http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Park, Young ,Ran,Seo, Seung ,Young,Kim, Se ,Lim,Zhu, Shi ,Mao,Chun, Sungkun,Oh, Jung-Mi,Lee, Min ,Ro,Kim, Seong ,Hun,Kim, In ,Hee,Lee, Seung ,Ok,Lee, Soo ,Teik,Kim, Portland Press Ltd. 2018 Bioscience reports Vol.38 No.5
<P>MiRNA (miR)-206 plays a tumor suppressor role in various cancer types. Here, we investigated whether miR-206 is involved in prostaglandin E2 (PGE2)-induced epithelial–mesenchymal transition (EMT) in colorectal cancer (CRC) cells through the targetting of transmembrane 4 L six family member 1 (TM4SF1).</P><P>The effect of PGE2 on growth and apoptosis of CRC cells was evaluated using the MTT assay and flow cytometry analysis, respectively. TM4SF1 and miR-206 expression levels were determined with quantitative polymerase chain reaction (qRT-PCR) in CRC tissues and cell lines. The concentration of PGE2 in the serum of CRC patients and healthy controls was measured with an ELISA kit. A miR-206 or TM4SF1 construct was transfected into cells with PGE2. Transwell migration and invasion assays were used to examine cell migration and invasion properties. Additionally, a luciferase assay was performed to determine whether TM4SF1 was directly targetted by miR-206.</P><P>We found that miR-206 was down-regulated and TM4SF1 was up-regulated in human CRC tissues and cell lines. Moreover, miR-206 was negatively correlated with TM4SF1 expression. Bioinformatics analysis and a luciferase reporter assay revealed that miR-206 directly targetted the 3′-untranslated region (UTR) of TM4SF1, and TM4SF1 expression was reduced by miR-206 overexpression at both the mRNA and protein levels. Additionally, PGE2 significantly suppressed the expression of miR-206 and increased the expression of TM4SF1 in CRC cells. PGE2 induction led to enhanced CRC cell proliferation, migration, and invasion. Moreover, the overexpression of miR-206 decreased CRC cell proliferation, migration, and invasion compared with control group in PGE2-induced cells, and these effects could be recovered by the overexpression of TM4SF1. Overexpression of miR-206 also suppressed the expression of β-catenin, VEGF, MMP-9, Snail, and Vimentin and enhanced E-cadherin expression in PGE2-induced cells. These results could be reversed by the overexpression of TM4SF1. At last, up-regulation of miR-206 suppressed expression of <I>p</I>-AKT and <I>p</I>-ERK by targetting TM4SF1 in PGE2-induced cells.</P><P>Our results provide further evidence that miR-206 has a protective effect on PGE2-induced colon carcinogenesis.</P>
Usefulness of DVS for Universal Public Service
Mi-Young Kim ,Chang-Hun Lee,Yae-Nae Huh ,Jae-Myoung Kim ,Hong-In Cheng 한국디자인지식학회 2007 한국디자인지식학회 Conference Vol.2007 No.8
Visually impaired and aged people have a problem to comprehend content of TV, movie, and mobile phone. DVS (Descriptive Video Service) was examined to find its applicability and usefulness for TV drama in this study. Accessibility of various audiences can be increased when DVS is provided. Experimental results showed that DVS can increase comprehensibility to TV drama and satisfaction of audience and suggested further researches related to DVS. In the future study, specific guide lines will be suggested based on factors which affect accessibility of the visually impaired people to TV broadcasting.