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Prevalence of Y chromosome microdeletions among infertile Mongolian men
Damdinsuren, Erdenesuvd,Naidansuren, Purevjargal,Gochoo, Mendsaikhan,Choi, Bum-Chae,Choi, Min-Youp,Baldandorj, Bolorchimeg The Korean Society for Reproductive Medicine 2022 Clinical and Experimental Reproductive Medicine Vol.49 No.2
Objective: Y chromosome microdeletions are the second most common genetic cause of male infertility after Klinefelter syndrome. The aim of this study was to determine the patterns of Y chromosome microdeletions among infertile Mongolian men. Methods: A descriptive study was performed on 75 infertile men from February 2017 to December 2018. Y chromosome microdeletions were identified by polymerase chain reaction. Semen parameters, hormonal levels, and testis biopsy samples were examined. Results: Among 75 infertile men, two cases of Y chromosome microdeletions were identified. The first case had an AZFa complete deletion and the other had an AZFc partial deletion. This study found that the proportion of Y chromosome microdeletions among infertile Mongolian men was 2.66%. Conclusion: The findings can be applied to in vitro fertilization and assisted reproductive technology, and our results will help clinicians improve treatment management for infertile Mongolian couples.
Damdinsuren Boldbaatar,Banzragch Battur,Rika Umemiya-Shirafuji,Min Liao,Tetsuya Tanaka,Kozo Fujisaki 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
Blood feeding tightly regulates the reproductive cycles in ticks. Vitellogenesis and nutritional signaling are a key event in the tick reproductive cycle. Here we report the identification of a Haemaphysalis longicornis GATA factor, (HlGATA), which is synthesized after a blood meal and acts as a transcriptional activator of vitellogenin (Vg). HlGATA shares structural similarity with other GATA factors of invertebrates and vertebrates. Tick GATA mRNA accumulated in the fat body and midgut prior to blood feeding. However, translation of GATA was activated by blood feeding because the GATA protein increased dramatically in engorged females. RNA interference (RNAi)-mediated knock down of GATA transcript resulted in a significant inhibition of Vg expression and effectively disrupts egg development after blood meal in engorged tick. In addition, HlGATA translation was inhibited by RNAi-mediated knock down of S6 kinase. These experiments have revealed that the GATA factor, which is the specific transcriptional activator of Vg gene, represents important molecule for tick reproduction.
Quintessence from virtual dark matter
Damdinsuren, Battsetseg,Sim, Jonghyun,Lee, Tae Hoon IOP 2017 Classical and quantum gravity Vol.34 No.17
<P>Considering a theory of Brans–Dicke gravity with general couplings of Higgs-like bosons including a non-renormalizable term, we derive the low-energy effective theory action in the Universe of a temperature much lower than the Higgs-like boson mass. Necessary equations containing gravitational field equations and an effective potential of the Brans–Dicke scalar field are obtained, which are induced through virtual interactions of the Higgs-like heavy field in the late-time Universe. We find a de Sitter cosmological solution with the inverse power law effective potential of the scalar field and discuss the possibility that the late-time acceleration of our Universe can be naturally explained by means of the solution. We also investigate stability properties of the quintessence model by using a linear approximation.</P>
Lipid Profile Investigation of Anti-HCV Positive Newly Diagnosed Diabetics in Eastern Mongolia
( Tsetsegmaa Damdinsuren ),( Ryenchindorj Erkhembayar ),( Saranchimeg Udirsaad ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Dyslipidemia prevalence is reported significantly higher in HCV patients, particularly among that viral RNA positive. In addition, chronic HCV infection is a known risk factor for developing diabetes in adults. Diabetes mellitus is a complex metabolic disorder that is profoundly associated with dyslipidemia and therefore could possibly share common pathophysiology through inflammation in the liver towards altering lipid metabolism. Mongolia has one of the highest HCV prevalence rates in the world, and at least 10% of the general population is expected to have HCV infection. With the rising impact of NCDs rate including obesity, we, therefore, aimed to examine the clinical relevance of dyslipidemia among diabetics and the role of HCV infection. Methods: We conducted a case-series analysis of newly diagnosed diabetic patients in the eastern-most province of Dornod, Mongolia. Participants were recruited from a cohort of 2019, were impaired fasting glucose initial diagnosis was made by primary healthcare centers. A total of 44 patients was included in the analysis for anthropometry, abdominal ultrasound, HBV and HCV serology, complete blood cell analysis, clinical chemistry including liver function tests, and viral load analysis. Consent forms were provided prior to investigation and statistical analysis was performed on GraphPad Prism 8.0 software. Continues variable were presented in Mean±SEM and the statistical significance level was set at P< 0.05. Results: Participants average age was 50.14±1.46 and male (56.8%) to female (43.2%) ratio was 1.32:1. Fasting glucose level, c peptide, insulin, and HBA1C did not differ between Anti-HCV positive and negative newly diagnosed diabetics (P >0.05). Among clinical lipid profiles, triglyceride levels were higher in the Anti-HCV positive population (P<0.05). HDL level was significantly lower in the Anti-HCV positive participants (P< 0.05). Meanwhile there was no difference in cholesterol and LDL levels (P >0.05). Conclusions: Triglyceride and HDL levels were significantly altered in HCV positive than Anti-HCV negative participants in this newly diagnosed diabetics cohort.