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Zheng Liu,Jianjun Chen,Lei Cheng,Huabin Li,Shixi Liu,Hongfei Lou,Jianbo Shi,Ying Sun,Dehui Wang,Chengshuo Wang,Xiangdong Wang,Yongxiang Wei,Weiping Wen,Pingchang Yang,Qintai Yang,Gehua Zhang,Yuan Zhan 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.2
The current document is based on a consensus reached by a panel of experts from the Chinese Society of Allergy and the Chinese Society of Otorhinolaryngology-Head and Neck Surgery, Rhinology Group. Chronic rhinosinusitis (CRS) affects approximately 8% of Chinese adults. The inflammatory and remodeling mechanisms of CRS in the Chinese population differ from those observed in the populations of European descent. Recently, precision medicine has been used to treat inflammation by targeting key biomarkers that are involved in the process. However, there are no CRS guidelines or a consensus available from China that can be shared with the international academia. The guidelines presented in this paper cover the epidemiology, economic burden, genetics and epigenetics, mechanisms, phenotypes and endotypes, diagnosis and differential diagnosis, management, and the current status of CRS in China. These guidelines—with a focus on China—will improve the abilities of clinical and medical staff during the treatment of CRS. Additionally, they will help international agencies in improving the verification of CRS endotypes, mapping of eosinophilic shifts, the identification of suitable biomarkers for endotyping, and predicting responses to therapies. In conclusion, these guidelines will help select therapies, such as pharmacotherapy, surgical approaches and innovative biotherapeutics, which are tailored to each of the individual CRS endotypes.
Bivariate zero truncated Poisson INAR(1) process
Yan Liu,Dehui Wang,Haixiang Zhang,Ningzhong Shi 한국통계학회 2016 Journal of the Korean Statistical Society Vol.45 No.2
In this paper, we propose a new stationary bivariate first order integer-valued autoregressive (BINAR(1)) process with zero truncated Poisson marginal distribution. Some properties about this process are considered, such as probability generating function, autocorrelations, expectations and covariance matrix under conditional and unconditional situation. We also establish the strict stationarity and ergodicity of the process. Estimators of unknown parameters are derived by using Yule–Walker, conditional least squares and maximum likelihood methods. The performance of the proposed estimation procedures are evaluated through Monte Carlo simulations. An application to a real data example is also provided.
Yongfu Qiu,Xiaozhen Jiao,Dehui Hu,Fang Liu,Fengkuan Huang,Rongbai Li 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.3
A total of 320 ESTs (Expressed Sequence Tags, 12.8%) of rice planthoppers were identified to carry SSR (Simple Sequence Repeat) motifs from2491 ESTs downloaded frompublic database, and 397 pairs of brown planthopper (BPH; Nilaparvata lugens Stål) and 25 pairs ofwhite-backed planthopper (WBPH; Sogatella furcifera) (Hemiptera: Delphacidae) EST-SSR were detected based on the motifs. The dinucleotide repeat was the dominant type with repeat motif AG/GA/TC/CT; and the trinucleotide repeat was the style of AAG/AGA/GAA/TTC/TCT/CTT among the BPH repeat motifs. A total of 20 EST-SSRs (16 developed in the present study and four fromprevious studies) were applied to survey the genetic diversity of the 15 rice planthoppers. Consequently, 18 pairs of primer amplifies clear, dominant and polymorphic gel bands among the collected planthoppers population; one ESTSSR amplified a single gel band; and one had no result. Furthermore, a total of 227 bands were produced by the selected 19 pairs of primers, of which 207 bands (91.2%) were polymorphic among the test insect populations. Genetic diversity analysis suggested that the BPH populations from Cuu Long, Thailand and Ho Chi Minh were clustered, respectively; and Hue and Long Xuyen were composed into one class; the others were clustered together when the similar coefficient was 0.76. The results show that it is an effective and available approach to develop SSR markers based on ESTs in rice planthoppers; and also the developed EST-SSR markers could detect the genetic diversity of the planthoppers population, which would be beneficial for rice planthoppers control strategy. ©
Zhong-Hua Pang,Guo-Ping Liu,Donghua Zhou,Dehui Sun 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.1
This paper is concerned with the design and performance analysis of networked control systems, whererandom network-induced delay, packet disorder, and packet dropout in the feedback and forward channels areconsidered simultaneously and further treated as the round-trip time (RTT) delay. To actively compensate forthe RTT delay, a networked predictive control scheme is designed based on the input-output difference equationmodel. For time-varying reference signals, the resulting closed-loop system can achieve the same output trackingperformance and closed-loop stability as the corresponding local control system. Specifically, for the step referenceinput, it can provide a zero steady-state output tracking error. The controller design problem is solved by usingthe augmented state-space model as well as the static output feedback strategy. In addition, the stability of theclosed-loop system is also discussed for the plant subject to bounded disturbances and modelling errors. Finally,simulation and experimental results are given to demonstrate the effectiveness of the proposed method.
Genetic diversity and selection of Tibetan sheep breeds revealed by whole-genome resequencing
Dehong Tian,Buying Han,Xue Li,Dehui Liu,Baicheng Zhou,Chunchuan Zhao,Nan Zhang,Lei Wang,Quanbang Pei,Kai Zhao Asian Australasian Association of Animal Productio 2023 Animal Bioscience Vol.36 No.7
Objective: This study aimed to elucidate the underlying gene regions responsible for productive, phenotypic or adaptive traits in different ecological types of Tibetan sheep and the discovery of important genes encoding valuable traits. Methods: We used whole-genome resequencing to explore the genetic relationships, phylogenetic tree, and population genetic structure analysis. In addition, we identified 28 representative Tibetan sheep single-nucleotide polymorphisms (SNPs) and genomic selective sweep regions with different traits in Tibetan sheep by fixation index (Fst) and the nucleotide diversity (θπ) ratio. Results: The genetic relationships analysis showed that each breed partitioned into its own clades and had close genetic relationships. We also identified many potential breed-specific selective sweep regions, including genes associated with hypoxic adaptability (MTOR, TRHDE, PDK1, PTPN9, TMTC2, SOX9, EPAS1, PDGFD, SOCS3, TGFBR3), coat color (MITF, MC1R, ERCC2, TCF25, ITCH, TYR, RALY, KIT), wool traits (COL4A2, ERC2, NOTCH2, ROCK1, FGF5, SOX9), and horn phenotypes (RXFP2). In particular, a horn-related gene, RXFP2, showed the four most significantly associated SNP loci (g. 29481646 A>G, g. 29469024 T>C, g. 29462010 C>T, g. 29461968 C>T) and haplotypes. Conclusion: This finding demonstrates the potential for genetic markers in future molecular breeding programs to improve selection for horn phenotypes. The results will facilitate the understanding of the genetic basis of production and adaptive unique traits in Chinese indigenous Tibetan sheep taxa and offer a reference for the molecular breeding of Tibetan sheep.
Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis
Lei Cheng,Jianjun Chen,Qingling Fu,Shaoheng He,Huabin Li,Zheng Liu,Guolin Tan,Zezhang Tao,Dehui Wang,Weiping Wen,Rui Xu,Yu Xu,Qintai Yang,Chonghua Zhang,Gehua Zhang,Ruxin Zhang,Yuan Zhang,Bing Zhou,Do 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.4
Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2-3 decades in developing countries including China, with the prevalence of AR varying widely in these countries. A survey of self-reported AR over a 6-year period in the general Chinese adult population reported that the standardized prevalence of adult AR increased from 11.1% in 2005 to 17.6% in 2011. An increasing number of original articles and imporclinical trials on the epidemiology, pathophysiologic mechanisms, diagnosis, management and comorbidities of AR in Chinese subjects have been published in international peer-reviewed journals over the past 2 decades, and substantially added to our understanding of this disease as a global problem. Although guidelines for the diagnosis and treatment of AR in Chinese subjects have also been published, they have not been translated into English and therefore not generally accessible for reference to non-Chinese speaking international medical communities. Moreover, methods for the diagnosis and treatment of AR in China have not been standardized entirely and some patients are still treated according to regional preferences. Thus, the present guidelines have been developed by the Chinese Society of Allergy to be accessible to both national and international medical communities involved in the management of AR patients. These guidelines have been prepared in line with existing international guidelines to provide evidence-based recommendations for the diagnosis and management of AR in China.