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Guangyue Huang,Bingqing Ma,Jie Yang 대한수학회 2020 대한수학회보 Vol.57 No.6
We study rigidity results for the Einstein metrics as the critical points of a family of known quadratic curvature functionals involving the scalar curvature, the Ricci curvature and the Riemannian curvature tensor, characterized by some pointwise inequalities involving the Weyl curvature and the traceless Ricci curvature. Moreover, we also provide a few rigidity results for locally conformally flat critical metrics.
Rigidity of complete Riemannian manifolds with vanishing Bach tensor
Guangyue Huang,Bingqing Ma 대한수학회 2019 대한수학회보 Vol.56 No.5
For complete Riemannian manifolds with vanishing Bach tensor and positive constant scalar curvature, we provide a rigidity theorem characterized by some pointwise inequalities. Furthermore, we prove some rigidity results under an inequality involving $L^{\frac{n}{2}}$-norm of the Weyl curvature, the traceless Ricci curvature and the Sobolev constant.
RIGIDITY OF COMPLETE RIEMANNIAN MANIFOLDS WITH VANISHING BACH TENSOR
Huang, Guangyue,Ma, Bingqing Korean Mathematical Society 2019 대한수학회보 Vol.56 No.5
For complete Riemannian manifolds with vanishing Bach tensor and positive constant scalar curvature, we provide a rigidity theorem characterized by some pointwise inequalities. Furthermore, we prove some rigidity results under an inequality involving $L^{\frac{n}{2}}$-norm of the Weyl curvature, the traceless Ricci curvature and the Sobolev constant.
RIGIDITY CHARACTERIZATIONS OF COMPLETE RIEMANNIAN MANIFOLDS WITH α-BACH-FLAT
Guangyue Huang,Qianyu Zeng 대한수학회 2021 대한수학회지 Vol.58 No.2
For complete manifolds with α-Bach tensor (which is defined by (1.2)) flat, we provide some rigidity results characterized by some point-wise inequalities involving the Weyl curvature and the traceless Ricci curvature. Moveover, some Einstein metrics have also been characterized by some L n 2 -integral inequalities. Furthermore, we also give some rigidity characterizations for constant sectional curvature.
Huang, Yanghui,Zheng, Guangyu The Korean Society for Microbiology and Biotechnol 2022 Journal of microbiology and biotechnology Vol.32 No.6
As circ_UBE2D2 has been confirmed to have targeted binding sites with multiple miRNAs involved in septic acute kidney injury (SAKI), efforts in this study are directed to unveiling the specific role and relevant mechanism of circ_UBE2D2 in SAKI. HK-2 cells were treated with lipopolysaccharide (LPS) to construct SAKI model in vitro. After sh-circ_UBE2D2 was transfected into cells, the transfection efficiency was detected by qRT-PCR, cell viability and apoptosis were determined by MTT assay and flow cytometry, and expressions of Bcl-2, Bax and Cleaved-caspase 3 were quantified by western blot. Target genes associated with circ_UBE2D2 were predicted using bioinformatics analysis. After the establishment of SAKI rat model, HE staining and TUNEL staining were exploited to observe the effect of circ_UBE2D2 on tissue damage and cell apoptosis. The expression of circ_UBE2D2 was overtly elevated in LPS-induced HK-2 cells. Sh-circ_UBE2D2 can offset the inhibition of cell viability and the promotion of cell apoptosis induced by LPS. Circ_UBE2D2 and miR-370-3p as well as miR-370-3p and NR4A3 have targeted binding sites. MiR-370-3p inhibitor reversed the promoting effect of circ_UB2D2 silencing on viability of LPS-treated cells, but shNR4A3 neutralized the above inhibitory effect of miR-370-3p inhibitor. MiR-370-3p inhibitor weakened the down-regulation of NR4A3, Bax and Cleaved caspase-3 and the up-regulation of Bcl-2 induced by circ_UB2D2 silencing, but these trends were reversed by shNR4A3. In addition, sh-circ_UBE2D2 could alleviate the damage of rat kidney tissue. Circ_UBE2D2 mitigates the progression of SAKI in rats by targeting miR-370-3p/NR4A3 axis.
Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage
Wang Guangyu,Wang Yongsi,Jiang Shaofeng,Fan Wentao,Mo Chune,Gong Weiwei,Chen Hui,He Dan,Huang Jinqing,Ou Minglin,Hou Xianliang 한국유전학회 2022 Genes & Genomics Vol.44 No.7
Background: The current pandemic of coronavirus disease 2019 (COVID-19), transmitted person-to-person by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2), poses a threat to global public health. Objective: In this study, we performed the comprehensive analysis of the T cell receptor (TCR) repertoire may contribute to a more in-depth understanding of the pathogenesis of COVID-19. Methods: A comprehensive immunological analysis was performed to explore the features of the TCR repertoire and identified TCR sequences correlated with SARS-CoV-2 viral antigens. Results: we analyzed the COVID-19 patients' TCR repertoires in peripheral blood mononuclear cells (PBMC) which obtained before (baseline), during (acute), and after rehabilitation (convalescent) by ImmunoSEQ-technology, and found that repertoire features of TCRβ-chain (TCRβ) complementary-determining region 3 (CDR3) in COVID-19 patients were remarkable difference, including decreased TCR diversity, abnormal CDR3 length, difference of TRBV/J gene usage and higher TCR sequence overlap. Besides, we identified some COVID-19 disease-associated TCRβ clones, and the abundance of them changed with the progression of the disease. Importantly, these disease-associated TCRβ clones could be used to distinguish COVID-19 patients from healthy controls with high accuracy. Conclusions: We provide a clear understanding of the TCR repertoire of COVID-19 patients, which lays the foundation for better diagnosis and treatment of COVID-19 patients.
Cui, Guangyu,Chen, Yu,Huang, De-Shuang,Han, Kyungsook Hindawi Publishing Corporation 2008 Journal of biomedicine & biotechnology Vol.2008 No.-
<P>Biological processes are often performed by a group of proteins rather than by individual proteins, and proteins in a same biological group form a densely connected subgraph in a protein-protein interaction network. Therefore, finding a densely connected subgraph provides useful information to predict the function or protein complex of uncharacterized proteins in the highly connected subgraph. We have developed an efficient algorithm and program for finding cliques and near-cliques in a protein-protein interaction network. Analysis of the interaction network of yeast proteins using the algorithm demonstrates that 59% of the near-cliques identified by our algorithm have at least one function shared by all the proteins within a near-clique, and that 56% of the near-cliques show a good agreement with the experimentally determined protein complexes catalogued in MIPS. </P>