Lack of Association between the MTHFR C677T Polymorphism and Lung Cancer in a Turkish Population

Yilmaz, Meral,Kacan, Turgut,Sari, Ismail,Kilickap, Saadettin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Background: In this case-control study, we aimed to investigate the relationship between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and lung cancer. Materials and Methods: Total 200 individuals including 100 patients with lung cancer and 100 controls were analyzed. Genotyping of MTHFR C677T was performed using PCR and RFLP methods. Results: The majority of the patients were men and 90% were smokers. We found that the risk ratio for development of LC was 13-times higher in smokers compared with non-smokers between patient and control groups in our study (OR:13.5, 95%CI:6.27-29.04, p:0.0001). Besides, the risk ratio for development of LC was nine times higher in individuals with cancer history in their family than those without cancer history (OR:9.65, 95%CI: 2.79-33.36; p:0.0001). When genotype distributions and allele frequencies were analyzed in the study groups, no significant difference was apparent (${\chi}^2$:0.53, p=0.76). In addition, no correlation between genotypes of MTHFRC677T polymorphism and histological type of LC was found (${\chi}^2$:0.99, p=0.60). Conclusions: These results suggest that there was no association between the MTHFR C677T polymorphism and lung cancer in the Turkish population.

HARMONIC CURVATURE FUNCTIONS OF SOME SPECIAL CURVES IN GALILEAN 3-SPACE

Yilmaz, Beyhan,Metin, Seyma,Gok, Ismail,Yayli, Yusuf The Honam Mathematical Society 2019 호남수학학술지 Vol.41 No.2

The aim of the paper is to characterize some curves with the help of their harmonic curvature functions. First of all, we have defined harmonic curvature function of an arbitrary curve and have re-determined the position vectors of helices in terms of their harmonic curvature functions in Galilean 3-space. Then, we have investigated the relation between rectifying curves and Salkowski (or anti-Salkowski) curves in Galilean 3-space. Furthermore, the position vectors of them are obtained via the serial approach of the curves. Finally, we have given some illustrated examples of helices and rectifying curves with some assumptions.

A Case of Adult-Onset Still’s Disease Complicated with Diffuse Alveolar Hemorrhage

Ismail Sari,Omer Binicier,Erkan Yilmaz,Merih Birlik,Servet Akar,Fatos Onen,Nurullah Akkoc 대한의학회 2009 Journal of Korean medical science Vol.24 No.1

Adult-onset Still’s disease (AOSD) is an inflammatory disease that presents with a variety of clinical symptoms. Pulmonary involvement is well-known in AOSD and is seen in up to 53% of AOSD cases, with the most common pulmonary diseases being pleural effusion and transient pulmonary infiltrates. We present the first case of chronic AOSD complicated with diffuse alveolar hemorrhage during the acute flare of the disease.

Determination of the Ground Station Locations for both Dual-Site Ranging and Site-Diversity at Q/V-band Satellite Communication for an Intersatellite System Scenario

Yilmaz, Umit C.,Cavdar, Ismail H. The Korean Society for Aeronautical and Space Scie 2015 International Journal of Aeronautical and Space Sc Vol.16 No.3

Generally, Low Earth Orbit (LEO) satellites are used to collect image or video from earth's surface. The collected data are stored on-board and/or transmitted to the main ground station directly or via polar ground station using terrestrial line. Today, an intersatellite link between a LEO and a GEO satellite allows transmission of the collected data to the main ground station through the GEO satellite. In this study, an approach for a continuous communication starting from LEO through GEO to ground station is proposed by determining the optimum ground station locations. In doing so, diverse ground stations help to determine the GEO orbit as well. Cross-correlation of the long term daily rainfall averages are multiplied with the logarithmic correlation of the sites to calculate the joint correlation of the diverse ground station locations. The minimum values of this joint correlation yield the optimum locations of the ground stations for Q/V-band communication and satellite control operations. Results for several case studies are listed.

The presence of MEFV gene mutations in patients with primary osteoarthritis who require surgery

( Sedat Yilmaz ),( Hakan Erdem ),( Servet Tunay ),( Deniz Torun ),( Halil Genc ),( Yusuf Tunca ),( Omer Karadag ),( Ismail Simsek ),( Muhterem Bahce ),( Salih Pay ),( Ayhan Dinc ) 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.5

Background/Aims: Chronic arthritis of familial Mediterranean fever (FMF) involves weight-bearing joints and can occur in patients without a history of acute attack. Our aim was to investigate a possible causal relationship between FMF and osteoarthritis in a population in which FMF is quite common. Methods: Patients with late stage primary osteoarthritis were enrolled, and five MEFV gene mutations were investigated. The frequency of MEFV gene mutations was compared among patients with osteoarthritis and a previous healthy group from our center. Results: One hundred patients with primary osteoarthritis and 100 healthy controls were studied. The frequency of MEFV gene mutations was significantly lower in the osteoarthritis group (9% vs. 19%). M694V was the most frequent mutation (5%) in the osteoarthritis group, whereas in the control group, E148Q was the most common (16%). In subgroup analyses, the mutation frequency of patients with hip osteoarthritis was not different from that of patients with knee osteoarthritis and controls (7.1%, 9.7%, and 19%, respectively). There were no differences among the three groups with respect to MEFV gene mutations other than E148Q (8.1% vs. 3.6%). E148Q was significantly lower in the osteoarthritis group than in the controls (16% vs. 1%), although the mutations did not differ between patients with knee osteoarthritis and controls. Conclusions: In a population with a high prevalence of MEFV gene mutations, we did not find an increased mutation rate in patients with primary osteoarthritis. Furthermore, we found that some mutations were significantly less frequent in patients with osteoarthritis. Although the number of patients studied was insufficient to claim that E148Q gene mutation protects against osteoarthritis, the potential of this gene merits further investigation.

Harmonic curvature functions of some special curves in Galilean $3-$Space

Beyhan Yilmaz,Seyma Metin,Ismail Gok,Yusuf Yayli 호남수학회 2019 호남수학학술지 Vol.41 No.2

The aim of the paper is to characterize some curves with the help of their harmonic curvature functions. First of all, we have defined harmonic curvature function of an arbitrary curve and have re-determined the position vectors of helices in terms of their harmonic curvature functions in Galilean $3-$space. Then, we have investigated the relation between rectifying curves and Salkowski (or anti-Salkowski) curves in Galilean $3-$space. Furthermore, the position vectors of them are obtained via the serial approach of the curves. Finally, we have given some illustrated examples of helices and rectifying curves with some assumptions.

miR-205 and miR-200c: Predictive Micro RNAs for Lymph Node Metastasis in Triple Negative Breast Cancer

Ufuk Berber,Ismail Yilmaz,Gizem Narli,Aptullah Haholu,Zafer Kucukodaci,Dilaver Demirel 한국유방암학회 2014 Journal of breast cancer Vol.17 No.2

Purpose: We examined expression profiles of 16 micro RNAs(miRNAs) in triple negative breast cancers to identify their potentialas biomarkers for lymph node metastasis. Methods: The expressionprofiles of miR-9, miR-21, miR-30a, miR-30d, miR-31,miR-34a, miR-34c, miR-100, miR-122, miR-125b, miR-146a,miR-146b, miR-155, miR-181a, miR-200c, and miR-205 wereexamined by using real-time quantitative reverse transcriptionpolymerase chain reaction in tumor samples and correspondingbenign breast tissues. Their associations with histopathologicalfeatures and prognostic parameters were assessed. Results:When compared with the expression in benign breast tissues,seven of the miRNAs (miR-31, miR-205, miR-34a, miR-146a,miR-125b, miR-34c, and miR-181a) were downregulated morethan 1.5-fold in tumor tissues, whereas, only miR-21 was foundto be upregulated more than 1.5-fold in tumor tissues. AlthoughmiR-200c levels were decreased only 1.12-fold in tumor tissues,the reduced expressions of miR-200c and miR-205 were significantlyassociated with lymph node metastasis (p=0.021 and p=0.016, respectively). Conclusion: Our results demonstrate thatmiR-205 and miR-200c expression levels may be useful in predictinglymph node metastasis in triple negative breast cancerpatients.

Determination of the Ground Station Locations for both Dual-Site Ranging and Site-Diversity at Q/V-band Satellite Communication for an Intersatellite System Scenario

Umit C. Yilmaz,Ismail H. Cavdar 한국항공우주학회 2015 International Journal of Aeronautical and Space Sc Vol.16 No.3

Generally, Low Earth Orbit (LEO) satellites are used to collect image or video from earth’s surface. The collected data are stored on-board and/or transmitted to the main ground station directly or via polar ground station using terrestrial line. Today, an intersatellite link between a LEO and a GEO satellite allows transmission of the collected data to the main ground station through the GEO satellite. In this study, an approach for a continuous communication starting from LEO through GEO to ground station is proposed by determining the optimum ground station locations. In doing so, diverse ground stations help to determine the GEO orbit as well. Cross-correlation of the long term daily rainfall averages are multiplied with the logarithmic correlation of the sites to calculate the joint correlation of the diverse ground station locations. The minimum values of this joint correlation yield the optimum locations of the ground stations for Q/V-band communication and satellite control operations. Results for several case studies are listed.

A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey

Gamsizkan, Mehmet,Yilmaz, Ismail,Buyukbabani, Nesimi,Demirkesen, Cuyan,Demiriz, Murat,Cetin, Emel Dikicioglu,Ince, Umit,Akalin, Taner,Demirkan, Nese Calli,Lebe, Banu,Erdem, Ozlem,Gokoz, Ozay,Sakiz, Da Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

Background: We defined melanoma distribution in a large series of Turkish patients and evaluated the prognostic parameters of melanomas. Materials and Methods: A total of 1574 patients' data was retrospectively collected at 18 centers in Turkey. Demographic characteristics were questioned and noted. Prognostic parametres were evaluated based on sentinel lymph node involvement. Results: Mean age was 56.7 (4-99) years. While 844 (53.6%) cases were male, 730 (46.4%) cases were female. One thousand four hundred forty-seven (92%) cases were invasive melanoma and 127 (8%) cases were in-situ melanoma. The most common histopathological form was the superficial spreading melanoma (SSM) which was found in 549 patients (37.9%). It was followed by nodular melanoma in 379 (26.2%), acral lentiginous melanoma (ALM) in 191 (13.2%) and lentigo maligna melanoma in 132 (9.1%), respectively. On univariate analysis, lymphovascular invasion (p<0.001), tumor thickness (p<0.001), histopathological subtype (p<0.001), Clark level (p=0.001), ulceration (p<0.001), ${\geq}6/mm^2$ mitosis (p=0.005), satellite formation (p=0.001) and gender (p=0.03) were found to be associated with sentinel lymph node positivity. Regression was associated with sentinel lymph node negativity (p=0.017). According to multivariate analysis, lymphovascular invasion and tumor thickness were significant independent predictive factors of SLN positivity. Patient age, tumor localization, precursor lesions, lymphocytic infiltration and neurotropism were not related with sentinel lymph node involvement. Conclusions: In this retrospective analysis, it was found that the prevalence of SSM is at a lower rate while the prevalence of ALM is at a higher rate when compared to western countries. According to Breslow index; most of the melanoma lesions' thickness were greater than 2 mm, corresponding Clark IV. Vascular invasion and tumor thickness are the most important factors for sentinel lymph node involvement.

CYP1A1 (Ile⁴⁶²Val), CYP1B1 (Ala¹¹⁹Ser and Val⁴³²Leu), GSTM1 (null), and GSTT1 (null) Polymorphisms and Bladder Cancer Risk in a Turkish Population

Berber, Ufuk,Yilmaz, Ismail,Yilmaz, Omer,Haholu, Aptullah,Kucukodaci, Zafer,Ates, Ferhat,Demirel, Dilaver Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

We aimed to investigate bladder cancer risk with reference to polymorphic variants of cytochrome p450 (CYP) 1A1, CYP1B1, glutathione S-transferase (GST) M1, and GSTT1 genes in a case control study. Polymorphisms were examined in 114 bladder cancer patients and 114 age and sex-matched cancer-free subjects. Genotypes were determined using allele specific PCR for CYP1A1 and CYP1B1 genes, and by multiplex PCR and melting curve analysis for GSTM1 and GSTT1 genes. Our results revealed a statistically significant increased bladder cancer risk for GSTT1 null genotype carriers with an odds ratio of 3.06 (95% confidence interval=1.39-6.74, p=0.006). Differences of CYP1A1, CYP1B1 and GSTM1 genotype frequencies were not statistically significant between patients and controls. However, the specific combination of GSTM1 null, GSTT1 null, and CYP1B1 codon 119 risk allele carriers and specific combination of GSTM1 present, GSTT1 null, and CYP1B1 432 risk allele carriers exhibited increased cancer risk in the combined analysis. We did not observe any association between different genotype groups and prognostic tumor characteristics of bladder cancer. Our results indicate that inherited absence of GSTT1 gene may be associated with bladder cancer susceptibility, and specific combinations of GSTM1, GSTT1 and CYP1B1 gene polymorphisms may modify bladder cancer risk in the Turkish population, without any association being observed for CYP1A1 gene polymorphism and bladder cancer risk.