한국인의 연, 망간, 알루미늄 및 실리콘의 혈중 농도

김정만,안정모,김원술,김정일,신해림,정갑열,김준연 동아대학교 산업의학연구소 2000 산업의학연구소 논총 Vol.- No.5

Blood Lead, Manganese, Aluminium and Silicon Concentrations in Korean Adults Jung Man Kim, Jung Mo Ahn, Won Sul Kim1), Jung Il Kim2), Hai Rim Shin, Kap Yeol Jung2), Joon Youn Kim Department of Preventive Medicine, College of Medicine and Industrial Medicine Research Institute. Dong-A University Department of Health Care, Handong University Sunlin Presbyterian Hotpital1) Department of Occupational Medicine, College of Medicine, Dong-A University2) 0bjectives : This study was performed to determine the reference values of blood lead, manganese, aluminium, and silicon in healthy adults. Methods : The subjects were 132 (67 male and 65 female), and classified to three age groups (≤39,40∼49, and 50≤). Hood lead, manganese and aluminium were analyzed by atomic absorption spectrophotometer, and blood silicon was analyzed by direct current plasma optical omission spectrometer. Results : Blood lead levels(geometric mean, S.D) were (3.49, 1.70) ㎍/dL in male auld (3.04, 1.65) ㎍/dL in female, but the difference is not significant, and there was no significant difference between age groups. Mean blood manganese level was 0.99±0.41㎍/dL, and there was no significant difference between sex or age groups. Mean blood aluminium level was 0.59±0.35㎍/dL and there was no significant difference between sex or age groups. Mean blood silicon level was 54.41±27.64㎍/dL in male and 43.34±23.51㎍/dL in female, and the level in male was significantly higher than that in female (p〈0.05). There was significant difference between age groups, and the oldest showed the highest level in male (p〈0.05), but no significant difference between age groups in female. Conclusions : Authors hope that this study would provide basic data for determininig reference values and evaluating health effects.

암의 위험요인과 예방

유근영,신해림 한국역학회 2003 Epidemiology and Health Vol.25 No.1

Cancer is one of the main cause of death worldwide. There are about 10 million new cases every year, and more than 6 million persons will die of the disease in a year. Many factors are responsible for the recent increase in cancer. Changing lifestyles, in particular as regards tobacco smoking, alcohol drinking and diet, also play a crucial part. Several different types of scientific studies contribute to identifying the causes of human cancer. IARC's prestigious series of Monographs on the Evaluation of Carcinogenic Risks to Humans publishes authoritative reports on the risks posed by potentially carcinogenic agents and exposures. Most cancers are thought to be caused by factors related to lifestyle and environment. In particular, tobacco, chronic infections and diet are involved in a substantial number of new cancers. Tobacco is responsible for about 15% of all cancers throughout the world. Chronic infections with viruses, bacteria and parasites are responsible for 16% of all cancers. It has been hypothesized that 30% of all cancers could be prevented by appropriate diet and physical activity. Other known causes of cancer, such as occupational, genetic, and reproductive factors, plays a lesser role in the global burden of cancer. Many types of cancer seem to be cluster in families, occurring more often in close relatives of affected individuals. The risks that a person inheriting a defect in a person inheriting a defect in a cancer susceptibility gene will develop a certain type of cancer must be estimated, and the role of environmental factors in modifying these risks must be ascertains. Researches into the causes of cancer has revealed how many of the most common cancers can be prevented. Detection of many forms of the disease at an early stage can greatly improve the prospects for effective treatment, reducing deaths and enhancing quality of life.

Current Status of Multicenter Cancer Cohort Study with Biological Materials Bank in Korea

Keun-Toung Yoo,Hai-Rim Shin외15명 한국역학회 1998 Epidemiology and Health Vol.20 No.2

음식물 섭취에 따른 요중 마뇨산 배설량의 변화

김정일,박태혁,정갑열,신해림,김준연 동아대학교 산업의학연구소 2000 산업의학연구소 논총 Vol.- No.5

Objectives ; Urinary hippuric acid levels have been usually determined to evaluate workers exposes to toluene. Food and drink intake could affect urinary hippuric acid excretion and chi study was carried out to investigate what kinds of food and drink would affect urinary hippuric acid excretion. Methods ; The subjects were 136 medical school students. Authors measured urinary hippuric acid levels three times from 10 a. m. to noon; before, one hour after and two hours after food or drink-intake, and they were asked not to eat from the previous night(9 p. m) of testing. We selected six diets(bread and coffee, brown sauce noodle, Korean style meal, noodle, pork-galbi and rice and soybean stew and rice) , six fruits(apple, grape, orange, pear, persimmon and plum) and five beverages(Alps-D□, Demisoda□, Orange juice□, Pear juice□ and Pocari sweat□). Analysis of urinary hippuric acid was performed by high performance liquid chromatography. Results ; Intake of popular Korean diets, fruits and some drinks didn't affect urinary hippuric acid excretion. But intake of sodium benzoate-contained Alpa-D□ increased urinary hippuric acid excretion. Conclusions ; For the health examination on workers exposed to toluene, the history of diet and fruit intake can be negligible, but that of beverage intake should be included.

Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea

Shin, Hai-Rim,Oh, Jin-Kyoung,Lim, Min Kyung,Shin, Aesun,Kong, Hyun-Joo,Jung, Kyu-Won,Won, Young-Joo,Park, Sohee,Park, Sang-Jae,Hong, Sung-Tae The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.7

<P>In 2009, infection with the liver fluke <I>Clonorchis sinensis</I> (<I>C. sinensis</I>) was classified as 'carcinogenic to humans' (Group 1) based on its involvement in the etiology of cholangiocarcinoma by the International Agency for Research on Cancer. However, little is known about the descriptive epidemiology of cholangiocarcinoma in Korea. We examined incidence trends of intrahepatic and extrahepatic cholangiocarcinomas, using data from the Korea National Cancer Incidence database for 1999-2005. The prevalence of <I>C. sinensis</I> infection was estimated from a recent population-based survey in rural endemic areas. Cholangiocarcinoma incidence rates are currently rising, even while primary liver cancer incidence rates are decreasing. Annual percent changes in cholangiocarcinoma incidence rates were 8% for males and 11% in females. Known areas of <I>C. sinensis</I> endemicity showed high incidence rates of cholangiocarcinoma. The positivity of <I>C. sinensis</I> eggs in stool samples from endemic areas was more than 25% of adults tested during 2005-2008. From a meta-analysis, the summary odds ratio for cholangiocarcinoma due to <I>C. sinensis</I> infection was 4.7 (95% confidence interval: 2.2-9.8). Approximately 10% of cholangiocarcinomas in Korea were caused by chronic <I>C. sinensis</I> infections. More specific policies, including health education and an extensive effort for early detection in endemic areas, are needed.</P>

Prevalence and risk factors of hepatits C virus infection among Koreans in rural area of Korea

Shin, Hai-Rim,Kim, Joon-Youn,Ohno, Tomoyoshi,Cao, Kun,Mizokami, Masashi,Risch, Harvey,Kim, SooRyang 동아대학교 산업의학연구소 2000 산업의학연구소 논총 Vol.- No.5

In a Korean rural area with a high incidence of liver cancer, a molecular epidemiological study was conducted to estimate the prevalence of hepatitis C virus (HCV) infection and to determine the distribution of HCV genotype and transmission routes of HCV infection, The study population is those who volunteered to participate in a health survey in 1993 and were over 10 years of age. Those who were anti-HCV-positive and 20 of their spouses were re-examined in 1995 and tested for HCV genotype. A phylogenetic tree was constructed after sequencing analysis of core and envelope regions from the subjects with genotype 2a without a blood transfusion history. The age- and sex-standardized prevalence of anti-HCV was 5.52%. In a multivariate analysis, transfusion history was not associated with anti-HCV-pos-itivity, but a history of acupuncture (adjusted odds ratio = 2.2, 95% confidence interval = 1.0, 4.7) and a history of surgical operation (adjusted odds ratio = 2.0, 95%, confidence interval = 1.0, 4.1) were associated. The prevalence of HCV genotype 2a was the highest, and genotype 1b was less frequent. The phylogenetic tree showed strong homology among our samples with Japanese HCV strains. The present study suggests that there is a highly endemic area of HCV infection in Korea and that this endemicity is probably associated with a parenteral source of HCV infection other than blood transfusion. The study also suggests that some of the HCV infection was spread through non-sterilized or non-disposable acupuncture needles in this HCV endemic

Recent trends and patterns in breast cancer incidence among Eastern and Southeastern Asian women

Shin, Hai-Rim,Joubert, Clementine,Boniol, Mathieu,Hery, Clarisse,Ahn, Sei Hyun,Won, Young-Joo,Nishino, Yoshikazu,Sobue, Tomotaka,Chen, Chien-Jen,You, San-Lin,Mirasol-Lumague, Maria Rica,Law, Stephen C Springer-Verlag 2010 Cancer causes & control Vol.21 No.11

Nationwide Cancer Incidence in Korea, 1999~2001; First ResultUsing the National Cancer Incidence Database

Hai-Rim Shin,Young-Joo Won,Kyu-Won Jung,Hyun-Joo Kong,Seon-Hee Yim,Jung-Kyu Lee,Hong-In Noh,Jong-Koo Lee,Paola Pisani,Jae-Gahb Park,Yoon-Ok Ahn,Soon Yong Lee,Choong Won Lee,Ze-Hong Woo,Tae-Yong Lee,최진 대한암학회 2005 Cancer Research and Treatment Vol.37 No.6

Purpose: The first Korean national population- based cancer registry using nationwide hospital-based recording system and the regional cancer registries provided the source to obtain national cancer incidences for the period 1999∼2001.Materials and Methods: The incidence of cancer in Korea was calculated based on the Korea Central Cancer Registry database, data from additional medical record review survey, the Regional Cancer Registry databases, site-specific cancer registry databases, and cancer mortality data from the Korea National Statistical Office. Crude and age-standardized rates were calculated by sex for 18 age groups.Results: The overall crude incidence rates (CR) were 247.3 and 188.3 per 100,000 for men and women and the overall age-standardized incidence rates (ASR) were281.2 and 160.3 per 100,000, respectively. Among men, five leading primary cancer sites werestomach (CR 58.6, ASR 65.6), lung (CR 42.1, ASR 50.9), liver (CR 41.9, ASR44.9), colon and rectum (CR 24.2, ASR 27.3) and bladder (CR 7.7, ASR 9.2). Among women, the most common cancers were stomach (CR 30.8, ASR 25.8), breast (CR25.7, ASR 21.7), colon and rectum (CR 19.6, ASR 16.7), uterine cervix (CR 18.4, ASR 15.5), and lung cancer (CR 15.1, ASR 12.4). In 0∼14 age group, leukemia was mostcommon for both sexes. For men, stomach cancer was most common in 15∼64 age group, but lung cancer was more frequent for over 65 age group. For women, thyroidcancer in 15∼34 age group, breast cancer in 35∼64 age group, and stomach cancer in over 65 age group were most common for each age group. The proportions ofdeath certificate only were 7.5% for men and 7.4% for women.Conclusion: This is the first attempt to determine the national cancer incidence and this data will be useful to plan for research and national cancer control in Korea.

National Cancer Incidence for the Year 2002 in Korea

Hai-Rim Shin,Kyu-Won Jung,Young-Joo Won,Hyun-Joo Kong,Seon-Hee Yim,Joohon Sung,Sun-Won Seo,Ki-Young Kim,Sang-Yi Lee,In-Sik Kong,In Kyoung Hwang,Choong Won Lee,Ze-Hong Woo,Tae-Yong Lee,Jin-Su Choi,Cheo 대한암학회 2007 Cancer Research and Treatment Vol.39 No.4

Prevalence of Hepatitis C Virus Genotype as a Risk Factor of Hepatocellular Carcinoma in Pusan, Korea

SHIN,Hai-Rim,SONG,Jue-Bok,SHIN,Woo-Won,JUNG,Kap-Yeol 동아대학교 부설 산업의학연구소 1999 산업의학연구소 논총 Vol.- No.4

최근 노년기에 간암을 일으키는 주요원인으로 보고된 C형 간염 바이러스(Hepatitis C virus : HCV)의 각종 간질환에서의 genotype 분포와 간염의 위험요인들과의 연관성을 알아보고자 본 연구를 시행하였다. 연구대상자들은 동아대학병원 건강관리과에서 종합건강진단을 받기 위하여 내원한 검진자 중에서 anti-HCV 양성인 사람(28명), anti-HCV 양성인 헌혈자(7명) [35명, Carrier군] 및 동병원 내과에 입원하였던 만성간질환 환자들 [만성간염과 간경화증 환자 93명 (Chronic liver disease: CLD군), 간세포암 환자 78명(Hepatocellular carcinoma: HCC군)]이었다. 연구방법은 각각의 연구대상자군별로 연령 및 B형 간염 표식자, anti-HCV 양성률을 비교하였으며, 또한 간질환의 위험요인의 양성률의 차이를 비교하였다. 전제 anti-HCV 양성인 연구대상자 중에서 40명의 혈청에서 genotyping ELISA방법으로 HCV genotype을 조사하였다. CLD군과 HCC군 모두에서 anti-HCV 음성인 경우 anti-HCV 양성인 환자들에 비해 HBsAg 양성률이 높았으며, anti-HBs 양성률은 더 낮았다. HBsAg 양성인 환자들의 평균 연령은 CLD군 43.8세, HCC군에 53.4세로 anti-HCV 양성인 환자들의 평균연령보다 낮았다 (CLD군 49.6세, HCC군 62.8세). 간 질환의 위험요인이라고 알려진 과거 수술력, 수혈력, 침을 맞은 과거력들은 Carrier, CLD, HCC군 모두에서 유의한 차이가 없었다. 40명의 anti-HCV 양성인 사람들을 대상으로 HCV genotype을 조사한 결과 SG-1 type이 47.5%로 가장 많았으며, SG-2 type은 35.0%였다. SG-1/2 type은 7.5%, SG-ud는 10.0%를 차지하였다. 이들에 대해서는 polymerase chain reaction, HCV RNA sequencing 등을 통한 분석이 더 필요하다고 하겠다. 위의 결과들을 종합하면 만성간염, 간경화에서 간세포암으로의 진행에 유의한 영향을 미치는 요인은 연령이라고 할 수 있으며, 부산지역의 C형 간염 바이러스 중에서 SG-1형이 가장 많았다. 앞으로 간염 표식자들이 양성인 사람들에 있어서는 정기적인 추적조사로 간세포암으로의 진행을 조기 발견하도록 하여야 할 것이며, HCV genotype과 간세포암과의 관계에 대해서는 더 많은 연구가 있어야 할 것이다. The epidemiologic study was conducted to determine the hepatitis C virus(HCV) genotype and to evaluate the association of known risk factors and chronic liver diseases in Pusan, Korea. The blood donors(n=7) and health check-up examinees(n=28) with positive anti-HCV were recruited as carrier group(carrier, n=35). Those who took anti-HCV test(ELISA, Lucky HCD 3.0) among in patients from September, 1995 at December, 1996 at Dong-A University Hospital were divided into chronic liver disease group(CLD, n=93) and hepatocellular carcinoma group(HCC, n=78). Among anti-HCV negative subjects, the hepatitis B surface antigen(HBsAg) positive rates(73.7% in CLD, 80.0% in HCC) were higher than those of anti-HCV positive subjects(11.4% in CLD, 7.1% in HCC). The average age was younger in HBsAg positive cases(43.8 years in CLD, 53.4 years in HCC) than in anti-HCV positive cases(49.6 years in CLD, 62.8 years in HCC) The Positive rates of past histories of surgical operation, acupuncture, and transfusion among anti-HCV positive cases were higher than those of negative cases(p<0.01). Most prevalent HCV genotype tested by genotyping ELISA was SG-1(47.5%). The mean ages of each HCV genotype were not significantly different (p>0.05). Most prevalent risk factor among each HCV genotype was acupuncture history. From this study, HCV genotype SG-1 was found to predominate in Korean patients with type C hepatitis. There were no significant association between the risk factors and HCV genotype. More research to evaluate the HCV genotype and the role of liver diseases, especially of the hepatocellular carcinoma are needed.