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Nobuhisa Kanahara(Nobuhisa Kanahara ),Hiroshi Kimura(Hiroshi Kimura ),Toshihiko Kinoshita(Toshihiko Kinoshita ),Masaomi Iyo(Masaomi Iyo ),Yoshiteru Takekita(Yoshiteru Takekita ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Dopamine supersensitivity psychosis (DSP) is an unstable clinical condition observed in individuals with schizophrenia who have been treated with an antipsychotic medication at a high dosage and/or for a long period. An up-regulation of dopamine D2 receptors (DRD2) is thought to be involved in the essential pathology of DSP. An antipsychotic agent with both tight binding to DRD2 and a long half-life is generally effective for treating DSP, but a patient who meets the criteria of treatment-resistant schizophrenia sometimes needs treatment with clozapine. We report the case details of two patients whose DSP was not controlled with several antipsychotics but was successfully controlled with asenapine. Asenapine binds to a broad range of dopamine receptors and serotonin receptors, and it is thus distinct from other atypical antipsychotics. The unique profile of asenapine may contribute to the control of severe DSP symptoms in individuals with schizophrenia.
Superconducting Properties of Ba2Ca7Cu8O16(O0.8+δF1.2) Studied via Reversible Magnetization
권용태,김영철,김헌정,Akira Iyo,Parasharam M. Shirage 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.61 No.11
The Ba<sub>2</sub>Ca<sub>7</sub>Cu<sub>8</sub>O<sub>16</sub>(O<sub>0.8+δ</sub>F<sub>1.2</sub>) (F-0278) superconductor with 8 CuO<sub>2</sub> planes in the structural unit was investigated by analyzing the reversible magnetization based on the Hao-Clem model and fluctuation theories. In spite of the superconducting block (SCB) being thicker than the charge reservoir block (CRB), the analysis clearly revealed two-dimensional (2D) superconducting properties in F-0278, such as a strong temperature dependence of the Ginzburg parameter κ and a relatively short effective interlayer distance. The extreme 2D behavior can be understood in terms of the significant charge imbalance in the SCB, which was previously proposed to exist in F-0278, where the carriers are distributed quite unequally to crystallographically different CuO2 planes; <i>i.e.</i>, the outer planes (OPs) adjacent to the CRB always contain more carriers than the inner planes (IPs). The 2D nature of F-0278 indicates a significant or complete suppression of the superconductivity in the IPs. The important superconducting parameters were also obtained from the analysis.
Yuko Tanibuchi,Yuko Fujita,Mao Horio,Masaomi Iyo,갠지하시모토 대한정신약물학회 2010 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.8 No.3
Objective: Accumulating evidence suggests that α1-adrenoceptors are involved in the mechanisms of action of some antipsychotic drugs. The purpose of this study is to examine the effects of quetiapine, an atypical antipsychotic drug with antagonist activity at α1-adrenoceptors, on prepulse inhibition (PPI) deficits in mice after a single administration of the NMDA receptor antagonist dizocilpine. Methods: Effects of quetiapine on dizocilpine-induced PPI deficits in mice were examined. Furthermore, we examined the role of α1-adrenoceptors in the mechanisms of action of quetiapine. Results: Pretreatment with quetiapine (3, 10, or 30 mg/kg, p.o.) significantly attenuated dizocilpine (0.1 mg/kg, s.c.)-induced PPI deficits in mice in a dose-dependent manner. Furthermore, dizocilpine-induced PPI deficits were also significantly ameliorated by pretreatment with the selective α1-adrenoceptor antagonist prazosin (1.0 mg/kg, p.o.). Conclusion: These findings suggest that quetiapine ameliorates dizocilpine-induced PPI deficits in mice viaα1-adrenoceptor antagonism, and hence, α1-adrenoceptor antagonism may play a prominent role in quetiapine’s psychopharmacological effects.
Cultivable butyrate-producing bacteria of elderly Japanese diagnosed with Alzheimer’s disease
Thi Thuy Tien Nguyen,Yuta Fujimura,Iyo Mimura,Yusuke Fujii,Ngoc Luong Nguyen,Kensuke Arakawa,Hidetoshi Morita 한국미생물학회 2018 The journal of microbiology Vol.56 No.10
The group of butyrate-producing bacteria within the human gut microbiome may be associated with positive effects on memory improvement, according to previous studies on dementia- associated diseases. Here, fecal samples of four elderly Japanese diagnosed with Alzheimer’s disease (AD) were used to isolate butyrate-producing bacteria. 226 isolates were randomly picked, their 16S rRNA genes were sequenced, and assigned into sixty OTUs (operational taxonomic units) based on BLASTn results. Four isolates with less than 97% homology to known sequences were considered as unique OTUs of potentially butyrate-producing bacteria. In addition, 12 potential butyrate-producing isolates were selected from the remaining 56 OTUs based on scan-searching against the PubMed and the ScienceDirect databases. Those belonged to the phylum Bacteroidetes and to the clostridial clusters I, IV, XI, XV, XIVa within the phylum Firmicutes. 15 out of the 16 isolates were indeed able to produce butyrate in culture as determined by high-performance liquid chromatography with UV detection. Furthermore, encoding genes for butyrate formation in these bacteria were identified by sequencing of degenerately primed PCR products and included the genes for butyrate kinase (buk), butyryl-CoA: acetate CoAtransferase (but), CoA-transferase-related, and propionate CoA-transferase. The results showed that eight isolates possessed buk, while five isolates possessed but. The CoA-transfer- related gene was identified as butyryl-CoA:4-hydroxybutyrate CoA transferase (4-hbt) in four strains. No strains contained the propionate CoA-transferase gene. The biochemical and butyrate-producing pathways analyses of butyrate producers presented in this study may help to characterize the butyrate-producing bacterial community in the gut of AD patients.
Genetic Diversity in Cultivated Sesame (Sesamum indicum L.) and Related Wild Species in East Africa
Nyongesa, Benson Ouma,Were, Beatrice Ang'iyo,Gudu, Samuel,Dangasuk, Otto George,Onkware, Augustino Osoro 한국작물학회 2013 Journal of crop science and biotechnology Vol.16 No.1
Genetic diversity of traditional sesame landraces and related wild species in East Africa remains largely unexplored. Knowing what fraction of the available genetic diversity is actually used by the farmers is of central importance for understanding how cultivation shapes the genetic structure of a crop and for the management of biodiversity preservation. Genetic diversity in cultivated sesame and related wild species in East Africa was determined using inter-simple sequence repeats (ISSR). Six reliable ISSR primers generated 51 amplification fragments of which 36 (70.6%) were polymorphic. The number of amplified fragments ranged from 7 to 12 with a mean of 8.5 fragments per primer. The overall gene diversity and Shannon's index were 0.28 and 0.34, Jaccard's similarity coefficient ranged from 0.26 to 0.96, with an average of 0.67. Forty-six accessions of sesame were divided into six clusters, although the clustering did not indicate any clear division among sesame accessions based on their geographical locations. Each wild species was more distant from cultivated sesame than from other wild species, indicating that no cross-pollination with these wild species occurred during sesame domestication. These results showed a relatively high genetic diversity in sesame and related wild species. Indian-1 and Indian-2 accessions showed a good amount of genetic divergence. The genetic diversity data uncovered in this study can be exploited to improve traditional landraces of sesame in East Africa.
Shigenori Tadokoro,Naho Nonomura,Nobuhisa Kanahara,갠지하시모토,Masaomi Iyo 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.1
Dopamine supersensitivity psychosis (DSP) is a type of acute exacerbation of recurrent psychosis caused by long-term treatment with antipsychotics in schizophrenic patients. Although DSP is exceedingly troublesome for clinicians, effective treatment has not yet been established. Based on clinical research and our animal study, we hypothesize that aripiprazole, an atypical antipsychotic, may reduce the exacerbation of recurrent psychotic episodes. We report the case of a 46-year-old female who suffered from schizophrenia with DSP. In this case, sustained treatment with a high dose of aripiprazole gradually reduced the severity of her recurrent psychotic episodes. In conclusion, sustained treatment with aripiprazole may reduce the exacerbation of recurrent psychotic episodes in schizophrenic patients with DSP, and may be an effective treatment of DSP.
Effects of Cilostazol on Cognitive Deficits in Mice after Repeated Administration of Phencyclidine
갠지하시모토,Yuko Fujita,Tamaki Ishima,Mao Horio,Hiroko Hagiwara,Yuko Tanibuchi,Masaomi Iyo 대한정신약물학회 2010 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.8 No.1
Objective : To examine the effects of cilostazol, a selective inhibitor of type III phosphodiesterase (PDE), on cognitive deficits in mice after repeated administration of the N-methyl-D-aspartate (NMDA) receptor antagonist phencyclidine (PCP). Methods:Saline (10 ml/kg/day) or PCP (10 mg/kg/day) were administered subcutaneously to mice for 10 days (once daily on days 1−5 and 8−12). Three days (day 15) after the final administration of saline or PCP, vehicle (0.5% carboxymethylcellulose)or cilostazol (0.3, 3, 10 or 30 mg/kg/day) were administered orally for 14 consecutive days (once daily on days 15−28). The novel object recognition test (NORT) was performed 24 hours (day 29) after the final administration. Results:In the NORT, PCP -induced cognitive deficits in mice were improved significantly by subsequent sub-chronic (14 days)administration of cilostazol (3, 10 or 30 mg/kg/day), but not by the lowest dose of cilostazol (0.3 mg/kg/day). Conclusion:This study suggests that cilostazol ameliorates PCP-induced cognitive deficits in mice. Therefore, it is likely that cilostazol has therapeutic potential for cognitive deficits in schizophrenia.
갠지하시모토,Yuko Fujita,Mao Horio,Hiroko Hagiwara,Yuko Tanibuchi,Masaomi Iyo 대한정신약물학회 2010 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.8 No.2
This study was undertaken to examine the effects of cilostazol, a selective inhibitor of type III phosphodiesterase (PDE), on hyperlocomotion and prepulse inhibition (PPI) deficits in mice after a single administration of the N-methyl-D-aspartate (NMDA)receptor antagonist dizocilpine. A single oral administration of cilostazol (0.1 and 0.3 mg/kg) significantly attenuated hyperlocomotion and PPI deficits in mice after the administration of dizocilpine (0.1 mg/kg, subcutaneously). This study suggests that cilostazol may have antipsychotic activity in animal models of schizophrenia. Therefore, cilostazol may be a potential therapeutic drug for schizophrenia, given that cilostazol has been safely used throughout the world.