40Gbps급 (4X10) VCSEL Array 구동기

김형수,정성재,김두근,이희현,최영완 중앙대학교정보통신연구소 2001 정보통신연구소논문집 Vol.3 No.2

본 논문에서는 VCSEL(Vertical Cavity Surface Emiting Laser)을 채널당 1Gbps로 동작시키고, DC Bias 전류 변화폭과 RF Modulation 전류 변화폭의 조절이 가능한 구동 드라이버를 현대 0.35㎛ 2-Poly 4-Matel CMOS공정을 이용하여 설계했다. In this paper, we present a 40 Gb/s VCSEL driver (4 x 10 channels, 1 Gbps/ch) designed and fabricated in HYNIX 0.35㎛ 2-poly 4-matel CMOS technology. The CMOS driver designed for a free space optical interconnect system is consisted of two NMOS for driving a VCSEL and protection circuit rejecting influence of electro-static discharge (ESD) or unexpected input signal with several tens voltage amplitude. Two NMOS with CMOS channel length of 0.4㎛ and width of 100 ㎛ are used for adjusting dc bias current from 0 to 27 mA and ac modulation current from 0 to 13.8 mA. Protection circuit is made of two diodes. The purpose of the protection circuit is to permit the input modulation voltage range only from 5 to 5 V.

반도체 공장의 제연설계

김운형,Michael J. Ferreira,안병국 한국화재소방학회 2000 한국화재소방학회논문지 Vol.14 No.4

반도체 공장의 제연설계를 위한 성능기준 설계를 분석하였다. 사례분석을 통하여 제연 설계 시스템의 성능평가 기준을 설정하고 최적의 배연 방법을 분석하기 위한 FDS 화재모델링을 수행하였다. 제연 설계 지침이나 관련 법규 또는 표준화된 기준이 부족한 한국과 미국의 현실에서 본 연구의 성능기준 설계 방법은 반도체공장의 제연 설계를 위한 현실적인 적용과 활용이 기대된다. A performance-based design of smoke management systems for semiconductor fabrication 77cilities is described in this paper The example of one such facility is discussed. Performance criteria for smoke control systems were established, effective smoke removal system features were identified, and optimal system exhaust capacity requirements were developed by applying engineering tools including Fire Dynamic Simulator model. Considering the fact that the absence of relevant design guide, codes or consensus standards for semiconductor smoke design in Korea and United States, this performance based approach can and should be applied to other fabrication facilities designs.

저탄소강의 플라즈마 육성층 특성 평가 (2) : 플라즈마 육성층의 조직 및 특성 비교 Microstructural Evaluation of PTA Coated Layers on the Hardness, Wear Resistance, and Corrosion for the Hardfacing of 16C and Stellite 6 Alloys

김형준,김용진 대한금속재료학회(대한금속학회) 1997 대한금속·재료학회지 Vol.35 No.4

The microstructures of PTA (Plasma Transferred Arc) weld-overlayers were evaluated for those of open arc weldoverlayer and spray & fused coating. DSRW (Dry Sand Rubber Wheel) abrasive wear and potentiostatic corrosion tests in 3% NaCl solution were conducted. The Stellite 6 weld-overlayer by PTA method contains more eutectic and hence shows a little higher hardness than that by open arc method. The 16C weld-overlayer by PTA method contains coarser borides and carbides, but shows a little lower hardness than that by spray & fuse method. The borides and carbides in the spray & fused 16C coating are fine and more or less needle shape, and porosities are still present after fusing treatment. PTA weld-surfaced Stellite 6 overlayer shows twice more wear resistant than that of open arc method largely due to higher eutectic content. PTA weld-surfaced 16C overlayer also shows more wear resistant than that of spray & fuse method due to the size difference in borides and carbides. The results of potentiostatic corrosion tests indicate that both overlayers of PTA are superior to those of open arc and spray & fuse processes.

한·중 성인의 비만도에 따른 영양소 및 식품 섭취 비교

왕?j쯔(Wang, Shuangzi),김형숙(Kim, Hyung-Sook) 충북대학교 생활과학연구소 2021 생활과학연구논총 Vol.25 No.2

This study compares the nutrient and food intake of Korean and Chinese adults. We analyzed data from the China Health and Nutrition Survey, Working Group of Obesity in China, and Korea National Health and Nutrition Examination Survey. The participants were 79,684 adults (17,431 Korean men; 22,133 Korean women; 21,497 Chinese men; and 18,623 Chinese women). The obesity rates of the Chinese men and women (38.8%, 28.4%) were higher than those of their Korean counterparts (37.2%, 26.9%). The Chinese participants also showed a higher intake of energy, fats, and carbohydrates. However, they had a lower intake of dietary fiber, calcium, and vitamin A. They had a higher intake of grains, meat, and milk products compared to the Korean group. However, they had a lower intake of vegetables. In both countries, obese adults had a higher nutrient density of fat, carbohydrates, and sodium compared to non-obese adults. In contrast, they had a lower nutrient density of dietary fiber, calcium, and vitamin A. In conclusion, there were significant differences in the nutrient and food intake of the Korean and Chinese participants. However, there were significant similarities in nutrient density between the obese participants across the two countries.

Electrical Transport Characterization of PEDOT:PSS/n-Si Schottky Diodes and Their Applications in Solar Cells

Khurelbaatar, Z.,Hyung, J.-H.,Kim, G.-S.,Park, N.-W.,Shim, K.-H.,Lee, S.-K. American Scientific Publishers 2014 Journal of Nanoscience and Nanotechnology Vol.14 No.6

We demonstrate locally contacted PEDOT:PSS Schottky diodes with excellent rectifying behavior, fabricated on n-type Si substrates using a spin-coating process and a reactive-ion etching process. Electrical transport characterizations of these Schottky diodes were investigated by both current-voltage (I-V) and capacitance-voltage (C-V) measurements. We found that these devices exhibit excellent modulation in the current with an on/off ratio of similar to 10(6). Schottky junction solar cells composed of PEDOT:PSS and n-Si structures were also examined. From the current density-voltage (J-V) measurement of a solar cell under illumination, the short circuit current (I-SC), open circuit voltage (V-OC), and conversion efficiency (eta) were similar to 19.7 mA/cm(2), similar to 578.5 mV, and similar to 6.5%, respectively. The simple and low-cost fabrication process of the PEDOT: PSS/n-Si Schottky junctions makes them a promising candidate for further high performance solar cell applications.

S. pneumoniae 호흡기감염 마우스에서 Rufloxacin의 항균력에 대한 조직학적 연구

구세광,이형식,김종대,최해윤,이재현 慶山大學校 基礎科學硏究所 2002 基礎科學 Vol.6 No.1

Streptococcus pneumoniae ATCC 6303을 이용한 국소 호흡기 감염 마우스 모델에서 Rufloxacin (RUFX)의 in vivo 항균력을 조직학적으로 평가하기 위하여 생균수와 폐의 조직·병리학적 변화를 관찰하였던 결과, 다음과 같은 결과를 얻었다. 1) 생균수는 RUFX 투여군에서 Control 군에 비해 유의성 있게 감소되었으며, 2). Control 군에서는 현저한 폐내 염증세포의 침윤, 출혈 및 폐포 벽의 비후가 조직학적으로 관찰되었으나, 이러한 조직학적 소견들은 RUFX 투여군에서 Control 군에 비해 현저히 있게 감소되었고, 3). LSA (luminal surface of alveoli %)는 Control 군에서 Sham 군에 비해 현저히 감소된 반면, RUFX 투여군에서 Control 군에 비해 유의성 있게 증가되었다. 이상에서 RUFX의 Sterptococcus pneumoniae에 대한 항균력이 조직학적으로 관찰되었다. In order to evaluate the in vivo effect of rufloxacin (RUFX), the viable bacterial number and histopathological changes were monitored after experimental respiratory infection with Sterptococcus pneumoniae ATCC 6303. In RUFX, the viable bacterial numbers were significantly and dose-dependently decreased compared to that of Control group. In Control group, severe infiltration of inflammatory cells, hemorrhage and hypertrophy of alveolar linings were demonstrated at microscopical levels. However, these abnormal histopathological changes were significantly and dose-dependently decreased compared to that of Control group in RUFX group. And also in RUFX group, the LSA (luminal surface of alveoli %) were significantly and dose-dependently increased compared to that of Control group. According to these results, it is considered as the in vivo antibacterial activity of RUFX was histologically showed against Steptococcus pneumoniae ATCC 6303 infection of respiratory tract in this study.

방광의 MALT 림프종 1예

이지연,김원석,송서영,이순일,박준오,김기현,고영혜,정철원,임영혁,강원기,이홍기,이희정,박찬형,박근칠 대한내과학회 2002 대한내과학회지 Vol.63 No.1

Primary lymphoma of the urinary bladder is a rare non-epithelial bladder tumor accounting for less than 1% of all bladder tumors. Approximately 17 cases of MALT lymphomas of bladder have been reported in the literature. Most reported MALT lymphomas of bladder have a female sexual preponderance with a mean age of 58 years with common presenting symptoms of hematuria, dysuria and urinary frequency. The reported prognosis of MALT lymphoma of the urinary bladder is excellent. We report a case of MALT lymphoma of urinary bladder in a 57-year-old woman patient who presented with a two-year history of persistent dysuria and urinary frequency. An intravenous pyelogram and cystoscopy revealed a 1 cm focal elevated lesion at the base of urinary bladder. The tissue obtained by transurethral resection (TUR) showed plasma cell infiltration consistent with low grade marginal zone B cell lymphoma. The immunohistochemical studies showed an immunoglobulin restriction to lambda light chain while the nested polymerase chain reaction analysis of the tissue showed a monoclonal Ig heavy-chain gene rearrangement. The clinical staging protocol revealed that the tumor was primarily arising from the urinary bladder with no evidence of other site involvements. The patient received radiation therapy of 3060 cGy in 17 fractions.

S. pneumoniae 호흡기감염 마우스에서 Ciprofloxacin의 항균력에 대한 조직학적 연구

구세광,이형식,김종대,최해윤,이재현 慶山大學校 基礎科學硏究所 2002 基礎科學 Vol.6 No.1

Sterptococcus pneumoniae ATCC 6303을 이용한 국소 호흡기 감염 마우스 모델에서 Ciprofloxacin (CPFX)의 in vivo 항균력을 조직학적으로 평가하기 위하여 생균수와 폐의 조직·병리학적 변화를 관찰하였던 결과, 다음과 같은 결과를 얻었다. 1) 생균수는 CPFX 투여군에서 Control 군에 비해 유의성 있게 감소되었으며, 2) Control 군에서는 현저한 폐내 염증세포의 침윤, 출혈 및 폐포 벽의 비후가 조직학적으로 관찰되었으나, 이러한 조직학적 소견들은 CPFX 투여군에서 Control 군에 비해 현저히 있게 감소되었고, 3) LSA (luminal surface of alveoli %)는 Control 군에서 Sham 군에 비해 현저히 감소된 반면, CPFX 투여군에서 Control 군에 비해 유의성 있게 증가되었다. 이상에서 본 실험의 결과, CPFX의 Sterptococcus pneumoniae에 대한 항균력이 조직학적으로 관찰되었다. In order to evaluate the in vivo effect of ciprofloxacin (CPFX), the viable bacterial number and histopathological changes were monitored after experimental respiratory infection with Sterptococcus pneumoniae ATCC 6303. In CPFX, the viable bacterial numbers were significantly and dose-dependently decreased compared to that of Control group. In Control group, severe infiltration of inflammatory cells, hemorrhage and hypertrophy of alveolar linings were demonstrated at microscopical levels. However, these abnormal histopathological changes were significantly and dose-dependently decreased compared to that of Control group in CPFX group. And also in CPFX group, the LSA (luminal surface of alveoli %) were significantly and dose-dependently increased compared to that of Control group. According to these results, it is considered as the in vivo antibacterial activity of CPFX was histologically showed against Sterptococcus pneumoniae ATCC 6303 infection of respiratory tract in this study.

Snail1 is Stabilized by O-GlcNAc Modification in Hyperglycemic Condition and Causes Epithelial-Mesenchymal Transition

Sang Yoon Park,Hyun Sil Kim,Nam Hee Kim,Suena Ji,So Young Cha,Jeong Gu Kang,Ichiro Ota,Keiji Shimada,Noboru Konishi,Hyung Wook Nam,Won Ho Yang,Jürgen Roth,Jong In Yook,Jin Won Cho 한국당과학회 2010 한국당과학회 학술대회 Vol.2010 No.1

Protein O-phosphorylation can occur reciprocal with O-GlcNAc modification and represents a regulatory principle for proteins. O-phosphorylation of serine by GSK-3β on Snail1, a transcriptional repressor of E-cadherin and a key regulator of the epithelial-mesenchymal transition (EMT) program, results in its proteasomal degradation. We show that Snail1 carries O-GlcNAc at serine112 that stabilizes it by suppressing O-phosphorylation-mediated degradation. Stabilization by O-GlcNAc of Snail1 results in attenuation of E-cadherin mRNA expression. Enhanced O-GlcNAc modification occurred under hyperglycemic conditions and initiated EMT by transcriptional suppression of E-cadherin through Snail1. Thus, a molecular link exists between cellular glucose metabolism and the control of EMT by dynamic reciprocal O-phosphorylation and O-GlcNAc modification of Snail1.

Prognostic factors in patients with advanced biliary tract cancer treated with first-line gemcitabine plus cisplatin: retrospective analysis of 740 patients

Kim, B. J.,Hyung, J.,Yoo, C.,Kim, K. p.,Park, S. J.,Lee, S. S.,Park, D. H.,Song, T. J.,Seo, D. W.,Lee, S. K. Springer 2017 Cancer chemotherapy and pharmacology Vol.80 No.1

<P>Our retrospective analysis of a large number of patients in a real-world setting found comparable efficacy outcomes to the ABC-02 trial. The prognostic factors identified here may help to predict clinical outcomes and design future clinical trials for advanced BTC.</P>