Regulation of morphogenesis and neural differentiation of human mesenchymal stem cells using carbon nanotube sheets

Kim, Jeong Ah,Jang, Eui Yun,Kang, Tae June,Yoon, Sungjun,Ovalle-Robles, Raquel,Rhee, Won Jong,Kim, Taewoo,Baughman, Ray H.,Kim, Yong Hyup,Park, Tai Hyun Oxford University Press 2012 Integrative biology Vol.4 No.6

Plenary Session 2 : PS-2-3 ; Validation of a new model, MESIAH to predict survival in a cohort of patients with hepatocellular carcinoma

( Bo Hyun Kim ),( Joong Won Park ),( Hee Won Kwak ),( Byung Ho Nam ),( W Ray Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Survival of hepatocellular carcinoma (HCC) patients is determined by hepatic function as well as tumor extent. Recently, a new model to predict survival of ambulatory patients with HCC has been proposed based on demographic (age), clinical (MELD and albumin), and tumor characteristics (tumor size, number, vascular invasion, extrahepatic metastasis, and alpha-fetoprotein). The aim of this study was to evaluate the predictive value of this new MESIAH (Model to Estimate Survival in Ambulatory HCC patients) score for prognosis in patients with HCC. Methods: A total of 2,608 patients diagnosed with HCC at the National Cancer Center between 2004 January and 2009 December were enrolled and analyzed. C-statistics of MESIAH score was assessed for overall mortality. To perform this test, patients censored before 6, 12, 36, and 60 months were excluded from the analysis. Results: The median age of the patients was 56 years (interquartile range [IQR], 49-64 years) and 83% were male. Hepatitis B virus was the predominant etiology (74.2%) and most were Child-Pugh class A (79.9%). The median MELD and MESIAH score was 9.3 (IQR, 8.0-11.3) and 4.7 (IQR, 3.8-5.8). The median overall survival was 21.2 months (95% confidential interval [CI]: 19.2-23.2 months). The c-statistics of MESIAH were 0.863, 0.873, 0.868, and 0.847 for 6-, 12-, 36-, and 60-month mortality, respectively; however, c-statistics of MELD and BCLC were 0.593 (95% CI: 0.570-0.616) and 0.810 (95% CI: 0.791-0.828) for 12-month mortality. For 3-month mortality, the c-statistic was 0.850 (95% CI: 0.830-0.870) 6-month 0.863 (95% CI: 0.847-0.880) 12-month 0.873 (95% CI: 0.858-0.887) 24-month 0.867 (95% CI: 0.852-0.882) 36-month 0.868 (95% CI: 0.852-0.884) 48-month 0.865 (95% CI: 0.846-0.884) 60-month 0.847 (95% CI: 0.823-0.871) Conclusions: A new risk score model, MESIAH, successfully estimates the survival of Korean HCC patients and could be applied to clinical practice and research.

Plenary Session 2 : PS-2-3 ; Validation of a new model, MESIAH to predict survival in a cohort of patients with hepatocellular carcinoma

( Bo Hyun Kim ),( Joong Won Park ),( Hee Won Kwak ),( Byung Ho Nam ),( W Ray Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: Survival of hepatocellular carcinoma (HCC) patients is determined by hepatic function as well as tumor extent. Recently, a new model to predict survival of ambulatory patients with HCC has been proposed based on demographic (age), clinical (MELD and albumin), and tumor characteristics (tumor size, number, vascular invasion, extrahepatic metastasis, and alpha-fetoprotein). The aim of this study was to evaluate the predictive value of this new MESIAH (Model to Estimate Survival in Ambulatory HCC patients) score for prognosis in patients with HCC. Methods: A total of 2,608 patients diagnosed with HCC at the National Cancer Center between 2004 January and 2009 December were enrolled and analyzed. C-statistics of MESIAH score was assessed for overall mortality. To perform this test, patients censored before 6, 12, 36, and 60 months were excluded from the analysis. Results: The median age of the patients was 56 years (interquartile range [IQR], 49-64 years) and 83% were male. Hepatitis B virus was the predominant etiology (74.2%) and most were Child-Pugh class A (79.9%). The median MELD and MESIAH score was 9.3 (IQR, 8.0-11.3) and 4.7 (IQR, 3.8-5.8). The median overall survival was 21.2 months (95% confidential interval [CI]: 19.2-23.2 months). The c-statistics of MESIAH were 0.863, 0.873, 0.868, and 0.847 for 6-, 12-, 36-, and 60-month mortality, respectively; however, c-statistics of MELD and BCLC were 0.593 (95% CI: 0.570-0.616) and 0.810 (95% CI: 0.791-0.828) for 12-month mortality. For 3-month mortality, the c-statistic was 0.850 (95% CI: 0.830-0.870) 6-month 0.863 (95% CI: 0.847-0.880) 12-month 0.873 (95% CI: 0.858-0.887) 24-month 0.867 (95% CI: 0.852-0.882) 36-month 0.868 (95% CI: 0.852-0.884) 48-month 0.865 (95% CI: 0.846-0.884) 60-month 0.847 (95% CI: 0.823-0.871) Conclusions: A new risk score model, MESIAH, successfully estimates the survival of Korean HCC patients and could be applied to clinical practice and research.

Survival Benefits of Direct-Acting Antiviral Therapy in Patients with Decompensated Hepatitis C Cirrhosis

( W. Ray Kim ),( Anu Osinusi ),( Ajitha Mannalithara ),( Bo Hyun Kim ),( Raul Aguilar Schall ),( Diana Brainard ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Current direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection leads to sustained virological response (SVR) in the vast majority of patients, even in those with decompensated cirrhosis. SVR in patients with decompensated cirrhosis has been associated with improvement in liver function; however, the extent to which DAA impacts on mortality remains to be determined. We analyze mortality in patients who participated in clinical trials evaluating sofosbuvir-based regimens in patients with decompensated HCV cirrhosis (GS-US-334-0125, SOLAR and ASTRAL studies), in comparison with mortality predicted by a survival model derived in untreated HCV patients. Methods: Current direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection leads to sustained virological response (SVR) in the vast majority of patients, even in those with decompensated cirrhosis. SVR in patients with decompensated cirrhosis has been associated with improvement in liver function; however, the extent to which DAA impacts on mortality remains to be determined. We analyze mortality in patients who participated in clinical trials evaluating sofosbuvir-based regimens in patients with decompensated HCV cirrhosis (GS-US-334-0125, SOLAR and ASTRAL studies), in comparison with mortality predicted by a survival model derived in untreated HCV patients. Results: There was a total of 492 patients, whose median age was 58 years, MELD 12, sodium 137mEq/l and albumin 2.9 g/ dl. Ascites and HE were common (79% and 63%, respectively). Altogether, 411/479 (86%) patients achieved SVR12. During the follow up, there were 25 deaths within one year of DAA therapy start, including 15 in the SOLAR and 10 in the ASTRAL data; no deaths occurred in GS-US-334-0125. The number of observed deaths in the clinical trials closely followed the expected/predicted numbers early in the treatment course (Figure). Starting at 100 days after initiation of DAA, however, the observed number of deaths was statistically significantly smaller than expected (SMR=0.54, 95% confidence interval [CI]=0.30- 0.98). All subsequent deaths occurred at a lower frequency than expected. The last (25th) death during the study period occurred on day 339, when the SMR had decreased to 0.44 (95% CI=0.30-0.65), which remained unchanged at the end of the analysis (day 365). Conclusions: DAA therapy in patients with decompensated HCV cirrhosis leads to significantly decreased mortality, which may be apparent as early as 100 days after the initiation of therapy with the risk of mortality decreasing to 44% of the expected by the end of the first year.

Distribution of Discharge Intensity along Small-Diameter Collector Well Laterals in a Model Riverbed Filtration

Kim, Seung-Hyun,Ahn, Kyu-Hong,Ray, Chittaranjan American Society of Civil Engineers 2008 Journal of irrigation and drainage engineering Vol.134 No.4

다문화 가정 유아의 발달에 관한 조사 연구

이현경 ( Hyun Kyung Lee ),서현 ( Hyun Seo ),김동례 ( Dong Ray Kim ) 미래유아교육학회 2009 미래유아교육학회지 Vol.16 No.3

본 연구는 다문화 가정 유아의 발달이 건강, 사회, 표현, 언어, 탐구 생활 영역별에 따라 어떠한지 그리고 유아와 어머니의 변인에 따라 차이가 있는지를 알아보고자 하였다. 이를 위해 전라남도 지역에 소재한 보육시설에 재원 중인 다문화 가정 유아를 대상으로 관찰 체크리스트를 사용하여 교사가 관찰·평정하도록 하였으며 총 267명의 유아가 참여하였다. 본 연구의 결과 다문화 가정 유아들의 발달 점수는 건강생활 영역에서 가장 높은 것으로 나타났다. 유아와 부모변인별에 따라 살펴본 결과는 유아의 연령, 성별, 선행교육 경험 유무에 따라서만 통계적으로 차이를 보였다. This study investigates the development of health, social, expressional, language, and exploration of the young children in multi cultural Family and the difference of young children`s and mother`s variables. The subjects of this study were 267 children, their teacher. teacher were asked to observe and keep records of children`s behavior. This study shows that the health developmental level of the children was high in Multi cultural Family. Also, The result shows significant difference in children`s age, sex, pre-educational experiences by children`s and mother`s variables.

보육시설 평가인증제 참여교사와 비참여교사이 직무만족도 비교 연구

김동례(Kim Dong Ray),이현경(Lee Hyun Kyung) 한국열린유아교육학회 2008 열린유아교육연구 Vol.13 No.2

본 연구는 보육시설 평가인증제 참여 여부에 따라 보육교사의 직무만족도어 차이가 있는지를 분석해보는 데 그 목적이 있다. 전라남도에 소재한 보육시설 중 평가인증제에 참여한 보육시설의 교사 200명과 평가인증제에 참여하지 않은 시설의 교사 200명을 대상으로 직무만족도 검사를 실시하였다. 수집된 자료는 t-검증으로 분석하였다. 연구결과 첫째, 평가인증제 참여교사의 직무만족도가 비참여 교사의 직무만족도 보다 높은 것으로 나타났다. 둘째, 보육교사의 개인적 특성별에 따른 차이를 분석한 결과 연령별, 최종학력별 직책별에 따른 분석에서 평가인증제 참여교시가 비참여 교사에 비해 유의미하게 더 높은 직무만족도를 나타냈다. 셋째. 보육시설의 특성별에 따른 분석에서는 모든 요인에서 평가인증제 참여교사의 만족도가 비참여 교사에 비해 유의미하게 높은 만족도를 나타냈다. 이러한 결과는 평가인증제 참여교부 교사의 개인적 특성 보육시설의 특성에 따라서 보육교사의 직무만족도에 차이가 나타날 수 있음을 시사한다. The purpose of this study was to analyze the effect of the evaluative accreditation system on child-care center teachers' job satisfaction. A questionnaire was conducted and to 200 child-care center teachers who participated in the evaluative accreditation system and to 200 child-care center teachers who did not. The data was then analyzed by t-test. The results of this study showed that the child-care center teachers' job satisfaction for those who participated in the evaluative accreditation system is higher than those who did not. Secondly, there were significant differences in child-care center teachers' job satisfaction for those who participated in the evaluative accreditation system when analyzed by the childcare center teacher's personal characteristics, such as age, education and their job position. Finally, on the analysis of each child-care center's atmosphere and conditions, every factor showed significant differences in teachers' job satisfaction for those who participated in the evaluative accreditation system and those who did not. This result implies that the evaluative accreditation system has a positive effect on teacher job satisfaction. This may in turn imply an effect on a teacher's personal characteristics and a child-care center's conditions.

Microscopically Buckled and Macroscopically Coiled Fibers for Ultra-Stretchable Supercapacitors

Choi, Changsoon,Kim, Ji Hwan,Sim, Hyun Jun,Di, Jiangtao,Baughman, Ray H.,Kim, Seon Jeong Wiley Blackwell (John Wiley Sons) 2017 Advanced energy materials Vol.7 No.6

Inhibition of Plaque Formation on the Titanium Surface by Anti-bacterial Varnish

정현주,이상현,김영준,Chung, Hyun-Ju,Lee, Sang-Hyun,Kim, Yung-Jun,Williams, Ray C. The Korean Academy of Periodontoloy 2000 Journal of Periodontal & Implant Science Vol.30 No.4

매식된 인공치아의 성공을 위해서는 적절한 교합과 수동적 적합성을 갖는 보철물의 제작과 구강내 노출 직후부터의 세균성 치태조절이 요구된다. 본 연구는 전처리(passivation과 tridodecyl - methyl - ammonium chloride(TDMAC) 처리)가 다른 타이타늄 표 면에 chlorhexidine varnish와 테트라사이클린 을 도포시 약제의 방출역학을 알아보고 구강내 치태형성의 억제정도를 평가하기 위하여 시행 되었다. 이를 위해 방출용액으로 인산완충액 성분의 인조타액을 1일${\sim}$1개월간 매일 교환하여 약제농도를 측정하고 타이타늄 박막에 잔류한 약제 활성을 측정하였으며 항균제 도포한 타이타늄 원판을 부착한 장치를 구강내 위치시킨 1일${\sim}$3주 후 원판을 제거하여 주사전자현미경으로 세균 부착상을 관찰하였다. 테트라사이클린은 TDMAC 처리된 표면에서 $10{\sim}18$일까지 유효농도로 방출되었고 표면의 유효 항균 활성은 $3{\sim}4$주간 유지되었으며, chlorhexidine varnish 도포 시에는 TDMAC 전처리시 초기에 $3{\sim}7$일 간 증가한 유효 항균 활성을 방출하여 매식지대치 등에 이러한 항균제도포 시 매식치 주위환경에 항균활성 공급원으로 작용할 수 있음을 보였다. 주사현미경적 관찰시 모든 타이타늄 표면에서 구강내 위치 30분 후에는 세균이 부착되어 있지 않고 타액 단백질 성분에서 유래한 것으로 보이는 피막물질이 표면을 부분 또는 전면에 걸쳐 덮고 있었다. 구강내 노출 2시간 후 항균제 미도포 표본들에는 약간의 구균이 단층으로, $1{\sim}3$일 후에는 부분적으로 두꺼운 세균층을 형성하였고 7일 후에는 표면전체에 걸쳐 세균층이 덮여있었으며 주로 구균과 약간의 간균이 주종을 이루었다. 항균제 도포시 구강내 노출 1주일 이전까지는 미도포군에 비해 치태형성이 지연되는 경향을 보였지만 2주 이후에는 세균 수나 치태형성 양상이 유사하였다. 이 연구로부터 항균제 도포시 1주일 이전의 초기 치태형성을 감소시킬 수 있음을 알 수 있었으며 이러한 연구결과는 타이타늄 임프란트 지대치 표면에 항균제의 도포가 임상적으로 유용할 수 있음을 시사하였다.

Free Paper Session : HCC ; A MELD-based risk score model for prediction of survival in patients with hepatocellular carcinoma (초)

( Ju Dong Yang ),( W. Ray Kim ),( Kyung Woo Park ),( Bo Hyun Kim ),( Schuyler O. Sanderson ),( Joseph J. Larson ),( Rachel A. Pedersen ),( Terry M. Therneau ),( Gregory J. Gores ),( Lewis R. Roberts ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)