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Sun-Ho Kwon,Yea-Il Joo,Seon Hahn Kim,Dae Ho Lee,Jeong-Heum Baek,Soon Sup Chung,Ji-Yeon Shin,Chang Soo Eun,Nam Kyu Kim 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.101 No.3
Purpose: Under the South Korea’s unique health insurance structure, any new surgical technology must be evaluated first by the government in order to consider whether that particular technology can be applied to patients for further clinical trials as categorized as ‘New Health Technology,’ then potentially covered by the insurance sometime later. The aim of this meta-analysis was to assess the safety and efficacy of transanal total mesorectal excision (TaTME) for rectal cancer, activated by the National Evidence-based Healthcare Collaborating Agency (NECA) TaTME committee. Methods: We systematically searched Ovid-MEDLINE, Ovid-Embase, Cochrane, and Korean databases (from their inception until August 31, 2019) for studies published that compare TaTME with laparoscopic total mesorectal excision (LaTME). End-points included perioperative and pathological outcomes. Results: Sixteen cohort studies (7 for case-matched studies) were identified, comprising 1,923 patients (938 TaTMEs and 985 LaTMEs). Regarding perioperative outcomes, the conversion rate was significantly lower in TaTME (risk ratio, 0.19; 95% confidence interval, 0.11–0.34; P < 0.001); whereas other perioperative outcomes were similar to LaTME. There were no statistically significant differences in pathological results between the 2 procedures. Conclusion: Our meta-analysis showed comparable results in preoperative and pathologic outcomes between TaTME and LaTME, and indicated the benefit of TaTME with low conversion. Extensive evaluations of well-designed, multicenter randomized controlled trials are required to come to unequivocal conclusions, but the results showed that TaTME is a potentially beneficial technique in some specific cases. This meta-analysis suggests that TaTME can be performed for rectal cancer patients as a ‘New Health Technology’ endorsed by NECA in South Korea.
Presence of the Raf-1 Responsive Element in Human MDR1 Promoter
CHUNG,Byung Seon,KIM,Dong Wan,HEO, Kyeong,KANG, Chi Dug,KIM,Sun Hee,TUNG, Yea Yzu 國立昌原大學校 基礎科學硏究所 1994 基礎科學硏究所論文集 Vol.6 No.-
We have shown that CV-1 cells transfected with the activated c-raf-1 cDNA, designated CV-1/raf, acquired a multidrug resistance (MDR) phenotype and revealed a correspondingly greater expression of MDR1 gene. Addition of H-87, a specific protein kinase A inhibitor, could overcome the acquired MDR in CV-1/raf cells and inhibited the increased activity by the expression of c-raf-1 gene of MDR1 promoter in a dose-dependent manner in chloramphenicol acetyltransferase assay. To analyze more precisely the location of functionally significant sequence for activation of MDR1 gene by c-raf-1 expression, deletion constructs with various lengths of MDR1 promoter were introduced into GHE-L cells. Our result demonstrated that DNA sequence exhibiting maximum activation of MDR1 promoter by c-raf-1 expression was located between-198 and-132 from the initiation site of MDR1 promoter and this DNA sequence is associated with the upstream heat shock element of MDR1 promoter.
( Jee Yea Choi ),( Joonkyung Kim ),( Min Ju Jo ),( Sung Jun Chung ),( Yoomi Yeo ),( Tai Sun Park ),( Dong Won Park ),( Ji-yong Moon ),( Sang-heon Kim ),( Tae Hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoo 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Most posterior mediastinal malignancies in adults are of neurogenic origin. Accordingly, metastatic posterior mediastinal tumors are very rare. We report a case where a metastatic endometrial cancer developed in the posterior mediastinum and compress the lower trachea and both main bronchi. A 71-year-old woman who had received concurrent chemoradiation for stage IV endometrial cancer 13 years ago was admitted for progressive dyspnea. A 10 cm-sized posterior mediastinal tumor compressing the lower trachea and both main bronchi was found on the chest computed tomography. Positron tomography showed no metastasis to organs other than the posterior mediastinum. For pathologic confirmation, we performed bronchoscopy and EBUS-TBNA. After the procedure, the patient developed respiratory failure and received mechanical ventilation. The patient was diagnosed with metastatic endometrial adenocarcinoma based on pathologic findings (positive for p16 and TTF-1). She received concurrent chemoradiotherapy to treat metastatic endometrial cancer compressing the airways while receiving mechanical ventilator treatment. Thereafter, the patient can be successfully weaned from the ventilator. To the best of our knowledge, this is the first case in which previous endometrial cancer recurred as a posterior mediastinal tumor without the involvement of other abdominal organs or lungs. Although it is very rare, clinicians should be aware that metastatic cancer can manifest as a single posterior mediastinal tumor and can cause respiratory failure by compressing large airways.
Kong, Jin-Sun,Yoo, Seung-Ah,Kim, Hyun-Sook,Kim, Hyun Ah,Yea, Kyungmoo,Ryu, Sung-Ho,Chung, Yeun-Jun,Cho, Chul-Soo,Kim, Wan-Uk Wiley Subscription Services, Inc., A Wiley Company 2010 Vol.62 No.1
<B>Objective</B><P>To investigate whether sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables such as broccoli, regulates synoviocyte hyperplasia and T cell activation in rheumatoid arthritis (RA).</P><B>Methods</B><P>Synoviocyte survival was assessed by MTT assay. The levels of Bcl-2, Bax, p53, and pAkt were determined by Western blot analysis. Cytokine concentrations in culture supernatants from mononuclear cells were analyzed by enzyme-linked immunosorbent assay. The in vivo effects of SFN were examined in mice with experimentally induced arthritis.</P><B>Results</B><P>SFN induced synoviocyte apoptosis by modulating the expression of Bcl-2/Bax, p53, and pAkt. In addition, nonapoptotic doses of SFN inhibited T cell proliferation and the production of interleukin-17 (IL-17) and tumor necrosis factor α (TNFα) by RA CD4+ T cells stimulated with anti-CD3 antibody. Anti-CD3 antibody–induced increases in the expression of retinoic acid–related orphan receptor γt and T-bet were also repressed by SFN. Moreover, the intraperitoneal administration of SFN to mice suppressed the clinical severity of arthritis induced by injection of type II collagen (CII), the anti-CII antibody levels, and the T cell responses to CII. The production of IL-17, TNFα, IL-6, and interferon-γ by lymph node cells and spleen cells from these mice was markedly reduced by treatment with SFN. Anti-CII antibody–induced arthritis in mice was also alleviated by SFN injection.</P><B>Conclusion</B><P>SFN was found to inhibit synovial hyperplasia, activated T cell proliferation, and the production of IL-17 and TNFα by rheumatoid T cells in vitro. The antiarthritic and immune regulatory effects of SFN, which were confirmed in vivo, suggest that SFN may offer a possible treatment option for RA.</P>
( Joonkyung Kim ),( Jee Yea Choi ),( Min Ju Jo ),( Sung Jun Chung ),( Yoomi Yeo ),( Hyun Lee ),( Tai Sun Park ),( Dong Won Park ),( Ji-yong Moon ),( Sang-heon Kim ),( Tae-hyung Kim ),( Jang Won Sohn ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Cough is frequently caused by drugs. However, little is known about the epidemiology and causative drugs leading to cough. We analyzed causative drugs and clinical features of drug-induced cough based on 10-year real-world data. Methods We used the database of the Korea Adverse Events Reporting System (KAERS) from January 2009 to December 2018. Cases of drug-induced cough were identified by selecting cases with a cough code of WHO-Adverse Response Terminology without any other adverse events. Causative drugs were compared between acute (<3 weeks) and delayed onset (≥3 weeks). Results In the study period of 10 years, there were 3,021 cases of drug-induced cough. Cough was most frequently caused by cardiovascular drugs (43.8%), followed by respiratory system drugs (14.9 %), including angiotensin-converting enzyme (ACE) inhibitors, antineoplastic and immune-modulating drugs (14.4 %), and anti-infective drug (8.3 %). In acute onset cough, perindopril, docetaxel, ramipril, paclitaxel, and acetylcysteine were found to be frequent causes, while delayed onset cough was commonly caused by perindopril, ramipril, indacaterol, captopril, and imidapril. Conclusion In this analysis of real-world data from a nationwide spontaneous reporting system, various drugs were found to cause cough, while cardiovascular drugs including ACE inhibitors were the most common cause. [This study was funded by the Korea Ministry of Environment (MOE) as ‘‘the Environmental Health Action Program (2016001360003)" and a research grant from the Korea Institute of Drug Safety & Risk Management].