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      • SCIESCOPUSKCI등재

        Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1

        Chao-Chieh Hsieh,Chiung-Yun Chang,Tania Xu Yar Lee,Jinfu Wu,Suchada Saovieng,Yu-Wen Hsieh,Maijian Zhu,Chih-Yang Huang,Chia-Hua Kuo The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.2

        Background: Effects of the major ginsenoside Rg1 on mammalian longevity and physical vitality are rarely reported. Purpose: To examine longevity, tumor, and spontaneous locomotor activity in rats consuming Rg1. Methods: A total of 138 Wistar rats were randomized into 2 groups: control (N = 69) and Rg1 (N = 69). Rg1 (0.1 mg/kg per day) were orally supplemented from 6 months of age until natural death. Spontaneous mobility was measured by video-tracking together with body composition (dual energy x-ray absorptiometry) and inflammation markers at 5, 14, 21, and 28 months of age. Results: No significant differences in longevity (control: 706 days; Rg1: 651 days, p = 0.77) and tumor incidence (control: 19%; Rg1: 12%, p = 0.24) were observed between the two groups. Movement distance in the control group declined significantly by ~60% at 21 months of age, together with decreased TNF-α (p = 0.01) and increased IL-10 (p = 0.02). However, the movement distance in the Rg1 group was maintained ~50% above the control groups (p = 0.01) at 21 months of age with greater magnitudes of TNF-α decreases and IL-10 increases. Glucose, insulin, and body composition (bone, muscle and fat percentages) were similar for both groups during the entire observation period. Conclusion: The results of the study suggest a delay age-dependent decline in physical vitality during late life by lifelong Rg1 consumption. This improvement is associated with inflammatory modulation. Significant effects of Rg1 on longevity and tumorigenesis were not observed.

      • Fatigue Analysis of Lower Limb Muscle Group Using Elliptical Machine with Constant Loading

        ( Li-cheng Hsieh ),( Ching-chia Hsieh ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

        The elliptical machine or trainer is one of the most popular sports equipment for cardiorespiratory fitness training. In recent years, it is widely used in the family and the gymnasium in Taiwan. Therefore, it is necessary for further discussion about the movements of the elliptical machine, and various levels of the lower-limb muscular fatigue using the elliptical machine in various strengths. The research collected the electromyography (EMG) signal of lower limb muscles, and used the commercially available software to analyze the possible timing that the fatigue appeared. The research applied this system to analyze the lower-limb muscular fatigue when using the elliptical machine with a constant resistance. It compiled the relevant literature, developed the experimental methods and analyzed the results. The subjects of this research arranged ten young people who used elliptical trainer for the first time. They carried the EMG and pedaled in a nature way. Then, Fourier transform was applied for all collected data, and the median frequency was calculated from 80% of the maximum value of the mild fatigue. The result showed that 60% of subject’s rectus muscle had been fatigued first. As a result, when using the elliptical trainer, it was much easier to use the muscles of the front thigh and get tired. Most of the fatigue occurred from overusing the lower limb muscle. By understanding the biomechanics of the elliptical trainer, it could avoid or reduce the fatigue and injuries during exercise. The system can analyze the fatigue timing as well. The fatigue analysis results would help the elliptical machine users avoid injuries, and increasing the efficiency of elliptical training.

      • SCISCIESCOPUS

        OBSERVATIONAL AND DYNAMICAL CHARACTERIZATION OF MAIN-BELT COMET P/2010 R2 (La Sagra)

        Hsieh, Henry H.,Yang, Bin,Haghighipour, Nader,Novaković,, Bojan,Jedicke, Robert,Wainscoat, Richard J.,Denneau, Larry,Abe, Shinsuke,Chen, Wen-Ping,Fitzsimmons, Alan,Granvik, Mikael,Grav, Tommy,Ip, American Institute of Physics 2012 The Astronomical journal Vol.143 No.5

        <P>We present observations of the recently discovered comet-like main-belt object P/2010 R2 (La Sagra) obtained by Pan-STARRS1 and the Faulkes Telescope-North on Haleakala in Hawaii, the University of Hawaii 2.2 m, Gemini-North, and Keck I telescopes on Mauna Kea, the Danish 1.54 m telescope (operated by the MiNDSTEp consortium) at La Silla, and the Isaac Newton Telescope on La Palma. An antisolar dust tail is observed to be present from 2010 August through 2011 February, while a dust trail aligned with the object's orbit plane is also observed from 2010 December through 2011 August. Assuming typical phase darkening behavior, P/La Sagra is seen to increase in brightness by >1 mag between 2010 August and December, suggesting that dust production is ongoing over this period. These results strongly suggest that the observed activity is cometary in nature (i.e., driven by the sublimation of volatile material), and that P/La Sagra is therefore the most recent main-belt comet to be discovered. We find an approximate absolute magnitude for the nucleus of H<SUB>R</SUB> = 17.9 ± 0.2 mag, corresponding to a nucleus radius of ~0.7 km, assuming an albedo of p = 0.05. Comparing the observed scattering surface areas of the dust coma to that of the nucleus when P/La Sagra was active, we find dust-to-nucleus area ratios of A<SUB>d</SUB>/A<SUB>N</SUB> = 30-60, comparable to those computed for fellow main-belt comets 238P/Read and P/2008 R1 (Garradd), and one to two orders of magnitude larger than for two other main-belt comets (133P/Elst-Pizarro and 176P/LINEAR). Using optical spectroscopy to search for CN emission, we do not detect any conclusive evidence of sublimation products (i.e., gas emission), finding an upper limit CN production rate of Q<SUB>CN</SUB> < 6 × 10<SUP>23</SUP> mol s<SUP>–1</SUP>, from which we infer an H<SUB>2</SUB>O production rate of <img SRC='http://ej.iop.org/images/1538-3881/143/5/104/aj423523ieqn1.gif' ALIGN='MIDDLE' ALT='$Q_{\rm H_2O}\,{<}\,10^{26}$'/> mol s<SUP>–1</SUP>. Numerical simulations indicate that P/La Sagra is dynamically stable for >100 Myr, suggesting that it is likely native to its current location and that its composition is likely representative of other objects in the same region of the main belt, though the relatively close proximity of the 13:6 mean-motion resonance with Jupiter and the (3,–2,–1) three-body mean-motion resonance with Jupiter and Saturn mean that dynamical instability on larger timescales cannot be ruled out.</P>

      • SCOPUSKCI등재

        HEALTH RISKS POSED BY MYCOTOXINS IN FOODS

        Hsieh, D.P.H. Korean Society of ToxicologyKorea Environmental Mu 1990 Toxicological Research Vol.6 No.2

        The ability of many toxigenic fungi to invade and develop in a wide variety of raw ingredients of human diet renders human exposure to mycotoxing very difficult to avoid. Most of the energy-rich commodities, such as cereal grains, oil seeds, tree nuts, and dehydrated fruits, are susceptible to mycotoxin contamination. Mycotoxins therefare have been recognized as an important class of hazardous substances in the human food chain. Although human exposure to mycotoxins is largely through ingestion, inhalation and skin contact may also be significant under conditions other than consumption of foods. Human ingestion of mycotoxins is due to consumption of contaminated dietary ingredients and the edible tissues and products of domestic animals that have been exposed to mycotoxins in moldy feed. Large scale acute human mycotoxicoses, such as ergotism in France, alimentary toxic aleukia in Russia, yellow rice syndrome in Japan, endemic nephropathy in Balkan countries, and acute aflatoxin poisonings in India and Taiwan, have been well documented, indicating that mycotoxicosis is a global problem. In some incidents, hundreds of victims were killed and many more became seriously ill. The mycotoxins that have been implicated in the etiology of these human diseases include aflatoxins, citreoviridin, cyclopiazonic acid, ergot alkaloids, moniliformin, ochratoxin A, trichothecenes, tenuazonic acid, and zearalenone. Among these, aflatoxins have been also implicated in the etiology of human primary liver cancer in those high-incidence countries in Africa and southeast Asia. It is well recognized that cause-effect relationship between mycotoxins and human diseases is very difficult to establish, especially for the cancer connection. Careful risk assessment must be performed to determine whether a mycotoxin indeed warrants costly regulatory actions.

      • KCI등재

        Determining optimal number of cores in a submarine power cable

        Hsieh Meng-Chang,Chen Bang-Fuh,Wang Yanyang,Chang Hsun-Cheng,Liu Wen-Hsiu,Hsu Hung-Lin 대한조선학회 2022 International Journal of Naval Architecture and Oc Vol.14 No.1

        Submarine power cables must be reinforced and must possess suitable mechanical properties to meet operational requirements for complex marine environments. This study numerically investigated the mechanical properties of submarine power cables under tensile, torsional, and compressive loading. The optimal number of cores was determined according to the variation in tensile and torsional stiffness with radial compressive pressure. As the radial compressive pressure increased, the tensile and torsional stiffness of the four- and five-core cable models decreased marginally compared with those of the threecore cable model; thus, the five-core cable model was superior to the two-, three-, and four-core cable models in terms of radial deformation and contact stress. The two-core cable model was superior to the three-, four-, and five-core cable models in terms of tensile and torsional strength. The results of this study can serve as a reference in the design of submarine power cables.

      • KCI등재후보

        Bond mechanism effect on the flexural behavior ofsteel reinforced concrete composite members

        Hsieh-Lung Hsu,Jia-Ling Juang 국제구조공학회 2006 Steel and Composite Structures, An International J Vol.6 No.5

        This paper discusses the composite mechanism and its effect upon the behavior of a steel reinforced concrete (SRC) member subjected to a flexural load. The relationship between member strength and deformation is established using the bond strength between the steel and reinforced concrete. An analytical model is proposed and used to incorporate the sectional strains and bond strength at the elastic and inelastic stages for moment-curvature relationship derivation. The results from the flexural load tests are used to validate the accuracy of the proposed model. Comparisons between the experimental information and the analytical results demonstrate close moment-curvature relevance, which justifies the applicability of the proposed method.

      • KCI등재

        Full-Duplex Underwater Acoustic Communications via Self-Interference Cancellation in Space

        Hsieh, Yung-Ting,Qi, Zhuoran,Pompili, Dario 한국통신학회 2023 Journal of communications and networks Vol.25 No.2

        Traditionally, underwater acoustic communicationsare half-duplex (HD), i.e., the hydrophones and transducersoperate in non-overlapping time-slots/frequency-bands in one di-rection. To double the spectral efficiency into the full-duplex (FD)mode, which transmit and receive signals simultaneously, a self-interference cancellation (SIC) technique in space is introducedand deployed. Specifically, a novel underwater acoustic system isproposed to perform FD-SIC efficiently via an integrated designcombining underwater acoustic vector sensor (AVS) and phasedarray transducer (PAT) to realize the spatial SIC. The energyfocusing function of the beamformer (BF) helps PAT avoid selfand mutual spatial interference. The AVS keeps updating thedirection of arrival information to let BF adjust the steeringangle via an adaptive protocol. The field-programmable gatearray (FPGA) Direction of Arrival Estimation (DOA) estimationis done by a 12-element AVS, run-time is 1.22×10−4 s byMUSIC method, which is promising for real-time applications. Inthis work, phase-shift keying (PSK) and PSK-based orthogonalfrequency-division multiplexing (OFDM) are deployed as theFD transmission modulation methods in the spacial SIC. Theproposal is evaluated and verified via both simulations andemulations in real underwater acoustic channels collected in theGulf of La Spezia, Italy, and it is able to achieve 59 dB SIC whilemodulating with binary phase-shift keying (BPSK) with carrierwave frequency 80 kHz and AVS steering angle −5◦. Moreover,it has at least 37 dB SIC within the steering angle region.

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