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- 저자 : Hayeon Jennifer Kim (검색결과 4 건)
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Hayeon Jennifer Kim,이문수,양재원 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.5
Purpose: The aim of this study was to clarify the relationship between the autonomic nervous system and attention deficit hyperactivitydisorder (ADHD) rating scales and to evaluate the usefulness of heart rate variability (HRV) as a psychophysiological biomarkerfor ADHD. Materials and Methods: Subjects were recruited from outpatients in the Department of Child and Adolescent Psychiatry at the Korea University Medical Center from August 2007 to December 2010. Subjects received methylphenidate. Time- and frequency-domain analyses of HRV, the Korean ADHD rating scale (K-ARS), and computerized ADHD diagnostic system were evaluated beforetreatment. After a 12-week period of medication administration, we repeated the HRV measurements and K-ARS rating. Results: Eighty-six subjects were initially enrolled and 37 participants completed the 12-week treatment and HRV measurements subsequent to the treatment. Significant correlations were found between the K-ARS inattention score and some HRV parameters. All of the HRV parameters, except the standard deviations of the normal-to-normal interval, very low frequency, and low frequencyto high frequency, showed a significant positive correlation between baseline and endpoint measures in completers. High frequency (HF) and the square root of the mean squared differences of successive normal-to-normal intervals (RMSSD), which are related to parasympathetic vagal tone, showed significant decreases from baseline to endpoint. Conclusion: The HRV test was shown to be reproducible. The decrease in HF and RMSSD suggests that parasympathetic dominancein ADHD can be altered by methylphenidate treatment. It also shows the possibility that HRV parameters can be used as psychophysiological markers in the treatment of ADHD.
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Song, Hayeon,Omori, Kikuko,Kim, Jihyun,Tenzek, Kelly E,Hawkins, Jennifer Morey,Lin, Wan-Ying,Kim, Yong-Chan,Jung, Joo-Young JMIR Publications Inc. 2016 Journal of medical Internet research Vol.18 No.3
<P><B>Background</B></P><P>The Internet has increasingly become a popular source of health information by connecting individuals with health content, experts, and support. More and more, individuals turn to social media and Internet sites to share health information and experiences. Although online health information seeking occurs worldwide, limited empirical studies exist examining cross-cultural differences in perceptions about user-generated, experience-based information compared to expertise-based information sources.</P><P><B>Objective</B></P><P>To investigate if cultural variations exist in patterns of online health information seeking, specifically in perceptions of online health information sources. It was hypothesized that Koreans and Hongkongers, compared to Americans, would be more likely to trust and use experience-based knowledge shared in social Internet sites, such as social media and online support groups. Conversely, Americans, compared to Koreans and Hongkongers, would value expertise-based knowledge prepared and approved by doctors or professional health providers more.</P><P><B>Methods</B></P><P>Survey questionnaires were developed in English first and then translated into Korean and Chinese. The back-translation method ensured the standardization of questions. Surveys were administered using a standardized recruitment strategy and data collection methods.</P><P><B>Results</B></P><P>A total of 826 participants living in metropolitan areas from the United States (n=301), Korea (n=179), and Hong Kong (n=337) participated in the study. We found significant cultural differences in information processing preferences for online health information. A planned contrast test revealed that Koreans and Hongkongers showed more trust in experience-based health information sources (blogs: <I>t</I><SUB>451.50</SUB>=11.21, <I>P</I><.001; online support group: <I>t</I><SUB>455.71</SUB>=9.30, <I>P</I><.001; social networking sites [SNS]: <I>t</I><SUB>466.75</SUB>=11.36, <I>P</I><.001) and also reported using blogs (<I>t</I><SUB>515.31</SUB>=6.67, <I>P</I><.001) and SNS (<I>t</I><SUB>529.22</SUB>=4.51, <I>P</I><.001) more frequently than Americans. Americans showed a stronger preference for using expertise-based information sources (eg, WebMD and CDC) compared to Koreans and Hongkongers (<I>t</I><SUB>360.02</SUB>=3.01, <I>P</I>=.003). Trust in expertise-based information sources was universal, demonstrating no cultural differences (Brown-Forsythe <I>F</I><SUB>2,654</SUB>=1.82, <I>P</I>=.16). Culture also contributed significantly to differences in searching information on behalf of family members (<I>t</I><SUB>480.38</SUB>=5.99, <I>P</I><.001) as well as to the goals of information searching.</P><P><B>Conclusions</B></P><P>This research found significant cultural differences in information processing preferences for online health information. Further discussion is included regarding effective communication strategies in providing quality health information.</P>
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Park, Hansoo,Lee, Seungbok,Kim, Hyun-Jin,Ju, Young Seok,Shin, Jong-Yeon,Hong, Dongwan,von Grotthuss, Marcin,Lee, Dong-Sung,Park, Changho,Kim, Jennifer Hayeon,Kim, Boram,Yoo, Yun Joo,Cho, Sung-Il,Sung, BMJ Publishing Group 2012 Journal of medical genetics Vol.49 No.12
<P><B>Background</B></P><P>Musical abilities such as recognising music and singing performance serve as means for communication and are instruments in sexual selection. Specific regions of the brain have been found to be activated by musical stimuli, but these have rarely been extended to the discovery of genes and molecules associated with musical ability.</P><P><B>Methods</B></P><P>A total of 1008 individuals from 73 families were enrolled and a pitch-production accuracy test was applied to determine musical ability. To identify genetic loci and variants that contribute to musical ability, we conducted family-based linkage and association analyses, and incorporated the results with data from exome sequencing and array comparative genomic hybridisation analyses.</P><P><B>Results</B></P><P>We found significant evidence of linkage at 4q23 with the nearest marker D4S2986 (LOD=3.1), whose supporting interval overlaps a previous study in Finnish families, and identified an intergenic single nucleotide polymorphism (SNP) (rs1251078, p=8.4×10<SUP>−17</SUP>) near <I>UGT8</I>, a gene highly expressed in the central nervous system and known to act in brain organisation. In addition, a non-synonymous SNP in <I>UGT8</I> was revealed to be highly associated with musical ability (rs4148254, p=8.0×10<SUP>−17</SUP>), and a 6.2 kb copy number loss near <I>UGT8</I> showed a plausible association with musical ability (p=2.9×10<SUP>−6</SUP>).</P><P><B>Conclusions</B></P><P>This study provides new insight into the genetics of musical ability, exemplifying a methodology to assign functional significance to synonymous and non-coding alleles by integrating multiple experimental methods.</P>
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