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Fan, Guang-Hua,Wang, Zhong-Ming,Yang, Xi,Xu, Li-Ping,Qin, Qin,Zhang, Chi,Ma, Jian-Xin,Cheng, Hong-Yan,Sun, Xin-Chen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Resveratrol has been examined in several model systems for potential effects against cancer. Adenosine monophosphate-activated protein kinase (AMPK) is reported to suppress proliferation in most eukaryocyte cells. Whether resveratrol via AMPK inhibits proliferation of oesophageal adenocarcinoma cells (OAC) is unknown. The aim of this study was to determine the roles of AMPK in the protective effects of resveratrol in OAC proliferation and to elucidate the underlying mechanisms. Treatment of cultured OAC derived from human subjects or cell lines with resveratrol resulted in decreased cell proliferation. Further, inhibition of AMPK by pharmacological reagent or genetical approach abolished resveratrol-suppressed OAC proliferation, reduced the level of $p27^{Kip1}$, a cyclin-dependent kinase inhibitor, and increased the levels of S-phase kinase-associated protein 2 (Skp2) of $p27^{Kip1}$-E3 ubiquitin ligase and 26S proteasome activity reduced by resveratrol. Furthermore, gene silencing of $p27^{Kip1}$ reversed resveratrol-suppressed OAC proliferation. In conclusion, these findings indicate that resveratrol inhibits Skp2-mediated ubiquitylation and 26S proteasome-dependent degradation of $p27^{Kip1}$ via AMPK activation to suppress OAC proliferation.
( Guang Fan Chi ),( Hyeong Won Choi ),( Mei Hua Jiang ),( Dai Wook Kim ),( Eun Kyung Chung ),( Young Sook Son ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.2
In this study, we tested whether the subcutaneous tissue and/or dermis retain inherently the spheroid forming cells or those spheroids are induced by the special induction condition and furthermore explored how much distinct or similar to neurospheroid derived from neural stem cells in the hippocampus. Based on immunofluorescence staining, nestin and p75 positive cells were abundant in both skin appendages of subcutaneous tissue and dermal compartment of neonatal rat skin and could generate numerous spheroids upon the incubation with bFGF and EGF containing spheroid inducing medium. Those spheroids were all identical in gene expressions of Twist, Slug, Sox9, Sox2, nestin, p75, and ABCG2. However, spheroids derived from the hippocampus, which were featured by the lack of p75 and fibronectin expression, were quite distinct from those from subcutaneous and dermis tissue. In the spheroid, nestin and p75 were initially expressed only in the central part of the spheroids but later became positive in all cells of the spheroids after two week culture and the cell proliferation was restricted within the spheroid structure. By neural differentiation and Schwann cell differentiation, the spheroid forming cells could be differentiated to β tubulin- III positive neural lineage cell and Sox10, GFAP positive Schwann cells, respectively. Therefore, our findings indicate that the subcutaneous tissue of neonatal rat skin comprised of numerous spheroid forming cells, possibly similar to neural crest derived stem cells and may be an alternative new source of neural and glial cell lineages for peripheral and central nervous system disease or disorders.
Icefex: Protocol Format Extraction from IL-based Concolic Execution
( Fan Pan ),( Li-fa Wu ),( Zheng Hong ),( Hua-bo Li ),( Hai-guang Lai ),( Chen-hui Zheng ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.3
Protocol reverse engineering is useful for many security applications, including intelligent fuzzing, intrusion detection and fingerprint generation. Since manual reverse engineering is a time-consuming and tedious process, a number of automatic techniques have been proposed. However, the accuracy of these techniques is limited due to the complexity of binary instructions, and the derived formats have missed constraints that are critical for security applications. In this paper, we propose a new approach for protocol format extraction. Our approach reasons about only the evaluation behavior of a program on the input message from concolic execution, and enables field identification and constraint inference with high accuracy. Moreover, it performs binary analysis with low complexity by reducing modern instruction sets to BIL, a small, well-specified and architecture-independent language. We have implemented our approach into a system called Icefex and evaluated it over real-world implementations of DNS, eDonkey, FTP, HTTP and McAfee ePO protocols. Experimental results show that our approach is more accurate and effective at extracting protocol formats than other approaches.
( Guang Fan Chi ),( Mi Ra Kim ),( Dae Wook Kim ),( Mei Hua Jiang ),( Eun Kyung Chung ),( Young Sook Son ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.2
Previously, we showed that rat subcutaneous fat tissue comprises of nestin-expressing spheroids, which are efficiently induced to Schwann cells (SCs) in vitro under the inducing condition and display Schwann cell properties in vivo. In this study, we investigated whether induced SCs could be engaged in the repair of the lateral hemisection lesion of the rat spinal cord using PKH26-labeled cells and also tested the feasibility of fibrin glue as a cell delivery vehicle in the blunt gap lesion. At the end of twelve weeks after the transplantation, the lesion site was fully filled with the regenerated tissue, which contained PKH26-labeled cells and P0 expressing cells. Some of PKH26-labeled cells were shown as a hollow tube-like structure, which was co-localized with the P0 antigen. Several types of neurons were also detected in the regenerated tissue. Among them, a few GABAnergic interneuron, CGRP positive neurons, and serotonergic neurons were found at the hemisection lesion site, which were probably infiltrated to the lesion site from the surrounding normal tissue. However, in the control lesion which received fibrin glue only, the majority of lesion site was filled with connective tissue containing numerous fibroblasts and relatively fewer SCs and neurons compared to those in SCs treated group. Thus, the induced SCs delivered with fibrin glue survived at the lesion site in the spinal cord and engaged in the myelin sheath regeneration. Furthermore, SCs along with the fibrin glue, applied as a cell delivery vehicle, seem to provide permissive microenvironment for the active infiltration of host neural and glial cells from the uninjured neighboring tissue.
Chi, Guang Fan,Kim, Mi-ra,Kim, Dae-Wook,Jiang, Mei Hua,Son, Youngsook Elsevier 2010 Experimental neurology Vol.222 No.2
<P><B>Abstract</B></P><P>In the present study, we found that nestin-expressing spheroid cells derived from multipotent adipose stem cells of subcutaneous fat tissue could efficiently differentiate into Schwann cells (SCs) <I>in vitro</I> based on expression of SC markers such as A2B5, GFAP, O4, p75, S100, Sox10, Krox-20, and L1. The induced SC is engrafted to spinal cord injury lesions and formed a peripheral nervous system (PNS)-type myelin sheath on central nervous system (CNS) axons. PNS-type myelin sheath formation in repaired tissue was confirmed by transplantation of both induced PKH26-labeled SC and induced EGFP-expressing SC generated from EGFP transgenic rats. In addition to direct participation as myelin sheath-forming SC in repaired tissue, the induced SC also expressed several neurotrophic factors, as did native SC, which may suggest an additional role for induced SC in stimulation of endogenous healing responses. Thus, spheroid-forming cells from subcutaneous fat tissue demonstrated rapid and efficient induction into SC, and such cells show therapeutic promise for repair of damage to the CNS and PNS.</P>
Schwann-like cells from human melanocytes and their fate in sciatic nerve injury
Chi, Guang Fan,Kim, Dae-wook,Jiang, Mei Hua,Yoon, Kang Jun,Son, Youngsook Lippincott Williams Wilkins, Inc. 2011 NEUROREPORT - Vol.22 No.12
We induced human melanocyte dedifferentiation to Schwann cell-like cells in vitro by a combination of forskolin, neuregulin-&bgr;1, neurotrophin-3, platelet-derived growth factor-aa, basic fibroblast growth factor, laminin, and heparin. Cultured human melanocytes constitutively expressed neural cell and melanocyte markers but melanocyte-specific marker, including microphthalmia-associated transcription factor and tyrosinase, expression was selectively lost after induction. In the sciatic nerve injury site, the induced cells were engrafted and closely aligned to axons and P0-expressing myelin sheaths, whereas uninduced cells were not colocalized with axons and myelin sheaths and reexpressed melanocyte-specific tyrosinase activity in vivo. Human melanocytes lose their melanocyte phenotype and transdifferentiate into Schwann cells under specific induction conditions and display their Schwann cell phenotype after transplantation to injured sciatic nerve tissue.
Jiang, Mei Hua,Lim, Ji Eun,Chi, Guang Fan,Ahn, Woosung,Zhang, Mingzi,Chung, Eunkyung,Son, Youngsook Wolters Kluwer Health | Lippincott Williams Wilkin 2013 NEUROREPORT - Vol.24 No.15
Previously, we have reported that substance P (SP) enhanced functional recovery from spinal cord injury (SCI) possibly by the anti-inflammatory modulation associated with the induction of M2-type macrophages at the injured lesion. In this study, we explored the cytokine expression profiles and apoptotic cell death in the lesion site of the SCI after an immediate intravenous injection of SP. SP injection increased the levels of interleukin-4 (IL-4), IL-6, and IL-10 at day 1 after the SCI approximately by 2-, 9-, and 10-folds when compared with the control SCI, respectively. On the basis of double immunofluorescence staining with IL-10 and CD11b, activated macrophages or microglia expressing IL-10 appeared in the margin of the lesion site at day 1 only after the SP injection. This SP-mediated alteration in the lesion microenvironment was shown to be associated with the lower cell death of neuronal cells at day 1 and oligodendrocytes at day 5 by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, which was also accompanied by a decrease in caspase-3 activation. These findings suggest that SP may reduce the inflammation-induced secondary cell death, possibly through immune modulation at an early stage after the SCI.
Yan Zhang,Hua-Xin Chen,Li Duan,Lei Ni,Ji-Bin Fan,Jie Wang,Guang-Teng Ci,Vincent Ji 한국자기학회 2019 Journal of Magnetics Vol.24 No.3
The structural, half-metallic (HM) and magnetic properties of the imperfect Pb₂FeReO6 containing eight different inherent defects of the FeRe or ReFe antisites, Fe1-Re1 or Fe1-Re4 interchanges, VFe, VRe, VO or VPb vacancies have been studied by first-principles calculations. No obvious structural changes are observed for FeRe or ReFe antisites, Fe1-Re1 or Fe1-Re4 interchanges and VPb vacancy defects, however, the six (two) nearest neighbors O (Fe or Re) of the vacancy move away from (close to) VFe or VRe (VO) vacancies. The HM character is maintained for FeRe or ReFe antisites, far Fe1-Re4 interchange, VFe, VO or VPb vacancies, while vanished for near Fe1-Re1 interchange or VRe vacancy. So the near Fe1-Re1 interchange or VRe vacancy defects should be avoided to preserve the HM character of the Pb₂FeReO6 and thus usable in spintronics devices. Except for the FeRe antisite case with a slightly higher total moment, the total moments μtot of the imperfect Pb₂FeReO6 with the other seven inherent defects are smaller than 3.96 μB/f.u. of the perfect Pb₂FeReO6.
Development of a position sensitive CsI(Tl) crystal array
Shi, Guo-Zhu,Chen, Ruo-Fu,Chen, Kun,Shen, Ai-Hua,Zhang, Xiu-Ling,Chen, Jin-Da,Du, Cheng-Ming,Hu, Zheng-Guo,Fan, Guang-Wei Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.4
A position-sensitive CsI(Tl) crystal array coupled with the multi-anode position sensitive photomultiplier tube (PS-PMT), Hamamatsu H8500C, has been developed at the Institute of Modern Physics. An effective, fast, and economical readout circuit based on discretized positioning circuit (DPC) bridge was designed for the 64-channel multi-anode flat panel PSPMT. The horizontal and vertical position resolutions are 0.58 mm and 0.63 mm respectively for the 1.0 × 1.0 × 5.0 ㎣ CsI(Tl) array, and the horizontal and vertical position resolutions are 0.86 mm and 0.80 mm respectively for the 2.0 × 2.0 × 10.0 ㎣ CsI(Tl) array. These results show that the CsI(Tl) crystal array with low cost could be applied in the fields of medical imaging and high-resolution gamma camera.