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Hyejin Sim,Ji Hyeon Ahn,Jae-Chul Lee,Jung Hoon Choi,Ki Yeon Yoo,Choong Hyun Lee,Joon Ha Park,Tae-Kyeong Lee,Moo-Ho Won 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Angelica gigas Nakai root contains decursin which exerts beneficial properties such as anti-amnesic and anti-inflammatory activities. Until now, however, the neuroprotective effects of decursin against transient ischemic injury in the forebrain have been insufficiently investigated. Here, we revealed that post-treatment with decursin and the root extract saved pyramidal neurons in the hippocampus following transient ischemia for 5 minutes in gerbil forebrain. Through HPLC, we defined that decursin was contained in the extract as 7.3 ± 0.2%. Based on this, we post-treated with 350 mg/kg extract which is corresponding dosage of 25 mg/kg decursin that exerted neuroprotection in gerbil hippocampus against the ischemia. In addition, behavioral tests were conducted to evaluate ischemia-induced dysfunctions via tests of spatial memory and learning memory, and post-treatment with the extract and decursin attenuated ischemia-induced memory impairments. Furthermore, we carried out histochemistry, immunohistochemistry and double immunohistofluorescence. Pyramidal neurons located in the subfield cornu ammonis 1 (CA1) among the hippocampal subfields were dead at 5 days after the ischemia; however, treatment with the extract and decursin save the pyramidal neurons after ischemia. IgG, which is not found in the parenchyma in normal brain tissue, was apparently shown in CA1 parenchyma from 2 days after the ischemia, but IgG leakage was dramatically attenuated in the CA1 parenchyma treated with the extract and decursin. Furthermore, astrocyte end feet, which are a component of the blood-brain barrier (BBB), were severely damaged at 5 days after the ischemia, however, post-treatment with the extract and decursin dramatically attenuated the damage of the endfeet. Based on these findings, we suggest that Angelica gigas Nakai root containing decursin can be employed as pharmaceutical composition to develop therapeutic strategy for brain ischemic injury.
Sim Hyejin,Kim Seoyoung,Paul Guyun Jung,Michael Bloomfield,Kim Euitae 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.7
Objective The Community Assessment of Psychic Experiences has been widely translated and commonly used as a measure for psychotic experiences and psychosis proneness in clinical and research environments worldwide. This study aimed to establish the psychometric properties (reliability and validity) and factor structure of a Korean version of the Community Assessment of Psychic Experiences (K-CAPE) in the general population.Methods A total of 1,467 healthy participants completed K-CAPE and other psychiatric symptom-related scales (Paranoia scale, Patient Health Questionnaire-9, Dissociative Experiences Scale-II, and Oxford-Liverpool Inventory of Feelings and Experiences) via online survey. K-CAPE’s internal reliability was analyzed using Cronbach’s alpha coefficient. Confirmatory factor analysis (CFA) was performed to investigate whether the original three-factor model (positive, negative, and depressive) and other hypothesized multidimensional models (including positive and negative subfactors) were suitable for our data. Exploratory factor analysis (EFA) was conducted to explore better alternative factor solutions with a follow-up CFA. To assess convergent and discriminant validity, we examined correlations between KCAPE subscales with other established measures of psychiatric symptoms.Results K-CAPE showed good internal consistency in all original three subscales (all greater than α=0.827). The CFA demonstrated that the multidimensional models exhibited relatively better quality than the original three-dimensional model. Although the model fit indices did not reach their respective optimal thresholds, they were within an acceptable range. Results from the EFA indicated 3–5 factor solutions. In 3-factor solution, “negative-avolition” items were founded to be loaded more consistently with depressive items than with the negative dimension. In 4-factor solution, positive items were divided into two subfactors: “positive-bizarre experiences” and “positive-delusional thoughts,” while negative symptoms were separated into two distinct subfactors in 5-factor solution: “negative-avolition (expressive),” and “negative-social (experiential).” The correlation coefficients between K-CAPE subscales and corresponding measurements were significant (p<0.001), confirming the convergent and discriminant validity.Conclusion Our study provides evidence to support the reliability and validity of the K-CAPE and its use as a measure of psychotic symptoms in the Korean population. Although alternative factor structures did not improve the model fit, our EFA findings implicate the use of subfactors to investigate more specific domains of positive and negative symptoms. Given the heterogeneous nature of psychotic symptoms, this may be useful in capturing their different underlying mechanisms.
외조모의 긍정적 양육행동과 어머니의 자기분화 및 긍정적 양육행동이 학령 후기 아동의 자아개념에 미치는 영향
김혜진(Hyejin Kim),도현심(Hyun-Sim Doh),박보경(Bokyung Park) 한국아동학회 2017 아동학회지 Vol.38 No.1
Objective: This study examined the effects of maternal grandmothers’ positive parenting behavior and mothers’ self-differentiation and positive parenting behavior on self-concept in late childhood. Methods: A total of 341 5<SUP>th</SUP>– and 6<SUP>th</SUP>– grade elementary school children and their mothers participated in the study. Children were surveyed regarding perceptions of their mothers’ positive parenting behavior and their own self-concept. Mothers responded to questionnaires regarding both positive parenting behavior of their mothers and their own self-differentiation. The data were analyzed using SEM. Results: Maternal grandmothers’ positive parenting behavior had an indirect effect through mothers’ self-differentiation and positive parenting behavior on children’s self-concept. Mothers who perceived positive parenting behavior in their mothers in their childhood showed positive parenting behavior (as perceived by their children), and those children reported a higher level of self-concept. Mothers who perceived their mother’s parenting behavior in their childhood more positively reported a higher level of self-differentiation, and those mothers showed more positive parenting behavior (as perceived by their children), which led to more positive self-concept in children. Conclusion: The findings specify the pathways from maternal grandmothers’ positive parenting behavior to children’s self-concept through mothers’ self-differentiation and positive parenting behavior in an aspect of the intergenerational transmission of parenting. The findings also emphasize the importance of mothers’ positive parenting behavior for positive self-concept in late childhood.
심보람(Boram Sim),황수희(Soo-Hee Hwang),이혜진(Hyejin Lee),윤지은(Jieun Yun),이진용(Jin Yong Lee) 한국자폐학회 2023 자폐성 장애연구 Vol.23 No.1
2010년부터 2019년까지의 국민건강보험공단 자료를 이용하여 자폐성장애인들에서 발생하는 상해의 유형은 무엇인지, 어떤 질환에 주로 이환되고 있는지 등에 대한 실태를 파악하기 위해 이 연구를 시행하였다. 연구 결과, 자폐성장애인의 상해 발생율은 전체 인구집단과 비교했을 때 높은 수준은 아니었으나, 지난 10년 간 꾸준히 증가하고 있음을 확인하였다. 또한 자폐성장애인의 질병이환은 정신 및 행동 장애가 가장 많았다. 특히 자폐성장애의 고유 특성에 기인한 질병이환외에도 조현병과 같은 정신 질환 관련 질병이환이 많았다. 입원진료에서 치과질환의 이환이 높은 것도 일반 인구집단에 비해 높은 것도 큰 특징이었다. 이러한 결과는 자폐성장애인의 상해를 줄이기 위한 예방 전략과 자폐성 장애인의 복합적인 의료 요구도를 고려한 의료서비스 전달체계 필요성에 대한 근거가 될 수 있다. 이 연구는 기존에 전국 단위로 산출되지 못하였던 국내 자폐성장애인의 상해 및 질병이환 현황을 파악한 최초의 연구라는 점에서 의의가 있다. 향후에도 이러한 역학 자료를 주기적으로 측정하고 추이 변화를 확인하는 과정이 지속적으로 이루어져야 한다. This study is an initial study providing nationwide statistics regarding the prevalence of injuries and comorbidities in people with Autism Spectrum Disorder (ASD). The prevalence of injuries and comorbidities in pleple with ASD was examined in the National Health Insurance Service (NHIS) data spanning from 2010 to 2019. We found that the prevalence of injuries in people with ASD was not higher than in the general population. However, this had increased steadily over 10 years. The most common comorbidities with ASD were found to be mental and behavioral disorders. Outpatient visits for mental diseases such as schizophrenia and hospitalization for dental treatment were more prevalent than in the general population.