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An hp-angular adaptivity with the discrete ordinates method for Boltzmann transport equation
Dai Ni,Zhang Bin,Wang Xinyu,Lu Daogang,Chen Yixue 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.2
This paper describes an hp-angular adaptivity algorithm in the discrete ordinates method for Boltzmann transport applications with strong angular effects. This adaptivity uses discontinuous finite element quadrature sets with different degrees, which updates both angular mesh and the degree of the underlying discontinuous finite element basis functions, allowing different angular local refinement to be applied in space. The regular and goal-based error metrics are considered in this algorithm to locate some regions to be refined. A mapping algorithm derived by moment conservation is developed to pass the angular solution between spatial regions with different quadrature sets. The proposed method is applied to some test problems that demonstrate the ability of this hp-angular adaptivity to resolve complex fluxes with relatively few angular unknowns. Results illustrate that a reduction to approximately 1/50 in quadrature ordinates for a given accuracy compared with uniform angular discretization. This method therefore offers a highly efficient angular adaptivity for investigating difficult particle transport problems.
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Discontinuous finite-element quadrature sets based on icosahedron for the discrete ordinates method
Dai, Ni,Zhang, Bin,Chen, Yixue Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.6
The discrete ordinates method (S<sub>N</sub>) is one of the major shielding calculation method, which is suitable for solving deep-penetration transport problems. Our objective is to explore the available quadrature sets and to improve the accuracy in shielding problems involving strong anisotropy. The linear discontinuous finite-element (LDFE) quadrature sets based on the icosahedron (in short, ICLDFE quadrature sets) are developed by defining projected points on the surfaces of the icosahedron. Weights are then introduced in the integration of the discontinuous finite-element basis functions in the relevant angular regions. The multivariate secant method is used to optimize the discrete directions and their corresponding weights. The numerical integration of polynomials in the direction cosines and the Kobayashi benchmark are used to analyze and verify the properties of these new quadrature sets. Results show that the ICLDFE quadrature sets can exactly integrate the zero-order and first-order of the spherical harmonic functions over one-twentieth of the spherical surface. As for the Kobayashi benchmark problem, the maximum relative error between the fifth-order ICLDFE quadrature sets and references is only -0.55%. The ICLDFE quadrature sets provide better integration precision of the spherical harmonic functions in local discrete angle domains and higher accuracy for simple shielding problems.
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Dai, Hong-Liang,Rao, Yan-Ni Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.40 No.1
An analytical method is presented to investigate electromagnetothermoelastic behaviors of a hollow sphere composed of functionally graded piezoelectric material (FGPM), placed in a uniform magnetic field, subjected to electric, thermal and mechanical loads. For the case that material properties obey an identical power law in the radial direction of the FGPM hollow sphere, exact solutions for electric displacement, stresses, electric potential and perturbation of magnetic field vector in the FGPM hollow sphere are determined by using the infinitesimal theory of electromagnetothermoelasticity. Some useful discussion and numerical examples are presented to show the significant influence of material inhomogeneity. The aim of this research is to understand the effect of composition on electromagnetothermoelastic stresses and to design optimum FGPM hollow spheres.
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An Evaluation of m-Learning Effectiveness : English Vocabulary Apps in China
Zang Li ni,민대환(Dai hwan Min) 한국IT서비스학회 2017 한국IT서비스학회 학술대회 논문집 Vol.2017 No.1
Recently, with the rapid development of mobile technology, English vocabulary learning has entered a new stage. English vocabulary learning might become effective when a mobile app as a MALL (Mobile Assisted Language Learning) tool provides a new platform for learners of English as a foreign language. The purpose of this study is to find out whether the social sharing function and the image function have a positive effect on learning English vocabulary. This study consists of two steps: The first step has surveyed apps for learning English as a foreign language and found twenty-eight apps from app stores. Among them, sixteen apps have features for learning vocabulary. Main design principles of these apps are reward, social comparison sharing, image, self-monitoring, personalization, and reminder. At the second step, this study employs a quasi-experimental method to compare two apps, one with the social sharing function and the other with the image function. A pre-test of 233 middle school students in China was conducted in order to find out their usage of English vocabulary apps. About half of the students have some experiences in apps for English vocabulary learning. Two apps, ZhiMi and LeCi, were selected for a quasi-experiment. Total 134 students participated and were assigned into three groups for the two-month experiment. We are analyzing the learning effectiveness of the social comparison sharing function and the image function of English vocabulary app.
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Wen-Ling Dai,Xin-Tong Liu,Yi-Ni Bao,Bing Yan,Nan Jiang,Bo-Yang Yu,Ji-Hua Liu 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Morphine tolerance remains a challenge in the management of chronic pain in the clinic. As shown in our previous study, the dopamine D2 receptor (D2DR) expressed in spinal cord neurons might be involved in morphine tolerance, but the underlying mechanisms remain to be elucidated. In the present study, selective spinal D2DR blockade attenuated morphine tolerance in mice by inhibiting phosphatidylinositol 3 kinase (PI3K)/serine–threonine kinase (Akt)-mitogen activated protein kinase (MAPK) signaling in a μ opioid receptor (MOR)-dependent manner. Levocorydalmine (l-CDL), which exhibited micromolar affinity for D2DR in D2/CHO-K1 cell lines in this report and effectively alleviated bone cancer pain in our previous study, attenuated morphine tolerance in rats with chronic bone cancer pain at nonanalgesic doses. Furthermore, the intrathecal administration of l-CDL obviously attenuated morphine tolerance, and the effect was reversed by a D2DR agonist in mice. Spinal D2DR inhibition and l-CDL also inhibited tolerance induced by the MOR agonist DAMGO. l-CDL and a D2DR small interfering RNA (siRNA) decreased the increase in levels of phosphorylated Akt and MAPK in the spinal cord; these changes were abolished by a PI3K inhibitor. In addition, the activated Akt and MAPK proteins in mice exhibiting morphine tolerance were inhibited by a MOR antagonist. Intrathecal administration of a PI3K inhibitor also attenuated DAMGO-induced tolerance. Based on these results, l-CDL antagonized spinal D2DR to attenuate morphine tolerance by inhibiting PI3K/Akt-dependent MAPK phosphorylation through MOR. These findings provide insights into a more versatile treatment for morphine tolerance.
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Hong-Liang Dai,Yan-Ni Rao 국제구조공학회 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.40 No.1
An analytical method is presented to investigate electromagnetothermoelastic behaviors of a hollow sphere composed of functionally graded piezoelectric material (FGPM), placed in a uniform magnetic field, subjected to electric, thermal and mechanical loads. For the case that material properties obey an identical power law in the radial direction of the FGPM hollow sphere, exact solutions for electric displacement, stresses, electric potential and perturbation of magnetic field vector in the FGPM hollow sphere are determined by using the infinitesimal theory of electromagnetothermoelasticity. Some useful discussion and numerical examples are presented to show the significant influence of material inhomogeneity. The aim of this research is to understand the effect of composition on electromagnetothermoelastic stresses and to design optimum FGPM hollow spheres.
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Bao Yi-Ni,Dai Wen-Ling,Fan Ji-Fa,Ma Bin,Li Shan-Shan,Zhao Wan-Li,Yu Bo-Yang,Liu Ji-Hua 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Dopamine D1 receptor (D1DR) and D2 receptor (D2DR) are closely associated with pain modulation, but their exact effects on neuropathic pain and the underlying mechanisms remain to be identified. Our research revealed that intrathecal administration of D1DR and D2DR antagonists inhibited D1–D2DR complex formation and ameliorated mechanical and thermal hypersensitivity in chronic constriction injury (CCI) rats. The D1–D2DR complex was formed in the rat spinal cord, and the antinociceptive effects of D1DR and D2DR antagonists could be reversed by D1DR, D2DR, and D1–D2DR agonists. Gαq, PLC, and IP3 inhibitors also alleviated CCI-induced neuropathic pain. D1DR, D2DR, and D1–D2DR complex agonists all increased the intracellular calcium concentration in primary cultured spinal neurons, and this increase could be reversed by D1DR, D2DR antagonists and Gαq, IP3, PLC inhibitors. D1DR and D2DR antagonists significantly reduced the expression of p-PKC γ, p-CaMKII, p-CREB, and p-MAPKs. Levo -corydalmine ( l -CDL), a monomeric compound in Corydalis yanhusuo W.T. Wang, was found to obviously suppress the formation of the spinal D1–D2DR complex to alleviate neuropathic pain in CCI rats and to decrease the intracellular calcium concentration in spinal neurons. l- CDL-induced inhibition of p-PKC γ, p-MAPKs, p-CREB, and p-CaMKII was also reversed by D1DR, D2DR, and D1–D2DR complex agonists. In conclusion, these results indicate that D1DR and D2DR form a complex and in turn couple with the Gαq protein to increase neuronal excitability via PKC γ, CaMKII, MAPK, and CREB signaling in the spinal cords of CCI rats; thus, they may serve as potential drug targets for neuropathic pain therapy.
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Shuixiu Zhou,Jiahuan Xu,Yanfei Dai,Yan Wei,Liang Chen,Wei Feng,Yu Chen,Xuejun Ni 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: As an emerging therapeutic modality, chemodynamic therapy (CDT), converting hydrogen peroxide (H2O2) into highly toxic reactive oxygen species (ROS), has been developed for tumor-specific therapy. However, the deficiency of endogenous H2O2 and high concentration of glutathione (GSH) in the tumor microenvironment (TME) weaken the CDT-based tumor-therapeutic efficacy. Herein, a photothermal-enhanced tumor-specific cascade catalytic nanosystem has been constructed on the basis of glucose oxidase (GOD)-functionalized molybdenum (Mo)-based polyoxometalate (POM) nanoclusters, termed as GOD@POMs. Methods: GOD@POMs were synthesized by a facile one-pot procedure and covalently conjugation. Then, its structure was characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), Fourier transform infrared (FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS). In addition, ultraviolet-visiblenear-infrared (UV-vis-NIR) absorption spectrum and infrared thermal camera were applied to evaluate the catalytic and photothermal performance, respectively. Moreover, to confirm the therapeutic effects in vitro, cell counting kit-8 (CCK-8) assay, live/dead staining and ROS staining were performed. Furthermore, the biosafety of GOD@POMs was investigated via blood routine, blood biochemistry and hematoxylin and eosin (H&E) staining in Kunming mice. Besides, the C6 glioma tumor-bearing mice were constructed to evaluate its anti-tumor effects in vivo and its photoacoustic (PA) imaging capability. Notably, RNA sequencing, H&E, TdT-mediated dUTP nick end labeling (TUNEL) and Ki-67 staining were also conducted to disclose its underlying anti-tumor mechanism. Results: In this multifunctional nanosystem, GOD can effectively catalyze the oxidation of intratumoral glucose into gluconic acid and H2O2, achieving the cancer starvation therapy. Meanwhile, the generated gluconic acid decreases the pH in TME resulting in POM aggregation, which enables PA imaging-guided tumor-specific photothermal therapy (PTT), especially in the second near-infrared (NIR-II) biological window. Importantly, the Mo (VI) sites on POM can be reduced to Mo (V) active sites in accompany with GSH depletion, and then the post-produced Mo (V) transforms in situ overproduced H2O2 into singlet oxygen (1O2) via Russell mechanism, achieving self-enhanced CDT. Moreover, the PTT-triggered local tumor temperature elevation augments the synergistic nanocatalytic-therapeutic efficacy. Conclusions: Consequently, the integration of GOD-induced starvation therapy, H2O2 self-supply/GSH-depletion enhanced Mo-based CDT, and POM aggregation-mediated PTT endow the GOD@POMs with remarkable synergistic anticancer outcomes with neglectable adverse effects.
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