다. $85^{\circ}C$와 $200^{\circ}C$에서 그리고 염분분사 환경에서 가볍게 냉연 가공된 시편의 SSRT 시험으로부터 얻은 항복강도와 극한 인장응력의 값은 공기 중의 값보다 약간 낮았다. 그러나 염분 분위기에서 부식으로 인한 20% 감소 냉연시편의 강도는 더 이상 변화하지 않았다. 예비결과는 냉연 304 스테인레스 강의 질과 성능이 건식저장용기의 제작을 위한 조건에 맞는다는 것을 증명하였다. 그러나 냉연 스테인레스 강의 장기적인 성능을 더 잘 이해하기 위해서는 염분분위기에서 이 재질의 부식거동에 관한 더 많은 연구가 필요하다. Saline corrosion is one of the major degradation mechanisms for stainless steel type 304 (SS304) dry storage cask during the spent fuel interim storage period. Slow strain rate test (SSRT) and neutral salt spray test (NSS) were performed at $85^{\circ}C$ and $200^{\circ}C$ with 0.5 wt% sodium chloride mist sprayed on the cold-rolled SS304 specimens of different degrees of reduction in this study. The weight changes of the NSS specimens tested at $85^{\circ}C$ for 2000 hours differed greatly from those at $200^{\circ}C$. The weight loss of NSS specimens was not significant at $85^{\circ}C$ but the weight gain decreased gradually with increasing the cold-rolled reduction. The yield strength (YS) and ultimate tensile stress (UTS) values obtained from the SSRT tests for lightly cold-rolled specimens in the salt spray environment at $85^{\circ}C$ and $200^{\circ}C$ are slightly lower than in air. But for those with 20% reductions, the specimen strengths were no longer changed by the saline corrosion. The preliminary results demonstrated that the quality and performance of cold-rolled SS304 is acceptable for fabrication of dry storage casks. However, more work on the corrosion behavior of cold-rolled stainless steel in the saline atmosphere is needed to better understand its long-term performance.

Constrained Vapor Bubble Heat Exchanger

J. Huang,M. Karthikeyan,J. Plawsky,P. C. Wayner 대한기계학회 1998 Heat transter conference Vol.6 No.1