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Song, Eunjung,Yang, Yung-Hun,Lee, Bo-Rahm,Kim, Eun-Jung,Kim, Ji-Nu,Park, Sung-Soo,Lee, Kwangwon,Kim, Woo-Seong,You, Sungyong,Hwang, Daehee,Kim, Byung-Gee De Gruyter 2010 Pure and Applied Chemistry Vol.82 No.1
<P>In an age of burgeoning information on genomes and proteomes, determining the specific functions of a gene of interest is still a challenging task, especially genes whose functions cannot be predicted from their sequence information alone. To solve this problem, we have developed an integrative approach for discovering novel transcriptional regulators (TRs) playing critical roles in antibiotic production and decoding their regulatory networks in<I>Streptomyces</I>species which contain many regulatory genes for synthesis of secondary metabolites and cell differentiation to spores. The DNA affinity capture assay (DACA) coupled with clustering of DNA chip data was used to find new TRs controlling antibiotic biosynthetic gene clusters. Functions of these newly identified TRs were characterized using 96-well-based minimal media screening (antibiotic production mapping, APM), pH indicator method, comparative two-dimensional gel electrophoresis (2D-gel), reverse-transcription polymerase chain reaction (RT-PCR), electrophoretic mobility shift assay (EMSA), and scanning electron microscopy (SEM). Using these techniques, we were able to reconstruct a regulatory network describing how these new TRs collectively regulate antibiotic production. This proposed approach providing additional key regulators and their interactions to an existing incomplete regulatory network can also be applied in studying regulators in other bacteria of interest.</P>
벌칙가능도함수를 이용한 1인가구와 저소득 독거노인의 공간군집 탐색
송은정(Eunjung Song),이우주(Woojoo Lee) 한국데이터정보과학회 2017 한국데이터정보과학회지 Vol.28 No.6
최근 1인 가구가 급격히 증가하고 있으며, 그 증가의 원인 중 하나는 독거노인 수의 증가이다. 이러한 거주형태 변화는 필연적으로 정책적인 변화를 요구하므로 1인 가구의 공간적인 분포를 파악하는 것은 중요한 문제로 볼 수 있다. 또한 공간적인 군집이 나타나게 된 요인들에 대해 이해하는 것은 효율적인 정책 수립에 유리 할 것이다. 본 연구에서는 사회경제적인 불평등을 반영하는 박탈지수 (deprivation index)를 설명변수로 고려하면서 1인 가구와 저소득 독거노인에 대한 공간 군집 탐색을 하였다. 이를 위해서 fused lasso를 이용한 공간 군집 탐색방법이 사용되었다. 이 방법을 통하여 낮은 사회경제적 수준이 l인가구와 저소득 독거노인의 수에 얼마나 영향을 미치는지 확인하고, 박탈 정도의 효과가 보정된 공간군집을 살펴보았다. 또한 정수형 자료에서 벌칙가능도함수를 이용한 공간 군집 탐색을 할 수 있도록 구현된 R패키지의 사용법을 자세히 소개하였다. Single-person households recently have been rapidly increasing and one reason may be the increment in elderly single-person. Since the change of living patterns is relevant to the government policy direction, it is important to understand how single-person households are clustered and which factors have influence on them. In this study, we tried to detect spatial clusters of single-person households and low-income elderly single-person households after adjusting for deprivation index. A recently developed fused lasso for Poisson data was used for data analysis and we provided the details on how to use it in R. From these analysis results, we observed the effect of socioeconomic level on the clusters and explained the reason why spatial clusters are shown after adjusting for deprivation index.
Song, Nu Ry,Kim, Jong-Eun,Park, Jun Seong,Kim, Jong Rhan,Kang, Heerim,Lee, Eunjung,Kang, Young-Gyu,Son, Joe Eun,Seo, Sang Gwon,Heo, Yong Seok,Lee, Ki Won MDPI 2015 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.16 No.3
<P>Licorice is a traditional botanical medicine, and has historically been commonly prescribed in Asia to treat various diseases. Glycyrrhizin (Gc), a triterpene compound, is the most abundant phytochemical constituent of licorice. However, high intake or long-term consumption of Gc has been associated with a number of side effects, including hypertension. However, the presence of alternative bioactive compounds in licorice with anti-carcinogenic effects has long been suspected. Licochalcone A (LicoA) is a prominent member of the chalcone family and can be isolated from licorice root. To date, there have been no reported studies on the suppressive effect of LicoA against solar ultraviolet (sUV)-induced cyclooxygenase (COX)-2 expression and the potential molecular mechanisms involved. Here, we show that LicoA, a major chalcone compound of licorice, effectively inhibits sUV-induced COX-2 expression and prostaglandin E2 PGE<SUB>2</SUB> generation through the inhibition of activator protein 1 AP-1 transcriptional activity, with an effect that is notably more potent than Gc. Western blotting analysis shows that LicoA suppresses sUV-induced phosphorylation of Akt/ mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinases (ERK)1/2/p90 ribosomal protein S6 kinase (RSK) in HaCaT cells. Moreover, LicoA directly suppresses the activity of phosphoinositide 3-kinase (PI3K), mitogen-activated protein kinase kinase (MEK)1, and B-Raf, but not Raf-1 in cell-free assays, indicating that PI3K, MEK1, and B-Raf are direct molecular targets of LicoA. We also found that LicoA binds to PI3K and B-Raf in an ATP-competitive manner, although LicoA does not appear to compete with ATP for binding with MEK1. Collectively, these results provide insight into the biological action of LicoA, which may have potential for development as a skin cancer chemopreventive agent.</P>
Song, Eun-Hye,Jeong, Jaesik,Park, Clara Yongjoo,Kim, Han-Yong,Kim, Eun-Hee,Bang, Eunjung,Hong, Young-Shick Elsevier 2018 Food Research International Vol.111 No.-
<P><B>Abstract</B></P> <P>Rice (<I>Oryza sativa</I> L.), the major staple food in many countries, has genetic diversity adapted to different environmental conditions. However, metabolic traits about diverse rice plants are rarely discovered. In the present study, rice leaves and grains were collected at whole growth stages from late (LMC) and early (EMC) maturing cultivars. Metabolic dependences of rice plants on both growth and cultivar were investigated in their leaves and grains through NMR-based metabolomics approach. Rice leaf metabolome were differently regulated between two rice cultivars, thereby affecting variations of rice grain metabolome. Sucrose levels in leaves of EMC were markedly decreased compared to those in LMC, and more accumulations of sucrose, amino acids and free fatty acids were found in grains of EMC. These distinct metabolisms between EMC and LMC rice cultivars were associated with temperature during their growing seasons and might affect the eating quality of rice. The current study highlights that metabolomic approach of rice leaves and grains could lead to better understanding of the relationship between their distinct metabolisms and environmental conditions, and provide novel insights to metabolic qualities of rice grains.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Dependences of rice leaf and grain metabolome on growth and cultivar were found. </LI> <LI> Metabolic variations of rice leaves and grains were associated with temperature. </LI> <LI> Metabolism in rice leaf affects rice grain metabolism. </LI> <LI> Rice grain metabolome could predict eating quality of rice. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Optimal geometry toward uniform current density electrodes
Song, Yizhuang,Lee, Eunjung,Woo, Eung Je,Seo, Jin Keun Institute of Physics 2011 Inverse problems Vol.27 No.7
<P>Electrodes are commonly used to inject current into the human body in various biomedical applications such as functional electrical stimulation, defibrillation, electrosurgery, RF ablation, impedance imaging, and so on. When a highly conducting electrode makes direct contact with biological tissues, the induced current density has strong singularity along the periphery of the electrode, which may cause painful sensation or burn. Especially in impedance imaging methods such as the magnetic resonance electrical impedance tomography, we should avoid such singularity since more uniform current density underneath a current-injection electrode is desirable. In this paper, we study an optimal geometry of a recessed electrode to produce a well-distributed current density on the contact area under the electrode. We investigate the geometry of the electrode surface to minimize the edge singularity and produce nearly uniform current density on the contact area. We propose a mathematical framework for the uniform current density electrode and its optimal geometry. The theoretical results are supported by numerical simulations.</P>
( Eunjung Ko ),( Hyun Il Jang ),( Sun Duk Hwang ),( Joon Ho Song ),( Seung Woo Lee ),( Moon-jae Kim ) 대한내과학회 2016 대한내과학회 추계학술발표논문집 Vol.2016 No.1
Posterior reversible encephalopathy syndrome (PRES) is characterized by a clinical and radiological entity with seizure, headache, hypertension, visual loss and encephalopathy with neuroimaging findings of reversible vasogenic subcortical edema. The co-morbid conditions is hypertension, renal disease, autoimmune disease, eclampsia and transplantation. A 42-year-old woman was admitted to our hospital with complaint of sudden onset of seizure. Her blood pressure is 210/110mmHg and mental is drowsy state. After this episode she compained of blindness for a few days. Brain MRI showed multifocal edema in bilateral occipital lobe, frontoparietal lobe. In several hypertensive work-up studies, renal doppler ultrasonography showed stenosis of right renal artery. Segmental stenosis in right renal artery was demonstrated by renal angiography. We performed stent insertion in renal artery narrowing portion. Her blood pressure was maintained less than 140/80mmHg without the antihypertensive drugs. PRES was induced by renal hypertension and it’s cause was right renal artery stenosis. Here we report a rare case of renal artery stnenosis with complication of PRES.