정상청력인에서 나이와 성별에 따른 DPOAE의 특성

홍빛나,남상길,김진숙 한국음성과학회 2004 음성과학 Vol.11 No.4

The primary goal of the present study was to explore more detailed evidence for the influence of aging and gender effects on the capability of Korean healthy, ears to generate DPOAEs. DPOAEs were examined in series of human subjects, with clinically normal hearing, ranging in age from 10 to 65 years. All 60 Koreans were divided into 6 age groups. Each age group included 10 participants, 5 females and 5 males. The gender effects on the difference between the absolute amplitude and noise floor value in DPOAEs did not exist. The difference increased as the frequency increased. The aging effects on the difference between the absolute amplitude and noise floor value in DPOAEs did exist. The difference increased as the frequency increased but orderly age effects could not be found. The principle finding was that, when compared between emissions in young and old ears, DPOAEs accurately tracked the systematic deterioration of high-frequency hearing in aging individuals. Such results support the need to reestablish the criterion for interpretation of DPOAEs in the elderly.

Validation Study of Auditory Middle Latency Response in Mouse Model

Bin Na Hong,Tong Ho Kang 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.2

Auditory middle latency response (AMLR) is an important biosignal of auditory pathway. Validated-AMLR test is required in research for neurodiagnosis and preclinical study for auditory diseases. However, the amplitude of AMLR is small and the latency time of AMLR has poor reproducibility. In this study, we have performed the validation of AMLR test in ketamine-anesthetized mouse model. The latency and amplitude of AMLR increased with higher ketamine dosage. The profiles of latency time were similar but the profiles of amplitude showed a decrease. When body temperature was lower or higher than normal temperature, the latency of AMLR increased. A bandpass filter of 10-250 ㎐ was used. It had the lowest relative standard deviation and its morphology was reliable to analyse AMLR responses. With increase in the stimulus rate, there was decrease in the amplitude of AMLR. Our investigation might reduce relative standard variations of AMLR and enhance the reproducibility of AMLR tests on ketamine-anesthetized mouse models.

The Validation Study of Otoacoustic Emission by the Regulation of Body Temperature in the Mouse Model

Bin-Na Hong,Tae-Gyu Park,Tong-Ho Kang 한국청각언어재활학회 2007 Audiology and Speech Research Vol.3 No.2

High Dosage Sildenafil Induces Hearing Impairment in Mice

Hong, Bin Na,Yi, Tae Hoo,Kim, Sun Yeou,Kang, Tong Ho Pharmaceutical Society of Japan 2008 Biological & pharmaceutical bulletin Vol.31 No.10

<P>Sildenafil is widely administered for the treatment of erectile dysfunction. Recently, sensorineural hearing loss following the ingestion of sildenafil was reported in one male patient. We examined hearing in mice that were administered high doses of sildenafil for up to 105 d. To assess hearing impairment, we evaluated auditory brainstem responses, auditory middle latency responses, and otoacoustic emissions. At high doses, sildenafil increased the hearing threshold shift of auditory brainstem responses. High-dose sildenafil treatment also resulted in delayed latency of both auditory brainstem responses and auditory middle responses. Otoacoustic emissions differed between control and high-dose sildenafil groups with long-term treatment. Collectively, these data demonstrate that high-dose and long-term sildenafil administration can induce hearing impairment in mice.</P>

Curculigo orchioides, Natural Compounds for the Treatment of Noise-induced Hearing Loss in Mice

Bin Na Hong,강동호,Yong-Ouk You 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.4

Noise exposure is one of the most common causes of hearing loss. Noise-induced hearing loss (NIHL) is thought to primarily involve damage to the sensory hair cells of the cochlea via mechanical and metabolic mechanisms. Curculigo orchioides Gaerten (C. orchioides) is considered to have immunostimulant, hepatoprotective, antioxidative, anticancer, and antidiabetic activities. But the effect of C. orchioides on NIHL is not yet reported, this study focused on examining the therapeutic effects of C. orchioides on NIHL in a mouse model. Oral treatment with the extract of C. orchioides began 24 h following an examination that determined a shift in hearing threshold induced by noise exposure. Hearing threshold shifts were assessed by analyzing auditory brainstem responses at 1, 5, and 7 days following noise exposure. Central auditory function was evaluated using auditory middle latency responses, and cochlear function was determined based on transient-evoked otoacoustic emissions. C. orchioides reduced hearing threshold shifts, central auditory function damage, and cochlear function deficits. Our results suggest that C. orchioides can be utilized as a potential therapeutic natural product for NIHL.

The Effects of <i>Panax ginseng</i> and <i>Panax quinquefolius</i> on Thermoregulation in Animal Models

Hong, Bin Na,Do, Moon Ho,Her, You Ri,Lee, Yeong Ro,Kang, Tong Ho Hindawi Publishing Corporation 2015 Evidence-based Complementary and Alternative Medic Vol.2015 No.-

<P>We devised a study using animal models of hyperthermia and hypothermia and also attempted to accurately assess the effects of <I>Panax ginseng</I> (PG) and <I>Panax quinquefolius</I> (PQ) on body temperature using these models. In addition, we investigated the effects of PG and PQ in our animal models in high and low temperature environments. The results of our experiments show that mice with normothermia, hyperthermia, and hypothermia maintained their body temperatures after a certain period in accordance with the condition of each animal model. In our experiments of body temperature change in models of normal, low, or high room temperature, the hyperthermic model did not show any body temperature change in either the PG- or PQ-administered group. In the normal and low room temperature models, the group administered PG maintained body temperature, while the body temperature of the PQ-administered group was lower than or similar to that of the control group. In conclusion, the fact that PG increases body temperature could not be verified until now. We also showed that the effect of maintaining body temperature in the PG-administered group was superior in a hypothermia-prone low temperature environment.</P>

Red ginseng amelioratesauditory neuropathy in mice

Bin Na Hong,Keun Ha Park,Tong Ho Kang 고려인삼학회 2011 고려인삼학회 학술대회 Vol.2011 No.4

Distinction between auditory electrophysiological responses in type 1 and type 2 diabetic animal models

Hong, Bin Na,Kang, Tong Ho Elsevier 2014 Neuroscience Letters Vol.566 No.-

Neurological research has focused recently on determining the molecular mechanisms of common causes of damage to the peripheral and central nervous systems. One of the metabolic systemic diseases that can result in sensorineural hearing loss is diabetic mellitus (DM). In this study, we aimed to compare the auditory electrophysiological responses present in animal models of type I and type 2 DM using auditory brainstem response (ABR), auditory middle latency response (AMLR), and transient evoked otoacoustic emission (TEOAE) in animal model. We found that ABR threshold shifts and latency delays were similar in both types of DM. On the other hand, we found that type 2 diabetic mice exhibited more severe dysfunction to the central auditory pathway, as measured AMLRs and the cochlear hair cells, as measured TEOAEs. These results together suggest that hyperglycemia associated with type I or type 2 DM causes auditory nerve dysfunction, while hyperinsulinemia associated with type 2 DM causes dysfunction to both the central auditory pathways and cochlear hair cells. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

High-Dosage Pyridoxine-Induced Auditory Neuropathy and Protection with Coffee in Mice

Hong, Bin Na,Yi, Tae Hoo,Kim, Sun Yeou,Kang, Tong Ho Pharmaceutical Society of Japan 2009 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.32 No.4

<P>Auditory neuropathy (AN) is a hearing disorder characterized by an abnormal auditory brainstem response (ABR). This study examined experimental AN model induced in mice following increased dosages of pyridoxine. Induced AN was examined for ≤10 weeks following the last pyridoxine treatment. To assess AN, we evaluated the ABR, auditory middle latency response (AMLR), otoacoustic emission (OAE), and histochemical morphology of the auditory nerve. Pyridoxine-treated mice exhibited an increase in the hearing threshold shift and delayed latency of both ABR and AMLR in proportion to pyridoxine dosage. Additionally, the extent of auditory nerve fiber loss increased in a dose-dependent manner following pyridoxine intoxication. Coffee or trigonelline treatment ameliorated the hearing threshold shift, delayed latency of the auditory evoked potential, and improved sensory fiber loss induced by pyridoxine intoxication. The present findings demonstrate that high-dose pyridoxine administration can be used to produce a new mouse model for AN, and coffee or trigonelline as a main active compound of coffee extract can potentially facilitate recovery from pyridoxine-induced auditory neuropathy.</P>

인공와우 이식 후 반대 귀의 보청기 착용이 방향 변별력에 미치는 영향

홍빛나(Bin Na Hong) The Research and Information Service 2006 남부대학교 논문집 Vol.6 No.-

본 연구는 인공와우를 착용한 21명의 아동을 대상으로 인공와우 이식 후 반대 귀에 보청기를 착용했을 때 나타나논 양이 착용 효과 중 방향 별별력 효과를 평가했다. 평가 결과 인공와우와 보청기 착용 시에는 비슷했으나 인공와우와 보청기를 함께 착용 했을 때에는 월등히 나은 변별력을 나타냈다. 인공와우와 보청기의 착용 역치에 따른 수행력 비교 사 인공와우의 착용 역치가 30dB HL 이하인 경우와 보청기의 착용 역치가 40 dB HL 이하인 경우가 그 이상인 경우보다 더 높은 방향 변별력을 나타내었고, 인공와우와 보청기의 역치 차이가 적을수록 변별력도 높아졌다. 상관관계 분석 시에는 보청기의 변별력이 좋을수록 인공와우와 보청기틀 함께 착용 했을 때의 변별력도 증가하여 보청기의 착용이 방향 변별력에 더 큰 영향을 미치고 있었다. 본 연구는 인공와우를 착용한 아동과 성인에게 반대 귀의 잔존 청력 활용에 대한 유용한 정보를 제공해 줄 수 있고 이를 근거로 인공와우 착용인을 대상으로 한 재활 시 양이 착용에 대한 검토를 제안한다.