Anti-wrinkle effect of rosa multiflora thunberg fruit extracts

( Hyerin Jeon ),( Noo Ri Lee ),( Dong Hye Kim ),( Eunjung Kim ),( Youn Hwa Nho ),( Su Nam Kim ),( Eung Ho Choi ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Rosa multiflora Thunberg fruit has been traditionally used as a dietary supplement and a herbal remedy for the treatment of various diseases, including inflammation, osteoarthritis, rheumatoid arthritis and chronic pain. We found that Rosa multiflora Thunberg fruit extracts have therapeutic effect on photo-aging skin without remarkable epidermal side-effects through PPAR メ/ャ dual agonistic effect. Objectives: We aim to evaluate the anti-wrinkle effect and the safety of Rosa multiflora Thunberg fruit extracts. Methods: Thirty three subjects were recruited and randomly applied with active cream (treated site) or vehicle cream (control site) to the left or right side of the face twice a day for 8 weeks. The active cream contains the active ingredients of Rosa multiflora Thunberg fruit extracts, while the vehicle cream has no active ingredients. Results: All subjects were women aged between 30 and 58 with the average age of 45.4 years. In gross evaluation, 12 subjects showed better results in the treated sites, whereas 6 subjects in the control sites. Based on clinical pictures, significant wrinkle reduction rate was observed in the treated sites. Analysis of replica showed the decrease in mean length of wrinkles and mean shape factor of wrinkles in the treated sites after 8 weeks. There were no remarkable side effects related with applied creams. Conclusion: Topical application of Rosa multiflora Thunberg fruit extracts could improve facial wrinkles without remarkable side-effects.

Topical eupatilin as a PPARα activator is effective for atopic dermatitis

( Hyerin Jeon ),( Bo Kyung Kim ),( Dong Hye Kim ),( Eunjung Kim ),( Youn Hwa Nho ),( Su Nam Kim ),( Eung Ho Choi ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: We observed that eupatilin, an active flavone derived from Artemisia plant species, functions as a PPAR メ activator through in vitro study. Objectives: We evaluated whether sequential application of topical eupatilin after topical glucocorticoid (GC) could be more effective than GC alone for AD lesion in AD murine model. Also, we conducted clinical trials to assess the efficacy and safety of Artemisia argyi extracts containing eupatilin for AD patients. Methods: In animal experiment, GC was applied on inflamed skin of hairless mice only in the first day of the experiment, with 3 subsequent consecutive days of treatment with eupatilin as well as bezafibrate as a positive control, or vehicle as a negative control. The efficacy of eupatilin was evaluated by gross feature and skin barrier function. For clinical study, thirty subjects were recruited and randomly applied with active cream (treated site) or vehicle cream (control site) to the left or right side of the whole body twice a day for 4 weeks. Treatment outcomes were assessed by EASI score, itch score and skin barrier function. Results: In the animal study, topical eupatilin improved eczema lesion and skin barrier function. In the clinical study, a significant decrease in the EASI and itch scores (p<0.05) was observed in the treated sites. The skin barrier function was also improved. Any remarkable side effects related with the active cream were not found. Conclusion: Topical application of eupatilin could improve AD lesions.

P004 : Natural herb extracts with PPAR alpha/gamma dual agonistic effect prevent photo-aging in hairless mice

( Hyerin Jeon ),( Donghye Kim ),( Jong Kyung Youm ),( Soo Nam Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: We found that extracts of natural herbs such as Kochia Scoparia and Rosa multiflora have PPAR α/γ dual agonistic effect. Objectives: We investigate whether and how they have anti-aging effect on photo-aging skin. Methods: Hairless mice were irradiated with UVA and UVB three times a week for 8 weeks. Natural herb extracts with PPAR α/γ dual agonistic effect were topically applied on photo-aging mice twice a day for 8 weeks. Tesaglitazar, a known PPAR α/γ agonist, were applied as a positive control and vehicle as a negative control. Epidermal effects including barrier function and dermal effects were measured respectively and compared. Results: Compared to UV exposed photoaging skin, the natural herb extracts with PPAR α/γ dual agonistic effect enhanced skin barrier function by normalizing basal TEWL and increasing SC integrity. They also increased the epidermal differentiation but decreased epidermal IL-1α expression. In the dermis, they increased dermal thickness, collagen density, and procollagen type 1 expression as well as TGF-β. Conclusion: The extracts of natural herbs such as Kochia Scoparia and Rosa multiflora with PPAR α/γ dual agonistic effect could prevent the epidermal processes of photo-aging by recovering the barrier function through correcting the epidermal differentiation, and the dermal process by increasing dermal thickness and collagen density through procollagen type 1 production induced by TGF-β

A Mixture of Extracts of <i>Kochia scoparia</i> and <i>Rosa multiflora</i> with PPAR α/γ Dual Agonistic Effects Prevents Photoaging in Hairless Mice

Jeon, Hyerin,Kim, Dong Hye,Nho, Youn-Hwa,Park, Ji-Eun,Kim, Su-Nam,Choi, Eung Ho MDPI AG 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.11

<P>Activation of peroxisome proliferator-activated receptors (PPAR) α/γ is known to inhibit the increases in matrix metalloproteinase (MMP) and reactive oxygen species (ROS) induced by ultraviolet light (UV). Extracts of natural herbs, such as <I>Kochia scoparia</I> and <I>Rosa multiflora</I>, have a PPAR α/γ dual agonistic effect. Therefore, we investigated whether and how they have an antiaging effect on photoaging skin. Eighteen-week-old hairless mice were irradiated with UVA 14 J/cm<SUP>2</SUP> and UVB 40 mJ/cm<SUP>2</SUP> three times a week for 8 weeks. A mixture of extracts of <I>Kochia scoparia</I> and <I>Rosa multiflora</I> (KR) was topically applied on the dorsal skin of photoaging mice twice a day for 8 weeks. Tesaglitazar, a known PPAR α/γ agonist, and vehicle (propylene glycol:ethanol = 7:3, <I>v</I>/<I>v</I>) were applied as positive and negative controls, respectively. Dermal effects (including dermal thickness, collagen density, dermal expression of procollagen 1 and collagenase 13) and epidermal effects (including skin barrier function, epidermal proliferation, epidermal differentiation, and epidermal cytokines) were measured and compared. In photoaging murine skin, KR resulted in a significant recovery of dermal thickness as well as dermal fibroblasts, although it did not change dermal collagen density. KR increased the expression of dermal transforming growth factor (TGF)-β. The dermal effects of KR were explained by an increase in procollagen 1 expression, induced by TGF-β, and a decrease in MMP-13 expression. KR did not affect basal transepidermal water loss (TEWL) or stratum corneum (SC) integrity, but did decrease SC hydration. It also did not affect epidermal proliferation or epidermal differentiation. KR decreased the expression of epidermal interleukin (IL)-1α. Collectively, KR showed possible utility as a therapeutic agent for photoaging skin, with few epidermal side effects such as epidermal hyperplasia or poor differentiation.</P>

청년 근로자의 자동화와 직무만족의 관계에서 미래에 대한 불안의 매개효과

전혜린(Jeon, Hyerin),하재영(Ha, Jaeyoung) 한국노동연구원 2023 노동정책연구 Vol.23 No.4

Medical students’ agenda-setting abilities during medical interviews

HyeRin Roh,Kyung Hye Park,Young Jee Jeon,Seung Guk Park,Jungsun Lee 한국의학교육학회 2015 Korean journal of medical education Vol.27 No.2

Purpose: Identifying patients’ agendas is important; however, the extent of Korean medical students’ agenda-setting abilities is unknown. The study aim was to investigate the patterns of Korean medical students’ agenda solicitation. Methods: A total of 94 third-year medical students participated. One scenario involving a female patient with abdominal pain was created. Students were video-recorded as they interviewed the patient. To analyze whether students identify patients’ reasons for visiting, a checklist was developed based on a modified version of the Calgary-Cambridge Guide to the Medical Interview: Communication Process checklist. The duration of the patient’s initial statement of concerns was measured in seconds. The total number of patient concerns expressed before interruption and the types of interruption effected by the medical students were determined. Results: The medical students did not explore the patients’ concerns and did not negotiate an agenda. Interruption of the patient’s opening statement occurred in 4.62±2.20 seconds. The most common type of initial interruption was a recompleter (79.8%). Closed-ended questions were the most common question type in the second and third interruptions. Conclusion: Agenda setting should be emphasized in the communication skills curriculum of medical students. The Korean Clinical Skills Exam must assess medical students’ ability to set an agenda.

GRADIENT EXPLOSION FREE ALGORITHM FOR TRAINING RECURRENT NEURAL NETWORKS

SEOYOUNG HONG,HYERIN JEON,BYUNGJOON LEE,CHOHONG MIN 한국산업응용수학회 2020 Journal of the Korean Society for Industrial and A Vol.24 No.4

Exploding gradient is a widely known problem in training recurrent neural networks. The explosion problem has often been coped with cutting off the gradient norm by some fixed value. However, this strategy, commonly referred to norm clipping, is an ad hoc approach to attenuate the explosion. In this research, we opt to view the problem from a different perspective, the discrete-time optimal control with infinite horizon for a better understanding of the problem. Through this perspective, we fathom the region at which gradient explosion occurs. Based on the analysis, we introduce a gradient-explosion-free algorithm that keeps the training process away from the region. Numerical tests show that this algorithm is at least three times faster than the clipping strategy.

Sn 첨가에 따른 CH₃NH₃PbBr₃ 페로브스카이트 나노입자의 광학적 특성

신문렬,전민기,박혜린,최지훈,Sihn, Moon Ryul,Jeon, Mingi,Park, Hyerin,Choi, Jihoon 한국표면공학회 2019 한국표면공학회지 Vol.52 No.2

Methylammonium lead bromide ($MAPbBr_3$) has attracted a lot of attention due to their excellent optoelectronic properties such as the compositional flexibility relevant to photoluminescence (PL) and UV-Vis absorbance spectrum, high diffusion length, and photoluminescence quantum yield (PLQY). Despite such advantages of organic-inorganic perovskite materials, more systematic study on manipulation of their optoelectronic properties in homo- or heterovalent metal ions doped halide perovskite nanocrystals is lacking. In this study, we systematically investigated the optical properties of colloidal $CH_3NH_3Pb_{1-x}Sn_xCl_{2x}Br_{3-2x}$ particles by addition of $SnCl_2$ into the typical methylammonium lead tribromide ($CH_3NH_3PbBr_3$) precursor solution. We found that only 1% addition of $SnCl_2$ shows a significant blue-shift from 540 nm to 420 nm in UV-Vis absorbance spectrum due to the strong quantum confinement effect. Furthermore, continuous blue-shift in photoluminescence spectra was observed as the amount of Cl increases. These experimental results provide new insights into the replacement of Pb within $MAPbBr_3$, required for the broadening of their application.

Graphene/carbon nanotube hybrid as a multi-functional interfacial reinforcement for carbon fiber-reinforced composites

Kwon, Yeon Ju,Kim, Youn,Jeon, Hyerin,Cho, Sehyeon,Lee, Wonoh,Lee, Jea Uk Elsevier 2017 Composites Part B, Engineering Vol.122 No.-

<P><B>Abstract</B></P> <P>A graphene/carbon nanotube hybrid material stabilized in an aqueous medium, was coated on carbon fibers by anodic electrophoretic deposition. Chemically oxidized graphene, graphene oxide, was used as a stabilizing agent for dispersion of carbon nanotubes and as a transport medium for the graphene oxide/carbon nanotube hybrid during electrophoretic deposition. This hybrid coating increased the wettability and surface roughness of carbon fibers, which led to improved affinity between the carbon fibers and epoxy matrix. The resulting hybrid-coated carbon fiber-reinforced composites showed an enhancement of over 10% in the short beam strength compared to un-coated carbon fiber composites and demonstrated significantly improved through-thickness electrical conductivity (increase of over 1400%).</P>

The effects of RF power on the interfacial property between Al₂O₃ and Si₃N₄ and on the memory property in a MANOS structure

Kim, Hyungchul,Woo, Sanghyun,Lee, Jaesang,Lee, Hyerin,Jeon, Hyeongtag Institute of Physics [etc.] 2010 Journal of Physics. D, Applied Physics Vol.43 No.50

<P>The interface stability and memory properties of an Al<SUB>2</SUB>O<SUB>3</SUB> blocking oxide deposited using remote plasma atomic layer deposition (RPALD) at various RF powers were investigated. The plasma density increased with an increase in radio frequency (RF) power from 50 to 300 W due to increased neutral impact excitation rate. Based on x-ray photoelectron spectroscopy and auger electron spectroscopy, an oxygen-deficient interfacial layer was formed for Al<SUB>2</SUB>O<SUB>3</SUB> film deposition at 50 W. In addition, increased migrations of Si and N atoms were observed at low power due to the formation of fewer oxygen radicals. While reduced migrations of Si and N atoms from Si<SUB>3</SUB>N<SUB>4</SUB> to Al<SUB>2</SUB>O<SUB>3</SUB> were observed when the RF power was sufficient due to the sufficient oxygen radicals. Therefore, the interfacial reaction between Al<SUB>2</SUB>O<SUB>3</SUB> and Si<SUB>3</SUB>N<SUB>4</SUB> is dependent on the RF power. After applying 18 V, the program speed of Al<SUB>2</SUB>O<SUB>3</SUB> with 100 W, 200 W and 300 W were 10<SUP>−2</SUP> s, 10<SUP>−5</SUP> s and 10<SUP>−6</SUP> s, respectively.</P>