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하수오 추출물, 분획물 및 주성분의 항산화, 세포 보호 및 항균 활성에 관한 평가
신혁수 ( Hyuk Soo Shin ),김민우 ( Minwoo Kim ),송제리 ( Jerry Song ),이준석 ( Junseok Lee ),하윤정 ( Yoonjeong Ha ),전영희 ( Young Hee Jeon ),김지웅 ( Ji Woong Kim ),이윤주 ( Yun Ju Lee ),박수남 ( Soo Nam Park ) 대한화장품학회 2018 대한화장품학회지 Vol.44 No.4
본 연구에서는 하수오를 이용하여 50% 에탄올 추출물과 에틸아세테이트 분획물을 제조하고, 추출물 및 분획물의 항산화, 세포 보호 및 항균 효능을 평가하여 기능성 소재로서의 가능성을 확인하였다. 또한, 하수오에 주요하게 존재하는 성분의 활성도 검증하였다. HPLC-DAD, LC-EIS-MS를 통해 분석한 결과, 하수오의 주성분은 2, 3, 5, 4'-tetrahydroxystilbene 2-O-β-D-glucoside (THSG)이었다. 페놀류 및 THSG 함량은 에틸아세테이트 분획물이 에탄올 추출물 보다 각각 11.1 및 3.0배 높게 나타났다. DPPH 자유 라디칼 및 Fe<sup>3+</sup>-EDTA/H<sub>2</sub>O<sub>2</sub> 시스템에서 생성된 ROS에 대한 소거 활성 평가에서, 에틸 아세테이트 분획물은 에탄올 추출물 보다 뛰어난 소거 활성을 나타냈다. 특히 ROS 소거 활성 평가에서 에틸 아세테이트 분획물과 THSG은 L-ascorbic acid와 동등한 소거 활성을 나타냈다. 이러한 결과를 바탕으로 수행된 광증감 반응으로 유도된 적혈구의 산화적 손상에 대한 세포 보호 활성은 에틸아세테이트 분획물, 에탄올 추출물, THSG 순서로 나타났으며, 모든 실험군이 양성 대조군으로 사용한 (+)-α-tocopherol보다 우수한 활성을 나타냄을 확인하였다. 항균 활성 평가는 S. aureus, E. coli, P. aeruginosa, C. albicans 균주를 대상으로, disc diffusion assay와 broth microdilution assay를 이용하여 수행하였다. 그 결과 추출물, 분획물 및 THSG 모두 모든 균주에 대해 항균 활성을 나타냈으며, 특히 그람 양성균인 S. aureus에 대해 methyl paraben보다 우수한 항균력을 나타냄을 확인하였다. 본 연구의 결과는 하수오가 항산화, 세포 보호 및 항균력에 관한 천연 소재로의 활용될 수 있는 가능성을 시사한다. In this study, the antioxidant, cytoprotective and antimicrobial activities of 50% ethanol extract of Polygoni multiflori Radix (PMR) and its ethyl acetate fraction were evaluated to confirm the applicability as a functional ingredient. The activities of the major constituent of PMR were verified and 2, 3, 5, 4′-tetrahydroxystilbene 2-O-β-D-glucoside (THSG) was confirmed to be the main component of extract and fraction using HPLC-DAD, LC-EIS-MS analysis. The phenolic and THSG contents of the ethyl acetate fraction were 11.1- and 3.0-folds higher than those of the ethanol extract, respectively. As a result of the DPPH assay and that of luminol dependent chemiluminescence assay in Fe<sup>3+</sup>-EDTA/H2O2 system. the ethylacetate fraction was superior to the ethanol extract in free radical and ROS scavenging activities. Especially, the ethyl acetate fraction and THSG exhibited the similar scavenging activity like L-ascorbic acid in ROS scavenging activity. The ethyl acetate fraction perceived the most potent cytoprotective effect against oxidative damage of erythrocytes induced by photosensitization reaction, followed by the ethanol fraction, THSG and that of (+)-α-tocopherol, which was used as a positive control. Antimicrobial activities were evaluated by disc diffusion and broth microdilution assay against S. aureus, E. coli, P. aeruginosa and C. albicans. In particular, the antibacterial activity of the extract and fraction against S. aureus was superior to that of methyl paraben. Taken together, our results suggest that PMR could be used as a natural ingredient for antioxidant, cytoprotective and antimicrobial activities.
Spinal Anesthesia with Isobaric Tetracaine in Patients with Previous Lumbar Spinal Surgery
Soo Hwan Kim,Dong-Hyuk Jeon,장철호,이성진,신양식 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.2
Purpose: Previous lumbar spinal surgery (PLSS) is not currently considered as a contraindication for regional anesthesia. However, there are still problems that make spinal anesthesia more difficult with a possibility of worsening the patient’s back pain. Spinal anesthesia using combined spinal-epidural anesthesia (CSEA) in elderly patients with or without PLSS was investigated and the anesthetic characteristics, success rates, and possible complications were evaluated. Materials and Methods: Fifty patients without PLSS (Control group) and 45 patients with PLSS (PLSS group) who were scheduled for total knee arthroplasty were studied prospectively. A CSEA was performed with patients in the left lateral position, and 10 mg of 0.5% isobaric tetracaine was injected through a 27 G spinal needle. An epidural catheter was then inserted for patient controlled analgesia. Successful spinal anesthesia was defined as adequate sensory block level more than T12. The number of skin punctures and the onset time were recorded, and maximal sensory block level (MSBL), time to 2-segment regression, success rate and complications were observed. Results: The success rate of CSEA in Control group and PLSS group was 98.0%, and 93.3%, respectively. The median MSBL in PLSS group was higher than Control group [T4 (T2-L1) vs. T6 (T3- T12)] (p < 0.001). There was a significant difference in the number of patients who required ephedrine for the treatment of hypotension in PLSS group (p = 0.028). Conclusion: The success rate of CSEA in patients with PLSS was 93.3%, and patients experienced no significant neurological complications. The MSBL can be higher in PLSS group than Control group. Purpose: Previous lumbar spinal surgery (PLSS) is not currently considered as a contraindication for regional anesthesia. However, there are still problems that make spinal anesthesia more difficult with a possibility of worsening the patient’s back pain. Spinal anesthesia using combined spinal-epidural anesthesia (CSEA) in elderly patients with or without PLSS was investigated and the anesthetic characteristics, success rates, and possible complications were evaluated. Materials and Methods: Fifty patients without PLSS (Control group) and 45 patients with PLSS (PLSS group) who were scheduled for total knee arthroplasty were studied prospectively. A CSEA was performed with patients in the left lateral position, and 10 mg of 0.5% isobaric tetracaine was injected through a 27 G spinal needle. An epidural catheter was then inserted for patient controlled analgesia. Successful spinal anesthesia was defined as adequate sensory block level more than T12. The number of skin punctures and the onset time were recorded, and maximal sensory block level (MSBL), time to 2-segment regression, success rate and complications were observed. Results: The success rate of CSEA in Control group and PLSS group was 98.0%, and 93.3%, respectively. The median MSBL in PLSS group was higher than Control group [T4 (T2-L1) vs. T6 (T3- T12)] (p < 0.001). There was a significant difference in the number of patients who required ephedrine for the treatment of hypotension in PLSS group (p = 0.028). Conclusion: The success rate of CSEA in patients with PLSS was 93.3%, and patients experienced no significant neurological complications. The MSBL can be higher in PLSS group than Control group.
Influence of Compressibility Modification to k-ε Turbulence Models for Supersonic Base Flow
Jeon, Sang-Eon,Park, Soo-Hyung,Byun, Yung-Hwan,Kwon, Jang-Hyuk The Korean Society for Aeronautical and Space Scie 2012 International Journal of Aeronautical and Space Sc Vol.13 No.2
An improvement to the k-${\varepsilon}$ turbulence model is presented and is shown to lead to better agreement with data regarding supersonic base flows. The improvement was achieved by imposing a grid-independent realizability constraint in the Launder-Sharma k-${\varepsilon}$ model. The effects of compressibility were also examined. The numerical results show that the modified Launder-Sharma model leads to some improvement in the prediction of the velocity and turbulent kinetic energy profiles. Compressibility corrections also lead to better agreement in both the turbulent kinetic energy and the Reynolds stress profiles with the experimental data.
( Hyuk Soo Eun ),( In Ki Min ),( Bo-ram Kim ),( Hyun Seok Lee ),( Hong Jae Jeon ),( Woo Sun Rou ),( Jong Seok Joo ),( Eaum Seok Lee ),( Seok Hyun Kim ),( Byung Seok Lee ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Hepatocellular carcinoma (HCC) is typically associated with prolonged inflammation in the cirrhotic liver, which results in the transition from chronic inflammation and fibrosis to dysplastic or regenerative nodules or HCC. As we previously reported, the expression of NOX4 in HCC is the highest compared to paired control tissues and the expression of NOX2 is the highest among NOX family genes in HCC. However, our understanding of the association of NOX2 or NOX4 expression with clinicopathological values in HCC is limited. Our study aimed to investigate correlation NOX2 and NOX4 expression levels with clinicopathological factors of HCC patients. Methods: A total of 134 matched tissue pairs of HCC cells and non-tumor hepatocytes from HCC patients were examined by immunohistochemical staining. Through these analysis, we tried to find the association of NOX2 and NOX4 expression with multiple clinicopathological parameters. Moreover, Immunoblotting in 4 HCC cell lines (HepG2, Hep3B, Huh-7, and SK-Hep-1) and reverse transcription digital droplet polymerase chain reaction (RT-ddPCR) in 20 pairs of HCC and non-tumor tissue samples were also performed to detect NOX4. Results: Cytoplasmic NOX2 and nuclear NOX4 expression levels were shown by immunohistochemistry to be higher in HCC cells than in nontumor hepatocytes (P<0.001, each). The Western blotting results for NOX4 in 4 HCC cell lines were consistent with the immunohistochemical results. Increased cytoplasmic expression of NOX2 and NOX4 was significantly correlated with liver cirrhosis (P<0.001 and P<0.031, respectively). However, decreased cytoplasmic expression of NOX2 and NOX4 was significantly correlated with advanced pathologic TNM stage (P<0.029 and P<0.007, respectively). Multivariate analysis with clinicopathologic parameters showed that high nuclear and low cytoplasmic NOX4 expression levels are correlated with short overall survival (P=0 .021). Our findings imply that cytoplasmic NOX2 and nuclear NOX4 expression is upregulated during HCC development. Conclusions: In particular, NOX4 translocation into the nucleus may affect the development and progression of HCC. NOX2 and NOX4 could be diagnostic markers and have therapeutic implications in HCC.
Enhanced Stability of Carbon Nanotube Transparent Conductive Film with Sol-Gel Silica Layer
Jeon, Joohee,Lee, Tae Il,Choi, Ji-Hyuk,Oh, Hyun Seok,Kang, Ji Yeon,Chae, Soo Sang,Baik, Hong Koo,Lee, Woong,Myoung, Jae-Min The Electrochemical Society 2011 Electrochemical and solid-state letters Vol.14 No.5
Efficacy and Safety of UI05MSP015CT in Functional Dyspepsia: A Randomized, Controlled Trial
( Hyuk Yoon ),( Dong Ho Lee ),( Yong-Hyun Lee ),( Ju-Cheol Jeong ),( Soo Teik Lee ),( Myung-Gyu Choi ),( Seong Woo Jeon ),( Ki-Nam Shim ),( Gwang Ho Baik ),( Jae Gyu Kim ),( Jeong Seop Moon ),( In-Kyu 대한소화기학회 2018 Gut and Liver Vol.12 No.5
Background/Aims: To evaluate the efficacy and safety of a controlled release, once-daily formulation of mosapride (UI05MSP015CT) in patients with functional dyspepsia (FD). Methods: Patients with FD were randomly assigned (1:1) to receive either UI05MSP015CT (15 mg once a day, study group) or mosapride (5 mg three times a day, control group) and corresponding placebo for 4 weeks. The primary endpoint was a change in the gastrointestinal symptom score (GIS) evaluated at enrollment and after 4 weeks. Secondary endpoints were changes in the Nepean Dyspepsia Index-Korean version (NDI-K), rate of satisfactory symptom relief, and rate of adverse events. Results: A total of 138 patients were enrolled (female, 73.9%; mean age, 44.0±15.4 years). After excluding patients who violated the study protocol, 59 and 58 patients from the study and control groups, respectively, were included in the per-protocol analysis. No difference was observed in drug compliance between the control and study groups (97.07%±4.52% vs 96.85%±6.05%, p=0.870). Changes in GIS scores were -9.69±6.44 and -10.01±5.92 in the study and control groups. The mean difference in GIS change between groups was 0.33 (95% confidence interval, -1.75 to 2.41), demonstrating non-inferiority of UI-05MSP015CT (p=0.755). The rate of satisfactory symptom relief was not different between the study and control groups (39.0% vs 56.9%, p=0.053). No differences in change in NDI-K score (14.3 vs 16.9, p=0.263) or rates of adverse events (12.9% vs. 4.4%, p=0.062) were observed between the study and control groups. Conclusions: Once-daily mosapride is not inferior to conventional mosapride in efficacy and is safe in patients with FD. (Gut Liver 2018;12:516-522)