http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Novel mutations of CDKN1C in Japanese patients with Beckwith-Wiedemann syndrome
Hitomi Yatsuki,Ken Higashimoto,Kosuke Jozaki,Kayoko Koide,Junichiro Okada,Yoriko Watanabe,Nobuhiko Okamoto,Yoshinobu Tsuno,Yoko Yoshida,Kazutoshi Ueda,Kenji Shimizu,Hirofumi Ohashi,Tsunehiro Mukai,Hid 한국유전학회 2013 Genes & Genomics Vol.35 No.2
Beckwith-Wiedemann syndrome (BWS) is an imprinting-related human disease that is characterized by macrosomia, macroglossia, abdominal wall defects, and variable minor features. BWS is caused by several genetic/epigenetic alterations, such as loss of methylation at KvDMR1,gain of methylation at H19-DMR, paternal uniparental disomy of chromosome 11, CDKN1C mutations, and structural abnormalities of chromosome 11. CDKN1C is an imprinted gene with maternal preferential expression, encoding for a cyclin-dependent kinase (CDK) inhibitor. Mutations in CDKN1C are found in 40 % of familial BWS cases with dominant maternal transmission and in *5 % of sporadic cases. In this study, we searched for CDKN1C mutations in 37BWS cases that had no evidence for other alterations. We found five mutations—four novel and one known—from a total of six patients. Four were maternally inherited and one was a de novo mutation. Two frame-shift mutations and one nonsense mutation abolished the QT domain, containing a PCNA-binding domain and a nuclear localization signal. Two missense mutations occurred in the CDK inhibitory domain,diminishing its inhibitory function. The above-mentioned mutations were predicted by in silico analysis to lead to loss of function; therefore, we strongly suspect that such anomalies are causative in the etiology of BWS.
Hitomi Suzuki,Koichiro Matsuo Asia Association for Disability and Oral Health 2020 대한장애인치과학회지 Vol.16 No.1
Introduction: Recently, everolimus has been used as a treatment for subependymal giant cell astrocytomas and renal angiomyolipoma in patients with tuberous sclerosis. Oral everolimus application often causes oral mucositis. However, dentists and dental hygienists do not yet fully understand the adverse events and how to deal with them. This report aimed to describe the successful oral health management of a tuberous sclerosis complex (TSC) patient with oral mucositis under everolimus. Case presentation: A 26-year-old man with TSC was referred by a urologist to our dental outpatient clinic for oral examination before commencing oral everolimus for the treatment of renal angiomyolipoma. Other TSC comorbidities included subependymal giant cell astrocytomas, epilepsy, and severe mental retardation. His oral condition was poor since he had not visited a dental office for an extended time due to extremely uncooperative behavior. Periodontal and caries treatments were carried out under behavior management techniques and immobilization by his mother and dental staff. Proper management of oral mucositis and oral care procedures were also instructed to the mother. His oral hygiene status improved and multiple oral mucositis lesions by everolimus did not deteriorate to cause infection or delayed healing. Conclusion: To prevent the deterioration of oral hygiene and oral mucositis by medication, dental professionals should be involved in a team-based approach to TSC treatment.
A survey of healthcare workers’ recommendations about human papillomavirus vaccination
Hitomi Nishioka,Tomoko Onishi,Taito Kitano,Masahiro Takeyama,Natsuko Imakita,Kei Kasahara,Ryuji Kawaguchi,Jennifer Akiko Masaki,Keiji Nogami 대한백신학회 2022 Clinical and Experimental Vaccine Research Vol.11 No.2
Purpose: The human papillomavirus (HPV) vaccine is safe and effective for preventing HPV-related diseases. However, HPV vaccination rates in Japan are low because the “Ministry of Health, Labour and Welfare” had stopped recommending vaccination. We assessed healthcare workers’ (HCWs) current recommendations regarding the HPV vaccine and how the provision of information about HPV vaccination affected their recommendations. Materials and Methods: A survey was conducted among nurses and physicians in Nara prefecture from March 2021 to July 2021. The questionnaire asked about their understanding, recommendations, and opinions regarding HPV vaccination. Before answering the last two questions (optional), the HCWs read evidence-based information quantifying the risks and benefits of HPV vaccination. Results: A total of 441 HCWs completed the questionnaire. Only 19% of HCWs always recommended HPV vaccination for girls aged 12–16 years. The evidence-based information significantly improved the percentage of HCWs who would “always recommend” vaccination. Conclusion: This study showed that the proportion of HCWs who recommend HPV vaccination to adolescent girls remains low in Japan. However, we found that evidence-based information describing the causal relationship between adverse events and vaccination, quantifying the risks and benefits, noting the importance of HCW communications with families, and reporting the recommendations of national societies, might increase HCWs’ recommendations for HPV vaccination.
Ukraine War and Just Energy Transition toward Carbon Neutrality in EU and Japan1
( Hitomi Kimura ) 한국EU학회 2023 Asia-Pacific Journal of EU Studies Vol.21 No.1
Ukraine war and its subsequent energy crisis, in particular, the global price hike of natural gas increased global emissions from fossil fuels, delayed the just energy transition or changes its path to achieve carbon neutrality in EU and Japan. Some countries accelerate their speed to expand renewable energy, but without alternative sources, more fossil fuel dependent countries are forced to go back to coal, oil and nuclear. Price cap is effective, but energy sanction against Russian itself cannot stop or prevent the war and takes time. To achieve carbon neutrality, while strengthening energy security, sovereignty and independence under the war, not only Europe in relation to Russia, but the whole international community needs to reconsider their energy supply and demand in the divided block economy and appropriate just energy transition.
Hitomi HAMADA,Yoko SAITO 한국펄프·종이공학회 1999 한국펄프종이학회 기타 간행물 Vol.- No.-
With a view to seek the influence of hollow sphere pigments of latex upon the printed color on coated paper surface, the hollow sphere pigments were compared with filled ones in a variety of experimental approaches.<br/> Colloidal properties of latices were determined by measuring zeta potential and particle size distribution. For the amphoteric filled sphere pigment of latex, the polarity was reversed from the negative side to the positive side with decreasing pH. An extraordinarily high peak in the particle size distribution of the amphoteric filled evidenced aggregation between latex particles near the isoelectric point, depending on the electrolyte concentration and pH of the suspending medium.<br/> Coated papers containing the hollow sphere pigment in their coating improved optical properties like gloss and brightness. Optical parameters solely of the coating could account for this finding. An equation derived from the<br/> Kubelka-Munk equation calculated them /Tom twice measurements of reflectance of a coated paper over two substrates of different reflectances. This method permitted to predict brightness of coated paper of which coat weight would be different from the actual one.<br/> The colorimetric parameters of solid-printed surfaces of the coated papers closely related to optical and structural properties of the coated papers. The color of the printed surfaces was dominated by the brightness and the smoothness of the coated papers.<br/> The hollow sphere pigments were proved to improve optical properties of coated paper and to control minutely colorimetric parameters of printed surfaces.