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      • The -765G>C Polymorphism in the Cyclooxygenase-2 Gene and Digestive System Cancer: a Meta-analysis

        Zhao, Fen,Cao, Yue,Zhu, Hong,Huang, Min,Yi, Cheng,Huang, Ying Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

        Background: Published data regarding associations between the -765G>C polymorphism in cyclooxygenase-2 (COX-2) gene and digestive system cancer risk have been inconclusive. The aim of this study was to comprehensively evaluate the genetic risk of the -765G>C polymorphism in the COX-2 gene for digestive system cancer. Materials and Methods: A search was performed in Pubmed, Medline (Ovid), Embase, CNKI, Weipu, Wanfang and CBM databases, covering all studies until Feb 10, 2014. Statistical analysis was performed using Revman5.2. Results: A total of 10,814 cases and 16,174 controls in 38 case-control studies were included in this meta-analysis. The results indicated that C allele carriers (GC+CC) had a 20% increased risk of digestive system cancer when compared with the homozygote GG (odds ratio (OR)=1.20, 95% confidence interval (CI), 1.00-1.44 for GC+CC vs GG). In the subgroup analysis by ethnicity, significant elevated risks were associated with C allele carriers (GC+CC) in Asians (OR = 1.46, 95% CI=1.07-2.01, and p=0.02) and Africans (OR=2.12, 95% CI=1.57-2.87, and p< 0.00001), but not among Caucasians, Americans and mixed groups. For subgroup analysis by cancer type (GC+CC vs GG), significant associations were found between the -765G>C polymorphism and higher risk for gastric cancer (OR=1.64, 95% CI=1.03-2.61, and p=0.04), but not for colorectal cancer, oral cancer, esophageal cancer, and others. Regarding study design (GC+CC vs GG), no significant associations were found in then population-based case-control (PCC), hospital-based case-control (HCC) and family-based case-control (FCC) studies. Conclusions: This meta-analysis suggested that the -765G>C polymorphism of the COX-2 gene is a potential risk factor for digestive system cancer in Asians and Africans and gastric cancer overall.

      • KCI등재
      • KCI등재

        오감체험을 통한 화장품 브랜드의 플래그쉽 스토어 디자인 연구

        후왕풘 ( Huang Fen ),최원재 ( Choi Won-jae ) 커뮤니케이션디자인학회 2024 커뮤니케이션 디자인학연구 Vol.86 No.-

        사회가 발전함에 따라 소비 패턴도 크게 변화하고 있으며, 사람들은 더 이상 기본적인 물질적 요구에 만족하지 않고, 소비 과정에서의 정신적 즐거움과 경험을 추구하기 시작했다. 최근 코로나19 종식 이후, 오프라인 매장의 가치가 변화하고 있다. 기업은 브랜드 이미지를 부각시키기 위해 다중 감각 경험에 주목하기 시작했다. 다중 감각 경험 디자인은 브랜드 디자인의 중요한 부분으로 간주되어, 사용자 공감 경험, 제품 포장 및 브랜드 플래그쉽(flagship)의 모든 측면에서 소비자를 감동시키고 좋은 브랜드 이미지를 구축한다. 이는 브랜드 의존도를 달성하고 우수한 경제적 이익을 얻을 수 있다. 본 연구에서는 참고문헌, 온라인 자료, 선행연구를 통해 감각 및 체험 전시의 개념과 이론을 조사하였다. 따라서 본 연구는 중국 화장품 오프라인 매장의 체험 마케팅을 어떻게 진행하고, 어떤 다중 감각 체험 요소가 브랜드 이미지를 효과적으로 표현하는지를 분석하고, 브랜드 이미지를 소비자에게 효과적으로 전달하는 방법을 제안하고자 한다. 본 연구의 완전성과 객관성을 향상시키기 위하여, 사례분석 부분와 전문가 인터뷰 대상자가 공동으로 관능성분을 분석하고, 이를 바탕으로 사례분석의 평가모형을 도출하였다. 사례분석은 2022년 중국 내 화장품 10대 브랜드 순위 중 4개 브랜드 화시즈(Florasis,花西子), 퍼펙트 다이어리(Perfect Diary, 完美日记), 카즈란(Carslan, 卡姿兰), 주유도어(Judydoll,橘朵)를 선정하였다. 브랜드별 플래그쉽 스토어의 오감과 공감 체험 요소를 분석했다. 평가 모델을 재사용하고 전문가 인터뷰를 통해, 브랜드 사례의 다중 감각 적용을 논의하고 최종적으로 분석 결과를 공동으로 도출한다. 다섯 개 사례분석에 대한 종합분석 결과, 시각적 경험의 경우 색상, 조명 및 형태를 기반으로 하는 직접적인 표현이 가장 많다. 청각적 경험 측면에서는 효과음을 사용하여 브랜드 이미지와 스토리를 연상시키는 방법은 소비자가 브랜드 이미지를 더욱 강력하게 연상할 수 있도록 했다. 후각적 체험은 브랜드의 시그니처향을 활용하였을때, 소비자들에게 익숙함과 호기심을 자극하는 역할을 담당할 수 있었다. 촉각적 체험은 인테리어 소재를 브랜드 아이덴티티와 접목했을 때, 브랜드의 품질을 고급스럽게 표현하고 소비자가 제품에 대한 친밀감을 느끼게 되어 접촉을 유도하는데 용이했다. 미각적 체험은 브랜드 이미지나 컨셉을 연상시킬 수 있도록 이벤트성 시식이나 시음을 통하여 브랜드에 대한 긍정적인 감성을 끌어낼 수 있었다. 분석 결과에 따르면, 화장품 플래그쉽 스토어 매장의 오감체험 표현요소가 어떻게 분배되어 있는지 알 수 있다. 화장품 플래그쉽 스토어 공간에서 소비자를 위한 공감성을 표현하기에는 모든 감각을 필요로 한다. 따라서 오감체험을 플래그쉽 스토어에 활용하는 것이 긍정적이라는 결론을 낼 수 있었다. 이를 통해 향후 설립되는 화장품 플래그쉽 스토어에서 체험 요소 활용에 도움이 되기를 바라는 바이다. As society develops, consumption patterns are also changing significantly, and people are no longer satisfied with basic material needs, but have begun to pursue mental enjoyment and experiences during the consumption process. Recently, after the end of COVID-19, the value of offline stores is changing. Companies are beginning to pay attention to multi-sensory experiences to highlight their brand image. Multi-sensory experience design is considered an important part of brand design, touching consumers and building a good brand image in all aspects of user empathy experience, product packaging and brand flagship. This can achieve brand dependence and obtain excellent economic benefits. In this study, the concepts and theories of sensory and experiential exhibitions were investigated through references, online materials, and previous research. Therefore, this study aims to analyze how experiential marketing is carried out in Chinese cosmetics offline stores, which multi -sensory experience elements effectively express brand image, and to suggest ways to effectively convey brand image to consumers. In order to improve the completeness and objectivity of this study, the case analysis section and expert interviewees jointly analyzed the sensory component s, and based on this, an evaluation model for the case analysis was derived. Case analysis show s four brands among the top 10 cosmetics brands in China in 2022: Florasis, Perfect Diary, Carslan, and Judydoll.) was selected. We analyzed the five senses and empathy experience elements of each brand's flagship store. By reusing evaluation models and interviewing experts, we discus s multi-sensory application of brand cases and finally jointly derive analysis results. As a result of comprehensive analysis, in the case of visual experiences, direct expressions based on color, lighting, and shape are the most common. In terms of auditory experience, the method of reminiscent of brand image and story using sound effects made consumers more strongly associate with the brand image. The posterior experience could play a role in stimulating familiarity and curiosity to consumers when the brand's signature scent was utilized. The tactile experience was easy to induce contact as the interior material was combined with the brand identity, the quality of the brand was expressed luxuriously and the consumer felt a sense of intimacy with the product. The taste experience was able to derive a positive sensibility for the brand through event tasting or tasting so that it could be reminiscent of the brand image or concept. According to the analysis results, you can see how the five senses experience expression elements of the cosmetics flagship store are distributed. It takes all senses to express empathy for consumers in the cosmetics flagship store space. Therefore, it was concluded that it would be positive to use the five senses experience in the flagship store. Through this, we hope that it will be helpful to utilize the experience elements in the cosmetics flagship store to be established in the future.

      • KCI등재

        화장품 브랜드 디자인 콜라보레이션이 소비자 구매의도에 미치는 영향 연구

        후왕풘(Fen Huang) 한국산업기술융합학회(구. 산업기술교육훈련학회) 2024 산업기술연구논문지 (JITR) Vol.29 No.2

        브랜드 콜라보레이션 제품은 최근 몇 십 년 동안 젊은 소비자 층이 선호하는 제품 유형 중 하나이다. 화장품 시장에서 치열한 경쟁이 이루어지는 가운데, 브랜드 간의 협력은 새로운 마케팅 모델로 인식되어 왔다. 특히 기업들은 소비자의 브랜드 선호도를 높이고 구매 의도를 자극하기 위해 다양한 콜라보레이션 제품을 출시하고 있다. 이러한 배경 하에 본고는 선행연구를 바탕으로 화장품 브랜드 다자인 콜라보레이션의 개념, 목적과 유형을 파악하고, 이를 바탕으로 콜라보레이션의 유형이 소비자의 구매 의도에 영향을 미치는 요인을 분석하는 데에 목적을둔다. 이를 위해 본고는 중국에서 인기를 끌고 있는 화장품 브랜드 이니스프리의 디자인 콜라보레이션을 연구 대상으로 선정하였으며, 중국 15~25대 소비자를 대상으로 조사하였다. 브랜드 디자인 콜라보레이션에 대한 인지도와 브랜드 선호도를 파악하고 이를 토대로 소비자의 구매 의도에 미치는 영향을 분석하였다. 또한 이 연구에서는 화장품 브랜드 디자인 콜라보레이션의 유형-브랜드 선호도-소비자의 구매의도 간의 상관관계를 가정하여 매개 관계를 점증하였다. 분석결과에 따르면 화장품 브랜드 디자인 콜라보레이션의 유형에서 캐릭터 콜라보레이션, 아트 콜라보레이션, 브랜드 콜라보레이션은 모두 소비자의 구매의도에 정(+)의 영향을 미친 것으로 나타났다. In recent years, brand collaboration products have become increasingly popular among young consumers. Amid fierce competition in the cosmetics market, cooperation between brands has emerged as a novel marketing model. Companies introduce sentiment-driven collaboration products to enhance consumer brand preference and stimulate purchase intentions. This study aims to define the concept, purpose, and types of multilateral collaborations for cosmetics brands, drawing on previous studies, and analyze the factors influencing consumers' purchase intention. This study selected Innisfree’s design collaboration, which is gaining popularity in China, as the focal point. Awareness and preference for brand design collaborations were identified, and their effect on consumers' purchase intentions was analyzed. In addition, the study also exploited the mediating relationship by examining the correlation between the type of cosmetic brand design collaboration, brand preference, and consumer purchase intention. The results indicated that character collaboration, art collaboration, and brand collaboration all positively impacted consumers' purchase intentions in the context of cosmetics brand design collaboration.

      • The 765G>C Polymorphism in the Cyclooxygenase-2 Gene and Gastric Cancer Risk: an Update by Meta-analysis

        Zhao, Fen,Zhu, Hong,Huang, Min,Yi, Cheng,Huang, Ying Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

        Background: The 765G>C polymorphism in cyclooxygenase-2 (COX-2) gene has been extensively investigated for association with gastric cancer (GC). However, the results of different studies have been inconsistent. The aim of this study is to comprehensively evaluate the genetic risk of -765G>C polymorphism in the COX-2 gene for GC. Materials and Methods: We searched Pubmed, Embase, Medline, CNKI database, Wanfang database, Weipu database, and Chinese Biomedical database, covering all publications (last search been performed on Jan 10, 2014). Statistical analyses were performed using Revman 5.2 and STATA 10.0 software. Results: A total of 1,874 cases and 3,005 controls in 10 case-control studies were included in this meta-analysis. The results indicated that the variant C allele carriers (GC+CC) had a 69% increased risk of GC when compared with the homozygote GG (odds ratio (OR)=1.69, 95% confidence interval (CI), 1.10-2.61 for GC+CC vs GG). In the subgroup analysis by ethnicity, significant elevated risks were associated with C allele carriers in Asians (OR=1.75, 95%CI=1.40-2.18, and p<0.00001) and in Indians (OR=8.38, 95%CI=4.34-16.16, and p<0.00001) but not in Caucasians (OR=1.07, 95%CI=0.81-1.42, and p=0.62) or in Dutch (OR=0.53, 95%CI= 0.33-0.87, and p= 0.01).In the subgroup analysis by Helicobacter pylori (H. pylori) status, a significantly increased risk was identified among H. pylori (+) (OR=3.58, 95%CI=2.33-3.50, and p<0.00001) and H. pylori (-) (OR=2.32, 95%CI=1.46-3.69, and p=0.0004). Conclusions: This meta-analysis suggested that the -765G>C polymorphism in the COX-2 gene could be a risk factor for GC in Asians and Indians.

      • Low Prevalence of HPV in Male Sexual Partners of HR-HPV Infected Females and Low Concordance of Viral Types in Couples in Eastern Guangdong

        Huang, Yue,Lin, Min,Luo, Zhao-Yun,Li, Wen-Yu,Zhan, Xiao-Fen,Yang, Li-Ye Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

        Objective: To investigate the prevalence of genital high-risk human papillomavirus (HR-HPV) in male sexual partners of HR-HPV infected women and the concordance of viral types in couples in China, and comprehend the role of men play in HPV transmission to women. Methods/Materials: 94 asymptomatic women and their husbands from rural Chaozhou participated in epidemiologic screening for HPV infection. Cervical cells from females were collected for high risk HPV screening by real time-PCR, and they were positive for at least 1 of 13 HR-HPV subtypes, then these samples were genotyped. Approximately one mouth later, penile epithelial cells from 94 asymptomatic husbands were collected for HPV genotyping. At the same time, a cross-sectional study was conducted in 366 male patients from sexually transmitted disease (STD) outpatient clinic in China for the prevalence of genital HR-HPV infection in men having frequent sex behavior. Penial epithelial cells were collected for HPV 6/11 and HPV 16/18 detection by fluorescent real-time quantified PCR. Results: Among 94 couples, the prevalence of genital HR-HPV infection in men whose wife was positive for cervical HR-HPV was 5.32% (5/94). Only 2.63% (2/76) had the same high risk viral type presented by their wife. HPV 16 proved to be the most prevalent viral type in men and in couples. Of 366 male patients from STD outpatient clinic, the prevalence of HPV 16/18 infection in men with or without HPV 6/11 was 6.85% and 8.16%, respectively. The incidence of HPV 16/18 was higher in men aged more than 35 years than the young men (18-35 years). Conclusion: The prevalence of genital HR-HPV infection in male sexual partners of HPV-positive women in China was lower than that expected, and the concordance of high risk viral type between couples was extremely low. These data suggested that infected men consitute an important viral reservoir, contributing to transmission of HR-HPV to women and maintenance of infection, but HR-HPV infection may be less likely to persist in men than in women.

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