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- 저자 : Haimei Li (검색결과 4 건)
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The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats
Xiaohuan Li,Shu Yang,Xiangyang Lv,Haimei Sun,Jing Weng,Yuanjing Liang,Deshan Zhou 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.2
Objective: Cisplatin is a widely used chemotherapeutic agent in the treatment of cancers in clinic; but it often induces adverse effects on ovarian functions such as reduced fertility and premature menopause. Mesna could attenuate the cisplatin-induced ovarian damages; however, the underlying mechanism is still unknown. This study aimed to figure out the underlying mechanism of the protection of mesna for ovaries against cisplatin therapy in cancers. Methods: We performed female adult Sprague-Dawley rats into normal saline control (NS), low-dose cisplatin (CL), high-dose cisplatin (CH), CL plus mesna (CL+M), and CH plus mesna (CH+M) groups and detected anti-Müllerian hormone (AMH)-positive follicle, oxidative stress status and anti-oxidative capability in ovaries. Results: AMH-positive follicles were significantly decreased after cisplatin administration, which was significantly reversed when mesna was co-administered with cisplatin. The end product of lipid peroxidation, malondialdehyde (MDA), was significantly increased, but the anti-oxidative enzymatic activity of superoxide dismutase (SOD) and glutathione (GSH) were significantly decreased in cisplatin groups when compared with NS group. In contrast, after co-administration of cisplatin with mesna, MDA was significantly decreased whereas the activity of SOD and the concentration of GSH were increased. Moreover, mesna did not decrease the anti-tumor property of cisplatin in HePG2 cell lines. Conclusion: Cisplatin damages the granulosa cells by oxidative stress to deplete the ovarian reserve and mesna could protect ovarian reserve through anti-oxidation. These results might highlight the mechanism of the protection of mesna for ovarian reserve and open an avenue for the application of mesna as a protective additive in cisplatin chemotherapy in clinical practise.
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Haiyan Li,Haimei Liu,Cheng Qian,Tao Wang,Sheng Wang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
Developing multifunctional purification systems that combine air filtration and antibacterial functionalityis a challenging task. However, in designing air filtration materials, achieving a balance between filtrationefficiency and pressure drop remains a significant challenge. In this study, we developed anovel filtration material composed of hierarchically 3D Cu-HHTP nanowiskers coated CuO nanowires thatwere grown in-situ on a copper mesh. Benefitted from the intrinsically electrical conductivity of Cu-HHTP, we combined the composite material with external electrical energy for air filtration. By applyinglower electric potential directly (voltage of 5 V), the 3D conductive mesh filter exhibited excellent performancesin terms of the PM2.5 removal efficiency (99.7%), pressure drop (32 Pa at 2 cm s -1), andquality factor (0.187 at 2 cm s -1). Furthermore, after ten cycles of filtration and cleaning, the materialmaintained a high PM removal rate. In addition to its excellent filtration performance, the compositemetal mesh also exhibited outstanding antibacterial activity against both E. coli and S. aureus. Theelectro-mechanical stability and recyclability of the composite filter make it a cost-effective and environmentallyfriendly solution for air purification, with promising potential for improving air quality.
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Yiwei Lin,Haimei Li,Jing Zhang,Ziqi Yang,Yi Zhou,Lu Liu,Qiujin Qian 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.8
Objective Attention deficit hyperactivity disorder (ADHD) is a polygenic neurodevelopmental disorder with significant gender differences. The sexual dimorphism of ADHD may be associated with estrogen acting through estrogen receptors (ESR). This study investigates the impact of <i>ESR</i> gene polymorphism and its interactions with neurodevelopmental genes on ADHD susceptibility.Methods The study compared genotyping data of single nucleotide polymorphisms in <i>ESR1</i> and <i>ESR2</i> in 1,035 ADHD cases and 962 controls. The gene-gene interactions between <i>ESR</i> genes and three neurodevelopmental genes (brain-derived neurotrophic factor [<i>BDNF</i>], synaptosomal-associated protein of 25 kDa gene [<i>SNAP25</i>], and cadherin-13 [<i>CDH13<i></i></i>]) in ADHD were investigated using generalized multifactor dimensionality reduction and verified by logistic regression analysis.Results The G allele of rs960070/<i>ESR2</i> (empirical p=0.0076) and the A allele of rs8017441/<i>ESR2</i> (empirical p=0.0426) were found significantly higher in ADHD cases than in the controls but not in male or female subgroups. Though no difference was found in all subjects or females, the A allele of rs9340817/<i>ESR1</i> (empirical p=0.0344) was found significantly higher in ADHD cases than controls in males. We also found genetic interaction models between <i>ESR2</i> gene, neurodevelopmental genes and ADHD susceptibility in males (<i>ESR2</i> rs960070/<i>BDNF</i> rs6265/<i>BDNF</i> rs2049046/<i>SNAP25</i> rs362987/<i>CDH13</i> rs6565113) and females (<i>ESR2<i></i></i> rs960070/<i>BDNF<i></i></i> rs6265/<i>BDNF</i> rs2049046) separately, though it was negative in overall subjects.Conclusion The <i>ESR</i> gene polymorphism associates with ADHD among Chinese Han children, with interactions between <i>ESR<i></i></i> genes and neurodevelopmental genes potentially influencing the susceptibility of ADHD.
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Yajing Tang,Sunwei Qiu,Haimei Li,Feifei Si,Mengjie Zhao,Min Dong,Meirong Pan,Xinxin Yue,Lu Liu,Qiujin Qian,Yufeng Wang 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.9
Objective Subthreshold attention-deficit/hyperactivity disorder (ADHD) has been suggested to be a “morbid condition” which also needs medical attention.Methods The present study recruited 89 children with subthreshold ADHD (sADHD), 115 children with diagnosed ADHD (cADHD), and 79 healthy controls (HC) to explore the clinical manifestation, executive functions (EFs) of sADHD, and the caregiver strain. The clinical manifestation was evaluated through clinical interviews and parent-reports. Executive functions were assessed both experimentally and ecologically. Caregiver strain was measured by a parent-reported questionnaire.Results For the clinical manifestation, both sADHD and cADHD indicated impairments when compared with HC. The comorbidities and the scaled symptoms indicated that the externalizing behaviors were relatively less serious in sADHD than cADHD, whereas the internalizing behaviors between two groups were comparable. For ecological EFs, sADHD scored between cADHD and HC in inhibition and working memory. For experimental EFs, sADHD was comparable to cADHD in inhibition, shifting, and was worse than cADHD in verbal working memory. For the caregiver strain, all scores of sADHD were between that in cADHD and that in HC.Conclusion Our present findings supported the suggestion of subthreshold ADHD as “morbid condition,” which should be treated with caution in clinical practice, especially for the internalizing behaviors and some key components of EFs.
KCI
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