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Guangzhi Li,Junchi Wang,Xiaojin Li,Jianguo Xu,Zhao Zhang,Jianyong Si 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.6
20-Z auraptene (1) is a synthesized monoterpenecoumarin with anticancer activity against human gastriccancer cells. In order to find new potential anticancer agent,Mucor polymorphosporus was used to transform cis-auraptene. Four new terpene coumarins with notable changesin the skeletal backbone, 20-Z auraptene A-D (2–5), wereobtained and evaluated for their antiproliferative effectsagainst human normal gastric epithelium cells and humangastric cancer cells. These new compounds showed selectivecytotoxic activity against MGC-803 cells with IC50values from 0.78 ± 0.13 to 10.78 ± 1.83 lM and thetherapeutic index could also be significantly improved(TI = 59.0) compared with that of 1 (TI = 5.5). Thestructures of these metabolites were elucidated throughextensive spectroscopic methods, and the possible biotransformationpathway of 1 by Mucor polymorphosporuswas also proposed. Furthermore, the mechanism of theantiproliferative effects against MGC-803 cells of the mostpotent compound, 20-Z auraptene A (2), was characterized. Annexin V/PI staining and abnormal expression of apoptosis-related protein suggested that compound 2 inducesapoptosis in gastric cancer MGC-803 cells. Therefore, it ispossible that compound 2 has the potential to be applied ingastric cancer therapy.
Improved dyes separation performance of reduced graphene by incorporation MoS2 nanosheets
Xiaojin Wei,Xiaotao Fan,Yimeng Deng,Liqiang Li,Xiaolong Han,Ping Lu,Chao Huang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-
The hydrothermal reduced graphene (rGO) and the layered MoS2 nanosheets prepared by the liquidphasestripping method were blended, and then the MoS2-rGO composite membranes were preparedon the polyvinylidene fluoride (PVDF) supporting membranes by vacuum filtration method. A varietyof characterization methods such as Fourier transform infrared spectrometer (FT-IR), X-ray photoelectronspectroscopy (XPS) and X-ray diffractometer (XRD) were used to verify the successful introduction ofMoS2 into rGO layers and the changes of interlayer structure of the MoS2-rGO membranes. Finally, theeffect of MoS2 loading on separation performance of the MoS2-rGO composite membrane was investigated. The results show that the separation performance of the membrane with 33.33% of MoS2 loading(MrG3) is the most excellent. The permeability of MrG3 membrane is 118.21 Lm-2h1 bar1, whichis about 4.4 times that of the pristine rGO membrane. Meanwhile, the rejection of the MrG3 membranefor Methyl blue, Crystal violet, Rhodamine B, and Congo red all exceed 80%.
Dong Liang,Zhang Xiaojin,Yan Xuhong,Shen Yifeng,Li Yulin,Yu Xujun 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.4
Purpose: Male infertility is a worldwide problem with limitations in the treatment. Phosphodiesterase-5 inhibitors (PDE5is) is the first choice for the treatment of erectile dysfunction, more and more studies show that it has a certain effect on male infertility in recent years. But there was currently no high quality of systematic review to evaluate the effects of PDE5is on semen quality. Materials and Methods: We retrieved the electronic databases of MEDLINE, PubMed, Web of Science, EMBASE, etc. Related randomized controlled trials (RCTs) were collected and selected up to May 20, 2020. We have searched literature with terms “male infertility”, “phosphodiesterase-5 inhibitors”, “PDE5i”, “Tadalafil”, “Sildenafil”, “Vardenafil”, “Udenafil”, “Avanafil”, “semen”, and “sperm”. Mean value and its standard deviation were used to perform quantitative analysis. All statistical analyses were conducted by RevMan 5.3 and Stata software. Results: There were a total of 1,121 participants in the nine included studies. There was a statistically significant improvement treated with PDE5is compared with sham therapy, which including sperm concentration (mean difference [MD]=1.96, 95% confidence interval [CI]=1.70–2.21, p<0.001; MD=3.22, 95% CI=1.96–4.48, p<0.001), straight progressive motility (%) Grade A (MD=3.71, 95% CI=2.21–5.20, p<0.001), sperm motility (MD=8.09, 95% CI=7.83–8.36, p<0.001), morphologically normal spermatozoa (%) (MD=0.67, 95% CI=0.20–1.15, p=0.005; MD=1.27, 95% CI=0.02–2.52, p=0.05), sperm abnormalities (%) (MD=-0.64, 95% CI=-0.81–-0.47, p<0.001), and progressive motile sperm (MD=5.34, 95% CI=3.87–6.81, p<0.001). Conclusions: In this meta-analysis of nine RCTs, treatment with PDE5is could improve some indicators of male sperm.