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Da Jeong Shin,Byoung Ok Cho,Jae Young Shin,Ji Hyeon Park,Feng Wang,Suping Hao,Seon Il Jang 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
The conversion of testosterone to dihydrotestosterone play a crucial role in hair baldness. Recent approach showed specific inhibitors for 5a-reductase and androgen receptor promoted hair growth in male pattern alopecia. The purpose of this study was to investigate the in vivo effects of complex extracts from Chrysanthemum zawadskii, Mentha piperita and Glycyrrrhiza glabra (CMG) on hair growth growth by regulating androgen signaling proteins. We investigated the effects of antioxidant activity, Androgen signaling pathway proteins, inflammatory cytokine proteins analysis to determine the hair growth effects. Five-week-old male C57BL/6 mice were used. The mice were divided into the sevene groups: Normal control, Positive control, 100mg/kg CMG, 200mg/kg CMG, 400 mg/kg CMG, pansidil. Each group was orally administrated, once a day, for 14 days. We analyzed hair growth and histological changes. The results revealed that CMG treatment decreased the 5 α-reductase enzyme and androgen receptor protein level in mice. To investigate regulation of the inflammatory cytokine from CMG-treated mice, we conducted western blot analysis. Inflammatory cytokine proteins level in mice treated with CMG was changed in a dose dependent manner. Moreover, CMG treatment increased hair growth score and antioxidant activity in mice. Our in vivo results that CMG treatment showed the increase of hair follicles and hair growth. These results suggest that the CMG promotes hair growth by regulating the inhibition androgen signaling pathway proteins and activation of inflammatory cytokine and antioxidant activity.
Shin, Da Jeong,Yoo, Sung-Je,Hong, Jeum Kyu,Weon, Hang-Yeon,Song, Jaekyeong,Sang, Mee Kyung The Korean Society of Plant Pathology 2019 Plant Pathology Journal Vol.35 No.2
Plants are exposed to biotic stresses caused by pathogen attack and complex abiotic stresses including heat and drought by dynamic climate changes. To alleviate these stresses, we investigated two bacterial stains, H26-2 and H30-3 in two cultivars ('Ryeokkwang' and 'Buram-3-ho') of Chinese cabbage in plastic pots in a greenhouse. We evaluated effects of bacterial strains on plant growth-promotion and mitigation of heat and drought stresses; the role of exopolysaccharides as one of bacterial determinants on alleviating stresses; biocontrol activity against soft rot caused by Pectobacterium carotovorum subsp. carotovorum PCC21. Strains H26-2 and H30-3 significantly increased fresh weights compared to a $MgSO_4$ solution; reduced leaf wilting and promoted recovery after re-watering under heat and drought stresses. Chinese cabbages treated with H26-2 and H30-3 increased leaf abscisic acid (ABA) content and reduced stomatal opening after stresses treatments, in addition, these strains stably colonized and maintained their populations in rhizosphere during heat and drought stresses. As well as tested bacterial cells, exopolysaccharides (EPS) of H30-3 could be one of bacterial determinants for alleviation of tested stresses in Chinese cabbages, however, the effects were different to cultivars of Chinese cabbages. In addition to bacterial activity to abiotic stresses, H30-3 could suppress incidence (%) of soft rot in 'Buram-3-ho'. The tested strains were identified as Bacillus aryabhattai H26-2 and B. siamensis H30-3 based on 16S rRNA gene sequence analysis. Taken together, H26-2 and H30-3 could be candidates for both plant growth promotion and mitigation of heat and drought stresses in Chinese cabbage.
Shin, Da-Yong,Cheon, Kwang-Hee,Song, Eun-Ho,Seong, Yun-Jeong,Park, Ji-Ung,Kim, Hyoun-Ee,Jeong, Seol-Ha Elsevier 2019 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.123 No.-
<P><B>Abstract</B></P> <P>The creation of a moist environment and promotion of cell proliferation and migration together with antibacterial property are critical to the wound-healing process. Alginate (Alg) is an excellent candidate for injectable wound dressing materials because it can form a gel in a mild environment. Taking advantage of its gelation property, an injectable nano composite hydrogel containing nano-sized (about 90 nm) calcium fluoride (CaF<SUB>2</SUB>) particles was developed using <I>in-situ</I> precipitation process. The amount of released fluorine (F<SUP>−</SUP>) ion from the nanocomposite hydrogel increased with increasing CaF<SUB>2</SUB> content inside the composite hydrogel and the ions stimulated both the proliferation and migration of fibroblast cells <I>in vitro</I>. The antibacterial property of the composite hydrogel against <I>E. coli</I> and <I>S. aureus</I> was confirmed through colony formation test where the number of bacterial colonies significantly decreased compared to Alg hydrogel. The <I>in vivo</I> results based on a full-thickness wound model showed that the nanocomposite hydrogel effectively enhanced the deposition of the extracellular matrix compared to that of the Alg hydrogel. This study demonstrates the potential of this nanocomposite hydrogel as a bioactive injectable wound-dressing material with the ability to inhibit bacterial growth and stimulate cell proliferation and migration for accelerated wound healing.</P>
Da Jeong Shin,Sung-Je Yoo,Jeum Kyu Hong,Hang-Yeon Weon,Jaekyeong Song,Mee Kyung Sang 한국식물병리학회 2019 Plant Pathology Journal Vol.35 No.2
Plants are exposed to biotic stresses caused by pathogen attack and complex abiotic stresses including heat and drought by dynamic climate changes. To alleviate these stresses, we investigated two bacterial stains, H26-2 and H30-3 in two cultivars (‘Ryeokkwang’ and ‘Buram-3-ho’) of Chinese cabbage in plastic pots in a greenhouse. We evaluated effects of bacterial strains on plant growth-promotion and mitigation of heat and drought stresses; the role of exopolysaccharides as one of bacterial determinants on alleviating stresses; biocontrol activity against soft rot caused by Pectobacterium carotovorum subsp. carotovorum PCC21. Strains H26-2 and H30-3 significantly increased fresh weights compared to a MgSO4 solution; reduced leaf wilting and promoted recovery after re-watering under heat and drought stresses. Chinese cabbages treated with H26-2 and H30-3 increased leaf abscisic acid (ABA) content and reduced stomatal opening after stresses treatments, in addition, these strains stably colonized and maintained their populations in rhizosphere during heat and drought stresses. As well as tested bacterial cells, exopolysaccharides (EPS) of H30-3 could be one of bacterial determinants for alleviation of tested stresses in Chinese cabbages, however, the effects were different to cultivars of Chinese cabbages. In addition to bacterial activity to abiotic stresses, H30-3 could suppress incidence (%) of soft rot in ‘Buram-3-ho’. The tested strains were identified as Bacillus aryabhattai H26-2 and B. siamensis H30-3 based on 16S rRNA gene sequence analysis. Taken together, H26-2 and H30-3 could be candidates for both plant growth promotion and mitigation of heat and drought stresses in Chinese cabbage.