Non-Gaussian time-dependent statistics of wind pressure processes on a roof structure

Huang, M.F.,Huang, Song,Feng, He,Lou, Wenjuan Techno-Press 2016 Wind and Structures, An International Journal (WAS Vol.23 No.4

Synchronous multi-pressure measurements were carried out with relatively long time duration for a double-layer reticulated shell roof model in the atmospheric boundary layer wind tunnel. Since the long roof is open at two ends for the storage of coal piles, three different testing cases were considered as the empty roof without coal piles (Case A), half coal piles inside (Case B) and full coal piles inside (Case C). Based on the wind tunnel test results, non-Gaussian time-dependent statistics of net wind pressure on the shell roof were quantified in terms of skewness and kurtosis. It was found that the direct statistical estimation of high-order moments and peak factors is quite sensitive to the duration of wind pressure time-history data. The maximum value of COVs (Coefficients of variations) of high-order moments is up to 1.05 for several measured pressure processes. The Mixture distribution models are proposed for better modeling the distribution of a parent pressure process. With the aid of mixture parent distribution models, the existing translated-peak-process (TPP) method has been revised and improved in the estimation of non-Gaussian peak factors. Finally, non-Gaussian peak factors of wind pressure, particularly for those observed hardening pressure process, were calculated by employing various state-of-the-art methods and compared to the direct statistical analysis of the measured long-duration wind pressure data. The estimated non-Gaussian peak factors for a hardening pressure process at the leading edge of the roof were varying from 3.6229, 3.3693 to 3.3416 corresponding to three different cases of A, B and C.

The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs

Huang Bao,He Yongqing,Li Shengwen,Wei Xiaoan,Liu Junhui,Shan Zhi,Huang Yue,Chen Jiang,Zhao Fengdong 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

Calcipressin-1, also known as regulator of calcineurin 1 (RCAN1), can specifically bind calcineurin at or near the calcineurin A catalytic domain and downregulate calcineurin activity. However, whether RCAN1 affects the hypoxic intervertebral disc (IVD) phenotype through the calcineurin/NFAT signaling pathway remains unclear. First, we confirmed the characteristics of the degenerative nucleus pulposus (NP) by H&E, safranin O/fast green and Alcian blue staining, and detected increased RCAN1 levels in the degenerative NP by immunohistochemistry. Then, we demonstrated that the protein level of RCAN1.4 was higher than that of RCAN1.1 and progressively elevated from the control group to the Pfirrmann grade V group. In vitro, both hypoxia (1% O2) and overexpression of HIF-1α reduced the protein level of RCAN1.4 in rat NP cells in a dose- and time-dependent manner. We further found that miRNA-124, through a nondegradative pathway (without the proteasome or lysosome), suppressed the expression of RCAN1.4. As expected, calcineurin in NP cells was activated and primarily promoted nuclear translocation of NFATc1 under hypoxia or RCAN1.4 siRNA transfection. Furthermore, SOX9, type II collagen and MMP13 were elevated under hypoxia, RCAN1.4 siRNA transfection or NFATc1 overexpression. Using chromatin immunoprecipitation (ChIP) and a luciferase reporter assay (with mutation), we clarified that NFATc1 increasingly bound the SOX9 promotor region (bp −367~−357). Interaction of HIF-1α and NFATc1 promoted MMP13 transcription. Finally, we found that FK506 reversed hypoxia-induced activation of the calcineurin/NFAT signaling pathway in NP cells and an ex vivo model. Together, these findings show that the RCAN1.4-calcineurin/ NFAT signaling pathway has a vital role in the hypoxic phenotype of NP cells. RCAN1.4 might be a therapeutic target for degenerative disc diseases.

Image Fusion and Evaluation by using Mapping Satellite-1 Data

He Huang,Yafei Hu,Yi Feng,Meng Zhang,DongSeob Song 한국측량학회 2013 한국측량학회지 Vol.31 No.6-2

Phenotypic and genomic characteristics of Brevibacterium zhoupengii sp. nov., a novel halotolerant actinomycete isolated from bat feces

Huang Yuyuan,Dong Lingzhi,Gong Jian,Yang Jing,Lu Shan,Lai Xin-He,Jin Dong,Huang Qianni,Pu Ji,Liu Liyun,Xu Jianguo 한국미생물학회 2022 The journal of microbiology Vol.60 No.10

Two strictly aerobic, Gram-staining-positive, non-spore-forming, regular rod-shaped (approximately 0.7 × 1.9 mm) bacteria (HY170T and HY001) were isolated from bat feces collected from Chongzuo city, Guangxi province (22°20 54 N, 106°49 20 E, July 2011) and Chuxiong Yi Autonomous Prefecture, Yunnan province (25°09 10 N, 102°04 39 E, October 2013) of South China, respectively. Optimal growth is obtained at 25–28°C (range, 4–32°C) on BHI-5% sheep blood plate with pH 7.5 (range, 5.0–10.0) in the presence of 0.5– 1.0% NaCl (w/v) (range, 0–15% NaCl [w/v]). The phylogenetic and phylogenomic trees based respectively on the 16S rRNA gene and 845 core gene sequences revealed that the two strains formed a distinct lineage within the genus Brevibacterium, most closely related to B. aurantiacum NCDO 739T (16S rRNA similarity, both 98.5%; dDDH, 46.7–46.8%; ANI, 91.9–92.1%). Strain HY170T contained MK-8(H2), diphosphatidylglycerol (DPG) and phosphatidylglycerol (PG), galactose and ribose as the predominant menaquinone, major polar lipids, and main sugars in the cell wall teichoic acids, respectively. The meso-diaminopimelic acid (meso-DAP) was the diagnostic diamino acid of the peptidoglycan found in strain HY170T. Anteiso-C15:0 and anteiso-C17:0 were the major fatty acids (> 10%) of strains HY170T and HY001, with anteiso-C17:1A predominant in strain HY170T but absent in strain HY001. Mining the genomes revealed the presence of secondary metabolite biosynthesis gene clusters encoding for non-alpha poly-amino acids (NAPAA), ectoine, siderophore, and terpene. Based on results from the phylogenetic, chemotaxonomic and phenotypic analyses, the two strains could be classified as a novel species of the genus Brevibacterium, for which the name Brevibacterium zhoupengii sp. nov. is proposed (type strain HY170T = CGMCC 1.18600T = JCM 34230T).

Image Fusion and Evaluation by using Mapping Satellite-1 Data

He Huang,Yafei Hu,Yi Feng,Meng Zhang,송동섭 한국측량학회 2013 한국측량학회지 Vol.31 No.6

China’s Mapping Satellite-1, developed by the China Aerospace Science and Technology Corporation (CASC),was launched in three years ago. The data from Mapping Satellite-1 are able to use for efficient surveyingand geometric mapping application field. In this paper, we fuse the panchromatic and multispectral images ofChangchun area, which are obtained from the Mapping Satellite-1, the one that is the Chinese first transmissiontypethree-dimensional mapping satellite. The four traditional image fusion methods, which are HPF, Mod.IHS,Panshar and wavelet transform, were used to approach for effectively fusing Mapping Satellite-1 remote sensingdata. Subsequently we assess the results with some commonly used methods, which are known a subjectivequalitative evaluation and quantitative statistical analysis approach. Consequently, we found that the wavelettransform remote sensing image fusion is the optimal in the degree of distortion, the ability of performance ofdetails and image information availability among four methods. To further understand the optimal methods tofuse Mapping Satellite-1 images, an additional study is necessary.

Energy Efficiency of Distributed Massive MIMO Systems

He, Chunlong,Yin, Jiajia,He, Yejun,Huang, Min,Zhao, Bo The Korea Institute of Information and Commucation 2016 Journal of communications and networks Vol.18 No.4

In this paper, we investigate energy efficiency (EE) of the traditional co-located and the distributed massive multiple-input multiple-output (MIMO) systems. First, we derive an approximate EE expression for both the idealistic and the realistic power consumption models. Then an optimal energy-efficient remote access unit (RAU) selection algorithm based on the distance between the mobile stations (MSs) and the RAUs are developed to maximize the EE for the downlink distributed massive MIMO systems under the realistic power consumption model. Numerical results show that the EE of the distributed massive MIMO systems is larger than the co-located massive MIMO systems under both the idealistic and realistic power consumption models, and the optimal EE can be obtained by the developed energy-efficient RAU selection algorithm.

Characteristics of the aerodynamic interference between two high-rise buildings of different height and identical square cross-section

Huang Dongmei,Zhu Xue,He Shiqing,He Xuhui,He Hua 한국풍공학회 2017 Wind and Structures, An International Journal (WAS Vol.24 No.5

In this work, wind tunnel tests of pressure measurements are carried out to assess the global aerodynamic interference factors, the local wind pressure interference factors, and the local lift spectra of an square high-rise building interfered by an identical cross-sections but lower height building arranged in various relative positions. The results show that, when the interfering building is located in an area of oblique upstream, the RMS of the along-wind, across-wind, and torsional aerodynamic forces on the test building increase significantly, and when it is located to a side, the mean across-wind and torsional aerodynamic forces increase; In addition, when the interfering building is located upstream or staggered upstream, the mean wind pressures on the sheltered windward side turn form positive to negative and with a maximum absolute value of up to 1.75 times, and the fluctuating wind pressures on the sheltered windward side and leading edge of the side increase significantly with decreasing spacing ratio (up to a maximum of 3.5 times). When it is located to a side, the mean and fluctuating wind pressures on the leading edge of inner side are significantly increased. The three-dimensional flow around a slightly-shorter disturbing building has a great effect on the average and fluctuating wind pressures on the windward or cross-wind faces. When the disturbing building is near to the test building, the vortex shedding peak in the lift spectra decreases and there are no obvious signs of periodicity, however, the energies of the high frequency components undergo an obvious increase.

Image Fusion and Evaluation by using Mapping Satellite-1 Data

Huang, He,Hu, Yafei,Feng, Yi,Zhang, Meng,Song, DongSeob Korean Society of Surveying 2013 한국측량학회지 Vol.31 No.6

China's Mapping Satellite-1, developed by the China Aerospace Science and Technology Corporation (CASC), was launched in three years ago. The data from Mapping Satellite-1 are able to use for efficient surveying and geometric mapping application field. In this paper, we fuse the panchromatic and multispectral images of Changchun area, which are obtained from the Mapping Satellite-1, the one that is the Chinese first transmission-type three-dimensional mapping satellite. The four traditional image fusion methods, which are HPF, Mod.IHS, Panshar and wavelet transform, were used to approach for effectively fusing Mapping Satellite-1 remote sensing data. Subsequently we assess the results with some commonly used methods, which are known a subjective qualitative evaluation and quantitative statistical analysis approach. Consequently, we found that the wavelet transform remote sensing image fusion is the optimal in the degree of distortion, the ability of performance of details and image information availability among four methods. To further understand the optimal methods to fuse Mapping Satellite-1 images, an additional study is necessary.

Decreased Expression of LKB1 Correlates with Poor Prognosis in Hepatocellular Carcinoma Patients Undergoing Hepatectomy

Huang, Yue-Han,Chen, Zhen-Kun,Huang, Ka-Te,Li, Peng,He, Bin,Guo, Xu,Zhong, Jun-Qiao,Zhang, Qi-Yu,Shi, Hong-Qi,Song, Qi-Tong,Yu, Zheng-Ping,Shan, Yun-Feng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Aim: To study any correlation of LKB1 expression with prognosis in hepatocellular carcinoma (HCC) cases. Methods: A total of 70 HCC patients and 20 primary intrahepatic stone patients in the first affiliated hospital of Wenzhou Medical College were enrolled in this study. LKB1 expression was detected by immunohistochemistry. Patients were followed-up and prognostic factors were evaluated. Result: LKB1 expression was decreased in the HCC samples. Loss of LKB1 expression in HCC was significantly related to histologic grade (P=0.010), vascular invasion (P=0.025) and TMN stage (P=0.011). Patients showing negative LKB1 expression had a significantly shorter disease-free and overall survival than those with positive expression (P = 0.001, P=0.000, respectively). Multivariate Cox regression analysis indicated that LKB1 expression level was an independent factor of survival (P = 0.033). Conclusion: HCC patients with decreased expression LKB1 have a poor prognosis. The loss of LKB1 expression is correlated with a lower survival rate.

Accurate Backbone Curves for Large-Amplitude Vibrations of Imperfect Rectangular Plate with Viscous Damping

He Huang,David Hui 대한토목학회 2015 KSCE JOURNAL OF CIVIL ENGINEERING Vol.19 No.5

This paper deals with the solution of modified-Duffing ordinary differential equation for large-amplitude vibrations of imperfect rectangular plate with viscous damping. Lindstedt's perturbation technique and Runge-Kutta method are applied. The results for both methods are presented and compared for a validity check. It is proved that Lindstedt’s perturbation technique only works accurately for a small range of vibration amplitude. For a structure with a sufficiently large geometric imperfection, the well-known softenspring to harden-spring transforming backbone curve is confirmed and better developed. Although the softening to hardening behavior occurs twice in one backbone curve, the turning points share the same vibration frequency. Yet the amplitude for turning points varies due to the existence of imperfection. Moreover, the effect of damping ratio on vibration mode and vibration amplitude is studied. The usual nonlinear vibration tends to behave more linearly under the effect of large damping.