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Hwang, Yu Im,Sung, Na Young,Koo, Hwa Seon,Cha, Sun Hwa,Park, Chan Woo,Kim, Jin Yeong,Yang, Kwang Moon,Song, In Ok,Koong, Mi Kyoung,Kang, Inn Soo,Kim, Hye Ok The Korean Society for Reproductive Medicine 2013 Clinical and Experimental Reproductive Medicine Vol.40 No.3
Objective: To evaluate correlations between serum anti-M${\ddot{u}}$llerian hormone (AMH) levels, phenotypes of polycystic ovary syndrome (PCOS), obesity, and metabolic parameters in patients with PCOS. Methods: A total of 175 patients with PCOS were diagnosed according to the Rotterdam Consensus were included. Exclusion criteria were age over 40, FSH>25 mIU/mL, and 17a-OHP>1.5 ng/mL. The Phenotypes of PCOS were divided into a severe form (oligo-anovulation, ANOV/hyperandrogenism/polycystic ovary morphology [PCOM]; n=59) and a mild form without HA (ANOV/PCOM, n=105). The serum AMH levels were classified into 3 groups (<5 vs. 5-10 vs. >10 ng/mL). Obesity was defined as body mass index (BMI) ${\geq}25kg/m^2$ (n=34). Results: The mean age was $25.9{\pm}5.7$ year and mean AMH level was $10.1{\pm}5.4$ ng/mL. The BMI ($kg/m^2$) was higher in group 1 ($24.2{\pm}6.3$) than in group 2 ($21.9{\pm}4.3$, p=0.046) or group 3 ($21.6{\pm}3.3$, p=0.019). There was no difference among the three groups in age, menstrual interval, antral follicle counts, androgens, or other metabolic parameters. The obesity group showed significantly lower AMH ($7.7{\pm}3.9$ ng/mL vs. $10.7{\pm}5.6$ ng/mL), p=0.004) and low-density lipoprotein levels ($93.1{\pm}21.2$ mg/dL vs. $107.5{\pm}39.3$ mg/dL, p=0.031), and showed higher total T ($0.74{\pm}0.59$ L vs. $0.47{\pm}0.36$ ng/mL, p=0.001), free T ($2.01{\pm}1.9$ vs. $1.04{\pm}0.8$ pg/mL, p=0.0001), and free androgen index ($6.2{\pm}7.9$ vs. $3.5{\pm}3.0$, p=0.003). After controlling for age factors and BMI, the serum AMH levles did not show any significant correlations with other hormonal or metabolic parmeters. Conclusion: For PCOS patients under the age 40, serum AMH is not negatively correlated with age. High serum AMH levels can not predict the phenotype of PCOS and metabolic disturbances in PCOS patients in the non-obese group. Further study might be needed to define the relation more clearly.
Hwang, Su-Jeong,Park, Dong-Ju,Gu, Pyeung-Tae,Koo, Hee-Soo,Lee, Mi-Ok 대한미생물학회 2016 Journal of Bacteriology and Virology Vol.46 No.3
Human respiratory syncytial virus (HRSV) is known as the leading cause of respiratory tract illness in infancy and elderly children worldwide. We investigate the prevalence pattern and genetic characteristics in the second variable region G protein gene of HRSV during 5 consecutive seasons from 2010 to 2015. A total of 4,793 specimens (throat swabs) were collected from patients with acute respiratory tract. HRSV were evaluated and classified as HRSV A (n=111) or HRSV B (n=64) by real-time RT-PCR or RT-PCR. In general HRSV were detected in winter season. Coughing, fever, rhinorrhea and sputum were confirmed main symptoms in patients with HRSV. There were no significant differences in clinical characteristics or severity according to the HRSV subgroup infections. Out of 175 HRSV positive samples, 94 samples were successfully sequenced using G gene. Phylogenetic analysis revealed that 62 HRSV-A strains clustered into genotypes ON1 (n=54, 87.1%), NA1 (n=7), NA2 (n=1) and 32 HRSV-B strains clustered into three genotypes: BA4 (n=28, 87.5%), BA5 (n=2), BA6 (n=2). These results provide a better understanding of HRSV prevalence pattern and genetic characteristics.
Hwang, In Yeong,Ku, Hyun Ok,Lim, Suk Kyung,Park, Choi Kyu,Jung, Gab Su,Jung, Suk Chan,Nam, Hyang Mi AAVLD 2009 Journal of veterinary diagnostic investigation Vol.21 No.6
<P>A total of 147 Enterococcus faecium and 165 Enterococcus faecalis isolates from fecal samples of chickens and pigs at slaughterhouses in Korea were tested for their resistance to 8 growth-promoting antimicrobials commonly used in animals and quinupristin and dalfopristin. Resistance to most antimicrobials was very common among both E. faecalis and E. faecium. In particular, E. faecalis showed almost no susceptibility to all the antimicrobials tested except penicillin and flavomycin, to which 1.4% and less than 24% showed resistance, respectively. Although the prevalence of resistance was lower than in E. faecalis, E. faecium showed relatively uniform resistance to all the agents tested. Among the antimicrobials tested, virginiamycin and penicillin were the most effective against E. faecium isolates: less than 31% and 41% showed resistance to those 2 antimicrobials, respectively. Penicillin was the only agent that showed relatively strong activity against both E. faecalis and E. faecium. Resistance observed in E. faecalis and E. faecium against most antimicrobials used for growth promotion was more prevalent in Korea than in European countries. The current study is the first report of resistance against feed additive antimicrobials in enterococcal isolates from livestock in Korea.</P>
Gene Expression Profile for Nicotiana tabacum in the Early Phase of Flooding Stress
( Mi Ok Lee ),( Ji Hye Hwang ),( Dong Hee Lee ),( Choo Bong Hong ) 한국식물학회 2007 Journal of Plant Biology Vol.50 No.4
Although flooding can often severely damage crop yields, few studies of this stress have been made at the genetic level. To identify the genes that probably function in plants at the onset of flooding stress, we constructed a cDNA library representing tobacco plants that experienced short-term stress, i.e., 2 to 4 h of submergence while under illumination. Differential screening of that library produced 73 cDNA clones that showed preferential hybridization with the probe prepared from these stressed plants. The cDNA inserts were isolated from the vector by restriction digest and subjected to reverse northern analysis, which confirmed preferential expression of 41 genes. The remainder either had no significant increase in expression under flooding stress or exhibited no identifiable signal. We then performed northern blot analyses for some selected genes to provide supporting evidence that strongly paralleled our results from the reverse-northern evaluation. Photosynthesisrelated genes were the major group, followed by those for well-known glycolysis enzymes and fermentation enzymes. Other genes include those for hydrolytic enzymes and components of the ethylene synthesis pathway. Although many others also were induced, their functions could not be characterized here.