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EFFECT OF EXTERNAL ELECTRICAL STIMULI ON DNA-BASED BIOPOLYMERS
GURU SUBRAMANYAM,CARRIE M. BARTSCH,JAMES G. GROTE,RAJESH R. NAIK,LAWRENCE L. BROTT,MORLEY STONE,ANGELA CAMPBELL 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2009 NANO Vol.4 No.2
Biopolymers, such as deoxyribonucleic acid-hexadecyltrimethyl ammonium chloride (DNA-CTMA) and bovine serum albumin-polyvinyl alcohol (BSA-PVA), were studied using a novel capacitive test structure. A variety of external electrical stimuli were applied, including a low frequency alternating current signal and a rf/microwave frequency signal combined with a DC bias. The dynamic responses of the DNA-based biopolymer to the external stimuli are presented in this paper. The electrical transport measurements support the space-charge-limited conduction and the low frequency capacitance–voltage (CV) measurements showed large depletion layer capacitance at the Au–biopolymer interface, at 20 Hz, and the capacitance approaching bulk values at 1 MHz. Electric force microscopy (EFM) was utilized for visualization of charge dynamics and to examine the effect of DC bias combined with an AC signal. Ionic charges in the DNA-CTMA system seem to be responsible for the dynamic response to the various external electrical stimuli.
Guru Trikudanathan,Shawn J. Mallery,Stuart K. Amateau 대한소화기내시경학회 2016 Clinical Endoscopy Vol.49 No.4
Surgical resection is considered the standard of care in the management of symptomatic insulinoma. In this video, we describe the successful management of a symptomatic insulinoma by using linear array endoscopic ultrasound (EUS)-guided ethanol ablation in a poor surgical candidate. EUS-guided ethanol ablation of insulinoma offers a safer, effective, and less invasive alternative to surgery.
Guru Karthikeyan Thirunavukkarasu,G.R. Nirmal,이황재,이민규,박인규,이재영 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.69 No.-
Dual cancer therapy is an attractive strategy that can generate synergistic effects and also reduce drug-related side effects. Here, we developed multifunctional nanocomplexes capable of remote on-demand production of hyperthermia and free radicals in response to near infrared (NIR) light irradiation To this end, thermal initiator and gold nanorods were embedded in nano-sized temperature-responsive poly(lactic acid-co-glycolic acid). In vitro studies demonstrated controllable heat and radical production from the nanocomplexes with NIR and effective eradication of CT26 colon cancer cells with our nanocomplexes. Hence, our smart nanomaterial will potentially contribute precise and effective dual cancer treatment.
Balamurugan Guru,Ramesh Veerappan,Francis Sangma,Somnath Bera 대한공간정보학회 2017 Spatial Information Research Vol.25 No.6
In the present research work, the landslide susceptibility zonation (LSZ) mapping was carried out for the landslide prone area Nilgiri hills, Tamil Nadu, India. The LSZ mapping was carried out using ten landslide influencing factors along with extensive field investigation. The geospatial database was prepared through integrated remote sensing, geographical information systems, and GPS technologies. The methods adopted for the present study are frequency ratio (FR) which is probabilistic and analytical hierarchical process (AHP) which is subjective and objective based model. The FR values were evaluated through evaluating relationship between causative factors and past landslide (training) locations. The FR values were considered as the base for assigning the weights in AHP method along with the subjective knowledge. The final LSZ map were derived through the spatial integration of all causative factors and classified as different susceptibility classes viz. very low, low, moderate, high, and very high. The prediction accuracy of final LSZ map were validated using past landslide (validation) locations using area under curve (AUC) method. The FR model shown the highest prediction accuracy with AUC value of 0.6279, while the AHP model shown the AUC value of 0.5620.
Magnetic field-inducible drug-eluting nanoparticles for image-guided thermo-chemotherapy
Thirunavukkarasu, Guru Karthikeyan,Cherukula, Kondareddy,Lee, Hwangjae,Jeong, Yong Yeon,Park, In-Kyu,Lee, Jae Young Elsevier 2018 Biomaterials Vol.180 No.-
<P><B>Abstract</B></P> <P>Multifunctional nanoparticles integrating cancer cell imaging and treatment modalities into a single platform are recognized as a promising approach; however, their development currently remains a challenge. In this study, we synthesized magnetic field-inducible drug-eluting nanoparticles (MIDENs) by embedding superparamagnetic iron oxide nanoparticles (Fe<SUB>3</SUB>O<SUB>4</SUB>; SPIONs) and cancer therapeutic drugs (doxorubicin; DOX) in a temperature-responsive poly (lactic-co-glycolic acid) (PLGA) nanomatrix. Application of an external alternating magnetic field (AMF) generated heat above 42 °C and subsequent transition of the PLGA polymer matrix (T<SUB>g</SUB> = 42–45 °C) from the glassy to the rubbery state, facilitating the controlled release of the loaded DOX, ultimately allowing for simultaneous hyperthermia and local heat-triggered chemotherapy for efficient dual cancer treatment. The average size of the synthesized MIDENs was 172.1 ± 3.20 nm in diameter. <I>In vitro</I> studies showed that the MIDENs were cytocompatible and especially effective in destroying CT26 colon cancer cells with AMF application. <I>In vivo</I> studies revealed that the MIDENs enabled enhanced T<SUB>2</SUB> contrast magnetic resonance imaging and a significant suppression of malignant tumor growth under an AMF. Our multifunctional MIDENs, composed of biocompatible substances and therapeutic/imaging modalities, will be greatly beneficial for cancer image-guided thermo-chemotherapy applications.</P>
( Kumar Guru Mishra ),( Vikas Bhatia ),( Ranjeeta Nayak ) 한국임상영양학회 2020 Clinical Nutrition Research Vol.9 No.3
Inadequate/excessive gestational weight gain (GWG) can cause adverse pregnancy outcomes and only few studies have described patterns of weight gain in Indian women. Also, studies pertaining to dietary intake throughout gestation are insufficient. This prospective cohort study was conducted to evaluate GWG and nutrient intake in all trimesters of pregnancy and investigate the relationship between themselves along with that of birth weight (BW). Our study was carried out in a population-based prospective birth cohort in Odisha, India. The 418 pregnant women were followed till delivery with measurements of maternal weight, weight gain throughout gestation, and BW. Macronutrients were assessed based on a 24-hour dietary recall method in each trimester. Women characterized by under-weight pre-pregnancy body mass index (BMI) were 16.20%, and a total of 6.45% did not comply with current weight gain recommendations. Particularly, overweight and obese women gained more weight than recommended. In a multivariate analysis GWG correlated significantly with BMI (p = 0.03), total calorie intake (p < 0.001) and fat intake (p < 0.001), while BW of newborns correlated significantly with adequacy of weight gain and fat intake (p < 0.001). Though measures are taken by health workers to record the weight but nutritional counseling is not being provided regularly. A high priority should be given to increase awareness among general population regarding the importance of diet in pregnancy and how to adhere to the balanced diet for optimal growth of child.
Neupane, Guru P.,Tran, Minh Dao,Kim, Hyun,Kim, Jeongyong Hindawi Limited 2017 Journal of nanomaterials Vol.2017 No.-
<P>Monolayer MoS2 (1L-MoS2) is an ideal platform to examine and manipulate two dimensionally confined exciton complexes, which provides a large variety of modulating the optical and electrical properties of 1L-MoS2. Extensive studies of external doping and hybridization exhibit the possibilities of engineering the optical and electrical performance of 1L-MoS2. However, biomodifications of 1L-MoS2 and the characterization and applications of such hybrid structures are rarely reported. In this paper, we present a bio-MoS2 hybrid structure fabricated by laterally stretching strands of DNAs on CVD-grown 1L-MoS2. We observed a strong modification of photoluminescence and Raman spectra with reduced PL intensity and red-shift of PL peak and Raman peaks, which were attributed to electron doping by the DNAs and the presence of tensile strain in 1L-MoS2. Moreover, we observed a significant enhancement of electric mobility in the DNA/1L-MoS2 hybrid compared to that in the pristine 1L-MoS2, which may have been caused by the induced strain in 1L-MoS2.</P>
Simple method of DNA stretching on glass substrate for fluorescence imaging and spectroscopy
Neupane, Guru P.,Dhakal, Krishna P.,Kim, Min Su,Lee, Hyunsoo,Guthold, Martin,Joseph, Vincent S.,Hong, Jong-Dal,Kim, Jeongyong SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS 2014 JOURNAL OF BIOMEDICAL OPTICS Vol.19 No.5
Neupane, Guru P.,Tran, Minh Dao,Yun, Seok Joon,Kim, Hyun,Seo, Changwon,Lee, Jubok,Han, Gang Hee,Sood, A. K.,Kim, Jeongyong American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.13
<P>The optical and electrical properties of monolayer transition-metal dichalcogenides (1L-TMDs) are critically influenced by two dimensionally confined exciton complexes. Although, extensive studies on controlling the optical properties of 1L-TIVIDs through external doping or defect engineering have been carried out, the effects of excess charges, defects, and the populations of exciton complexes on the light emission of 1L-TMDs are not yet fully understood. Here, we present a simple chemical treatment method for n dope 1L-TMDs, which also enhances their optical and electrical properties. We show that dipping lLs of MoS2 WS2, and WSe2, whether exfoliated or grown'y chemical vapor deposition, into methanol for several hours can increase the electron density and also can reduce the defects, resulting in the enhancement of their photoluminescence, light absorption, and the carrier mobility:. This methanol treatment was effective for both n- and p-type 1L-TMDs, suggesting that the surface restructuring around structural defects by methanol is responsible for the enhancement of optical and electrical characteristics. Our results have revealed a simple process for external doping.that can enhance both the optical and electrical properties of 1L-TMDs and help us understand how the exciton emission in 1L-TMDs can be modulated by chemical treatments.</P>