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Im, Gun-Il,Lee, Jin Ho Wiley Subscription Services, Inc., A Wiley Company 2010 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B Vol.b92 No.2
<P>The purpose of this work was to evaluate the in vivo effectiveness of a TGF-β<SUB>2</SUB> and bone morphogenetic protein (BMP)-7-immobilized porous polycaprolactone (PCL)/F127 scaffold to enhance the healing of cartilage defect. An osteochondral defect was created on the patellar groove of the right distal femur of 12 rabbits and managed by one of the following methods: filling it with the scaffold only (Group I); the scaffold seeded with adipose stem cells (ASCs) (Group II); a TGF-β<SUB>2</SUB> and BMP-7-immobilized scaffold (Group III); and a TGF-β<SUB>2</SUB> and BMP-7-immobilized scaffold seeded with ASCs (Group IV). Each group had three rabbits. Nine weeks after the implantation, the implanted scaffolds were filled with yellowish, dense tissue, and had distinct margins with adjacent normal cartilage. The histological findings showed infiltration of foreign-body giant cells and blood vessel, more prominently in Groups III and IV. The presence of growth factor significantly increased the ICRS Macroscopic Score (p = 0.045) while the presence of ASC did not. The ICRS Visual Histological Score was not significantly affected by the presence of either growth factors or ASCs, showing similar values in all groups. In conclusion, the use of TGF-β<SUB>2</SUB> and BMP-7-immobilized PCL/F127 scaffolds improved gross appearances of the osteochondral defects while not actually leading to better histological results and induced a greater degree of foreign body reaction. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010</P>
Chondrogenesis from mesenchymal stem cells derivedfrom adipose tissue on the fibrin scaffold
Gun-Il Im 한국물리학회 2005 Current Applied Physics Vol.5 No.5
The purpose of this study was to answer the question whether adipose tissue derived mesenchymal stem cells (ATMSCs) areequal to bone marrow derived MSC (BMMSCs) regarding cartilage forming potential. BMMSCs were obtained from the medullarycanal of femur and ATMSCs were isolated from liposuction procedures. MSCs were cultured in brin scaold with chondrogenicmedium for 4 weeks, then Safranin-O staining and immunohistochemical staining for type II collagen were performed to test chon-drogenesis. The general appearance of BMMSC cultured in brin gel looked more like chondrocytes than ATMSCs. The amount ofproteoglycan as shown by Safranin-O staining was greater in BMMSCs than in ATMSCs. The intensity of type II collagen immu-nohistochemical staining also was greater in BMMSCs than in ATMSCs. The results of our study suggest that the ATMSCs mayhave inferior potential in chondrogenesis compared with the BMMSCs, and cast doubts on the value of adipose tissue as a source ofMSC although further investigation including in vivo implantation study are necessary to corroborate our results..
Perspective on Intra-articular Injection Cell Therapy for Osteoarthritis Treatment
Gun-Il Im 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.4
BACKGROUND: Osteoarthritis (OA), the most common arthritis, is one of the most frequently encountered orthopaedic conditions. As a small number of large joints such as knee and hip are affected in OA, OA is an ideal target for local therapy. Although corticosteroid and hyaluronic acid have been traditionally used for joints through intra-articular (IA) injection, IA injection also provides a minimally invasive route to apply cell therapy to treat OA. IA cell therapy has drawn attention because it may provide regeneration of articular cartilage in addition to palliative anti-inflammatory effects. METHODS: Current progress of IA injection therapy and the author’s perspective on this issue are described narratively. RESULTS: It is too premature to have any conclusion on the eventual efficacy of IA cell therapy concerning regeneration of articular cartilage based on current data. Prospective radiological and histological data from larger numbers of patients are needed to prove cost effectiveness of IA cell therapy. CONCLUSIONS: Expanding research in this field will produce further evidences to provide guidance on the eventual effectiveness of IA cell therapy in the future.
Wnt inhibitors enhance chondrogenesis of human mesenchymal stem cells in a long-term pellet culture.
Im, Gun-Il,Lee, Jong-Min,Kim, Hye-Joung Kluwer Academic Publishers 2011 Biotechnology letters Vol.33 No.5
<P>The long-term effects (~3 weeks) of two Wnt inhibitors (dickkopf [DKK]-1 and secreted frizzled-related protein [sFRP]-1), on the chondrogenic differentiation of human mesenchymal stem cells (hMSCs) was determined. Wnt inhibitors significantly increased the amount of glycosaminoglycan (GAG) in treated pellets (P<0.05). The gene expression of COL2A1 increased and COL1A1 decreased while the gene expression of SOX-9 and COL10A1 did not change significantly after three weeks of in vitro culture. The protein expression of type II collagen significantly increased (P<0.05) and that of type I collagen significantly decreased (P<0.05) while SOX-9 and type X collagen protein expression was unaffected. These findings suggest that Wnt inhibitors promote the chondrogenic differentiation of hMSCs when treated for three weeks.</P>
임군일 ( Gun Il Im ),태석기 ( Suk Kee Tae ),오종수 ( Jong Soo Oh ),김지영 ( Ji Young Kim ) 대한고관절학회 2009 Hip and Pelvis Vol.21 No.2
The hip is a true ball and socket joint. The hip joint is held in place with ligaments, tendons, and muscles. It is surrounded by a series of bursae which are fluid filled sacs designed to cushion the area. Hip pain may arise from the joint itself, the femur, the pelvic bone, the pelvis, blood vessels and nerves near the hip joint, and even the abdomen. It is important to differentiate true hip pain from other types of pain in the hip region. True hip pain is felt towards the front, in the groin region. It may radiate down the front of the thigh. Physical examination can point to the correct diagnosis. The skilled physician will evaluate range of motion as well as those factors which reproduce the pain. The diagnosis of hip disease usually requires the use of radiologic imaging. The imaging studies include plain films, arthrography, computed tomography (CT) scanning, ultrasound, nuclear imaging, and magnetic resonance imaging (MRI).