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Kumagai, Hideki,Yokoyama, Koji,Imagawa, Tomoyuki,Inoue, Shun,Tulyeu, Janyerkye,Tanaka, Mamoru,Yamagata, Takanori The Korean Society of Pediatric Gastroenterology 2016 Pediatric gastroenterology, hepatology & nutrition Vol.19 No.3
Fecal microbiota transplantation (FMT) is a treatment designed to correct gut dysbiosis by administration of feces from a healthy volunteer. It is still unclear whether FMT for children with ulcerative colitis (UC) is effective or hazardous. Here we describe a young patient to have received FMT for UC. A three-year-old girl was admitted to our hospital with severe active UC, and treated with aminosalicylates and various immunosuppressive drugs. As remission was not achieved, we decided to try FMT before colectomy. We administered donor fecal material a total of six times by retention enema (${\times}2$) and via a nasoduodenal tube (${\times}4$) within 10 days. The patient developed abdominal pain and pyrexia after each FMT session. Analyses revealed the transferred donor fecal microbiota had not been retained by the patient, who ultimately underwent colectomy. The severity of the UC and/or timing of FMT may have partly accounted for the poor outcome.
Liver Pathology : Composite Liver tumors: A radiologic-pathologic
( Megha Nayyar ),( David K Imagawa ),( Temel Tirkes ),( Aram N Demirjian ),( Roozbeh Houshyar ),( Kumar Sandrasegaran ),( Chaitali S Nangia ),( Tara Seery ),( P Bhargava ),( Joon Ii Choi ),( Chandana 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4
Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis. (Clin Mol Hepatol 2014;20:406-410)
( Joon Il Choi ),( David K Imagawa ),( Priya Bhosale ),( Puneet Bhargava ),( Temel Tirkes ),( Tara E Seery ),( Chandana Lall ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.2
Hepatocellular carcinomas are highly vascular tumors, showing progressive hypervascularity by the process of neoangiogenesis. Tumor angiogenesis is critical for tumor growth as well as metastatic spread therefore, imaging and quantification of tumor neo-angiogenesis is essential for monitoring response to targeted therapies and predicting disease progression. Sorafenib is a molecular targeting agent used for treating hypervascular tumors. This drug is now the standard of care in treatment of patients with advanced hepatocellular carcinoma. Due to its anti-angiogenic and anti-proliferative actions, imaging findings following treatment with Sorafenib are quite distinct when compared to conventional chemotherapeutic agents. Liver MRI is a widely adopted imaging modality for assessing treatment response in hepatocellular carcinoma and imaging features may reflect pathophysiological changes within the tumor. In this mini-review, we will discuss MRI findings after Sorafenib treatment in hepatocellular carcinoma and review the feasibility of MRI as an early biomarker in differentiating responders from non-responders after treatment with molecular targeting agents. (Clin Mol Hepatol 2014;20:218-222)
Masafumi Kobune,Hisashi Oshima,Akihiro Tamura,Kazuki Imagawa,Yusuke Daiko,Atsushi Mineshige,Tetsuo Yazawa,Hitoshi Morioka,Keisuke Saito,Hideshi Yamaguchi,Koichiro Honda 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.31
a- and b-axis-oriented (Bi_(3.25)Nd_(0.75))Ti_3O_(12) films, 3.0 mm thick, were fabricated on conductive IrO_2(101)/Al_2O_3(012) and Nb:TiO_2(101) [Nb = 0, 0.05 and 0.79 mass%] substrates by high-temperature sputtering. A BNT film grown on an IrO_2(101)/Al_2O_3(012) substrate had a low crystallinity (2.83˚), a low degree of a- and b-axis orientations [a_((h00/0k0)) = 49.2%] and a dense microstructure that a- and b-axis-oriented crystals existed locally in the film, while a BNT film grown on Nb:TiO_2(101) substrate with 0.79 mass% Nb showed a high crystallinity (0.57˚), a high a_((h00/0k0)) (99.9%) and a porous microstructure that was comprised of many nanoplate-like crystals. It is shown that the BNT film grew with a heteroepitaxial relationship to the underlying Nb:TiO_2 substrate has a symmetric loop shape, with a remanent polarization (2P_r) of 29 mC/cm^2 and a coercive field (2E_c) of 297 kV/cm.
An evaluation study on advanced public transport priority system using traffic simulation
Takashi Oguchi,Akira Mitsuyasu,Daisuke Oshima,Takane Imagawa 서울시립대학교 도시과학연구원 2017 도시과학국제저널 Vol.21 No.2
For the reasons of environmental issues, congestion mitigation, and vulnerable road users, the surface mass public transport (PT) system in urban area should be improved and promoted in Japan. This paper provides an overview of the current state of public transport priority system (PTPS) and the possibility of advanced PTPS. The effects of advanced PTPS by microscopic traffic simulation are estimated. As a result, it is found that advanced PTPS improves time reliability and transportability of buses, even if a congestion around an intersection occurs. The introduction of combination of bus lane and advanced PTPS improves time reliability and the transportability more. On the other hand, the introduction of bus lane reduces the acceptable volume of other vehicles because of reduction in the number of lanes for them. It is considered that the other users are also expected to shift to PT along with the PT level of service improvement.
Plasma free amino acid profiles of canine mammary gland tumors
Kazuo Azuma,Takeshi Tsuka,Tomohiro Imagawa,Saburo Minami,Yoshiharu Okamoto,Tomohiro Osaki 대한수의학회 2012 Journal of Veterinary Science Vol.13 No.4
The purpose of this study was to elucidate the relationship between plasma free amino acid (PFAA) levels and the clinical stages of mammary gland tumors (MGT) in dogs. PFAA levels in canines with malignant mammary tumors were decreased compared to those of healthy animals. The levels of aspartate and ornithine, in the dogs with tumor metastasis were significantly decreased when compared to those of dogs that did not have metastases. Results of this study indicate that PFAA levels could be a risk factor or biomarker for canine MGT metastasis.
Hideki Kumagai,Koji Yokoyama,Tomoyuki Imagawa,Shun Inoue,Janyerkye Tulyeu,Mamoru Tanaka,Takanori Yamagata 대한소아소화기영양학회 2016 Pediatric gastroenterology, hepatology & nutrition Vol.19 No.3
Fecal microbiota transplantation (FMT) is a treatment designed to correct gut dysbiosis by administration of feces from a healthy volunteer. It is still unclear whether FMT for children with ulcerative colitis (UC) is effective or hazardous. Here we describe a young patient to have received FMT for UC. A three-year-old girl was admitted to our hospital with severe active UC, and treated with aminosalicylates and various immunosuppressive drugs. As remission was not achieved, we decided to try FMT before colectomy. We administered donor fecal material a total of six times by retention enema (×2) and via a nasoduodenal tube (×4) within 10 days. The patient developed abdominal pain and pyrexia after each FMT session. Analyses revealed the transferred donor fecal microbiota had not been retained by the patient, who ultimately underwent colectomy. The severity of the UC and/or timing of FMT may have partly accounted for the poor outcome.