ZIF-8 Modified Nanofiber Composite Window Screen for Efficient Indoor PM2.5 and Formaldehyde Removal

Fan Liu,Tong Lu,Wanjun Bu,Hewei Xiang,Junjie Yang,Junli Li,Xu Zhao,Weili Shao,Qingqing Ni,Jianxin He 한국섬유공학회 2022 Fibers and polymers Vol.23 No.8

Because people spend a lot of time indoors every day, the presence of particulate matter with a diameter less than2.5 μm (PM2.5) and volatile organic molecular substances in indoor air adversely affect public health. These toxic compoundscan be removed from the air using high-efficiency air-filter materials with adsorption capacity. Metal-organic frameworks(MOFs) are among the most suitable materials for air purification as they are synthetic porous materials with excellentadsorption ability. In this study, the zeolitic imidazolate framework-8 (ZIF-8) is uniformly grown on the surface ofpolyacrylonitrile (PAN) nanofibers using an in situ growth method to prepare ZIF-8@PAN nanofiber composite membranes. The nanofiber composite membrane effectively removes PM2.5 and formaldehyde from the air. After loading the optimalamount of ZIF-8, the filtration efficiency of the nanofiber membrane for salt aerosol with a diameter of 0.3 μm increases from90.3 % to 96.9 %, and the removal rate of formaldehyde becomes 98 % within 20 min in the enclosed space of the laboratory. Moreover, after five repeated tests, the formaldehyde adsorption rate remains above 80 %. In addition, ZIF-8@PANnanofiber membranes are used to fabricate anti-haze window screens, which have great potential to improve indoor airquality and mitigate related health risks.

The role of botulinum toxin type A related axon transport in neuropathic pain induced by chronic constriction injury

Huilian Bu,Pengfei Jiao,Xiaochong Fan,Yan Gao,Lirong Zhang,Haiming Guo 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.4

Background: The mechanism of peripheral axon transport in neuropathic pain is still unclear. Chemokine ligand 13 (CXCL13) and its receptor (C-X-C chemokine receptor type 5, CXCR5) as well as GABA transporter 1 (GAT-1) play an important role in the development of pain. The aim of this study was to explore the axonal transport of CXCL13/CXCR5 and GAT-1 with the aid of the analgesic effect of botulinum toxin type A (BTX-A) in rats. Methods: Chronic constriction injury (CCI) rat models were established. BTX-A was administered to rats through subcutaneous injection in the hind paw. The pain behaviors in CCI rats were measured by paw withdrawal threshold and paw withdrawal latencies. The levels of CXCL13/CXCR5 and GAT-1 were measured by western blots. Results: The subcutaneous injection of BTX-A relieved the mechanical allodynia and heat hyperalgesia induced by CCI surgery and reversed the overexpression of CXCL13/CXCR5 and GAT-1 in the spinal cord, dorsal root ganglia (DRG), sciatic nerve, and plantar skin in CCI rats. After 10 mmol/L colchicine blocked the axon transport of sciatic nerve, the inhibitory effect of BTX-A disappeared, and the levels of CXCL13/CXCR5 and GAT-1 in the spinal cord and DRG were reduced in CCI rats. Conclusions: BTX-A regulated the levels of CXCL13/CXCR5 and GAT-1 in the spine and DRG through axonal transport. Chemokines (such as CXCL13) may be transported from the injury site to the spine or DRG through axonal transport. Axon molecular transport may be a target to enhance pain management in neuropathic pain.

수출 중소기업의 마케팅믹스요인이 마케팅성과에 미치는 영향

범경기(Fan Qing-ji),김원겸(Kim Won-Kyum),맹부영(Maeng Bu-Young) 한국콘텐츠학회 2011 한국콘텐츠학회 종합학술대회 논문집 Vol.9 No.1

An Engineered Outer Membrane-Defective Escherichia coli Secreting Protective Antigens against Streptococcus suis via the Twin-Arginine Translocation Pathway as a Vaccine

( Wenyu Li ),( Fan Yin ),( Zixuan Bu ),( Yuying Liu ),( Yongqing Zhang ),( Xiabing Chen ),( Shaowen Li ),( Lu Li ),( Rui Zhou ),( Qi Huang ) 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.3

Live bacterial vector vaccines are one of the most promising vaccine types and have the advantages of low cost, flexibility, and good safety. Meanwhile, protein secretion systems have been reported as useful tools to facilitate the release of heterologous antigen proteins from bacterial vectors. The twin-arginine translocation (Tat) system is an important protein export system that transports fully folded proteins in a signal peptide-dependent manner. In this study, we constructed a live vector vaccine using an engineered commensal Escherichia coli strain in which amiA and amiC genes were deleted, resulting in a leaky outer membrane that allows the release of periplasmic proteins to the extracellular environment. The protective antigen proteins SLY, enolase, and Sbp against Streptococcus suis were targeted to the Tat pathway by fusing a Tat signal peptide. Our results showed that by exploiting the Tat pathway and the outer membrane-defective E. coli strain, the antigen proteins were successfully secreted. The strains secreting the antigen proteins were used to vaccinate mice. After S. suis challenge, the vaccinated group showed significantly higher survival and milder clinical symptoms compared with the vector group. Further analysis showed that the mice in the vaccinated group had lower burdens of bacteria load and slighter pathological changes. Our study reports a novel live bacterial vector vaccine that uses the Tat system and provides a new alternative for developing S. suis vaccine.

Effect of Iron Ore Tailings Replacing Porous Basalt on Properties of Cement Stabilized Macadam

Qifang Ren,Fan Bu,Qinglin Huang,Haijun Yin,Yuelei Zhu,Rui Ma,Yi Ding,Libing Zhang,Jingchun Li,Lin Ju,Yanyan Wang,Wei Xu,Haixia Ji,Won-Chun Oh 한국재료학회 2024 한국재료학회지 Vol.34 No.6

In this paper, iron ore tailings (IOT) were separated from the tailings field and used to prepare cement stabilized macadam (CSM) with porous basalt aggregate. First, the basic properties of the raw materials were studied. Porous basalt was replaced by IOT at ratios of 0, 20 %, 40 %, 60 %, 80 %, and 100 % as fine aggregate to prepare CSM, and the effects of different cement dosage (4 %, 5 %, 6 %) on CSM performance were also investigated. CSM’s durability and mechanical performance with ages of 7 d, 28 d, and 90 d were studied with the unconfined compression strength test, splitting tensile strength test, compressive modulus test and freeze-thaw test, respectively. The changes in Ca2+ content in CSM of different ages and different IOT ratios were analyzed by the ethylene diamine tetraacetic acid (EDTA) titration method, and the micro-morphology of CSM with different ages and different IOT replaced ratio were observed by scanning electron microscopy (SEM). It was found that with the same cement dosage, the strengths of the IOT-replaced CSM were weaker than that of the porous basalt aggregate at early stage, and the strength was highest at the replaced ratio of 60 %. With a cement dosage of 4 %, the unconfined compressive strength of CSM without IOT was increased by 6.78 % at ages from 28 d to 90 d, while the splitting tensile strength increased by 7.89 %. However, once the IOT replaced ratio reached 100 %, the values increased by about 76.24 % and 17.78 %, which was better than 0 % IOT. The CSM-IOT performed better than the porous basalt CSM at 90 d age. This means IOT can replace porous basalt fine aggregate as a pavement base.

MCPH1 Protein Expression in Normal and Neoplastic Lung Tissues

Zhang, Ji,Wu, Xiao-Bin,Fan, Jian-Jun,Mai, Li,Cai, Wei,Li, Dan,Yuan, Cheng-Fu,Bu, You-Quan,Song, Fang-Zhou Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Lung cancer is the most common cause of cancer-related death in the world. The main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC), the latter including squamous cell carcinoma (SCC), adenocarcinoma and large cell carcinoma. NSCLCs account for about 80% of all lung cancer cases. Microcephalin (MCPH1), also called BRIT1 (BRCT-repeat inhibitor of hTERT expression), plays an important role in the maintenance of genomic stability. Recently, several studies have provided evidence that the expression of MCPH1 gene is decreased in several different types of human cancers. We evaluated the expression of protein MCPH1 in 188 lung cancer and 20 normal lung tissues by immunohistochemistry. Positive MCPH1 staining was found in all normal lung samples and only some cancerous tissues. MCPH1-positive cells were significantly lower in lung carcinoma compared with normal tissues. Furthermore, we firstly found that MCPH1 expression in lung adenocarcinoma is higher than its expression in squamous cell carcinoma. Change in MCPH1 protein expression may be associated with lung tumorigenesis and may be a useful biomarker for identification of pathological types of lung cancer.

Clinical and Prognostic Significance of SOX11 in Breast Cancer

Liu, Dao-Tong,Peng-Zhao, Peng-Zhao,Han, Jing-Yan,Lin, Fan-Zhong,Bu, Xian-Min,Xu, Qing-Xia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Recently, the transcription factor SOX11 has gained extensive attention as a diagnostic marker in a series of cancers. However, to date, the possible roles of SOX11 in breast cancer has not been investigated. In this study, immunohistochemical staining for SOX11 was performed for 116 cases of breast cancer. Nuclear SOX11 was observed in 42 (36.2%) and cytoplasmic SOX11 in 52 (44.8%) of breast cancer samples. Moreover, high expression of cytoplasmic and nuclear SOX11 was associated with clinicopathological factors, including earlier tumor grade, absence of lymph node metastasis and smaller tumor size. Kaplan-Meier survival curves demonstrated high nuclear SOX11 expression to be associated with more prolonged overall survival than those with low expression and it could be an independent predictor of survival for breast cancer patients. It is worthwhile to note that cytoplasmic SOX11 was not correlated with prognosis of breast cancer patients. These data suggest the possibility that nuclear SOX11 could be as a potential target for breast cancer therapy.

Influence of Polyurethane Polymer on the Strength and Mechanical Behavior of Sand-root Composite

Jin Liu,Zhihao Chen,Zhaojun Zeng,Debi Prasanna Kanungo,Fan Bu,Yuxia Bai,Changqing Qi,Wei Qian 한국섬유공학회 2020 Fibers and polymers Vol.21 No.4

Vegetation has good application in slope stabilization, but its beneficial effects on reinforcing topsoil are generallylimited by the soil properties it was cultivated in. This study aims at evaluating the strength improvements of sand-rootcomposite by treating with polyurethane polymer and hence investigating the mechanism of polymer-root-soil interactions. Vegetation roots were selected and mixed with dry sand and polymer solution to prepare remolded specimens. A series ofexperimental tests were then performed at different percentages of root content (0, 0.4, 0.8, 1.2, and 1.6 % by weight of drysand) and polymer content (1, 2, and 4 % by weight of dry sand) to evaluate the shear parameters and unconfinedcompressive strength (UCS). The combined mechanism was studied by scanning electron microscopy (SEM) images. Theresults showed that the strengthening effect has greater efficiency with higher polymer content. Through varying contents ofvegetation root, it was found that low root content induced an undesirable weakening effect on the strength of the treated soil. However, this situation was somewhat improved with the increase in root content. The good flexibility of polymers not onlypromote the capacity of soil to energy absorption, but also impart good ductility to soil. The presence of polymers greatlystrengthens soil stability due to its special network structure, by which the improved shear resistance at the root-soil interfaceprovides sufficient anchorage effect for the tensile strength of roots to be fully mobilized. Overall, the synergistic effect ofroot reinforcement and polymer treatment has the potential for its use in soil stabilization.

Electrospun PS/PAN Nanofiber Membranes Formed from Doped Carbon Nanotubes with a Fluffy and Multi-scale Construction for Air-Filtration Materials

Weili Shao,Wanli Yue,Gaihuan Ren,Chen Cui,Junpeng Xiong,Ling Wang,Tong Lu,Wanjun Bu,Fan Liu,Jianxin He 한국섬유공학회 2022 Fibers and polymers Vol.23 No.5

Electrospun nanofibers are widely used in air-filtration materials because of their fine fiber diameter, small poresize, and high porosity. However, nanofiber membranes exhibit a dense structure, such that they present a large resistance toany air flow. In this study, we set out to design and develop composite nanofiber materials with fluffy structures, as well asblended structures of coarse and fine fibers, through electrospinning technology. These materials could be used in airfiltration applications, given that they offer high efficiency and low resistance. The results show that, compared with purePAN nanofibers, the diameter of PAN nanofibers doped with CNT decreased from 192.36 to 124.37 nm; when the spinningratio of PS coarse fiber (1053 nm) and PAN/CNT fine fiber is 3:1, the resulting nanofiber membrane materials has an obviousthree-dimensional structure, with a specific surface area of 103.16 m2/g, a pore size of 2.25 μm, and a quality factor of0.0947 Pa-1. Under test conditions featuring an air flow of 32 L/min, and 0.3 μm NaCl aerosol particles, the filtrationefficiency was 99.37 % and the resistance was 35 Pa. Furthermore, the dust-holding capacity of the nanofiber air-filter paperwas found to be almost the same as that of melt-blown air-filter papers. Even after being water-soaked 50 times, the filteringefficiency of the nanofiber air-filter paper was still higher. Interestingly, the nanofiber membrane materials doped with CNTalso exhibited excellent sound-absorption abilities. Thus, the composite nanofiber material could potentially be applied toareas with serious air pollution and high noise pollution.