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Structure-Based Insight on the Mechanism of N-Glycosylation Inhibition by Tunicamycin
Danbi Yoon,Ju Heun Moon,Anna Cho,Hyejoon Boo,Jeong Seok Cha,Yoonji Lee,Jiho Yoo Korean Society for Molecular and Cellular Biology 2023 Molecules and cells Vol.46 No.6
N-glycosylation, a common post-translational modification, is widely acknowledged to have a significant effect on protein stability and folding. N-glycosylation is a complex process that occurs in the endoplasmic reticulum (ER) and requires the participation of multiple enzymes. GlcNAc-1-P-transferase (GPT) is essential for initiating N-glycosylation in the ER. Tunicamycin is a natural product that inhibits N-glycosylation and produces ER stress, and thus it is utilized in research. The molecular mechanism by which GPT triggers N-glycosylation is discussed in this review based on the GPT structure. Based on the structure of the GPT-tunicamycin complex, we also discuss how tunicamycin reduces GPT activity, which prevents N-glycosylation. This review will be highly useful for understanding the role of GPT in the N-glycosylation of proteins, as well as presents a potential for considering tunicamycin as an antibiotic treatment.
Danbi Jo,Yoon Seok Jung,Juhyun Song 한국임상영양학회 2023 Clinical Nutrition Research Vol.12 No.2
Hepatic encephalopathy (HE) associated with liver failure is accompanied by hyperammonemia, severe inflammation, depression, anxiety, and memory deficits as well as liver injury. Recent studies have focused on the liver-brain-inflammation axis to identify a therapeutic solution for patients with HE. Lipocalin-2 is an inflammation-related glycoprotein that is secreted by various organs and is involved in cellular mechanisms including iron homeostasis, glucose metabolism, cell death, neurite outgrowth, and neurogenesis. In this study, we investigated that the roles of lipocalin-2 both in the brain cortex of mice with HE and in Neuro-2a (N2A) cells. We detected elevated levels of lipocalin-2 both in the plasma and liver in a bile duct ligation mouse model of HE. We confirmed changes in cytokine expression, such as interleukin-1β, cyclooxygenase 2 expression, and iron metabolism related to gene expression through AKT-mediated signaling both in the brain cortex of mice with HE and N2A cells. Our data showed negative effects of hepatic lipocalin-2 on cell survival, iron homeostasis, and neurite outgrowth in N2A cells. Thus, we suggest that regulation of lipocalin-2 in the brain in HE may be a critical therapeutic approach to alleviate neuropathological problems focused on the liver-brain axis.
The sex and age dependant differences in ECG values in C57BL6/N mice
Danbi Ka,Jieun Kim,Eun-Kyoung Kim,Hae-Rim Kim,Sang-Mi Cho,Seulgi Park,Faiz Ur Rahman,Mini Lee,Ki-Hoon Lee,Hoyoung Ghang,Won-Kee Yoon,Young-Suk Won,Hyoung-Chin Kim,Kyoung-Chul Choi,Ki-Hoan Nam 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Eelectrocardiogram (ECG) is a surface recording of the electric current passing through the heart, revealing the electrical activity associated with each heartbeat, and allowing visualization of the electrical state of the heart. In a state of consciousness, normal rat heart rates range from 500 to 700 beats per minute (bpm). ECG reflects the cycle of the heart and consists of P, Q, R, S and T waves. The non-invasive ECG system has the advantage of acquiring information not only on heart rate, but also on heart rate variability, RR, QT and PR intervals, as well as acquiring cardiac abnormalities in conscious animals. In this study, we conducted experiments ECG analysis with 12 weeks and 56 weeks aged male and female C57BL/6N mice. We compared the ECG values between male and female mice and between 12 weeks and 56 weeks aged mice, comparing age and gender differences. There were sex differences in HR and RR in 12 weeks aged mice and in HR and QRS in 56 weeks aged mice. We also found age dependant differences in QRS, ST, HR and RR in male mice and in PR, ST and QTc in female mice. These result indicate that there is age and sex differences in ECG values.
Danbi Jo,Seo Yeon Ahn,Seo Yoon Choi,Yoonjoo Choi,Dong Hoon Lee,Juhyun Song 한국임상영양학회 2024 Clinical Nutrition Research Vol.13 No.2
The prevalence of metabolic syndrome caused by diets containing excessive fatty acids is increasing worldwide. Patients with metabolic syndrome exhibit abnormal lipid profiles, chronic inflammation, increased levels of saturated fatty acids, impaired insulin sensitivity, excessive fat accumulation, and neuropathological issues such as memory deficits. In particular, palmitic acid (PA) in saturated fatty acids aggravates inflammation, insulin resistance, impaired glucose tolerance, and synaptic failure. Recently, adiponectin, brainderived neurotrophic factor (BDNF), and glucose-like peptide-1 (GLP-1) have been investigated to find therapeutic solutions for metabolic syndrome, with findings suggesting that they are involved in insulin sensitivity, enhanced lipid profiles, increased neuronal survival, and improved synaptic plasticity. We investigated the effects of adiponectin, BDNF, and GLP-1 on neurite outgrowth, length, and complexity in PA–treated primary cortical neurons using Sholl analysis. Our findings demonstrate the therapeutic potential of adiponectin, BDNF, and GLP-1 in enhancing synaptic plasticity within brains affected by metabolic imbalance. We underscore the need for additional research into the mechanisms by which adiponectin, BDNF, and GLP-1 influence neural complexity in brains with metabolic imbalances.
Younghyun Yoon,Danbi Choi,Jeongjin Roh IEEE 2015 IEEE journal of solid-state circuits Vol.50 No.10
<P>This paper presents a delta-sigma modulator operating at a supply voltage of 0.4 V. The designed delta-sigma modulator uses a proposed hybrid switching integrator and operates at a low supply voltage without clock boosting or bootstrapped switches. The proposed integrator consists of both switched-resistor and switched-capacitor operations and significantly reduces distortion at a low supply voltage. Variation in the turn-on resistance, which is the main source of distortion, is avoided by placing the switches at the virtual ground node of the amplifier. The proposed low-voltage design scheme can replace commonly-used clock boosting techniques, which rely on internal high-voltage generation circuits. A fabricated modulator achieves a 76.1 dB signal-to-noise-plus-distortion ratio (SNDR) and an 82 dB dynamic range at a 20 kHz bandwidth. The measured total power consumption is 63 mu W from a 0.4 V supply voltage. The measured results show robust SNDR performance, even at +/- 10% supply voltage variations. The measured results also show stable performance over a wide temperature range.</P>
조단비(Danbi Cho),최성경(Sungkyoung Choi),이원(Won Lee),오혜미(Haemi Oh),김소윤(So Yoon Kim) 대한약학회 2020 약학회지 Vol.64 No.3
The purpose of this study is to examine the perceptions of patient safety pharmacy education account of educator perspectives in order to provide basic materials for the development of patient safety education in pharmacy curriculum. For our research purpose, Key Informants Interview (KII) and Focus Group Interview (FGI) with one professor in college of pharmacy and five pharmacists who have experienced educating pharmacy undergraduate students were conducted and analyzed. KII and FGI analysis results were classified into three categories and ten subcategories. Our findings could suggest that we should develop practical educational contents and it should be closely linked with clinical practice in pharmacy students. Furthermore, securing faculty members with clinical experience and developing effective teaching method are important in order to successfully introduce patient safety in pharmacy curriculum. Based on the findings of this study, recommendations for implications and future research are given for the introduction of patient safety curriculum.