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Youngheun Jee, Hyunyoung Oh, So Jin Bing, Areum Kim, Jinhee Cho 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.4
Our previous research on sulfated polysaccharide purified from Ecklonia cava, a brown alga found in Jeju island, Korea, showed that sulfated polysaccharides modulate the apoptotic threshold of intestinal cells, thereby preventing intestinal damage caused by ionizing radiation. In this study, we investigated the ability of sulfated polysaccharide to augment restoration of small intestinal stem cells from γ-ray-induced damage. In our results, sulfated polysaccharide treatment increased the numbers of Ki-67-positive cells as well as inducible nitric oxide synthase (iNOS)-expressing cells in the small intestine compared with those of irradiated only mice. Meanwhile, exposure to irradiation increased the number of paneth cells, which are frequently associated with intestinal inflammation, whereas sulfated polysaccharide treatment reduced the number of paneth cells in the small intestinal crypt. Conclusively, our data suggest that reduction of iNOS-expressing cells and paneth cells in sulfated polysaccharide-treated mice contributes to the inhibition of radiation-induced intestinal inflammation.
유현영(Hyunyoung Yoo),오병근(Byungkeun Oh),황수홍(Suhong Hwang) 한국디자인학회 2023 디자인학연구 Vol.36 No.4
Background : Korean Agency for Technology and Standards recommends the use of standard pictograms set by the International Standardization Organization(ISO) since 2017. Hence, this study aims to prove whether the standard pictograms are appropriately recognized and to suggest design ways for new pictograms by grasping the expressive characteristics effective in understanding. Methods : Based on the results of three-step user test, this research has presented a design plan for new pictograms. Intended to figure out how the pictogram in current use has been interpreted by the user, the first and second tests have measured the recognition of standard pictograms targeting three age groups. And conducted a comparative evaluation of the level of understanding of both standard and nonstandard pictograms in terms of familiarity, semantic adequacy, and aesthetics. In the third test to identify a proper expressive level of new pictograms, new step-by-step pictograms were created based on the results obtained from the above-mentioned test. And suggest effective expressive methods in message delivery by probing into the ranking of comprehension targeting locals and foreigners. Results : The standard pictograms were low in recognition in the sequence of similar → example → arbitrary → symbol in compliance with the expressive category. With respect to the comparative evaluation of the level of understanding of standard and nonstandard pictograms, the nonstandardconventional type was higher than the standard in terms of familiarity, semantic adequacy, and aesthetics. The investigation of the ranking of comprehension of the new pictogram indicated that pictograms, in which signs have been added to things and behaviors of humans, were most effective in pictogram understanding. Conclusions : This study bears significance in the sense that it analyzes the current status of pictograms applied to public buildings and suggests expressive methods and application ways to improve user understanding by achieving a grasp of the expressive characteristics.