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MARCH-I: a New Regulator of Dendritic Cell Function
Ishido, Satoshi,Matsuki, Yohei,Goto, Eiji,Kajikawa, Mizuho,Ohmura-Hoshino, Mari Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.3
We and other groups have demonstrated that the expression level of MHC class II (MHC II) is regulated through ubiquitination of the MHC II ${\beta}$ chain. We also reported that MARCH-I, an E3 ubiquitin ligase, is critical for this process. At present, however, the importance of MARCH-I-mediated MHC II regulation in vivo is still unknown. In this review, we will summarize recent advances in our understanding of MARCH-I-mediated MHC II ubiquitination, and discuss how we can overcome the difficulties inherent in these studies.
Global value chains and liberalization of trade in services Implications for the Republic of Korea
Hikari Ishido 한국무역학회 2017 Journal of Korea trade Vol.21 No.1
Purpose – The purpose of this paper is to address the importance of establishing global value chains (GVCs) through the liberalization of trade in services, with the Republic of Korea comprising part of these value chains. Design/methodology/approach – The construction of a database has revealed rather disconnected policy arrangements across Asia-Pacific Economic Cooperation (APEC) members in terms of service trade liberalization. Findings – Although the economic benefits arising from harmonized and liberalized policies across APEC members are widely recognized in the business sector, the relevant policy coordination seems to be missing. Research limitations/implications – With this status quo in mind, APEC could work on establishing its own harmonized “service trade commitment table” centering on simple foreign capital participation criteria. This would surely contribute to forming an APEC-wide GVC surrounding Korea, which actively aims to expand its economic ties in the Asia-Pacific region. Originality/value – The comparison of WTO-based and free trade agreement-based service trade commitments by APEC members (including Korea) and Association of Southeast Asian Nations ten members is an original research area, with many policy implications for Korea in the Asia-Pacific Region.
MARCH-I: a New Regulator of Dendritic Cell Function
Satoshi Ishido,Yohei Matsuki,Eiji Goto,Mizuho Kajikawa,Mari Ohmura-Hoshino 한국분자세포생물학회 2010 Molecules and cells Vol.29 No.3
We and other groups have demonstrated that the expres-sion level of MHC class II (MHC II) is regulated through ubiquitination of the MHC II chain. We also reported that MARCH-I, an E3 ubiquitin ligase, is critical for this process. At present, however, the importance of MARCH-I-mediated MHC II regulation in vivo is still unknown. In this review, we will summarize recent advances in our understanding of MARCH-I-mediated MHC II ubiquitination, and discuss how we can overcome the difficulties inherent in these studies.
Robust l<SUP>∞</SUP> stabilization under datarate constraints
Yumiko Ishido,Kiyotsugu Takaba 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper is concerned with robust stabilization of an uncertain system over a rate-limited digital channel from the view point of input-out put stability. Because of the quantization in the communication channel, it is impossible to apply the traditional small gain theorem to establish robust stability of the feedback system. To over come this difficulty, we in troduce a new notion of small l<SUP>∞</SUP> signal l<SUP>∞</SUP> stability, and derive a sufficient robust stability condition a gainst l<SUP>∞</SUP> gain-bounded uncertainty based on this notion. Furthermore, for the case of a scalar nominal system, a sufficientd a tarate for the existence of a robustly stabilizing encoder-controller pairis explicitly given.
Liberalization of Trade in Services under ASEAN+n FTAs: A Mapping Exercise
Hikari Ishido 대외경제정책연구원 2012 East Asian Economic Review Vol.16 No.2
This study maps out the degree of liberalization of trade in services under four ASEAN+n frameworks. After constructing a database showing the existence of limitations on market access and/or national treatment by each service sector, the study finds that the commitment level differs greatly between sensitive and less sensitive sectors, and that the commitment level under the ASEAN Framework Agreement (AFAS) is the highest among the four FTAs studied. It also finds that there are cross-country and sector-wide similarities in the pattern of service sector commitment under and across each of the FTAs; this implies that the shared domestic sensitivities can be overcome by a shared economic cooperation scheme for enhancing competitiveness in the ASEAN+n region.
Yo Kubota,Satoshi Tanabe,Mizutomo Azuma,Kazue Horio,Yoshiki Fujiyama,Takafumi Soeno,Yasuaki Furue,Takuya Wada,Akinori Watanabe,Kenji Ishido,Chikatoshi Katada,Keishi Yamashita,Wasaburo Koizumi,Chika Ku 대한위암학회 2021 Journal of gastric cancer Vol.21 No.4
Purpose: Promoter DNA methylation of various genes has been associated with metachronous gastric cancer (MGC). The cancer-specific methylation gene, cysteine dioxygenase type 1 (CDO1), has been implicated in the occurrence of residual gastric cancer. We evaluated whether DNA methylation of CDO1 could be a predictive biomarker of MGC using specimens of MGC developing on scars after endoscopic submucosal dissection (ESD). Materials and Methods: CDO1 methylation values (TaqMeth values) were compared between 33 patients with early gastric cancer (EGC) with no confirmed metachronous lesions at >3 years after ESD (non-MGC: nMGC group) and 11 patients with MGC developing on scars after ESD (MGCSE groups: EGC at the first ESD [MGCSE-1 group], EGC at the second ESD for treating MGC developing on scars after ESD [MGCSE-2 group]). Each EGC specimen was measured at five locations (at tumor [T] and the 4-point tumor-adjacent noncancerous mucosa [TAM]). Results: In the nMGC group, the TaqMeth values for T were significantly higher than that for TAM (P=0.0006). In the MGCSE groups, TAM (MGCSE-1) exhibited significantly higher TaqMeth values than TAM (nMGC) (P<0.0001) and TAM (MGCSE-2) (P=0.0041), suggesting that TAM (MGCSE-1) exhibited CDO1 hypermethylation similar to T (P=0.3638). The area under the curve for discriminating the highest TaqMeth value of TAM (MGCSE-1) from that of TAM (nMGC) was 0.81, and using the cut-off value of 43.4, CDO1 hypermethylation effectively enriched the MGCSE groups (P<0.0001). Conclusions: CDO1 hypermethylation has been implicated in the occurrence of MGC, suggesting its potential as a promising MGC predictor.