http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Anti-inflammatory effect of quetiapine on collagen-induced arthritis of mouse
Kim, Hyeongseok,Bang, Jihye,Chang, Hyuk Won,Kim, Jin Young,Park, Keon Uk,Kim, Sang-Hyon,Lee, Kyung-Jae,Cho, Chul-Hyun,Hwang, Ilseon,Park, Sung Dong,Ha, Eunyoung,Jung, Sung-Won Elsevier 2012 european journal of pharmacology Vol.678 No.1
<P><B>Abstract</B></P><P>Quetiapine is an atypical antipsychotic and has also been used in the treatment of depression. Since anti-inflammatory effects of antidepressants are well established, we hypothesized that quetiapine may also exert anti-inflammatory effects. Thus this study was designed to examine the anti-inflammatory effect of quetiapine in murine collagen-induced arthritis. Mice were immunized with collagen type II for the induction of arthritis and treated with quetiapine (10mg/kg) daily for 2weeks. Mice were divided into 3 groups: control, CIA, and CIA+quetiapine treatment. Arthritic index and paw thickness were used to compare severity of arthritis. In additions, radiological and histological assessments were employed. Anti-type II collagen-specific antibody, interleukin-6 (IL-6), interleukin-17 (IL-17), and prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) were evaluated at the end of the treatment period. Both arthritic index and paw thickness were markedly improved in CIA+quetiapine treatment group compared with those in CIA groups (arthritic index; <I>P</I><0.01, paw thickness; <I>P</I><0.05). Radiologic assessment revealed decreased cartilage damage and bone erosion in CIA+quetiapine treatment group compared with those in CIA groups. Articular cartilage destruction observed in CIA group was not found in CIA+quetiapine group. The concentrations of anti-type II collagen-specific antibody, IL-6, IL-17, and PGE<SUB>2</SUB> in CIA+quetiapine group were significantly lower than those in CIA groups (<I>P</I><0.05). Weight gain which is commonly observed with the treatment of antipsychotics was not observed. Taken together, these results suggest that quetiapine shows anti-inflammatory effects in murine collagen-induced arthritis.</P>
β-cell serotonin production is associated with female sex, old age, and diabetes-free condition
Kim, Yeong Gi,Moon, Joon Ho,Kim, Kyuho,Kim, Hyeongseok,Kim, Juok,Jeong, Ji-Seon,Lee, Junguee,Kang, Shinae,Park, Joon Seong,Kim, Hail Academic Press 2017 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>Serotonin is known to be present in pancreatic β-cells and to play several physiological roles, including insulin secretion, β-cell proliferation, and paracrine inhibition of α-cells. However, the serotonin production of different cell lines and islets has not been compared based on age, sex, and diabetes related conditions. Here, we directly compared the serotonin concentrations in βTC and MIN6 cell lines, as well as in islets from mice using ultra-performance liquid chromatography tandem mass spectrometry. The average serotonin concentration was 5–10 ng/mg protein in the islets of male and non-pregnant female mice. The serotonin level was higher in females than males at 8 weeks, although there was no difference at 1 year. Furthermore, we observed serotonin by immunofluorescence staining in the pancreatic tissues of mice and human. Serotonin was detected by immunofluorescence staining in a portion of β-cells from islets of old female mice, but not of male or young female mice. A similar pattern was observed in human pancreas as well. In humans, serotonin production in β-cells was associated with a diabetes-free condition. Thus, serotonin production in β-cells was associated with old age, female sex, and diabetes-free condition.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Actual serotonin concentrations in cell lines and islets are compared. </LI> <LI> Serotonin over-production in mouse β-cell is aged and female specific. </LI> <LI> Ovariectomy lowers serotonin concentrations in islets. </LI> <LI> Serotonin over-production in human β-cell is aged, female, and non-diabetes specific. </LI> </UL> </P>
Kim, Yong Kyung,Joung, Kyong Hye,Ryu, Min Jeong,Kim, Soung Jung,Kim, Hyeongseok,Chung, Hyo Kyun,Lee, Min Hee,Lee, Seong Eun,Choi, Min Jeong,Chang, Joon Young,Hong, Hyun Jung,Kim, Koon Soon,Lee, Sang-H Springer Verlag 2015 Diabetologia Vol.58 No.4
<P>Although mitochondrial oxidative phosphorylation (OxPhos) dysfunction is believed to be responsible for beta cell dysfunction in insulin resistance and mitochondrial diabetes, the mechanisms underlying progressive beta cell failure caused by defective mitochondrial OxPhos are largely unknown.</P>
A novel pre-processing technique for improving image quality in digital breast tomosynthesis
Kim, Hyeongseok,Lee, Taewon,Hong, Joonpyo,Sabir, Sohail,Lee, Jung-Ryun,Choi, Young Wook,Kim, Hak Hee,Chae, Eun Young,Cho, Seungryong Wiley (John WileySons) 2017 Medical physics Vol.44 No.2
<P>Conclusions: In this work, we report a novel pre-processing technique that improves detectability of lesions in DBT and has potential advantages over the global threshold-based post-reconstruction processing technique. The proposed method not only increased the lesion detectability but also reduced typical image artifacts pronounced in conventional FBP-based DBT. (C) 2016 American Association of Physicists in Medicine</P>
EFFICIENT AND ACCURATE FINITE DIFFERENCE METHOD FOR THE FOUR UNDERLYING ASSET ELS
( Hyeongseok Hwang ),( Yongho Choi ),( Soobin Kwak ),( Youngjin Hwang ),( Sangkwon Kim ),( Junseok Kim ) 한국수학교육학회 2021 純粹 및 應用數學 Vol.28 No.4
In this study, we consider an efficient and accurate finite difference method for the four underlying asset equity-linked securities (ELS). The numerical method is based on the operator splitting method with non-uniform grids for the underlying assets. Even though the numerical scheme is implicit, we solve the system of discrete equations in explicit manner using the Thomas algorithm for the tri-diagonal matrix resulting from the system of discrete equations. Therefore, we can use a relatively large time step and the computation of the ELS option pricing is fast. We perform characteristic computational test. The numerical test confirm the usefulness of the proposed method for pricing the four underlying asset equity-linked securities.
Kim, Hyeongseok,Jo, Jeonghoo,Lee, Ganghoo,Shin, Myunghun,Lee, Joo-Cheol Elsevier 2017 SOLAR ENERGY -PHOENIX ARIZONA THEN NEW YORK- Vol.155 No.-
<P><B>Abstract</B></P> <P>The design methodologies for large-area transparent dye-sensitized solar cells (DSSCs) and modules for building-integrated photovoltaic (BIPV) windows are presented. Using electrochemical impedance spectroscopy and the optical/electrical measurements of a small-sized (∼9×5mm) test cell, the basic circuitry of a DSSC is generated in a unit cell for building the 2-dimensional equivalent circuit model of a large-area Z-type transparent DSSC module (300×300mm) on P-Spice. Based on solar irradiation at a window-side monitored for a year, we have proposed a DSSC module design that generates the maximal electrical energy for the best levelized cost of electricity. While simulations using the developed model estimated a module efficiency of ∼3.23% and an annual electrical energy generation of 448kWh/m<SUP>2</SUP>, the fabricated module with a cell width of ∼18mm exhibited an efficiency of ∼3.19%; the design is also conducive for practical manufacturing and thermal reliability. The developed model demonstrates the operational behaviors of DSSC modules under local shadowing conditions that match with the experiments. The feasibility of the DSSC as a reverse diode, working as a distributed by-pass diode eliminating the current mismatch loss is also demonstrated; this is beneficial for long-term operations. This work can be applied to other types of DSSCs and can be used for producing DSSC-based BIPV windows.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The design methodologies for DSSCs and modules for BIPV windows are presented. </LI> <LI> Equivalent circuit models are established using EIS and the optical/electrical measurements. </LI> <LI> Large-area Z-type transparent DSSC module (300×300mm) are designed and fabricated. </LI> <LI> Annual maximal electricity of 448kWh/m<SUP>2</SUP> are expected for the best LCOE. </LI> </UL> </P>