http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Chung, Sung Yun,Kim, Sunyoung,Lee, Ju‐,Hyuck,Kim, Kyongjun,Kim, Sang‐,Woo,Kang, Chong‐,Yun,Yoon, Seok‐,Jin,Kim, Youn Sang WILEY‐VCH Verlag 2012 ADVANCED MATERIALS Vol.24 No.45
<P>An all‐solution‐processed flexible piezoelectric nanogenerator, composed of polycrystalline ZnO thin film and functional polymer layers such as P3HT/PCBM and PEDOT:PSS, generates energy through a mechanical rolling and muscle stretching system. On page 6022, Youn Sang Kim, Sang‐Woo Kim, and co‐workers show that this all‐solution‐processed nanogenerator is feasible as a piezoelectric patchable device and is promising for use in future energy harvesters such as wearable human patches and mobile electronics. </P>
( Yun Bin Lee ),( Hyue Mee Kim ),( Sung Won Chung ),( Minseok Albert Kim ),( Sun Woong Kim ),( Jun Sik Yoon ),( Hyo Young Lee ),( Young Chang ),( Eun Ju Cho ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung- H 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Liver cirrhosis is known to decrease the cardiac performance. However, it is unclear whether this change is related to the change in myocardial muscle itself, or is a secondary functional phenomenon. In this study, we aimed to characterize myocardial tissue using cardiovascular magnetic resonance (CMR) imaging in cirrhotic patients. Methods: Thirty-five patients with cirrhosis who were listed for liver transplantation and 20 normal healthy controls were prospectively enrolled. All included subjects underwent conventional echocardiography, speckle-tracking echocardiography, and CMR imaging with T1 mapping and late gadolinium enhancement. Native T1 and extracellular volume (ECV) were measured for assessing myocardial fibrosis. Echocardiography and CMR imaging were performed at just before and 1 year after liver transplantation. Results: Both echocardiography and CMR imaging demonstrated hyperdynamic left ventricular (LV) function in cirrhotic patients. There were no significant differences in LV size, LV wall thickness, LV mass index, E/A ratio, and deceleration time between cirrhotic patients and non-cirrhotic healthy controls (all P>0.1). However, cirrhotic patients showed significantly higher values of native T1 (1230.1±79.0 vs 1173.3±34.7, P=0.001) (Table 1 and Figure 1A) and ECV (31.4±4.9 vs 25.4±1.9, P<0.001) (Table 1 and Figure 1B) compared to non-cirrhotic controls. Specifically, ECV had a significant correlation with Child-Pugh class (26.2±3.4 in Child class A or B vs 33.2±4.3 in Child class C; P=0.001). At 1 year after liver transplantation, native T1 (from 1224.0±55.7 to 1155.8±77.0, P=0.010) and ECV (from 30.9±3.6 to 25.2±2.6, P<0.001) values significantly decreased, but there was no difference in other parameters regarding LV function and LV size. Conclusions: Decreased cardiac performance in cirrhotic patients may result from myocardial change reflected by the increase in native T1 and ECV values, which was normalized after liver transplantation. Native T1 and ECV values of CMR imaging could be more straightforward diagnostic indices for cirrhotic cardiomyopathy.
Upregulation of P21-Activated Kinase 1 (PAK1)/CREB Axis in Squamous Non-Small Cell Lung Carcinoma
Chung, Jae Heun,Kim, Dae Hyun,Kim, Yun Seong,Son, Bong Soo,Kim, Dohyung,Hwang, Chungsu,Shin, Donghoon,Noh, Sang Gyun,Han, Jun Hee,Kim, Dae Kyung,Kim, Jae Ho,Koo, Ja Seok,Chung, Hae Young,Yoon, Seong H S. Karger AG 2018 CELLULAR PHYSIOLOGY AND BIOCHEMISTRY Vol.50 No.1
<P><B><I>Background/Aims:</I></B> p21-activated Ser/Thr kinase 1 (PAK1) is essential for the genesis and development of many cancers. The purpose of this study was to investigate the role of the PAK1–cyclic AMP response element-binding (CREB) axis in non-small cell lung cancer (NSCLC) tumorigenesis and its related mechanisms. <B><I>Methods:</I></B> Western blot assay and immunohistochemical staining were employed to investigate the PAK1 and CREB expression in the tissue microarray of human squamous NSCLC. Co-immunoprecipitation and immunofluorescence confocal assays were performed to determine the link between PAK1 and CREB. NSCLC xenograft models were used to study oncogenic function of PAK1 <I>in vivo</I>. <B><I>Results:</I></B> We observed that PAK1 and CREB expression levels were significantly elevated in human squamous NSCLC-tissue specimens, compared with those in adjacent normal bronchial or bronchiolar epithelial-tissue specimens, as well as their phosphorylated forms, based on western blotting. We showed <I>in vitro</I> that <I>PAK1</I> knockdown by small-interfering RNA (siRNA) blocked CREB phosphorylation, whereas plasmid-based PAK1 overexpression resulted in CREB phosphorylation at Ser133, based on western blotting. In addition, PAK1 interacted with CREB in co-immunoprecipitation assays. Additionally, our <I>in vitro</I> findings detected by flow cytometry revealed that PAK1 silencing attenuated cell cycle progression, inducing apoptosis. Inhibition of PAK1 expression reduced tumor sizes and masses by modulating CREB expression and activation in xenograft models. <B><I>Conclusion:</I></B> These results suggest a novel mechanism whereby the PAK1–CREB axis drives carcinogenesis of squamous-cell carcinomas, and have important implications in the development of targeted therapeutics for squamous-cell lung cancer.</P>
Chung, Yun Shin,Kim, Hye Joung,Kim, Tae-Min,Hong, Sung-Hyun,Kwon, Kyung-Rim,An, Sungwhan,Park, Jung-Hoon,Lee, Suman,Oh, Il-Hoan American Society of Hematology 2009 Blood Vol.114 No.24
<B>Abstract</B><P>Evidence for the epigenetic regulation of hematopoietic stem cells (HSCs) is growing, but the genome-wide epigenetic signature of HSCs and its functional significance remain unclear. In this study, from a genome-wide comparison of CpG methylation in human CD34+ and CD34− cells, we identified a characteristic undermethylation dip around the transcription start site of promoters and an overmethylation of flanking regions in undifferentiated CD34+ cells. This “bivalent-like” CpG methylation pattern around the transcription start site was more prominent in genes not associated with CpG islands (CGI−) than CGI+ genes. Undifferentiated hematopoietic cells also exhibited dynamic chromatin associated with active transcription and a higher turnover of histone acetylation than terminally differentiated cells. Interestingly, inhibition of chromatin condensation by chemical treatment (5-azacytidine, trichostatin A) enhanced the self-renewal of “stimulated” HSCs in reconstituting bone marrows but not “steady-state” HSCs in stationary phase bone marrows. In contrast, similar treatments on more mature cells caused partial phenotypic dedifferentiation and apoptosis at levels correlated with their hematopoietic differentiation. Taken together, our study reveals that the undifferentiated state of hematopoietic cells is characterized by a unique epigenetic signature, which includes dynamic chromatin structures and an epigenetic plasticity that correlates to level of undifferentiation.</P>
F-18 FDG PET Scan Findings in Patients With Loeffler’s Syndrome
Chung, Soo Yoon,Lee, Jae Hoon,Kim, Tae Hoon,Yun, Mijin,Kim, Tae Sung,Kim, Sang Jin,Kim, Hyung Joong,Pai, Moonsun,Lee, Jong Doo,Ryu, Young Hoon Lippincott Williams Wilkins, Inc. 2009 Clinical nuclear medicine Vol.34 No.9
PURPOSE:: This study aimed to evaluate the F-2-fluoro-2-deoxyglucose positron emission tomography (F-18 FDG PET) findings of Loeffler’s syndrome and to determine differential features between lung malignancy and Loeffler’s syndrome. MATERIALS AND METHODS:: F-18 FDG PET and low-dose chest CT scans were performed to screen for lung cancer. Eleven patients who showed pulmonary lesions on CT scan with peripheral blood eosinophilia were included. PET scans were evaluated by mean and maximum standardized uptake values (SUVs) of abnormalities. CT findings were reviewed and correlated with the PET findings. In all patients, follow-up CT scans and PET scans were done from 1 to 4 weeks after the initial study. RESULTS:: F-18 FDG PET scans identified metabolically active lesions in 9 of 11 patients. Maximum SUVs ranged from 2.8 to 10.6, and mean SUVs ranged from 2.2 to 7.2. The other 2 patients had maximum SUVs of 1.3 and 2.2. Follow-up PET scans showed a decreased degree of initially noted FDG uptakes or migration of the lesion. The CT scan showed nodular lesions with a peripheral halo (n = 6), ground-glass attenuation (n = 4), and consolidation (n = 1). Follow-up CT scans revealed decreased size and extent of the initial lesions in 7 patients and migration in 2 patients. The other 2, who had relatively mild F-18 FDG uptakes, showed complete radiographic resolution of the lesions. CONCLUSIONS:: A single F-18 FDG PET study is not useful in differentiating benign and malignancy in patients with Loeffler’s syndrome. Correlation and follow-up of PET and CT scan for the identification of abnormalities and their changes can be helpful for the differentiation between lung malignancy and Loeffler’s syndrome.