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Guangzhi Li,Junchi Wang,Xiaojin Li,Jianguo Xu,Zhao Zhang,Jianyong Si 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.6
20-Z auraptene (1) is a synthesized monoterpenecoumarin with anticancer activity against human gastriccancer cells. In order to find new potential anticancer agent,Mucor polymorphosporus was used to transform cis-auraptene. Four new terpene coumarins with notable changesin the skeletal backbone, 20-Z auraptene A-D (2–5), wereobtained and evaluated for their antiproliferative effectsagainst human normal gastric epithelium cells and humangastric cancer cells. These new compounds showed selectivecytotoxic activity against MGC-803 cells with IC50values from 0.78 ± 0.13 to 10.78 ± 1.83 lM and thetherapeutic index could also be significantly improved(TI = 59.0) compared with that of 1 (TI = 5.5). Thestructures of these metabolites were elucidated throughextensive spectroscopic methods, and the possible biotransformationpathway of 1 by Mucor polymorphosporuswas also proposed. Furthermore, the mechanism of theantiproliferative effects against MGC-803 cells of the mostpotent compound, 20-Z auraptene A (2), was characterized. Annexin V/PI staining and abnormal expression of apoptosis-related protein suggested that compound 2 inducesapoptosis in gastric cancer MGC-803 cells. Therefore, it ispossible that compound 2 has the potential to be applied ingastric cancer therapy.
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Peng Wanga,Wei Huang,GuangZhi Zhang,Zhi-hua Gao,Yu Tang,Kai Sun,XiaoYu Zhang 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.26 No.-
Modified aluminum alkoxide prepared by alcoholysis was used as an aluminum source in the complete liquid-phase technology for the preparation of slurry catalysts. The use of the modified aluminum alkoxide afforded control over the rate of the hydrolysis/condensation reactions during the preparation of the catalyst precursors, thereby generating catalysts with a fine nano-structured active metal and metallic oxide particles. Four types of Cu–Zn–Al (molar ratio is 2:1:4) catalysts were prepared using different procedures. These catalysts were tested for CO hydrogenation at 553 K, 4.0 MPa and H2/ CO = 1.0 in a kettle with a mechanical agitator. The results indicated that the activity of the catalysts was greatly dependent on the rate of the hydrolysis/condensation reactions, and the catalyst with the best catalytic performance was obtained by controlling the hydrolysis/alcoholysis rate during catalyst synthesis by pre-alcoholysis of AIP as the aluminum source, over which the CO conversion and dimethyl ether selectivity could reach 62.6% and 62.5%, respectively.
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Li Zhen,Shi Chao,Gao Shanjun,Zhang Xiulei,Lu Di,Liu Guangzhi 한국미생물학회 2020 The journal of microbiology Vol.58 No.12
The Gram-positive bacterium Enterococcus faecalis is currently one of the major pathogens of nosocomial infections. The lifestyle of E. faecalis relies primarily on its remarkable capacity to face and survive in harsh environmental conditions. Toxin-antitoxin (TA) systems have been linked to the growth control of bacteria in response to adverse environments but have rarely been reported in Enterococcus. Three functional type II TA systems were identified among the 10 putative TA systems encoded by E. faecalis ATCC29212. These toxin genes have conserved domains homologous to MazF (DR75_ 1948) and ImmA/IrrE family metallo-endopeptidases (DR75_ 1673 and DR75_2160). Overexpression of toxin genes could inhibit the growth of Escherichia coli. However, the toxin DR75_1673 could not inhibit bacterial growth, and the bacteriostatic effect occurred only when it was coexpressed with the antitoxin DR75_1672. DR75_1948–DR75_1949 and DR75_ 160–DR75_2161 could maintain the stable inheritance of the unstable plasmid pLMO12102 in E. coli. Moreover, the transcription levels of these TAs showed significant differences when cultivated under normal conditions and with different temperatures, antibiotics, anaerobic agents and H2O2. When DR75_2161 was knocked out, the growth of the mutant strain at high temperature and oxidative stress was limited. The experimental characterization of these TAs loci might be helpful to investigate the key roles of type II TA systems in the physiology and environmental stress responses of Enterococcus.
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Wang, Zhonghao,Hu, Xun,Wang, Lina,Jin, Bingjun,Zou, Guojun,Huang, Zhiwei,Liu, Qing,Hu, Guangzhi,Zhang, Kan,Park, Jong Hyeok Elsevier 2019 ELECTROCHIMICA ACTA Vol.299 No.-
<P><B>Abstract</B></P> <P>Herein, electrochemically sluggish polymeric carbon nitride (PCN) is successfully introduced into NiCo<SUB>2</SUB>O<SUB>4</SUB> to form hybrids of NiCo<SUB>2</SUB>O<SUB>4</SUB> and PCN, in which PCN nanosheets are regarded as a substrate to promote the nucleation and subsequent in-situ growth of NiCo<SUB>2</SUB>O<SUB>4</SUB> nanosheets. The surface of as-prepared hybrids are rich in Ni and Co ions in low and high valence state, respectively. In addition, the hybrids exhibit more hydrophilic compared with that of pristine NiCo<SUB>2</SUB>O<SUB>4</SUB> due to its higher amounts of hydroxyl group. It has been found that the nitrogen species originated from PCN nanosheets tend to bond with the metal ions and electrolyte used, resulting in tuning the electronic structural states and coupling effects with NiCo<SUB>2</SUB>O<SUB>4</SUB> nanosheets. Owing to these structural characteristics, the electrochemical performance as faradaic electrode materials and long-term stability of optimized hybrid is much superior to the bare NiCo<SUB>2</SUB>O<SUB>4</SUB> nanosheets.</P> <P><B>Highlights</B></P> <P> <UL> <LI> NiCo<SUB>2</SUB>O<SUB>4</SUB>-PCN samples were prepared via a facile and scalable strategy. </LI> <LI> The NiCo<SUB>2</SUB>O<SUB>4</SUB>-PCN-40 exhibited much higher supercapacitor performance than that of pure NiCo<SUB>2</SUB>O<SUB>4</SUB>. </LI> <LI> The PCN nanosheets can promote the nucleation and subsequent in-situ growth of NiCo<SUB>2</SUB>O<SUB>4</SUB> nanosheets in oriented way. </LI> <LI> The presence of PCN can tune the electronic structural states and coupling effects with NiCo<SUB>2</SUB>O<SUB>4</SUB> nanosheets. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>The vertically growth of NiCo<SUB>2</SUB>O<SUB>4</SUB> on PCN nanosheets substrate with 3D open frameworks synthesized here is beneficial for facilitating electrolyte ions transport and electron trapping, thus boosting the supercapacitor performance of NiCo<SUB>2</SUB>O<SUB>4</SUB>.</P> <P>[DISPLAY OMISSION]</P>
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