Low Complexity Zero-Forcing Beamforming for Distributed Massive MIMO Systems in Large Public Venues

Li, Haoming,Leung, Victor C.M. The Korea Institute of Information and Commucation 2013 Journal of communications and networks Vol.15 No.4

Distributed massive MIMO systems, which have high bandwidth efficiency and can accommodate a tremendous amount of traffic using algorithms such as zero-forcing beam forming (ZFBF), may be deployed in large public venues with the antennas mounted under-floor. In this case the channel gain matrix H can be modeled as a multi-banded matrix, in which off-diagonal entries decay both exponentially due to heavy human penetration loss and polynomially due to free space propagation loss. To enable practical implementation of such systems, we present a multi-banded matrix inversion algorithm that substantially reduces the complexity of ZFBF by keeping the most significant entries in H and the precoding matrix W. We introduce a parameter p to control the sparsity of H and W and thus achieve the tradeoff between the computational complexity and the system throughput. The proposed algorithm includes dense and sparse precoding versions, providing quadratic and linear complexity, respectively, relative to the number of antennas. We present analysis and numerical evaluations to show that the signal-to-interference ratio (SIR) increases linearly with p in dense precoding. In sparse precoding, we demonstrate the necessity of using directional antennas by both analysis and simulations. When the directional antenna gain increases, the resulting SIR increment in sparse precoding increases linearly with p, while the SIR of dense precoding is much less sensitive to changes in p.

Low Complexity Zero-Forcing Beamforming for Distributed Massive MIMO Systems in Large Public Venues

Haoming Li,룽빅터 한국통신학회 2013 Journal of communications and networks Vol.15 No.4

Distributed massive MIMO systems, which have high bandwidth efficiency and can accommodate a tremendous amount of traffic using algorithms such as zero-forcing beamforming (ZFBF), may be deployed in large public venues with the antennas mounted under-floor. In this case the channel gain matrix H can be modeled as a multi-banded matrix, in which off-diagonal entries decay both exponentially due to heavy human penetration loss and polynomially due to free space propagation loss. To enable practical implementation of such systems, we present a multibanded matrix inversion algorithm that substantially reduces the complexity of ZFBF by keeping the most significant entries in H and the precoding matrix W. We introduce a parameter p to control the sparsity of H andWand thus achieve the tradeoff between the computational complexity and the system throughput. The proposed algorithmincludes dense and sparse precoding versions, providing quadratic and linear complexity, respectively, relative to the number of antennas. We present analysis and numerical evaluations to show that the signal-to-interference ratio (SIR) increases linearly with p in dense precoding. In sparse precoding, we demonstrate the necessity of using directional antennas by both analysis and simulations. When the directional antenna gain increases, the resulting SIR increment in sparse precoding increases linearly with p, while the SIR of dense precoding ismuch less sensitive to changes in p.

The Risk of Bladder Cancer in Korean Diabetic Subjects Treated with Pioglitazone (Diabetes Metab J 2012;36: 371-8)

Sheyu Li,Haoming Tian 대한당뇨병학회 2013 Diabetes and Metabolism Journal Vol.37 No.1

The effect of canagliflozin on gut microbiota and metabolites in type 2 diabetic mice

Zeng Li,Ma Jideng,Wei Tiantian,Wang Hao,Yang Guitao,Han Chongxiang,Zhu Tao,Tian Haoming,Zhang Min 한국유전학회 2024 Genes & Genomics Vol.46 No.5

Background Sodium glucose cotransporter 2 inhibitor (SGLT2i) represent a new type of hypoglycemic medicine that can cause massive loss of glucose from the urine, which have several benefits of reducing body weight and improving the prognosis of cardiovascular and kidney diseases. Although they are oral medicated hypoglycemic agents, their effects on the gut microbiome and function have been unclear. Objective In order to describe the effects of canagliflozin on intestinal flora and metabolites, diabetic mice were randomized to receive canagliflozin or isoconcentration carboxymethylcellulose sodium by gavage for 8 weeks. Feces were collected for 16 S rRNA gene and LC-MS/MS analysis and enriched metabolic pathways through Kyoto Encyclopedia of Genes and Genomes (KEGG). Liver, muscle, intestinal, fat were collected for qRT-PCR according to KEGG enriched metabolic pathways. Results Our results showed that canagliflozin significantly increased GLP-1 level and impacted on the composition of gut microbiota and metabolites. It mainly increased Muribaculum, Ruminococcaceae_UCG_014, Lachnospiraceae-UCG-001, decreased ursodeoxycholic acids (UDCA) and hyodeoxycholic acids (HDCA), and increased fatty acids metabolites in feces. Conclusion In conclusion, we analyzed the changes of intestinal microbial composition and metabolites in diabetic mice after canagliflozin intervention and found that canagliflozin influenced intestinal fatty acid and bile acid (BA) metabolism. This study will provide reference for subsequent SGLT2i and intestinal related research. Background Sodium glucose cotransporter 2 inhibitor (SGLT2i) represent a new type of hypoglycemic medicine that can cause massive loss of glucose from the urine, which have several benefits of reducing body weight and improving the prognosis of cardiovascular and kidney diseases. Although they are oral medicated hypoglycemic agents, their effects on the gut microbiome and function have been unclear. Objective In order to describe the effects of canagliflozin on intestinal flora and metabolites, diabetic mice were randomized to receive canagliflozin or isoconcentration carboxymethylcellulose sodium by gavage for 8 weeks. Feces were collected for 16 S rRNA gene and LC-MS/MS analysis and enriched metabolic pathways through Kyoto Encyclopedia of Genes and Genomes (KEGG). Liver, muscle, intestinal, fat were collected for qRT-PCR according to KEGG enriched metabolic pathways. Results Our results showed that canagliflozin significantly increased GLP-1 level and impacted on the composition of gut microbiota and metabolites. It mainly increased Muribaculum, Ruminococcaceae_UCG_014, Lachnospiraceae-UCG-001, decreased ursodeoxycholic acids (UDCA) and hyodeoxycholic acids (HDCA), and increased fatty acids metabolites in feces. Conclusion In conclusion, we analyzed the changes of intestinal microbial composition and metabolites in diabetic mice after canagliflozin intervention and found that canagliflozin influenced intestinal fatty acid and bile acid (BA) metabolism. This study will provide reference for subsequent SGLT2i and intestinal related research.

PROM2 promotes gemcitabine chemoresistance via activating the Akt signaling pathway in pancreatic cancer

Wenbin Li,Yue Zhu,Kelin Zhang,Xianhuan Yu,Haoming Lin,Wenrui Wu,Yaorong Peng,Jian Sun 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

In recent years, the deoxycytidine analogue gemcitabine (2′,2′,-difluorodeoxycytidine) has become the first-line chemotherapeutic agent for patients with pancreatic cancer. However, due to the intrinsic resistance of pancreatic cancer cells, gemcitabine-based chemotherapy yields limited disease control, with >85% disease progression at 6 months from diagnosis. Therefore, elucidating the mechanisms of chemoresistance is a critical step in improving cancer therapy, especially for the treatment of pancreatic cancer. We show PROM2, a transmembrane glycoprotein, is ubiquitously upregulated in pancreatic cancer cell. We also found higher PROM2 expression is associated with shortened overall and disease-free survival times in patients diagnosed with pancreatic cancer. We provide evidence that PROM2 promotes chemoresistance to gemcitabine both in vivo and in vitro. Mechanistically, we demonstrate that PROM2 could directly interacted with Akt and activates the Akt signaling pathway, which thus inhibiting gemcitabineinduced apoptosis. As further evidence, we show PROM2 expression and Akt phosphorylation both promote gemcitabine chemoresistance, and cause poorer survival in clinical samples with pancreatic cancer. Combining gemcitabine with the Akt inhibitor MK-2206 facilitated significant tumor shrinkage and dramatically elevated the survival status in mice xenografted with pancreatic cancer cells. Our findings not only establish PROM2 as a novel positive regulator of the Akt signaling pathway and a candidate prognostic indicator of gemcitabine response, but also provide a neo-therapeutic approach for patients resistant to gemcitabine treatment.

Wireless Three-Pad ECG System: Challenges, Design, and Evaluations

Cao, Huasong,Li, Haoming,Stocco, Leo,Leung, Victor C.M. The Korea Institute of Information and Commucation 2011 Journal of communications and networks Vol.13 No.2

Electrocardiography (ECG) is a widely accepted approach for monitoring of cardiac activity and clinical diagnosis of heart diseases. Since cardiologists have been well-trained to accept 12-lead ECG information, a huge number of ECG systems are using such number of electrodes and placement configuration to facilitate fast interpretation. Our goal is to design a wireless ECG system which renders conventional 12-lead ECG information.We propose the three-pad ECG system (W3ECG). W3ECG furthers the pad design idea of the single-pad approach. Signals obtained from these three pads, plus their placement information, make it possible to synthesize conventional 12-lead ECG signals.We provide one example of pad placement and evaluate its performance by examining ECG data of four patients available from online database. Feasibility test of our selected pad placement positions show comparable results with respect to the EASI lead system. Experimental results also exhibit high correlations between synthesized and directly observed 12-lead signals (9 out of 12 cross-correlation coefficients higher than 0.75).

Isolation and characterization of a protease from the Actinidia arguta fruit for improving meat tenderness

Juan Wang,Haoming Liu,Haili Wang,Mingxun Cui,Qing Jin,Tie Jin,Fushun Cui,Taihua Cui,Cheng Yun Liang,김범식,Guanhao Li 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.4

An protease from Actinidia arguta for improving meat tenderness was purified, characterizedfrom wild A. arguta fruit by ammonium sulfate precipitation, Sephdex G-25 gel filtration chromatography,and DEAE Sepharose Fast Flow ion exchange chromatography, and its activity was investigated. Thepurified protease was subjected to sodium dodecyl sulfate polyacrylamide gel electrophoresis toobtain a single band of protease. The protease was purified successfully, and found to have a molecularweight of 23.8 kDa (mass spectrometry). The specific activity of the purified protease reached 53,428U/mg with a 25.5-fold purification factor and 9% activity recovery. Based on N-terminal sequencingresults, the A. arguta protease was derived from the class of actinidia proteases that have an Nterminalsequence of VLPDY VDWRS AGAVV. The protease was effective for tenderizing beef anddecomposing actomyosin, suggesting the potential application for improving meat tenderness.

Wireless Three-Pad ECG System: Challenges, Design, and Evaluations

Huasong Cao,Haoming Li,Victor C.M. Leung 한국통신학회 2011 Journal of communications and networks Vol.13 No.2

Electrocardiography (ECG) is a widely accepted approach for monitoring of cardiac activity and clinical diagnosis of heart diseases. Since cardiologists have been well-trained to accept 12-lead ECG information, a huge number of ECG systems are using such number of electrodes and placement configuration to facilitate fast interpretation. Our goal is to design a wireless ECG system which renders conventional 12-lead ECG information.We propose the three-pad ECG system (W3ECG). W3ECG furthers the pad design idea of the single-pad approach. Signals obtained from these three pads, plus their placement information, make it possible to synthesize conventional 12-lead ECG signals.We provide one example of pad placement and evaluate its performance by examining ECG data of four patients available from online database. Feasibility test of our selected pad placement positions show comparable results with respect to the EASI lead system. Experimental results also exhibit high correlations between synthesized and directly observed 12-lead signals (9 out of 12 cross-correlation coefficients higher than 0.75).

Isolation and characterization of a protease from the Actinidia arguta fruit for improving meat tenderness

Wang, Juan,Liu, Haoming,Wang, Haili,Cui, Mingxun,Jin, Qing,Jin, Tie,Cui, Fushun,Cui, Taihua,Liang, Chengyun,Kim, Bumsik,Li, Guanhao 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.4

An protease from Actinidia arguta for improving meat tenderness was purified, characterized from wild A. arguta fruit by ammonium sulfate precipitation, Sephdex G-25 gel filtration chromatography, and DEAE Sepharose Fast Flow ion exchange chromatography, and its activity was investigated. The purified protease was subjected to sodium dodecyl sulfate polyacrylamide gel electrophoresis to obtain a single band of protease. The protease was purified successfully, and found to have a molecular weight of 23.8 kDa (mass spectrometry). The specific activity of the purified protease reached 53,428 U/mg with a 25.5-fold purification factor and 9% activity recovery. Based on N-terminal sequencing results, the A. arguta protease was derived from the class of actinidia proteases that have an N-terminal sequence of VLPDY VDWRS AGAVV. The protease was effective for tenderizing beef and decomposing actomyosin, suggesting the potential application for improving meat tenderness.