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( Hank S. Wang ),( David S. Oh ),( Ariana Anderson ),( Jose Nieto ),( Phuong Tien ),( Gordon Ohning ),( Joseph R. Pisegna ) 대한소화기기능성질환·운동학회 2008 Gut and Liver Vol.2 No.1
Background/Aims: Nocturnal reflux is a largely undiagnosed and unmanaged condition predisposing to multiple esophageal complications. We evaluated the effects of rabeprazole and pantoprazole on nocturnal intragastric pH and gastric acid output during Day 1 of therapy following the consumption of standard meals. Methods: The study had a double-blinded, randomized, two-way crossover design, and involved 15 patients with a history of mild reflux. Following an overnight fast, patients were given either rabeprazole (20 mg) or pantoprazole (40 mg) prior to the first of three standard Western meals. They then underwent overnight continuous intragastric pH monitoring and gastric acid output measurement. The drug effect was analyzed using a two-treatment, two-period crossover mixed model. Results: The percentage of time during which the mean intragastric pH was greater than 4.0 and gastric acid output was less than 2.0 was higher for oral rabeprazole (p<0.05). The inhibition of acid output was greater for rabeprazole at almost all time points. Furthermore, the mean time-matched pH values differed significantly over the first 8.3 hours (p <0.05). Conclusions: On day 1, oral rabeprazole inhibited acid output to a greater extent and for a longer period than pantoprazole, and the intragastric pH was significantly higher for rabeprazole than for pantoprazole over the first 8.3 hours. (Gut and Liver 2008;2:30-38)
Young-Eun C Lee,David R Williams,Jacqueline F I Anderson 대한파킨슨병및이상운동질환학회 2018 Journal Of Movement Disorders Vol.11 No.2
Introduction: Clinicopathological studies over the last decade have broadened the clinical spectrum of progressive supranclear palsy (PSP) to include several distinct clinical syndromes. We examined the cognitive profiles of patients with PSP-Richardson’s syndrome (PSP-RS) and two atypical ‘brainstem predominant’ PSP phenotypes (PSP-Parkinsonism; PSP-P and PSP- Pure Akinesia with Gait Freezing; PSP-PAGF) using a comprehensive neuropsychological battery. Methods: Fourteen patients diagnosed as PSP-RS, three patients with PSP-P and four patients with PSP-PAGF were assessed using a comprehensive battery of neuropsychological tests. Results: The classic PSP-RS subgroup demonstrated greater impairments in processing speed, t (19) = -4.10, p = 0.001 (d = 1.66), and executive function, t (19) = -2.63, p = 0.02 (d = 1.20) compared to the ‘brainstem predominant’ PSP phenotypes. Conclusion: This is the first prospective study to demonstrate that PSP-RS and ‘brainstem predominant’ PSP phenotypes can be differentiated on cognitive grounds. These differences correspond with variations in pathological profile reported in the literature.
Kim, Soochan,Han, Sinsuk,Withers, David R.,Gaspal, Fabrina,Bae, Jingyu,Baik, Song,Shin, Hyun‐,Chool,Kim, Kyung‐,Su,Bekiaris, Vasileios,Anderson, Graham,Lane, Peter,Kim, Mi‐,Yeon WILEY‐VCH Verlag 2011 European journal of immunology Vol.41 No.6
<P><B>Abstract</B></P><P>Here, we identify cells within human adult secondary lymphoid tissues that are comparable in phenotype and location to the lymphoid tissue inducer (LTi) cells that persist in the adult mouse. Identified as CD117<SUP>+</SUP>CD3<SUP>−</SUP>CD56<SUP>−</SUP> cells, like murine LTi cells, they lack expression of many common lineage markers and express CD127, OX40L and TRANCE. These cells were detected at the interface between the B‐ and T‐ zones, as well as at the subcapsular sinus in LNs, the location where LTi cells reside in murine spleen and LNs. Furthermore, like murine LTi cells, these cells expressed high levels of IL‐22 and upregulated IL‐22 expression upon IL‐23 stimulation. Importantly, these cells were not an NK cell subset since they showed no expression of IFN‐γ and perforin. Interestingly, a subset of the CD117<SUP>+</SUP>CD3<SUP>−</SUP>CD56<SUP>−</SUP>OX40L<SUP>+</SUP> population expressed NKp46, again similar to recent findings in mice. Finally, these cells supported memory CD4<SUP>+</SUP> T‐cell survival in an OX40L‐dependent manner. Combined, these data indicate that the CD117<SUP>+</SUP>CD3<SUP>−</SUP>CD56<SUP>−</SUP>OX40L<SUP>+</SUP> cells in human secondary lymphoid tissues are comparable in phenotype, location and function to the LTi cells that persist within adult murine secondary lymphoid tissues.</P>
Synergistic OX40 and CD30 signals sustain CD8<sup>+</sup> T cells during antigenic challenge
Bekiaris, Vasileios,Gaspal, Fabrina,Kim, Mi‐,Yeon,Withers, David R.,Sweet, Clive,Anderson, Graham,Lane, Peter J. L. WILEY‐VCH Verlag 2009 European journal of immunology Vol.39 No.8
<P><B>Abstract</B></P><P>Prior to acquiring a memory phenotype, antigen‐activated CD8<SUP>+</SUP> T cells need to expand and then undergo a contraction phase. Utilizing two different antigenic stimuli, we provide evidence that the tumor necrosis factor receptors OX40 and CD30 integrate synergistic signals during the expansion phase to help maintain CD8<SUP>+</SUP> effectors. Thus, double deficiency in OX40 and CD30 leads to CD8<SUP>+</SUP> cell loss during expansion after immunization either with OVA or with murine CMV. Following their contraction, OX40‐ and CD30‐deficient CD8<SUP>+</SUP> T cells persist normally in CMV‐infected mice. In contrast, persistence after OVA challenge is dependent on OX40 and CD30. Collectively, our data define the important role of both OX40 and CD30 during CD8<SUP>+</SUP> T‐cell activation, and show that long‐term CD8 persistence after contraction is regulated not only by stimulatory receptors but also by the nature of the antigen or how the antigen is presented.</P>
Lee, Kyu-Tae,Yao, Yuan,He, Junwen,Fisher, Brent,Sheng, Xing,Lumb, Matthew,Xu, Lu,Anderson, Mikayla A.,Scheiman, David,Han, Seungyong,Kang, Yongseon,Gumus, Abdurrahman,Bahabry, Rabab R.,Lee, Jung Woo,P National Academy of Sciences 2016 Proceedings of the National Academy of Sciences Vol.113 No.51
<P>Emerging classes of concentrator photovoltaic (CPV) modules reach efficiencies that are far greater than those of even the highest performance flat-plate PV technologies, with architectures that have the potential to provide the lowest cost of energy in locations with high direct normal irradiance (DNI). A disadvantage is their inability to effectively use diffuse sunlight, thereby constraining widespread geographic deployment and limiting performance even under the most favorable DNI conditions. This study introduces a module design that integrates capabilities in flat-plate PV directly with the most sophisticated CPV technologies, for capture of both direct and diffuse sunlight, thereby achieving efficiency in PV conversion of the global solar radiation. Specific examples of this scheme exploit commodity silicon (Si) cells integrated with two different CPV module designs, where they capture light that is not efficiently directed by the concentrator optics onto large-scale arrays of miniature multi-junction (MJ) solar cells that use advanced III-V semiconductor technologies. In this CPV+ scheme ('+' denotes the addition of diffuse collector), the Si and MJ cells operate independently on indirect and direct solar radiation, respectively. On-sun experimental studies of CPV+ modules at latitudes of 35.9886 degrees N (Durham, NC), 40.1125 degrees N (Bondville, IL), and 38.9072 degrees N (Washington, DC) show improvements in absolute module efficiencies of between 1.02% and 8.45% over values obtained using otherwise similar CPV modules, depending on weather conditions. These concepts have the potential to expand the geographic reach and improve the cost-effectiveness of the highest efficiency forms of PV power generation.</P>