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Panax ginseng Protects Against Global Ischemia Injury in Rat Hippocampus
Kim, Young-Ock,Kim, Hak-Jae,Kim, Geum-Soog,Park, Ho-Gi,Lim, Sang-Jong,Seong, Nak-Sul,Ham, Yung-Woon,Lee, Sung-Dong,Jang, Ki-Hyo,Jung, Kyung-Hee,Chung, Joo-Ho,Kang, Soon-Ah The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.1
Based on the use of Panax ginseng C.A. Meyer (Family Araliaceae) for the treatment of stroke in traditional Korean medicine, the present study was carried out to evaluate neuroprotective effects of P. ginseng after transient global cerebral ischemia using the four-vessel occlusion rat model. Nissl staining, lipid peroxidation (malondialdehyde [MDA] formation), and activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) of rat brain were assessed. Ethanolic P. ginseng extract (200 mg/kg, i.p.) significantly protected CA1 neurons against 10 minutes of transient forebrain ischemia as demonstrated by measuring the density of neuronal cells. P. ginseng also significantly decreased the level of MDA and increased the expression of GPx and SOD. These results suggest that P. ginseng might be neuroprotective against cerebral ischemia-induced injury in rat brain by decreasing lipid peroxides and increasing the expression of GPx and SOD.
Geum Soog Kim,Tae Sook Jeong,Young Ock Kim,Nam In Baek,Seon Woo Cha,Jong Won Lee,Kyung Sik Song 한국응용생명화학회 2010 Journal of Applied Biological Chemistry (J. Appl. Vol.53 No.4
In the process of screening for anti-human acyl-CoA:cholesterol acyltransferase (hACAT) agents from plant resources, we found that the 80% methanolic extract of Rhus chinensis (R. chinensis) exhibited significant antioxidative and hACAT activities in rats.
Human Acyl-CoA:Cholesterol Acyltransferase (hACAT)-inhibiting Triterpenes from Lythrum salicaria L.
Kim, Geum-Soog,Lee, Seung-Eun,Jeong, Tae-Sook,Park, Chun-Geun,Sung, Jung-Sook,Kim, Jung-Bong,Hong, Yoon-Pyo,Kim, Young-Chul,Song, Kyung-Sik The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
${\beta}$-Sitosterol (1), betulinic acid (2), and $3{\beta}$-hydroxy-20(29)-lupen-28-oic acid methyl ester (3) were isolated from the herbal parts of Lythrum salicaria. Compounds 2 and 3 were isolated for the first time from L. salicaria and they showed inhibitory activities on both hACAT1 and hACAT2. These results suggested that L. salicaria, which contains triterpenes 2 and 3, might be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis due to its inhibitory effect on hACAT.
Geum-Soog Kim,Seung-Eun Lee,Hyung-Jun Noh,Hyuck Kwon,Sung-Woo Lee,Seung-Yu Kim,Yong-Bum Kim 고려인삼학회 2012 Journal of Ginseng Research Vol.36 No.4
This study was conducted to evaluate the effects of natural bioactive products such as Manda enzyme (T1), Yangmyeongwon (T2), effective microorganisms (T3), and Kelpak (T4) on the growth and ginsenoside contents of Panax ginseng cultured in an aeroponic system using a two-layer vertical type of nutrient bath under natural light conditions. The growth of ginseng plants showed specifi c characteristics according to the positions in which they were cultured due to the difference of light transmittance and temperature in the upper and lower layers during aeroponic culture in a two-layer vertical type of system. The growth of the aerial part of the leaves and stems of ginseng plants cultured in the lower layer (4,000 to 6,000 lx, 23°C to 26°C) of the nutrient bath was observed to be superior to that of the ginseng plants cultured in the upper layer (12,000 to 15,000 lx, 25°C to 28°C). The leaf area was signifi cantly larger in the treatment of T2 and T4 (46.70 cm2) than with other treatments. Conversely, the values of the root weight and root diameter were higher in ginseng plants cultured in the upper layer of the nutrient bath. The root weight was signifi cantly heavier in the treatment of T4 (6.46 g) and T3 (6.26 g) than with other treatments. The total ginsenoside content in the leaves and roots was highest in the ginseng plants cultured by the treatment of T1, at 16.20%, while the total ginsenoside content obtained by other treatments decreased in the order of T4, T5 (control), T2, and T3, at 13.21%, 12.30%, 14.84%, and 14.86%, respectively. The total ginsenoside content of the ginseng leaves was found to be signifi cantly higher in the treatment of T1 in the lower layer of the nutrient bath, at 15.30%, while the content of the ginseng roots in the treatments of T3 and T4, at 1.27% and 1.23%, respectively, was signifi cantly higher than in other treatments in the upper layer of the nutrient bath.
Human Acyl-CoA:Cholesterol Acyltransferase-inhibiting Dammarane Triterpenes from Rhus chinensis
Kim, Geum-Soog,Jeong, Tae-Sook,Kim, Young-Ock,Baek, Nam-In,Cha, Seon-Woo,Lee, Jong-Won,Song, Kyung-Sik The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.4
In the process of screening for anti-human acyl-CoA:cholesterol acyltransferase (hACAT) agents from plant resources, we found that the 80% methanolic extract of Rhus chinensis (R. chinensis) exhibited significant antioxidative and hACAT activities in rats. Two compounds were isolated as active principles from the ethyl acetate soluble fraction of the branches of R. chinensis. The structures of compounds 1 and 2 were determined as hydroxydammarenone and semialactone, respectively, by means of MS and NMR spectroscopic analysis. Compound 1 has been isolated from this plant for the first time. Compounds 1 and 2 showed inhibitory activities on both human ACAT1 with $IC_{50}$ values of 12.4, and $79.1\;{\mu}M$ and on human ACAT2 with $IC_{50}$ values of 30.5 and $76.9\;{\mu}M$, respectively. These results suggested that R. chinensis containing dammarane triterpenes 1 and 2 might be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis via inhibitory effect on hACAT.
Kim, Geum-Soog,Lee, Seung-Eun,Noh, Hyung-Jun,Kwon, Hyuck,Lee, Sung-Woo,Kim, Seung-Yu,Kim, Yong-Bum The Korean Society of Ginseng 2012 Journal of Ginseng Research Vol.36 No.4
This study was conducted to evaluate the effects of natural bioactive products such as Manda enzyme (T1), Yangmyeongwon (T2), effective microorganisms (T3), and Kelpak (T4) on the growth and ginsenoside contents of Panax ginseng cultured in an aeroponic system using a two-layer vertical type of nutrient bath under natural light conditions. The growth of ginseng plants showed specific characteristics according to the positions in which they were cultured due to the difference of light transmittance and temperature in the upper and lower layers during aeroponic culture in a two-layer vertical type of system. The growth of the aerial part of the leaves and stems of ginseng plants cultured in the lower layer (4,000 to 6,000 lx, $23^{\circ}C$ to $26^{\circ}C$) of the nutrient bath was observed to be superior to that of the ginseng plants cultured in the upper layer (12,000 to 15,000 lx, $25^{\circ}C$ to $28^{\circ}C$). The leaf area was significantly larger in the treatment of T2 and T4 (46.70 $cm^2$) than with other treatments. Conversely, the values of the root weight and root diameter were higher in ginseng plants cultured in the upper layer of the nutrient bath. The root weight was significantly heavier in the treatment of T4 (6.46 g) and T3 (6.26 g) than with other treatments. The total ginsenoside content in the leaves and roots was highest in the ginseng plants cultured by the treatment of T1, at 16.20%, while the total ginsenoside content obtained by other treatments decreased in the order of T4, T5 (control), T2, and T3, at 13.21%, 12.30%, 14.84%, and 14.86%, respectively. The total ginsenoside content of the ginseng leaves was found to be significantly higher in the treatment of T1 in the lower layer of the nutrient bath, at 15.30%, while the content of the ginseng roots in the treatments of T3 and T4, at 1.27% and 1.23%, respectively, was significantly higher than in other treatments in the upper layer of the nutrient bath.
Characterization of gene expression regulated by Panax ginseng in SH -SY5Y cells
Kim, Hak-Jae,Kang, Sung-Wook,Kim, Mi-Ja,Kim, Young-Ock,Kim, Geum-Soog,Park, Yoon-Hyung,Chung, Joo-Ho The Korean Society of Toxicogenomics and Toxicopro 2010 Molecular & cellular toxicology Vol.6 No.3
To investigate the effects of Panax ginseng (PG) on SH-SY5Y human neuroblastoma cells, we profiled gene expressions of both normal and PG-treated groups using cDNA microarray. We performed 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays to determine the effect on PG-induced cytotoxicity. The gene expression profiles in normal group were compared to PG-treated group using 24K human cDNA microarray. MTT assay showed that PG was not cytotoxic at the concentrations of $1-100\;{\mu}g/mL$ in SH-SY5Y cells. Consequently, 210 genes exhibited differential expression levels between normal and PG-treated groups through cDNA microarray analysis, and it was found that 52 of the 210 genes were up-regulated while 146 of them were down-regulated by two-fold. PG may induce changes in the expression of genes in SH-SY5Y cells possibly relevant to signal transduction and cellular development. These results help to further understand the molecular framework of PG as a signal transduction inducer of neuronal cells.
Human Acyl-CoACholesterol Acyltransferase-inhibiting Dammarane Triterpenes from Rhus chinensis
( Geum Soog Kim ),( Tae Sook Jeong ),( Young Ock Kim ),( Nam In Baek ),( Seon Woo Cha ),( Jong Won Lee ),( Kyung Sik Song ) 한국응용생명화학회 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.4
In the process of screening for anti-human acyl-CoA:cholesterol acyltransferase (hACAT) agents from plant resources, we found that the 80% methanolic extract of Rhus chinensis (R. chinensis) exhibited significant antioxidative and hACAT activities in rats. Two compounds were isolated as active principles from the ethyl acetate soluble fraction of the branches of R. chinensis. The structures of compounds 1 and 2 were determined as hydroxydammarenone and semialactone, respectively, by means of MS and NMR spectroscopic analysis. Compound 1 has been isolated from this plant for the first time. Compounds 1 and 2 showed inhibitory activities on both human ACAT1 with IC50 values of 12.4, and 79.1 μM and on human ACAT2 with IC(50) values of 30.5 and 76.9 μM, respectively. These results suggested that R. chinensis containing dammarane triterpenes 1 and 2 might be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis via inhibitory effect on hACAT.