Sublingual Dexmedetomidine for the Treatment of Agitation in Patients with Schizophrenia and Bipolar Disorder

Colin M. Smith(Colin M. Smith ),Morgan Santalucia(Morgan Santalucia ),Hannah Bunn(Hannah Bunn ),Andrew Muzyk(Andrew Muzyk ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2

Acute agitation is common amongst individuals with bipolar disorder and schizophrenia and represents a medical emergency. Commonly used medications for agitation, such as benzodiazepines and antipsychotics, are often delivered intramuscularly and may cause adverse effects. Non-invasive, effective, and safe alternative treatment options are needed. The purpose of this review article is to describe the efficacy and safety of sublingual formulation of dexmedetomidine (Igalmi), a selective α2-adrenergic receptor agonist, U.S. Food and Drug Administration approved for the treatment of acute agitation in adults with schizophrenia or bipolar I and II disorder. In two phase 3 trials, two dose strengths of sublingual dexmedetomidine 180 μg and 120 μg were safe and effective in managing acute agitation in patients with bipolar disorder or schizophrenia. Both doses significantly reduced Positive and Negative Syndrome Scale-Exited Component scores two hours after receiving a single dose as compared to placebo, indicating a substantial improvement in agitation. The beneficial effects of sublingual dexmedetomidine were achieved without serious adverse events with the most common side effect being mild somnolence. The clinical trial data suggest that sublingual dexmedetomidine represents a safe and effective treatment option in the armamentarium for acute agitation for people with schizophrenia or bipolar disorder.

Where ‘Each Word is Empire’: Margaret Atwood’s Politicised Poetics

Colin Nicholson(Colin Nicholson ) 한국캐나다학회 2009 Asia-Pacific Journal of Canadian Studies (APJCS) Vol.14·15 No.-

When Atwood began writing, feminism in its modern forms had not yet mobilised. Because her sense of politics is lived as a personally involving relationship that will be existentialised, archaeologised, satirised and reconstructed across a range of texts and intertexts, her poetry develops energy and impact on the page by negotiating a political infrastructure felt on the pulse. Atwood’s writing has from the beginning elaborated notions of politically gendered subjectivity marked in performing selves whose seeming privacy articulates public administrations (and suppressions) of experiential possibility. Personal immediacies confront both the pressure of externally determined postcolonial priorities and the difficulty of negotiating already internalised language practices. Atwood’s poetics of resistance to a wide range of assumptions, discourses and histories with which it is inevitably complicit generates political resonance from personalised context. Reading her with and against the social and constitutional contexts described by political scientist Alan Cairns discloses a Canadian subjectivity fascinated with what the record does not say, and with gaps and fissures in the systems of recognition archived as cultural heritage and practiced as customary norms. Canada’s historic and continuing ethnic/ cultural diversity is encoded in work which predates the formal inception of what Cairns calls ‘the new role of the constitution in Canadian society’. In this light, and by expressing an already compromised subjectivity, Atwood devises representational latitude for a coherent, autonomous feminine self.

Canadian Studies: in Canada and abroad

Colin M. Coates(Colin M. Coates ) 한국캐나다학회 2017 Asia-Pacific Journal of Canadian Studies (APJCS) Vol.23 No.2

This paper was written at the request of Prof. Seung Ryul Lee, president of the Korean Association for Canadian Studies. During his time as visiting professor at the Robarts Centre for Canadian Studies at York University, Professor Lee asked me to write about the shape of Canadian Studies in Canada and abroad, and the challenges facing the study of the country. The focus here is on the conditions which led to the rise of Canadian Studies within Canada and outside. In both instances, Canadian Studies projects developed in the context of considerable anti-Americanism, and they shared the goal of encouraging sustained research and teaching on Canadian issues. While the Canadian government supported the endeavors of international scholars from the 1970s to the 2012, current levels of support have decreased substantially. Nonetheless, specialists on Canada outside the country, alongside their colleagues in Canada, continue to contribute to the critical evaluation of Canadian culture, history and social policy. While Canadian Studies is inherently multidisciplinary in Canada, in its international context it is multidisciplinary of necessity.

Dr. Colin Lee 교수 캐나다 음악치료 특강

Dr. Colin Lee,이정실 한국예술치료학회 2002 월례학술발표회 Vol.6 No.-

THE PITFALLS OF EMPLOYMENT TENURE IN JAPAN: A CASE STUDY

( Colin P. A. Jones ),( Hakuya Kido ) 고려대학교 법학연구원 2022 The Asian Business Lawyer Vol.29 No.-

Executive summary: this article will use a recent Japanese court case to illustrate the pitfalls of employment tenure within the larger context of employment regulation in Japan.

The Potential of Biochar for Carbon Sequestration: The UK Demonstrator Programme

Colin E. Snape 한국신재생에너지학회 2021 AFORE Vol.2021 No.10

海洋戰略과 太平洋

Colin S. Gray,문봉근 해군대학 1987 海洋戰略 Vol.- No.49

Xunzi’s Ritual Program as a Response to Han Feizi’s Criticism of Confucianism

( Colin J. Lewis ) 성균관대학교 유교문화연구소 2020 儒敎文化硏究(中文版) Vol.0 No.34

One of Han Feizi’s most subtle criticisms of Confucianism targets a central feature of its moral cultivation program, namely an appeal to modelling oneself on ancient sages. According to Han Feizi, this ideal of model emulation is doomed to failure due to imperfect knowledge of past exemplars, the fact that certain ideals of practice may not be applicable to (or catastrophic for) some practitioners, and the additional fact that one cannot always rely on past examples to provide good guidance for future events. As Eric Hutton points out, this line of critique bears striking similarities to one offered by Bernard Williams against virtue ethics. Accordingly, this emulation problem poses difficulties not only for Confucianism, but also more generally for virtue ethics. This paper argues that the emulation problem can be overcome by appealing to the Confucian Xunzi’s account of the role of ritual (li) in moral cultivation. Specifically, the ways in which ritual promotes moral development provide the Confucians (and, by association, virtue ethics) with the means of devising a sufficiently sophisticated account of emulation to meet the challenge lobbied by Han Feizi and Williams.

Evaluation of Intrinsic Bioremediation of Methyl Tert-butyl Ether (MTBE) Contaminated Groundwater

Colin S. Chen,Chien-Jun Tien,Kai-Van Zhan 한국지하수토양환경학회 2014 지하수토양환경 Vol.19 No.5

This paper reported the use of real-time polymerase chain reaction (PCR), denaturing gradient gel electrophoresis(DGGE), and the culture-based method in the intrinsic bioremediation study at a petroleum contaminated site. The studyshowed that phenol hydroxylase gene was detected in groundwater contaminated with benzene, toluene, ethylbenzene,xylene isomers (BTEX) and methyl tert-butyl ether (MTBE). This indicated that intrinsic bioremediation occurred at thesite. DGGE analyses revealed that the petroleum-hydrocarbon plume caused the variation in microbial communities. MTBE degraders including Pseudomonas sp. NKNU01, Bacillus sp. NKNU01, Klebsiella sp. NKNU01, Enterobacter sp. NKNU01, and Enterobacter sp. NKNU02 were isolated from the contaminated groundwater using the cultured-basedmethod. Among these five strains, Enterobacter sp. NKNU02 is the most effective stain at degrading MTBE without theaddition of pentane. The MTBE biodegradation experiment indicated that the isolated bacteria were affected by propane. Biodegradation of MTBE was decreased but not totally inhibited in the mixtures of BTEX. Enterobacter sp. NKNU02degraded about 60% of MTBE in the bioreactor study. Tert-butyl alcohol (TBA), acetic acid, 2-propanol, and propenoicacid were detected using gas chromatography/mass spectrometry during MTBE degraded by the rest cells of Enterobactersp. NKNU02. The effectiveness of bioremediation of MTBE was assessed for potential field-scale application.

Integration of Palliative Care in the Hospital Setting

Colin Wozencraft,Rodney O. Tucker,Stephen Howell 한국호스피스완화의료학회 2012 한국호스피스.완화의료학회지 Vol.15 No.4

Palliative medicine has shown demonstrated benefit for patients with serious illness, their families, and hospital systems. As such, the demand for palliative care services is growing at a fast pace, and health care facilities frequently struggle to develop and implement effective and sustainable methods of providing this care. As with any new system, challenges and barriers naturally exist to instituting palliative care. Undertaking careful assessment, planning, and resource allocation can provide the greatest likelihood of success when developing these novel yet much needed models of care. This summary paper offers a qualitative overview of the potential benefits and the rationale to implement robust palliative care systems. We briefly review the history of palliative medicine in the broadest sense and address several seminal works from the US palliative care literature. Core practices to establish and advance palliative medicine are suggested. Commentary is provided on some of the particular barriers to palliative system development that may need to be addressed in the context of Korean medical culture. Collectively, we hope this overview can contribute to a framework within which such research and development can occur, leading to increasingly effective and sustainable palliative medicine in Korea.