Association between High Diffusion-Weighted Imaging-Derived Functional Tumor Burden of Peritoneal Carcinomatosis and Overall Survival in Patients with Advanced Ovarian Carcinoma

An He,Perucho Jose AU,Chiu Keith WH,Hui Edward S,Chu Mandy MY,Ngu Siew Fei,Ngan Hextan YS,Lee Elaine YP 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.5

Objective: To investigate the association between functional tumor burden of peritoneal carcinomatosis (PC) derived from diffusion-weighted imaging (DWI) and overall survival in patients with advanced ovarian carcinoma (OC). Materials and Methods: This prospective study was approved by the local research ethics committee, and informed consent was obtained. Fifty patients (mean age ± standard deviation, 57 ± 12 years) with stage III–IV OC scheduled for primary or interval debulking surgery (IDS) were recruited between June 2016 and December 2021. DWI (b values: 0, 400, and 800 s/mm2) was acquired with a 16-channel phased-array torso coil. The functional PC burden on DWI was derived based on K-means clustering to discard fat, air, and normal tissue. A score similar to the surgical peritoneal cancer index was assigned to each abdominopelvic region, with additional scores assigned to the involvement of critical sites, denoted as the functional peritoneal cancer index (fPCI). The apparent diffusion coefficient (ADC) of the largest lesion was calculated. Patients were dichotomized by immediate surgical outcome into high- and low-risk groups (with and without residual disease, respectively) with subsequent survival analysis using the Kaplan-Meier curve and log-rank test. Multivariable Cox proportional hazards regression was used to evaluate the association between DWI-derived results and overall survival. Results: Fifteen (30.0%) patients underwent primary debulking surgery, and 35 (70.0%) patients received neoadjuvant chemotherapy followed by IDS. Complete tumor debulking was achieved in 32 patients. Patients with residual disease after debulking surgery had reduced overall survival (p = 0.043). The fPCI/ADC was negatively associated with overall survival when accounted for clinicopathological information with a hazard ratio of 1.254 for high fPCI/ADC (95% confidence interval, 1.007–1.560; p = 0.043). Conclusion: A high DWI-derived functional tumor burden was associated with decreased overall survival in patients with advanced OC.

Effect of MoS2-Based Composite Coatings on Tribological Behavior and Efficiency of Gear

Hui-Bo He,Hua-Ying Li,Zhe-Zhu Xu,Donguk Kim,류성기 한국정밀공학회 2010 International Journal of Precision Engineering and Vol. No.

MoS2-based Ti composite coatings were deposited on the SCM420 alloy and gears using an RF magnetron sputtering (RFMS) system. While MoS2 coating had been coated on the silicon substrate. The coatings structures were compared to each other to find the effect of Ti. The composite coatings have been tested in a ball-on-disk tribometer to investigate tribological behavior at various conditions. The scratch test was conducted to characterize adhesion force between composite coatings and substrates. The structure of the coatings has been extensively studied by a variety of techniques, including optical microscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM), etc. The composite coatings were also applied to the gears of a reduction gearbox. The efficiency of uncoated and MoS2-based Ti coated gear was measured and compared at various input rotating speed under absorption oil film condition. It was found that the efficiency of gear had significantly improved after MoS2-based Ti composite coatings deposition.

A Two-level Application Transparent Checkpointing Scheme in Cloud Computing Environment

He Hui,Zhang Zhan,Wang Bai-Ling,Zuo De-Cheng,Yang Xiao-Zong 보안공학연구지원센터 2013 International Journal of Database Theory and Appli Vol.6 No.2

Fault Localization Method of Software Defects based on Dependencies Analysis of Program Structure

Hui He,Lei Zhao,Qiao Li,Weizhe Zhang,Dongmin Gao,Yongtan Liu 보안공학연구지원센터 2013 International Journal of Security and Its Applicat Vol.7 No.3

Effect of $MoS_2$-Based Composite Coatings on Tribological Behavior and Efficiency of Gear

He, Hui-Bo,Li, Hua-Ying,Xu, Zhe-Zhu,Kim, Dong-Uk,Lyu, Sung-Ki 한국정밀공학회 2010 International Journal of Precision Engineering and Vol.11 No.6

$MoS_2$-based Ti composite coatings were deposited on the SCM420 alloy and gears using an RF magnetron sputtering (RFMS) system. While $MoS_2$ coating had been coated on the silicon substrate. The coatings structures were compared to each other to find the effect of Ti. The composite coatings have been tested in a ball-on-disk tribometer to investigate tribological behavior at various conditions. The scratch test was conducted to characterize adhesion force between composite coatings and substrates. The structure of the coatings has been extensively studied by a variety of techniques, including optical microscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM), etc. The composite coatings were also applied to the gears of a reduction gearbox. The efficiency of uncoated and $MoS_2$-based Ti coated gear was measured and compared at various input rotating speed under absorption oil film condition. It was found that the efficiency of gear had significantly improved after $MoS_2$-based Ti composite coatings deposition.

Analysis of higher order composite beams by exact and finite element methods

He, Guang-Hui,Yang, Xiao Techno-Press 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.53 No.4

In this paper, a two-layer partial interaction composite beams model considering the higher order shear deformation of sub-elements is built. Then, the governing differential equations and boundary conditions for static analysis of linear elastic higher order composite beams are formulated by means of principle of minimum potential energy. Subsequently, analytical solutions for cantilever composite beams subjected to uniform load are presented by Laplace transform technique. As a comparison, FEM for this problem is also developed, and the results of the proposed FE program are in good agreement with the analytical ones which demonstrates the reliability of the presented exact and finite element methods. Finally, parametric studies are performed to investigate the influences of parameters including rigidity of shear connectors, ratio of shear modulus and slenderness ratio, on deflections of cantilever composite beams, internal forces and stresses. It is revealed that the interfacial slip has a major effect on the deflection, the distribution of internal forces and the stresses.

사회적 실재감이 쇼핑 사이트 이용의도에 미치는 영향에 관한 연구

He Hui, 민대환(DaiHwan Min) 한국IT서비스학회 2011 한국IT서비스학회 학술대회 논문집 Vol.2011 No.9

페이스북,트워터 등의 소셜 네트워크 서비스(SNS: Social network service)의 지속적인 성장과 더불어,소셜 네트워크 서비스를 이용하여 공동구매자를 모아 저렴한 가격으로 쇼핑을 하는 소셜 쇼핑(Social Shopping) 또한 활발하게 이용되고 있다. 이 과정에서 소셜쇼핑 사이트 이용자가 일반 쇼핑 사이트보다 더 큰 사회적 실재감을 느끼게 된다. 본 연구에서는 사회적 실재감을 '감정', '자기표현감', 자기효능감', '소통 정도', '인간관계유지성'의 다섯 가지 요소로 세분화하고 이러한 사회적 실재감이 쾌락적 쇼핑가치를 통해 사이트 사용의도에 어떤 영향을 미치는지를 알아본다.

An integrated structural health monitoring system for the Xijiang high-speed railway arch bridge

He, Xu-hui,Shi, Kang,Wu, Teng Techno-Press 2018 Smart Structures and Systems, An International Jou Vol.21 No.5

Compared with the highway bridges, the relatively higher requirement on the safety and comfort of vehicle makes the high-speed railway (HSR) bridges need to present enhanced dynamic performance. To this end, installing a health monitor system (HMS) on selected key HSR bridges has been widely applied. Typically, the HSR takes fully enclosed operation model and its skylight time is very short, which means that it is not easy to operate the acquisition devices and download data on site. However, current HMS usually involves manual operations, which makes it inconvenient to be used for the HSR. Hence, a HMS named DASP-MTS (Data Acquisition and Signal Processing - Monitoring Test System) that integrates the internet, cloud computing (CC) and virtual instrument (VI) techniques, is developed in this study. DASP-MTS can realize data acquisition and transmission automatically. Furthermore, the acquired data can be timely shared with experts from various locations to deal with the unexpected events. The system works in a Browser/Server frame so that users at any places can obtain real-time data and assess the health situation without installing any software. The developed integrated HMS has been applied to the Xijiang high-speed railway arch bridge. Preliminary analysis results are presented to demonstrate the efficacy of the DASP-MTS as applied to the HSR bridges. This study will provide a reference to design the HMS for other similar bridges.

Inhibition of ERK and Activation of p38 are Involved in Diallyl Disulfide Induced Apoptosis of Leukemia HL-60 Cells

Hui Tan,Hui Ling,Jie He,Lan Yi,Jianguo Zhou,Min Lin,Qi Su 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.6

We investigated the effects of diallyl disulfide (DADS) on the induction of apoptosis in human Leukemia cell line HL-60 and explored the roles of mitogen-activated protein kinase (ERK and p38 MAPK) pathways in the growth inhibition and apoptosis induced by DADS. MTT assay was used to determine the DADS induced cell growth inhibition in HL-60 cells. Flow cytometry and DNA fragmentation were used to examine the roles of apoptosis in DADS-mediated cell death. Western blot analysis of the expression of phospho-MAPKs (ERK and p38) was employed to elucidate the possible mechanisms of DADS induced apoptosis. We found that growth inhibition of HL-60 cells treated with DADS exhibited a dose-dependent response (P<0.05) and DADS induced significant apoptosis. DADS at the concentration of 10 mg/L persistently activated p38 and simultaneously reduced ERK activity. PD98059, an inhibitor of ERK upstream activators MAPK kinase MKK1 and MKK2, promoted cytotoxicity and apoptosis in HL-60 cells treated with DADS. In contrast, SB203580, an inhibitor of p38, decreased cytotoxicity and apoptosis induced by DADS. Therefore, DADS can effectively inhibit the proliferation and induce apoptosis of human leukemia cell line HL-60. Inhibition of ERK signaling pathways and activation of p38 signaling pathways are likely involved in DADS induced apoptosis in HL- 60 cells.

Optimal Design of a Tilling Machine Reduction Gearbox Using Matlab

Hui-Bo He,Hua-Ying Li,Sung-Ki Lyu,Sung-Hoon Tak,Sung-Min Moon,Qi Zhang 한국정밀공학회 2009 International Journal of Precision Engineering and Vol.10 No.2

This paper describes the optimal design of the reduction gearbox of a tillage machine. The minimum center diameter was selected as the objective, and the contact fatigue strength. bending fatigue strength, condition of nonintervention, and oil film thickness ratio of the gearbox were applied as constraint conditions. The optimal model was solved by a Matlab program. The results show that the center diameter of the reduction gearbox decreased by about 10%. The resulting decrease in weight and volume led to a reduction in the amount of gearbox matelial and a consequent decrease in production cost.